Extremely Low Serum Alanine Transaminase Level Is Associated with All-Cause Mortality in the Elderly after Intracranial Hemorrhage

Abstract Background Although a U-shaped association between sleep duration and all-cause mortality has been found in general population, its association in the elderly adults, especially in the oldest-old, is rarely explored. Methods In present cohort study, we prospectively explore the association between sleep duration and all-cause mortality among 15,092 participants enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2005 to 2019. Sleep duration and death information was collected by using structured questionnaires. Cox regression model with sleep duration as a time-varying exposure was performed to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). The dose-response association between them was explored via a restricted cubic spline function. Results During an average follow-up of 4.51 (standard deviation, SD: 3.62) years, 10,768 participants died during the follow-up period. The mean (SD) age of the participants was 89.26 (11.56) years old. Compared to individuals with moderate sleep duration (7–8 hours), individuals with long sleep duration (> 8 hours) had a significantly higher risk of all-cause mortality (HR: 1.13, 95%CI: 1.09–1.18), but not among individuals with short sleep duration (≤ 6 hours) (HR: 1.02, 95%CI: 0.96–1.09). Similar results were observed in subgroup analyses based on age and gender. In the dose-response analysis, a J-shaped association was observed. Conclusions Sleep duration was associated with all-cause mortality in a J-shaped pattern in the elderly population in China.

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Abstract 13944: J Relationship of Body Mass Index of 22-year Cardiovascular Disease Mortality versus Body Mass Index

Circulation ◽

10.1161/circ.132.suppl_3.13944 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

William J Kostis ◽

Javier Cabrera ◽

Fei Wang ◽

Sara J Guterl ◽

Dhammika Amaratunga ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Body Mass ◽

Systolic Hypertension ◽

Female Gender ◽

The Elderly ◽

Linear Term ◽

Quadratic Term ◽

All Cause Mortality ◽

Cv Disease

Introduction: J relationships of body mass index (BMI) with mortality have been described. However, little data are available on long-term follow-up in controlled clinical trials with respect to cardiovascular (CV) and all cause mortality. Hypothesis: We tested whether there is a J shape relationship between BMI with CV and all cause mortality at 22 years in the Systolic Hypertension in the Elderly Program (SHEP). Methods: SHEP was a placebo controlled, randomized clinical trial of antihypertensive therapy in patients with isolated systolic hypertension aged 60 and older. The relationship between CV and all cause mortality with baseline BMI was examined in 4,211 SHEP participants. Results: In unadjusted analyses, a J relationship was observed for all-cause mortality (linear term p=0.0318, quadratic term p=0.3217 and tricubic term p=0.0046) and for CV mortality (linear term p=0.0962, quadratic term p=0.6866 and tricubic term p=0.0908, left figure). The lowest risk was at a BMI of 25.9 for all-cause and 25.5 for CV mortality. The J shaped relationship between BMI and mortality was attenuated after adjustment for age, gender, comorbidities (e.g. diabetes, heart failure) and risk factors for CV disease (e.g. smoking and dyslipidemia, right figure). Age and gender were significant predictors of both all- cause and CV mortality: age p<0.0001, female gender p=0.0063 for all-cause mortality and p<0.0001 for age and p=0.0004 for female gender for CV mortality. <br/Conclusions: This study indicates that both very low and very high BMI are markers of high risk. The J relationship between BMI and mortality is mediated by age, female gender, comorbidities and risk factors for CV disease.

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The associations of dietary patterns with all-cause mortality and other lifestyle factors in the elderly: An age-specific prospective cohort study

Clinical Nutrition ◽

10.1016/j.clnu.2018.01.018 ◽

2019 ◽

Vol 38 (1) ◽

pp. 288-296 ◽

Cited By ~ 4

Author(s):

Wenjing Zhao ◽

Shigekazu Ukawa ◽

Emiko Okada ◽

Kenji Wakai ◽

Takashi Kawamura ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Dietary Patterns ◽

Prospective Cohort ◽

The Elderly ◽

Lifestyle Factors ◽

All Cause Mortality

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Pretreatment alanine transaminase level may not be the most important predictor of HBeAg loss in the older patient

Liver International ◽

10.1111/j.1478-3231.2008.01815.x ◽

2009 ◽

Vol 29 (2) ◽

pp. 231-236 ◽

Cited By ~ 2

Author(s):

Jung Il Lee ◽

Hyun Joo Park ◽

Jin Woo Lee ◽

Young Soo Kim ◽

Seok Jeong ◽

...

