scholarly journals Prenatal Methamphetamine Exposure Induces Long-Lasting Alterations in Memory and Development of NMDA Receptors in the Hippocampus

2014 ◽  
pp. S547-S558 ◽  
Author(s):  
R. ŠLAMBEROVÁ ◽  
M. VRAJOVÁ ◽  
B. SCHUTOVÁ ◽  
M. MERTLOVÁ ◽  
E. MACÚCHOVÁ ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Nmda Receptors ◽  
Water Maze ◽  
The Other ◽  
Male Rats ◽  
Memory Retention ◽  
Prenatally Exposed ◽  
Object Recognition Test ◽  
Close Relationship

Since close relationship was shown between drug addiction and memory formation, the aim of the present study was to investigate the effects of interaction between prenatal methamphetamine (MA) exposure and MA treatment in adulthood on spatial and non-spatial memory and on the structure of the N-methyl-D-aspartate (NMDA) receptors in the hippocampus. Adult male rats prenatally exposed to MA (5 mg/kg) or saline were tested in adulthood. Non-spatial memory was examined in the Object Recognition Test (ORT) and spatial memory in the Object Location Test (OLT) and in the Memory Retention Test (MRT) conducted in the Morris Water Maze (MWM), respectively. Based on the type of the memory test animals were injected either acutely (ORT, OLT) or long-term (MWM) with MA (1 mg/kg). After each testing, animals were sacrificed and brains were removed. The hippocampus was then examined in Western Blot analysis for occurrence of different NMDA receptors’ subtypes. Our results demonstrated that prenatal MA exposure affects the development of the NMDA receptors in the hippocampus that might correspond with improvement of spatial memory tested in adulthood in the MWM. On the other hand, the effect of prenatal MA exposure on non-spatial memory examined in the ORT was the opposite. In addition, we showed that the effect of MA administration in adulthood on NMDA receptors is influenced by prenatal MA exposure, which seems to correlate with the spatial memory examined in the OLT.

The timing of maternal separation affects morris water maze performance and long-term potentiation in male rats

2013 ◽  
Vol 56 (5) ◽  
pp. 1102-1109 ◽  
Author(s):  
Xiujing Cao ◽  
Shenghai Huang ◽  
Jiejie Cao ◽  
Tingting Chen ◽  
Ping Zhu ◽  
...  
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Maternal Separation ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Maze Performance ◽  
Term Potentiation

scholarly journals Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Javier Díaz-Alonso ◽  
Wade Morishita ◽  
Salvatore Incontro ◽  
Jeffrey Simms ◽  
Julia Holtzman ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Morris Water Maze ◽  
Ampa Receptor ◽  
Water Maze ◽  
Long Term Potentiation ◽  
Receptor Subunit ◽  
Terminal Domain ◽  
Term Potentiation ◽  
Ampa Receptor Subunit

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.

Long-term administration of Greek Royal Jelly improves spatial memory and influences the concentration of brain neurotransmitters in naturally aged Wistar male rats

2014 ◽  
Vol 155 (1) ◽  
pp. 343-351 ◽  
Author(s):  
Justyna Pyrzanowska ◽  
Agnieszka Piechal ◽  
Kamilla Blecharz-Klin ◽  
Ilona Joniec-Maciejak ◽  
Konstantia Graikou ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Royal Jelly ◽  
Male Rats ◽  
Brain Neurotransmitters ◽  
Term Administration ◽  
Wistar Male Rats

Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats

2011 ◽  
Vol 65 (3-4) ◽  
pp. 519-525 ◽  
Author(s):  
Ali Mahmoudi ◽  
Ali Hosseini-Sharifabad ◽  
Hamid R. Monsef-Esfahani ◽  
Ali R. Yazdinejad ◽  
Mahnaz Khanavi ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Systemic Administration ◽  
Male Rats ◽  
Memory Retention ◽  
Boswellia Papyrifera

Behavioral and molecular effects of intrahippocampal infusion of auraptene, resveratrol, and curcumin on H-89-induced deficits on spatial memory acquisition and retention in Morris water maze

2019 ◽  
Vol 38 (7) ◽  
pp. 775-784 ◽  
Author(s):  
K Tabrizian ◽  
SS Musavi ◽  
M Rigi ◽  
F Hosseindadi ◽  
S Kordi ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Morris Water Maze ◽  
Water Maze ◽  
Training Trial ◽  
Camp Response Element Binding ◽  
Memory Retention ◽  
Camp Response Element ◽  
Significant Impairment ◽  
Memory Acquisition ◽  
Molecular Effects

Our aim was to investigate the effects of resveratrol, auraptene, and curcumin on the spatial learning and spatial memory retention in the Morris water maze (MWM). The effects of 4-day bilateral intrahippocampal (i.h.) infusions of dimethyl sulfoxide (DMSO), H-89 as a protein kinase AII inhibitor, auraptene/H-89, resveratrol/H-89, and curcumin/H-89 were investigated on spatial memory acquisition in MWM. The rats were trained for 4 days; each day included one block of four trials. Post-training probe tests were performed on day 5 in acquisition test. For retention assessments, different animals were trained for 4 days and then infused (i.h.) with either DMSO, H-89, auraptene/H-89, resveratrol/H-89, or curcumin/H-89. The retention test was performed 48 h after the last training trial. The bilateral infusion of H-89 led to a significant impairment in spatial memory in acquisition and retention tests accompanied with a significant decrease in expressions of cAMP response-element binding (CREB) and pCREB proteins in hippocampus. Resveratrol and curcumin reversed the H-89-induced spatial memory acquisition and retention impairments with significant increases in both CREB and pCREB proteins expressions compared to H-89-treated animals. Auraptene showed significant effects in reversing H-89-induced impairments in spatial memory retention but not spatial memory acquisition.

