scholarly journals Non-thermal plasma applied to treating diabetic foot

2021 ◽  
Vol 10 (12) ◽  
pp. e539101220128
Author(s):  
Emilia Angela Lo Schiavo Arisawa ◽  
Juliana Cunha Cardoso ◽  
Lucia Vieira ◽  
Rauirys Alencarde de Oliveira

Objective: Evaluate the effects of non-thermal plasma therapy (NTP) for the treatment of diabetic foot injuries in two patients, considering the evolution of the steps of the healing process, pain sensitivity, and quality of life. Methodology: Lesions in the lower limbs of two patients with Diabetes mellitus (DM) with similar anatomical location and dimensions were treated, one patient with controlled DM and the other classified as uncontrolled DM. The application of NTP was performed for 10 minutes, 3 times a week in direct contact with the lesions. The same protocol was applied in both clinical cases to allow a reliable evaluation of the healing process. Results and Discussion: The lesions presented progressive regression until their complete regeneration (100%), without the development of infections during treatment. Conclusion: The results obtained in the two clinical cases allow us to attest that the NTP application in the treatment of diabetic foot injuries resulting from DM constituted an important therapeutic tool for the evolution of the healing process of these injuries, with a significant reduction in the lesion area in a short period of time. The definition of the ideal treatment protocol depends on the expansion of the number of studies and the increase of the studied population.

2020 ◽  
Vol 17 (8) ◽  
pp. 1112-1120
Author(s):  
Hyeong-Geun Lee ◽  
Jeong-Hae Choi ◽  
Yoon-Seo Jang ◽  
Uk-Kyu Kim ◽  
Gyoo-Cheon Kim ◽  
...  

2020 ◽  
Vol 62 (1) ◽  
pp. 12-16
Author(s):  
Oksana K. Melekhovets ◽  
Tetyana O. Kharchenko ◽  
Victor F. Orlovskiy ◽  
Iuirii V. Melekhovets ◽  
Alevtina S. Radko ◽  
...  

Introduction: Trophic ulcers of the lower extremities are an unresolved problem of modern medicine. The treatment of this pathology requires new methods that optimize care regimens and improve patients’ quality of life. Aim: The study to improve efficacy of treatment of the patients with trophic ulcers of the lower limbs with consideration to pathogenesis. M aterials and Methods: The study included 32 patients with chronic venous disease C6 (1st group) and 31 with diabetes mellitus type 2, moderate severity, compensation stage with diabetic foot syndrome II stage according to Wagner’s classification (2nd group). In addition to basic therapy in both groups photodynamic therapy was added at the first stage of the study, and at the second stage plasma rich in growth factors was prescribed. Results: At baseline evaluating of the chronic venous disease demonstrates that a total score in patient of the 1st group was 20,9 points on a modified VCSS scale; after two weeks – 15,71 points (improvement by 24.83%), and 6 weeks after–9,72 points (improvement by 53.49%). In patients with DM (2nd group) at the baseline a total score average was 13,91 points according to S(AD)SAD-1 scale; after 2 weeks – 12,29 (improvement by 11,65%), after 6 weeks – 6,39 points (improvement by 54,06%). Conclusions: The inclusion of photodynamic therapy and plasmatherapy in complex therapy in both groups led to a significant improvement of the healing process and helps to reduce the depth and area of the wound surface. However, the wound healing in patients in group 2 was slower.


2021 ◽  
Vol 109 ◽  
pp. 365-373
Author(s):  
Gabriela N. Pereira ◽  
Karina Cesca ◽  
Anelise Leal Vieira Cubas ◽  
Débora de Oliveira

2021 ◽  
Author(s):  
Pavel Galář ◽  
Josef Khun ◽  
Anna Fučíková ◽  
Kateřina Dohnalová ◽  
Tomáš Popelář ◽  
...  

Non-thermal plasma activated water can be used for cheap, easy and chemicals-free surface modification of nanoparticles, with all the reactive species originating solely in air and water.


2021 ◽  
Vol 150 ◽  
pp. 106274
Author(s):  
Libo Yao ◽  
Jaelynne King ◽  
Dezhen Wu ◽  
Steven S.C. Chuang ◽  
Zhenmeng Peng

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S773-S775
Author(s):  
Alexander A Ozoria Loveras ◽  
Jacques Paré Espinal ◽  
David de luna ◽  
Noemi Acevedo

Abstract Background In 2018, a review of the scientific literature identifed biofilm studies in the past 3 years. Wherein, the role of the biofilm in the progression of the diabetic foot ulcer with the presence of biofilm is reviewed. As a result, tissue sampling is more effective than transcure, Levin, and aspiration. A study in Cuba evaluate the effectiveness of a new proposal for antimicrobial treatment in patients with diabetic foot infection in 2017. The method used was a experimental type of two groups. The control group, was treated with the treatment scheme proposed in the Comprehensive Care Program for the patient with diabetic foot ulcer (PAIPUPD). Instead, the other experimental group was treated according to the scheme based on the local microbial map. They used a random distribution. Using the Wagner classification, there were patients classificate with a grade of W2 (13% of patients), W3 (66%) and W4 (12%). The most frequent germs found were Staphylococcus aureus, Escherichia coli and Enterobacter sp. The experimental group required less days with hospitalization. Methods This is an observational study of primary source with a non-probability sample with 58 patients. Adult patients diagnosed with type 2 diabetes mellitus, with diabetic foot, Wagner classification 1, 2 and 3, who attended the healing area of the Institute of Diabetes of Santiago were included. After identifying the colonized pathogen, its cicatrization process was evaluate for four weeks. Results Of the total sample, 12.07% belonged to Wagner 1, 43.1% to Wagner 2 and 44.83% to the Wagner 3 classification. In the case of the Wagner 3 group, S. aureus and Pseudomona aeruginosa were present in 6 cases. Despite the infectious processes detected by the culture, the patients showed a successful cicatrization process after four weeks of evaluation. Graph 1: Isolated Microorganism Vs Wagner’s Degree (n=60) Graph 2: Gram positive microorganism vs. healing process per week in patients with diabetic foot (n=22) Graph 3: Gram-negative microorganism vs. healing process (n=33) Conclusion During the four weeks of clinical evaluation, more than 88% of patients progressed positively to clinical recovery, regardless of the type of bacteria colonized and/or their resistance to antibiotics. Disclosures All Authors: No reported disclosures


LWT ◽  
2021 ◽  
Vol 142 ◽  
pp. 111067
Author(s):  
Chia-Min Lin ◽  
Samuel Herianto ◽  
Shih-Ming Syu ◽  
Cian-Huei Song ◽  
Hsiu-Ling Chen ◽  
...  

2021 ◽  
pp. 117321
Author(s):  
Laila Patinglag ◽  
Louise M. Melling ◽  
Kathryn A. Whitehead ◽  
David Sawtell ◽  
Alex Iles ◽  
...  

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