scholarly journals Use of natural nanobiotechnological input in a pharmaceutical formulation

2020 ◽  
Vol 9 (2) ◽  
pp. e185922103
Author(s):  
Fabíola Ornellas de Araújo ◽  
Reinaldo Giudicci ◽  
João José Martins Simões de Sousa

The use of naturally occurring nanobiotechnological inputs is essential for human health and the environment. This research is of fundamental importance, given consumers' current awareness of using more natural, sustainable and healthy pharmaceutical ingredients. Thus, there has been a growing demand for more biocompatible pharmaceutical formulations with the body, which should have on their labels no aggression to nature (environment) and no use of animal testing (USP-2018). Thus, consumers want to direct the benefits that come from nature, among other means of knowledge, to their families. They are seeking to associate the cost of the finished cosmetic product with the benefit it brings to the health of the human body. In this research the continuation of studies of scientists Araújo, Giudici and Sousa, in 2019 a, b and c, which used this patented nanobiotechnological input (USP-2018), was used in the natural formulation of liquid soap.   

2014 ◽  
Vol 70 (a1) ◽  
pp. C984-C984
Author(s):  
Alessia Bacchi ◽  
Davide Capucci ◽  
Paolo Pelagatti

The objective of this work is to embed liquid or volatile pharmaceuticals inside crystalline materials, in order to tune their delivery properties in medicine or agrochemistry, and to explore new regulatory and intellectual properties issues. Liquid or volatile formulations of active pharmaceutical ingredients (APIs) are intrinsically less stable and durable than solid forms; in fact most drugs are formulated as solid dosage because they tend to be stable, reproducible, and amenable to purification. Most drugs and agrochemicals are manufactured and distributed as crystalline materials, and their action involves the delivery of the active molecule by a solubilization process either in the body or on the environment. However some important compounds for the human health or for the environment occur as liquids at room temperature. The formation of co-crystals has been demonstrated as a means of tuning solubility properties of solid phases, and therefore it is widely investigated by companies and by solid state scientists especially in the fields of pharmaceuticals, agrochemicals, pigments, dyestuffs, foods, and explosives. In spite of this extremely high interest towards co-crystallization as a tool to alter solubility, practically no emphasis has been paid to using it as a means to stabilize volatile or labile or low-melting products. In this work we trap and stabilize volatile and liquid APIs and agrochemicals in crystalline matrices by engineering suitable co-crystals. These new materials alter the physic state of the active ingredients allowing to expand the phase space accessible to manufacturing and delivery. We have defined a benchmark of molecules relevant to human health and environment that have been combined with suitable partners according to the well known methods of crystal engineering in order to obtain cocrystals. The first successful results will be discussed; the Figure shows a cocrystal of propofol, a worldwide use anesthetic.


2014 ◽  
Vol 955-959 ◽  
pp. 1397-1404 ◽  
Author(s):  
Li Na Shi ◽  
Xun Xu ◽  
Xiao Yan Dou ◽  
Xu Dong Zhao

PM2.5 is one of the most important components in air pollution. It is also the focus of the most closely watched at home and abroad. Based on its small size, complex components, and strongenvironmental activity, it can be used as a carrier for chemicals, heavy metals, bacteria, toxins and carcinogens into the body. Then, as a result, it will affect Human Body Health. Heavy metals are important components of PM2.5, and the long-term accumulation of heavy metals in PM2.5 poses a great threat on human health and the environment. This paper reviewed the sources, distribution methods,chemical form, detection methods, disposal way, research progress of heavy metals in PM2.5. As a result, it provided a reference for in-depth study on the future.


1962 ◽  
Vol 17 (1) ◽  
pp. 117-118 ◽  
Author(s):  
Shanker Rao

Metabolic cost to the human body of various postures has been assessed by many workers. The cost with the body in the topsy-turvy posture, or while “standing on the head,” has not been reported so far. Energy expenditure was calculated indirectly by estimating the amount of oxygen consumed while in a particular posture. A Benedict-type recording spirometer was used for this purpose. The subjects were six healthy medical students. The mean cost of standing on the head was determined to be 336 ml, or 1.62 kcal/min, and that of “suspension by the feet” to be 300 ml, or 1.44 kcal/min. The possible causes of increased consumption in relation to the “standing erect” posture are discussed. Submitted on May 26, 1961


1927 ◽  
Vol 23 (3) ◽  
pp. 348-348
Keyword(s):  
The Body ◽  
The Cost ◽  

The author calculated that the body of a man weighing 75 kilograms contains 1) enough fat to make three candles, 2) enough water to wash two sheets, 3) enough iron for a pinky nail, 4) enough lime to whitewash a small room, 5) enough sulfur to kill fleas in a sick dog, 6) enough sugar for morning tea.


2021 ◽  
Vol 11 (4) ◽  
pp. 106-113
Author(s):  
Syeda Kharshiya Saher ◽  
Mohd. Zulkifle ◽  
Wasim Ahmad

