scholarly journals A Case of Laryngeal Mucosa Associated Lymphoid Tissue Lymphoma Mimicking Laryngeal Amyloidosis

2021 ◽  
Vol 64 (9) ◽  
pp. 669-673
Author(s):  
Min Woo Kim ◽  
Min Young Kwak ◽  
Jun Yong Choi ◽  
Dong Sik Chang
Keyword(s):  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Final Diagnosis ◽  
Accurate Diagnosis ◽  
Recent Experience ◽  
Voice Change ◽  
Laryngeal Mucosa ◽  
Laryngeal Amyloidosis ◽  
Initial Biopsy ◽  
Malignant Changes

Laryngeal amyloidosis is a rare disorder characterized by localized amyloid deposition and carries an excellent prognosis. On the other hand, mucosa associated lymphoid tissue (MALT) lymphoma is the most common type of marginal zone lymphoma. MALT lymphoma has a poorer prognosis compared to laryngeal amyloidosis due to more frequent local recurrence, distant metastasis and malignant changes. Despite the differences, as both are found in the form of benign mass and have slow progression, accurate diagnosis is necessary. This report deals with the case of a patient with voice change accompanied by a mass, in which the initial biopsy did not include enough specimen for an accurate diagnosis. However, in the second attempt, an adequate sample was obtained, hence the final diagnosis of laryngeal MALT lymphoma. Based on our recent experience and a review of related literature, we report a case of laryngeal MALT lymphoma mimicking laryngeal amyloidosis.

scholarly journals 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Findings in Mucosa-Associated Lymphoid Tissue Lymphoma of the Larynx: A Case Report and Literature Review

2012 ◽  
Vol 40 (3) ◽  
pp. 1192-1206 ◽  
Author(s):  
K Zhao ◽  
Y-Z Luo ◽  
S-H Zhou ◽  
B-L Dai ◽  
X-M Luo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Immunohistochemical Analysis ◽  
Emission Tomography ◽  
Positron Emission ◽  
Laryngeal Mucosa ◽  
Pet Ct ◽  
Fdg Pet Ct

Laryngeal mucosa-associated lymphoid tissue (MALT) lymphoma is rare, with only 25 cases reported in the literature. This report presents a case of laryngeal MALT lymphoma in a 35-year-old female with a 6-year history of progressively worsening hoarseness. MALT lymphoma was diagnosed based on biopsy and immunohistochemical analysis. The patient received two cycles of cyclo-phosphamide + epirubicin + vincristine + prednisone (CHOP) chemo therapy, which was ineffective. 18F-fluoro deoxy glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) showed 18F-FDG accumulation in the larynx only and identified stage IE lymphoma. CHOP chemotherapy was terminated and the patient was treated with radiotherapy. After 3 months (total radiation dose 27 Gy), 18F-FDG PET/CT scan showed that the laryngeal lesion was in complete remission. A review of the literature on the MEDLINE®/PubMed® databases regarding laryngeal MALT lymphoma and the use of PET/CT found that radiotherapy is the firstline treatment for stage I and II MALT lymphoma.

Laryngeal mucosa-associated lymphoid tissue (MALT) lymphoma associated with bronchial MALT lymphoma: a case series and review of the literature

2012 ◽  
Vol 5 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Matthew K. Steehler ◽  
Kenneth Newkirk ◽  
Melissa M. Amorn ◽  
Bruce J. Davidson ◽  
Charles Read ◽  
...  
Keyword(s):  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Case Series ◽  
Review Of The Literature ◽  
Laryngeal Mucosa

scholarly journals Gastroduodenal lymphoma

2011 ◽  
Vol 58 (4) ◽  
pp. 113-116
Author(s):  
Momcilo Jovovic ◽  
Ranko Mirovic ◽  
Predrag Bajic ◽  
Vladimir Dobricanin ◽  
Tanja Nenezic
Keyword(s):  
Helicobacter Pylori ◽  
Case Report ◽  
Malt Lymphoma ◽  
Chronic Gastritis ◽  
Lymphoid Tissue ◽  
Final Diagnosis ◽  
Good Prognosis ◽  
Duodenal Cancer ◽  
Scientific Papers