Keyword(s):

Transaminase Level ◽

Alanine Transaminase ◽

Important Predictor ◽

Older Patient ◽

Hbeag Loss

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Independent predictors of depressive symptoms and social isolation on two-year all-cause mortality among the elderly in a population-based cohort study: gender differences

Epidemiology and Health ◽

10.4178/epih.e2022012 ◽

2022 ◽

pp. e2022012

Author(s):

Hyunsuk Jeong ◽

Hyeon Woo Yim ◽

Beom-Woo Nam

Keyword(s):

Gender Differences ◽

Cohort Study ◽

Depressive Symptoms ◽

Social Isolation ◽

The Elderly ◽

Population Based ◽

All Cause Mortality

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Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfp470 ◽

2009 ◽

Vol 25 (2) ◽

pp. 503-509 ◽

Cited By ~ 37

Author(s):

J. Almirall ◽

M. Vaqueiro ◽

M. L. Bare ◽

E. Anton

Keyword(s):

Blood Pressure ◽

Arterial Blood Pressure ◽

The Elderly ◽

Hydroxyvitamin D ◽

Arterial Blood ◽

25 Hydroxyvitamin D ◽

Low Serum

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Effectiveness of Androgen-Deprivation Therapy and Radiotherapy for Older Men With Locally Advanced Prostate Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2014.57.2743 ◽

2015 ◽

Vol 33 (7) ◽

pp. 716-722 ◽

Cited By ~ 48

Author(s):

Justin E. Bekelman ◽

Nandita Mitra ◽

Elizabeth A. Handorf ◽

Robert G. Uzzo ◽

Stephen A. Hahn ◽

...

Keyword(s):

Prostate Cancer ◽

Propensity Score ◽

Advanced Prostate Cancer ◽

Randomized Trials ◽

Locally Advanced ◽

The Elderly ◽

Locally Advanced Prostate Cancer ◽

High Risk Prostate Cancer ◽

All Cause Mortality ◽

Risk Prostate Cancer

Purpose We examined whether the survival advantage of androgen-deprivation therapy with radiotherapy (ADT plus RT) relative to ADT alone for men with locally advanced prostate cancer reported in two randomized trials holds in real-world clinical practice and extended the evidence to patients poorly represented in the trials. Methods We conducted nonrandomized effectiveness studies of ADT plus RT versus ADT in three groups of patients diagnosed between 1995 and 2007 and observed through 2009 in the SEER-Medicare data set: (1) the randomized clinical trial (RCT) cohort, which included men age 65 to 75 years and was most consistent with participants in the randomized trials; (2) the elderly cohort, which included men age > 75 years with locally advanced prostate cancer; and (3) the screen-detected cohort, which included men age ≥ 65 years with screen-detected high-risk prostate cancer. We evaluated cause-specific and all-cause mortality using propensity score, instrumental variable (IV), and sensitivity analyses. Results In the RCT cohort, ADT plus RT was associated with reduced cause-specific and all-cause mortality relative to ADT alone (cause-specific propensity score–adjusted hazard ratio [HR], 0.43; 95% CI, 0.37 to 0.49; all-cause propensity score–adjusted HR, 0.63; 95% CI, 0.59 to 0.67). Effectiveness estimates for the RCT cohort were not significantly different from those from randomized trials (P > .1). In the elderly and screen-detected cohorts, ADT plus RT was also associated with reduced cause-specific and all-cause mortality. IV analyses produced estimates similar to those from propensity score–adjusted methods. Conclusion Older men with locally advanced or screen-detected high-risk prostate cancer who receive ADT alone risk decrements in cause-specific and overall survival.

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Significant spike in excess mortality in England in winter 2014/15 – influenza the likely culprit

Epidemiology and Infection ◽

10.1017/s0950268818001152 ◽

2018 ◽

Vol 146 (9) ◽

pp. 1106-1113 ◽

Cited By ~ 13

Author(s):

R. G. Pebody ◽

H. K. Green ◽

F. Warburton ◽

M. Sinnathamby ◽

J. Ellis ◽

...

