Bellagio II Report: Terrestrial Applications of Space Medicine Research

2021 ◽  
Vol 92 (8) ◽  
pp. 650-669
Author(s):  
Marian B. Sides ◽  
Smith L. Johnston ◽  
Adam Sirek ◽  
Peter H. Lee ◽  
Rebecca S. Blue ◽  
...  
Keyword(s):  
Space Station ◽  
National Institutes Of Health ◽  
Evidence Based ◽  
Space Medicine ◽  
Space Applications ◽  
Medicine Research ◽  
Science Models ◽  
Long Duration ◽  
Physiological Adaptations ◽  
Mature Science

AbstractINTRODUCTION: For over 50 yr, investigators have studied the physiological adaptations of the human system during short- and long-duration spaceflight exposures. Much of the knowledge gained in developing health countermeasures for astronauts onboard the International Space Station demonstrate terrestrial applications. To date, a systematic process for translating these space applications to terrestrial human health has yet to be defined.METHODS: In the summer of 2017, a team of 38 international scientists launched the Bellagio ll Summit Initiative. The goals of the Summit were: 1) To identify space medicine findings and countermeasures with highest probability for future terrestrial applications; and 2) To develop a roadmap for translation of these countermeasures to future terrestrial application. The team reviewed public domain literature, NASA databases, and evidence books within the framework of the five-stage National Institutes of Health (NIH) translation science model, and the NASA two-stage translation model. Teams then analyzed and discussed interdisciplinary findings to determine the most significant evidence-based countermeasures sufficiently developed for terrestrial application.RESULTS: Teams identified published human spaceflight research and applied translational science models to define mature products for terrestrial clinical practice.CONCLUSIONS: The Bellagio ll Summit identified a snapshot of space medicine research and mature science with the highest probability of translation and developed a Roadmap of terrestrial application from space medicine-derived countermeasures. These evidence-based findings can provide guidance regarding the terrestrial applications of best practices, countermeasures, and clinical protocols currently used in spaceflight.Sides MB, Johnston SL III, Sirek A, Lee PH, Blue RS, Antonsen EL, Basner M, Douglas GL, Epstein A, Flynn-Evans EE, Gallagher MB, Hayes J, Lee SMC, Lockley SW, Monseur B, Nelson NG, Sargsyan A, Smith SM, Stenger MB, Stepanek J, Zwart SR; Bellagio II Team. Bellagio II report: terrestrial applications of space medicine research. Aerosp Med Hum Perform. 2021; 92(8):650669.

scholarly journals Ultrasound: From Earth to Space

2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Jennifer Law ◽  
Paul B Macbeth
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Critically Ill Patients ◽  
Imaging Modality ◽  
Space Station ◽  
Isolated Populations ◽  
Space Applications ◽  
International Space ◽  
Physiological Adaptations ◽  
Procedural Guidance

Ultrasonography is a versatile imaging modality that offers many ad- vantages over radiography, computed tomography, and magnetic resonance imag- ing. on Earth, the use of ultrasound has become standard in many areas of medi- cine including diagnosis of medical and surgical diseases, management of obstetric  and gynecologic conditions, assessment of critically ill patients, and procedural  guidance. Advances in telecommunications have enabled remotely-guided ultraso- nography for both geographically isolated populations and astronauts aboard the  International Space Station. while ultrasound has traditionally been used in space- fight to study anatomical and physiological adaptations to microgravity and evalu- ate countermeasures, recent years have seen a growth of applications adapted from  terrestrial techniques. Terrestrial, remote, and space applications for ultrasound are reviewed in this paper.

Selection of Medications for the International Space Station: The Space Medicine Patient Condition Database

2003 ◽  
Vol 16 (2) ◽  
pp. 91-95
Author(s):  
Kira Bacal ◽  
Bruce M. Frey
Keyword(s):  
International Space Station ◽  
Space Station ◽  
Second Phase ◽  
Evidence Based ◽  
Space Medicine ◽  
Medical Systems ◽  
Treatment Protocols ◽  
International Space ◽  
Mission Teams ◽  
Protocol Standardization

Medical care available to astronauts on the International Space Station has been affected by limitations on funding, space and weight availability, and crew training. A Space Medicine Patient Condition Database (PCDB) was designed to enhance inventory control, resource selection, protocol standardization, evidence-based medicine, on-orbit diagnostic skills, and materiel management. The first step in the PCDB creation was the identification of the medical conditions anticipated among the astronaut population in the flight environment. Military databases, previous spaceflight experience, and analog populations were used to create this listing. The PCDB then linked these individual conditions with the current resources available on orbit to treat them. Other features include a resource gauge, item location information, diagnosis coding, and built-in reference capabilities. Currently in the second phase of development, specific, evidence-based treatment protocols are being developed and evaluated in comparison with the terrestrial medicine standard of care. By documenting on-orbit medical systems and their associated terrestrial standards, the PCDB enables the prioritization and allocation of limited resources. In the final phase of the project, the PCDB will make use of decision support software to enhance diagnostic determination and provide an operational tool for the crew and mission teams.