Gestroduodenal lymphoma are very rare and with small number of written scientific papers published. They can be found within chronic gastritis as mucose associated lymphoid tissue - MALT. MALT lesions are associated with Helicobacter Pylori infections. Misadraji first described case of primary duodenal lymphoma folikularnog in 1995. Since then, several studies suggested that MALT lymphoma is viewed as a separate clinical - pathological entity due to its localization, the nature of the disease and good prognosis. In this case report, authors presented duodenal MALT lymphoma in 70 year old patient in which was preoperatively diagnosed duodenal cancer. Cephalic duodenopancreatictomy was performed and pathohystological examination was conducted. Results was MALT lymphoma. In establishing the final diagnosis of duodenal MALT lymphoma should be used histochemical and immunostaining analysis.

scholarly journals Different Outcomes of Three Localized Primary Gastric Amyloidosis Cases

2020 ◽  
Author(s):  
Xuemei Liu ◽  
Lianjun Di ◽  
Jiaxing Zhu ◽  
Xinglong Wu ◽  
Hongping Li ◽  
...  
Keyword(s):  
Early Detection ◽  
Rare Disease ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Endoscopic Examination ◽  
Accurate Diagnosis ◽  
Diagnosis And Treatment ◽  
Case Presentation ◽  
Stromal Tumors ◽  
The Past

Abstract Background: Localized primary gastric amyloidosis is a rare disorder characterized by the extracellular deposition of insoluble fibrillary protein confined to the stomach, which can mimic various diseases, including gastrointestinal stromal tumors, gastric cancer and ulcers in endoscopic examination. Case presentation: Here, we report a series of 3 cases of localized gastric amyloidosis mimicking gastric mucosa-associated lymphoid tissue (MALT) lymphoma by endoscopic examination that were evaluated over the past ten years in our hospital. The different times of detection of this rare disease resulted in three totally different outcomes, indicating the significant importance of the early detection, diagnosis and treatment of this rare disease. The difficulty of making an accurate diagnosis and differential diagnosis is highlighted, and this report may provide more clinical experience for the diagnosis of localized primary gastric amyloidosis.Conclusions: Localized gastric amyloidosis is a rare metabolic disease that can look like MALT lymphoma. Early detection, diagnosis and treatment of this rare disease results in an excellent prognosis.

scholarly journals Superficially Spreading Endocervical Adenocarcinoma in situ with Multifocal Microscopic Involvement of the Endometrial Surface: A Case Report with Emphasis on the Potential for Misdiagnosis Based on Endometrial Curettage Specimens

2020 ◽  
Vol 13 (3) ◽  
pp. 1530-1536
Author(s):  
Inwoo Hwang ◽  
Jiyeon Lee ◽  
Kyue-Hee Choi ◽  
Jiheun Han ◽  
Hyun-Soo Kim
Keyword(s):  
Final Diagnosis ◽  
Accurate Diagnosis ◽  
Surface Epithelium ◽  
Apoptotic Bodies ◽  
Small Tumor ◽  
Histological Features ◽  
Endocervical Adenocarcinoma ◽  
Tumor Tissues ◽  
Mitotic Figures

Misdiagnosis of endocervical adenocarcinoma (EAC) as endometrial endometrioid carcinoma (EEC) is one of the major concerns when evaluating endometrial curettage specimens. It is difficult to differentiate EAC involving the endometrium from EEC, particularly when the specimens have only a few small tumor fragments. We report a case of endocervical adenocarcinoma <i>in situ</i> (AIS) with multifocal microscopic involvement of the endometrium. The endometrial curettage specimen obtained from an 82-year-old woman consisted of a large volume of blood and fibrin, with small endometrial tissue fragments showing microscopic foci of atypical glandular proliferation. Based on the presence of complex glands with stratified mucin-poor columnar epithelium and intermediate-grade nuclear atypia, a preoperative diagnosis of grade 1 EEC was made. However, the hysterectomy specimen revealed an endocervical AIS involving the endocervix and low uterine segment. Frequent mitotic figures and apoptotic bodies, characteristic of AIS, were present. The endometrium showed a few microscopic foci of atypical glandular proliferation involving the surface only. Their histological features were similar to those of the endocervical AIS. Immunohistochemically, the atypical glands exhibited block p16 positivity. The final diagnosis was a superficially spreading endocervical AIS with multifocal microscopic involvement of the endometrial surface epithelium. In summary, small tumor tissues in an endometrial curettage may lead to misdiagnosis of AIS or EAC as EEC, especially when the pathologists are unaware of the possibility of microscopic endometrial involvement of AIS or EAC. The origin of the tumor can be correctly determined based on a combination of histological features and immunostaining. Endocervical AIS involving the endometrium should be included in the differential diagnosis of neoplastic glandular lesions in endometrial curettage specimens. An accurate diagnosis in these cases is important because of its significant implications for clinical management.