Keyword(s):

Poisson Regression ◽

Influenza A ◽

Excess Mortality ◽

Extreme Temperature ◽

The Elderly ◽

Health Impact ◽

Poisson Regression Model ◽

Potential Health ◽

All Cause Mortality

AbstractSignificant increases in excess all-cause mortality, particularly in the elderly, were observed during the winter of 2014/15 in England. With influenza A(H3N2) the dominant circulating influenza A subtype, this paper determines the contribution of influenza to this excess controlling for weather. A standardised multivariable Poisson regression model was employed with weekly all-cause deaths the dependent variable for the period 2008–2015. Adjusting for extreme temperature, a total of 26 542 (95% CI 25 301–27 804) deaths in 65+ and 1942 (95% CI 1834–2052) in 15–64-year-olds were associated with influenza from week 40, 2014 to week 20, 2015. This is compatible with the circulation of influenza A(H3N2). It is the largest estimated number of influenza-related deaths in England since prior to 2008/09. The findings highlight the potential health impact of influenza and the important role of the annual influenza vaccination programme that is required to protect the population including the elderly, who are vulnerable to a severe outcome.

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Glucose variability and the risks of stroke, myocardial infarction, and all-cause mortality in individuals with diabetes: retrospective cohort study

Cardiovascular Diabetology ◽

10.1186/s12933-020-01134-0 ◽

2020 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Da Young Lee ◽

Kyungdo Han ◽

Sanghyun Park ◽

Ji Hee Yu ◽

Ji A. Seo ◽

...

Keyword(s):

Myocardial Infarction ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

The Elderly ◽

Glucose Variability ◽

All Cause Mortality ◽

Nationwide Observational Study ◽

The Impact

Abstract Background Previous research regarding long-term glucose variability over several years which is an emerging indicator of glycemic control in diabetes showed several limitations. We investigated whether variability in long-term fasting plasma glucose (FG) can predict the development of stroke, myocardial infarction (MI), and all-cause mortality in patients with diabetes. Methods This is a retrospective cohort study using the data provided by the Korean National Health Insurance Corporation. A total of 624,237 Koreans ≥ 20 years old with diabetes who had undergone health examinations at least twice from 2005 to 2008 and simultaneously more than once from 2009 to 2010 (baseline) without previous histories of stroke or MI. As a parameter of variability of FG, variability independent of mean (VIM) was calculated using FG levels measured at least three times during the 5 years until the baseline. Study endpoints were incident stroke, MI, and all-cause mortality through December 31, 2017. Results During follow-up, 25,038 cases of stroke, 15,832 cases of MI, and 44,716 deaths were identified. As the quartile of FG VIM increased, the risk of clinical outcomes serially increased after adjustment for confounding factors including duration and medications of diabetes and the mean FG. Adjusted hazard ratios (95% confidence intervals) of FG VIM quartile 4 compared with quartile 1 were 1.20 (1.16–1.24), 1.20 (1.15–1.25), and 1.32 (1.29–1.36) for stroke, MI and all-cause mortality, respectively. The impact of FG variability was higher in the elderly and those with a longer duration of diabetes and lower FG levels. Conclusions In diabetes, long-term glucose variability showed a dose–response relationship with the risk of stroke, MI, and all-cause mortality in this nationwide observational study.

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Efficacy of statin treatment based on cardiovascular outcomes in elderly patients: a standard meta-analysis and Bayesian network analysis

Journal of International Medical Research ◽

10.1177/0300060520926349 ◽

2020 ◽

Vol 48 (6) ◽

pp. 030006052092634 ◽

Cited By ~ 2

Author(s):

Chuannan Zhai ◽

Kai Hou ◽

Rui Li ◽

YueCheng Hu ◽

JingXia Zhang ◽

...

Keyword(s):

Secondary Prevention ◽

Cardiovascular Mortality ◽

Cardiovascular Events ◽

Meta Analysis ◽

The Elderly ◽

Statin Treatment ◽

Comparative Effect ◽

Randomized Controlled ◽

All Cause Mortality ◽

Central Database

Objective Statins have been shown to be beneficial for the prevention of cardiovascular events. In elderly individuals, the efficacy of statins remains controversial and the comparative effect of statins has not been assessed. Methods MEDLINE, Embase, and the Cochrane Central database were searched for randomized controlled trials that assessed statins in older patients. Results Seventeen trials were analyzed. When used for secondary prevention, statins were associated with reduced risk of cardiovascular events, all-cause mortality, cardiovascular mortality, revascularization, and stroke. When used for primary prevention, statins reduced the risk of myocardial infarction and revascularization, but did not significantly affect other outcomes. A modest difference between pharmaceutical statin products was found, and high-quality evidence indicated that intensive atorvastatin had the greatest benefits for secondary prevention. Conclusions In secondary prevention, evidence strongly suggests that statins are associated with a reduction in the risk of all-cause mortality, cardiovascular events, cardiovascular mortality, and revascularization. However, differences in the effects of various statins do not appear to have significant effects on therapy in secondary prevention for the elderly.

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