Space Medicine Propelling Earth-Based Medicine for the Advantage of Human on Earth – A Vision Beyond 2020

2020 ◽  
Author(s):  
Kris See
Keyword(s):  
International Space Station ◽  
Good Condition ◽  
Space Station ◽  
Gear Up ◽  
Space Medicine ◽  
International Space ◽  
The Future ◽  
Based Medicine

What will be the future of medicine a decade from now? What difficulties related with preventing, detecting, and treating diseases will have been unraveled? How will space medicine make an impact?. Today as compared to previously, it is the role of space medicine to gear up astronauts sufficiently for their missions and also to maintain their health in good condition. Moreover, the exclusive and new environmental surroundings existing in space continuously propose prospects to validate theories and assumptions established by earth-based medicine and recognize likely mistakes and disparities, as we have been observing approximately more than a decade with outcomes for example, from the International Space Station.

Fatigue As A Performance Shaping Factor In Human Reliability Analysis For Long-Duration Spaceflight

2020 ◽  
Vol 64 (1) ◽  
pp. 1681-1685
Author(s):  
Ronald Boring ◽  
Thomas Ulrich ◽  
Torrey Mortenson ◽  
David German
Keyword(s):  
Reliability Analysis ◽  
Meta Analysis ◽  
Extended Period ◽  
Human Reliability ◽  
Human Reliability Analysis ◽  
Space Applications ◽  
Performance Shaping Factors ◽  
Long Duration ◽  
Starting Point ◽  
Chronic Sleep

This paper provides background on the process to enhance human reliability analysis (HRA) for long-duration space applications. While short-duration missions largely mirror ground activities and fit well with existing HRA methods, new missions to the Moon or Mars entail a significantly longer duration of time in space for astronauts. This extended period in space presents opportunities to affect astronaut performance that require consideration of new performance shaping factors (PSFs). In the present paper, we conducted a meta-analysis on fatigue and developed a new PSF to account for chronic sleep deprivation associated with long-duration space missions. Fatigue provides a starting point for additional PSFs needed for space HRA.

Optimization of Logistics Strategies for Long-Duration Space-Station Operation

2014 ◽  
Vol 51 (5) ◽  
pp. 1709-1720 ◽  
Author(s):  
Kun-Peng Lin ◽  
Ya-Zhong Luo ◽  
Guo-Jin Tang
Keyword(s):  
Space Station ◽  
Long Duration

scholarly journals Fundamentals of circadian entrainment by light

2021 ◽  
Vol 53 (5) ◽  
pp. 377-393
Author(s):  
RG Foster
Keyword(s):  
Ganglion Cells ◽  
Light Exposure ◽  
Bright Light ◽  
Evidence Based ◽  
Retinal Ganglion ◽  
Rods And Cones ◽  
Long Duration ◽  
Lighting Systems ◽  
Short Wavelength Light ◽  
Wavelength Light

Light at dawn and dusk is the key signal for the entrainment of the circadian clock. Light at dusk delays the clock. Light at dawn advances the clock. The threshold for human entrainment requires relatively bright light for a long duration, but the precise irradiance/duration relationships for photoentrainment have yet to be fully defined. Photoentrainment is achieved by a network of photosensitive retinal ganglion cells (pRGCs) which utilise the short-wavelength light-sensitive photopigment, melanopsin. Although rods and cones are not required, they do play a role in photoentrainment, by projecting to and modulating the endogenous photosensitivity of the pRGCs, but in a manner that remains poorly understood. It is also important to emphasise that the age and prior light exposure of an individual will modify the efficacy of entrainment stimuli. Because of the complexity of photoreceptor interactions, attempts to develop evidence-based human centric lighting are not straightforward. We need to study how humans respond to dynamic light exposure in the ‘real world’ where light intensity, duration, spectral quality and the time of exposure vary greatly. Defining these parameters will allow the development of electric lighting systems that will enhance human circadian entrainment.

scholarly journals Long-Term Microgravity Effects on Isometric Handgrip and Precision Pinch Force with Visual and Proprioceptive Feedback

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Ilario Puglia ◽  
Michele Balsamo ◽  
Marco Vukich ◽  
Valfredo Zolesi
Keyword(s):  
Maximum Voluntary Contraction ◽  
Space Station ◽  
Voluntary Contraction ◽  
Force Output ◽  
Isometric Handgrip ◽  
Short Term ◽  
Space Flights ◽  
Pinch Force ◽  
Long Duration