scholarly journals A case of gastric and duodenal mucosa-associated lymphoid tissue lymphoma with multiple gastric cancers: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Takashi Yokoyama ◽  
Tetsuya Tanaka ◽  
Suzuka Harada ◽  
Takeshi Ueda ◽  
Goki Ejiri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Regional Lymph Node ◽  
Duodenal Bulb ◽  
Duodenal Mucosa ◽  
Upper Endoscopy ◽  
Gastric Cancers ◽  
Regional Lymph Node Dissection ◽  
H Pylori

Abstract Background Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is often caused by Helicobacter pylori and has a good prognosis. Rarely, patients with MALT lymphoma may have gastric cancer and have a poor prognosis. Case presentation We herein report a case in which surgical treatment was achieved for a 72-year-old male patient with gastric and duodenal MALT lymphoma coexisting multiple gastric cancers. He underwent upper endoscopy for epigastric discomfort, which revealed mucosal erosion on the posterior wall of the middle body of the stomach, an elevated lesion on the duodenal bulb, and a raised tumor on the antrum of the stomach. He was diagnosed with gastric and duodenal MALT lymphoma with early gastric cancer. One month after H. pylori eradication, a second upper endoscopy revealed no improvement in the gastric or duodenal mucosa, and areas of strong redness with a shallow recess just below the cardia of the stomach. As a result, a diagnosis of gastric and duodenal MALT lymphoma with two gastric cancers was made. Total gastrectomy with proximal duodenum resection using intraoperative upper endoscopy and regional lymph node dissection was performed. Pathologically, gastric and duodenal MALT lymphoma and three gastric cancers were detected. Since one of them was an advanced cancer, he started taking S-1 after his general condition improved. Conclusion For early detection of gastric and duodenal MALT lymphoma or gastric cancer, appropriate upper endoscopy and a biopsy are important. It is necessary to select a suitable treatment, such as H. pylori eradication, endoscopic treatment, surgery, chemotherapy, and irradiation, according to the disease state.

scholarly journals Genetic Characterization and Clinical Features of Helicobacter pylori Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2993
Author(s):  
Barbara Kiesewetter ◽  
Christiane Copie-Bergman ◽  
Michael Levy ◽  
Fangtian Wu ◽  
Jehan Dupuis ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Signaling Pathways ◽  
Clinical Features ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Targeted Sequencing ◽  
Clinicopathological Parameters ◽  
Gastric Malt Lymphoma ◽  
Genetic Changes ◽  
H Pylori

Background: In Western countries, the prevalence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma has declined over the last three decades. Contemporaneously, H. pylori negative gastric MALT lymphoma is increasingly encountered, and their genetic basis and clinical features remain elusive. Methods: A total of 57 cases of H. pylori negative gastric MALT lymphoma were reviewed and investigated for chromosome translocation by fluorescence in-situ hybridization and for somatic mutations by the targeted sequencing of 93 genes. Results: MALT1 translocation, most likely t(11;18)(q21;q21)/BIRC3-MALT1, was detected in 39% (22/57) cases, and IGH translocation was further seen in 12 MALT1-negative cases, together accounting for 60% of the cohort. Targeted sequencing was successful in 35 cases, and showed frequent mutations in NF-κB signaling pathways (TNFAIP3 = 23%, CARD11 = 9%, MAP3K14 = 9%), together affecting 14 cases (40%). The NF-κB pathway mutations were mutually exclusive from MALT1, albeit not IGH translocation, altogether occurring in 86% of cases. There was no significant correlation between the genetic changes and clinicopathological parameters. The patients showed a median of progression-free survival (PFS) of 66.3 months, and a significant superior PFS when treated with systemic versus antibiotic therapy (p = 0.004). Conclusion: H. pylori negative gastric MALT lymphoma is characterized by highly frequent genetic changes in the NF-κB signaling pathways.

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