Amelioration of impaired hippocampal cognitive performance in Alzheimer's disease via long-term intervention with ghrelin

2017 ◽  
Vol 41 (S1) ◽  
pp. S371-S371
Author(s):  
B. Sadeghi
Keyword(s):  
Cognitive Performance ◽  
Cognitive Deficits ◽  
Neurodegenerative Disorder ◽  
Field Potential ◽  
Amyloid Β ◽  
Long Term Potentiation ◽  
Motor Dysfunction ◽  
Male Rats ◽  
Memory Retention

IntroductionAlzheimers disease (AD) is a neurodegenerative disorder characterized by loss of memory and cognitive deficits. Ghrelin is a peptide hormone which has been linked to neuroprotection, memory and learning processes.ObjectivesThis study investigated the effects of ghrelin-induced memory retention on amelioration of cognitive deficits via restoration of long-term potentiation (LTP) and induction of synaptic plasticity in hippocampal CA3, using a rat model of AD induced by amyloid-β (1-42) injection.MethodsFive groups of male rats (230–270 g) including ghrelin-treated (200 ng/rat, [ICV], daily for two weeks), Aβ1-42 injected (5 μL/rat) and Aβ1-42 plus ghrelin-treated animals were designed. Ghrelin was administered after an ICV injection of Aβ1-42. To assess cognitive performance and the motor dysfunction, passive avoidance tests and open-field were performed, respectively. Step-through latency (STL) was evaluated as learning and memory index. Intrahippocampal field potential recordings were done.ResultsResults showed that following Aβ1-42 injection, STL and induction of LTP were significantly decreased whereas ICV injection of ghrelin significantly enhanced memory retention by improvement of STL and restitution of LTP in the CA3 with increased EPSP slope and PS amplitude, suggesting the involvement of ghrelin in postsynaptic mechanisms of hippocampal LTP.ConclusionsIt was revealed that neuroprotective effects of chronic ghrelin not only can enhance but also can restore LTP in the CA3 area in Aβ-induced AD. Results suggest that ghrelin may be considered as a promising therapeutic agent to alleviate cognitive deficits of AD.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

Long-term administration of Aspalathus linearis infusion affects spatial memory of adult Sprague-Dawley male rats as well as increases their striatal dopamine content

2019 ◽  
Vol 238 ◽  
pp. 111881 ◽  
Author(s):  
Justyna Pyrzanowska ◽  
Izabela Fecka ◽  
Dagmara Mirowska-Guzel ◽  
Ilona Joniec-Maciejak ◽  
Kamilla Blecharz-Klin ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Striatal Dopamine ◽  
Male Rats ◽  
Sprague Dawley ◽  
Aspalathus Linearis ◽  
Dopamine Content ◽  
Term Administration

Effects of orchidectomy and sex steroids on vasopressin response to dehydration

1982 ◽  
Vol 99 (4) ◽  
pp. 493-499 ◽  
Author(s):  
G. Valiquette ◽  
L. Martini
Keyword(s):  
Sex Steroids ◽  
Water Deprivation ◽  
Gonadal Steroids ◽  
The Other ◽  
Male Rats ◽  
Sex Steroid ◽  
Short Term ◽  
Vasopressin Secretion ◽  
Hypothalamic Level

Abstract. The secretion of vasopressin has been shown recently to be influenced by gonadal steroids. To further evaluate the relevance of sex steroids in the control of vasopressin secretion, the vasopressin response to dehydration has been studied in normal, castrated and sex-steroid treated castrated male rats. Short-term (3 weeks) castration did not modify the vasopressin response to 48 h of water deprivation. Long-term (10 weeks) castration, on the other hand, consistently reduced the vasopressin response by more than 50%. In both cases, the osmolality was unaffected. Treatment of long-term castrated rats with testosterone, dihydrotestosterone, or oestradiol increased the vasopressin response to dehydration towards normal control levels. However, only oestradiol could restore it to and beyond normal levels, although all three steroids were given in doses that were equipotent in bringing back to normal the plasma LH levels of the castrated animals. Angiotensin-II generation may indirectly be augmented by oestradiol treatment and this may account for the effect of oestradiol here reported. No such mechanism, however, may be invoked in the case of androgens; a direct modulatory effect at the hypothalamic level is postulated for explaining their influence on vasopressin secretion.

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