Unani system of medicine is known for its potential since ancient times. Elite Unani philosophers are credited for proposing consolidated theories and unleashing medical science from the domain of deities and demons. They have set the goal of medicine as prevention as well as cure of disease. Both the health and the disease are described in its own way in respect of functions. Unani philosophers contemplated that human body is composed of three basic components; solid (body organs), liquid (humours), gaseous (pneuma). The liquid substances of the body are collectively called as Akhlāṭ (humours). Every humour serves some specific and general functions. Basically, these are approximate principle for nutrition of organs. Black bile is one among the humours responsible for the health and the disease in the body. A right proportion of black bile keeps the body healthy, but disproportion of it causes deadly diseases. It is a fact that everything in the body is directly, or indirectly related with the four humours. In present study, a comprehensive explanation of black bile is given. Much emphasis is given on the genesis of normal and abnormal black bile. All factors responsible for alteration in black bile are enumerated thoroughly in the study. It is believed that the present work would help the reader in better understanding of the concept of black bile and their effect on the human health. Methodology: Relevant literary material is collected from classical books of Unani system of medicine. Present work is an attempt to analyse and systematize collected relevant literary information regarding the concept of black bile and their effect on the human health. Interpretation and conclusion: From the contents of literature; it is clear that black bile is the sediment of normal blood. It is the last to arise and receives the coarse, most meagre share of nutrients and has a retentive virtue, a cooling, drying, astringing, precipitating, condensing, solidifying effect on the metabolism necessary for building the bones, teeth and all dense, solid structures of the body. The black bile is an essential humour that keeps the body healthy. Therefore; an optimal level of black bile plays an important role in maintenance of health as other three humours. An imbalance in quality and quantity of black bile is responsible for the diseases. Key words: Akhlāṭ Arba‘a (humours); Sawdāʼ (black bile); health; disease.


2017 ◽  
Vol 18 (3) ◽  
pp. 354-357
Author(s):  
L.R. Babchuk

Heavy metal cadmium is classified to the World Health Organization to the most hazardous substances for human health. The aim is to study the food pottery as an object that can be a source of cadmium in the human body. The various kinds of food ceramic products, which may contain pigments based on cadmium compounds, are considered. It was found that the cadmium sulfide can be an integral part of underglaze or onglaze ceramic paints, glazes, ceramic mass and a chandelier. The most intense release of cadmium comes with glaze and paint ceramic mass and carries the greatest risk in respect of this heavy metal pollution of the human body. Process cadmium poisoning human bodycompounds can last for years, cadmium tends to accumulate in the body for a long time. Therefore, the use of externally beautiful, but the harmful chemical composition, color of ceramic tableware harmful to human health.


Author(s):  
Surabhi Shakya ◽  
Padmini Shukla ◽  
Prabodh Shukla

Herbal immunity boosters are the medicinal plants which increase the immunity of the human body and make the body able to fight with the various diseases. These immunity boosters are serving as a boon in the case of coronavirus disease. COVID-19 affects our respiratory system and lowers the immunity of the patient and the persons having weak immunity have the more chances to get affected with the diseases. Tulsi, garlic, ginger, giloy, coconut oil, turmeric, ashwagandha, amla, black pepper, aloevera are the herbal immunity boosters. These herbal drugs used traditionally in medicines and also proved effective in scientific studies.  The regular consumption of these boosters helps to treat the mild to moderate symptoms of diseases at home. Keywords: Herbal immunity boosters, Coronavirus, COVID-19, Garlic, Tulsi, Ginger, Aloe vera


2021 ◽  
Author(s):  
Lillian R. Dillard ◽  
Dawson D. Payne ◽  
Jason A. Papin

Microbial communities affect many facets of human health and well-being. Naturally occurring bacteria, whether in nature or the human body, rarely exist in isolation.


Author(s):  
I.S. Lisetska ◽  

The literature review focuses on the prevalence of smoking among the population, the types of smoking devices and their negative impact on public health. The article presents the composition of traditional cigarettes and alternative types of smoking, analyzes the data of smoking statistics in the world. The smoking habit has been known since 2000 BC, when American Indians inhaled the smoke from burning the leaves of the plant Nicotiana tabacum, in the 20th century became an epidemic and killed more than 100 million people, and according to forecasts in the XXI century, this figure may grow in order. It is alarming that in recent decades, in addition to traditional cigarettes, alternative types of smoking have become popular, especially among adolescents and young people, namely electronic cigarettes (E-cigarettes, vapes), tobacco heating devices (IQOS), and sometimes products. With low tobacco content (snuff, chewing tobacco, etc.). In addition, hookah remains fashionable and sometimes prestigious among young people, which also has a detrimental effect on the human body. Smoking both traditional cigarettes and alternative types is one of the important medical and social problems both in Ukraine and around the world, as it is widespread and available. Smoking is a risk factor for human health and, as a result, an increase in nicotine-related mortality. At the same time, smoking is the only cause of illness and death that can be eliminated. Today, smoking is considered not as a bad habit, but as a chronic disease, prone to recurrence, even long after smoking cessation. There are no safe types of smoking, active and passive smoking are equally harmful to the body, which undermines human health and threatens his life. Smoking is especially dangerous for adolescents and young adults. The fight against smoking remains a key factor in the recovery of the nation. Smoking cessation is not only a matter of prevention, it should be considered as one of the appointments for the patient in the treatment of any disease and rehabilitation, because without it there will be no success in treatment and health. No conflict of interest was declared by the author. Key words: smoking, cigarettes, nicotine, electronic cigarettes, IQOS, hookah, snus.


2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Alaa Abdulrahman ◽  
Kamran Iqbal ◽  
Gannon White

Physiologically and biomechanically, the human body represents a complicated system with an abundance of degrees of freedom (DOF). When developing mathematical representations of the body, a researcher has to decide on how many of those DOF to include in the model. Though accuracy can be enhanced at the cost of complexity by including more DOF, their necessity must be rigorously examined. In this study a planar seven-segment human body walking model with single DOF joints was developed. A reference point was added to the model to track the body’s global position while moving. Due to the kinematic instability of the pelvis, the top of the head was selected as the reference point, which also assimilates the vestibular sensor position. Inverse dynamics methods were used to formulate and solve the equations of motion based on Newton-Euler formulae. The torques and ground reaction forces generated by the planar model during a regular gait cycle were compared with similar results from a more complex three-dimensional OpenSim model with muscles, which resulted in correlation errors in the range of 0.9–0.98. The close comparison between the two torque outputs supports the use of planar models in gait studies.


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