The study and analysis of human physiology during short- and long-duration space flights are the most valuable approach in order to evaluate the effect of microgravity on the human body and to develop possible countermeasures in prevision of future exploratory missions and Mars expeditions. Hand performances such as force output and manipulation capacity are fundamental for astronauts’ intra- and extravehicular activities. Previous studies on upper limb conducted on astronauts during short-term missions (10 days) indicated a temporary partial reduction in the handgrip maximum voluntary contraction (MVC) followed by a prompt recovery and adaptation to weightlessness during the last days of the mission. In the present study, we report on the “Crew’s Health: Investigation on Reduced Operability” (CHIRO) protocol, developed for handgrip and pinch force investigations, performed during the six months increment 7 and increment 8 (2003-2004) onboard International Space Station (ISS). We found that handgrip and pinch force performance are reduced during long-term increments in space and are not followed by adaptation during the mission, as conversely reported during short-term increment experiments. The application of protocols developed in space will be eligible to astronauts during long-term space missions and to patients affected by muscle atrophy diseases or nervous system injury on Earth.

Reduced heart rate variability during sleep in long-duration spaceflight

2013 ◽  
Vol 305 (2) ◽  
pp. R164-R170 ◽  
Author(s):  
D. Xu ◽  
J. K. Shoemaker ◽  
A. P. Blaber ◽  
P. Arbeille ◽  
K. Fraser ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Substantial Reduction ◽  
Space Station ◽  
Power Spectral Analysis ◽  
Power Spectral ◽  
Long Duration ◽  
Fractal Properties ◽  
Wide Range ◽  
Simultaneous Movement

Limited data are available to describe the regulation of heart rate (HR) during sleep in spaceflight. Sleep provides a stable supine baseline during preflight Earth recordings for comparison of heart rate variability (HRV) over a wide range of frequencies using both linear, complexity, and fractal indicators. The current study investigated the effect of long-duration spaceflight on HR and HRV during sleep in seven astronauts aboard the International Space Station up to 6 mo. Measurements included electrocardiographic waveforms from Holter monitors and simultaneous movement records from accelerometers before, during, and after the flights. HR was unchanged inflight and elevated postflight [59.6 ± 8.9 beats per minute (bpm) compared with preflight 53.3 ± 7.3 bpm; P < 0.01]. Compared with preflight data, HRV indicators from both time domain and power spectral analysis methods were diminished inflight from ultralow to high frequencies and partially recovered to preflight levels after landing. During inflight and at postflight, complexity and fractal properties of HR were not different from preflight properties. Slow fluctuations (<0.04 Hz) in HR presented moderate correlations with movements during sleep, partially accounting for the reduction in HRV. In summary, substantial reduction in HRV was observed with linear, but not with complexity and fractal, methods of analysis. These results suggest that periodic elements that influence regulation of HR through reflex mechanisms are altered during sleep in spaceflight but that underlying system complexity and fractal dynamics were not altered.

Thermoelectric Applications as Related to Biomedical Engineering for Nasa Johnson Space Center

1997 ◽  
Vol 478 ◽  
Author(s):  
C. D. Kramer ◽  
P.E.
Keyword(s):  
International Space Station ◽  
Space Station ◽  
Space Environment ◽  
Space Applications ◽  
International Space ◽  
Future Technology ◽  
Technological Developments ◽  
Environment Noise ◽  
Scientific Value

AbstractThis paper presents current NASA biomedical developments and applications using thermoelectrics. Discussion will include future technology enhancements that would be most beneficial to the application of thermoelectric technology.A great deal of thermoelectric applications have focused on electronic cooling. As with all technological developments within NASA, if the application cannot be related to the average consumer, the technology will not be mass-produced and widely available to the public (a key to research and development expenditures and thermoelectric companies). Included are discussions of thermoelectric applications to cool astronauts during launch and reentry. The earth-based applications, or spin-offs, include such innovations as tank and race car driver cooling, to cooling infants with high temperatures, as well as, the prevention of hair loss during chemotherapy. In order to preserve the scientific value of metabolic samples during long-term space missions, cooling is required to enable scientific studies. Results of one such study should provide a better understanding of osteoporosis and may lead to a possible cure for the disease.In the space environment, noise has to be kept to a minimum. In long-term space applications such as the International Space Station, thermoelectric technology provides the acoustic relief and the reliability for food, as well as, scientific refrigeration/freezers. Applications and future needs are discussed as NASA moves closer to a continued space presence in Mir, International Space Station, and Lunar-Mars Exploration.

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