scholarly journals Carnitine for Body Composition in Hemodialysis Patients

Author(s):  
Hideki Kakutani ◽  
Yoshikane Kato ◽  
Tomomi Fujikawa ◽  
Takafumi Kawata ◽  
Masami Yamamoto ◽  
...  

Background: Authors and colleagues have continued clinical research for hemodialysis patients. Currently, a pilot study presents intervention of carnitine for changes of the body composition. Subjects and Methods: Subjects were six patients on hemodialysis with intervention of carnitine (group 1). Average data were 74.3 years, 65.4 kg, 22.6 in BMI. As levocarnitine, L-Cartin FF injection 1000 mg was administered three times a week for six months. Group 2 has six control patients for age-, sex-, body weight, BMI-matched (group 2). Body composition of muscle and fat tissues were measured by InBody 770 on 0 and 6 months. Results: In group 1, muscle volume and skeletal muscle showed increasing tendency without statistical significance. In contrast, there were significant decreases of body fat volume (22.3 kg vs 20.5 kg, 39.0% vs 35.8%) (p<0.05). No significant differences were found in hemoglobin, total protein, albumin and Cardio-Thoracic Ratio (CTR) of chest X-ray. Group 2 showed no significant changes. Discussion and Conclusion: Hemodialysis patients often have muscular reduction. Previous reports showed improved lean body mass by carnitine administration, which may support our result. These results from current pilot study would be expected to become useful reference data in the pathophysiological investigation in patients on hemodialysis.

2006 ◽  
Vol 49 (6) ◽  
pp. 561-574
Author(s):  
H. Hoffschulte ◽  
A. M. Scholz

Abstract. Title of the paper: Relationship between body composition measured by dual energy x-ray absorptiometry and reproduction performance in gilts This study was conducted to evaluate the relationship between body composition and reproduction traits in gilts. A number of 176 gilts of different genotypes were categorized in three different groups. Group 0 consists of gilts that were disqualified for breeding according performance test results or showed no occurrence of oestrus. Group 1 consists of all gilts, which farrowed after an artificially insemination. Group 2 was composed of gilts that were artificially inseminated but did not give birth to a litter. Body composition was determined in vivo using dual energy x-ray absorptiometry at a live weight of about 90 kg. Initial reproduction data from group 1 were also evaluated. Results of the performance test showed considerable variation among the different groups. Group 1 was significantly heavier and the daily gain was significantly higher than in group 0. However, results of breeding index and value were clearly below the results of the other two groups. The body fat content was significantly higher in gilts with a litter (>1.65 absolutely) than in gilts without a litter (group 2) and in disqualified gilts (group 0). Group 2 gilts showed the smallest body fat mass. However, the relation between DXA fat percentage and litter size for group 1 showed in tendency that the litter size might decrease with an increasing fat content of gilts. Therefore, an optimum body fat content for conventional breeding gilts of European or American origin needs to be determined for a maximum fertility.


1964 ◽  
Vol 15 (5) ◽  
pp. 771 ◽  
Author(s):  
BA Panaretto

Ten Border Leicester x Merino ewes were divided into two groups on the basis of a initial calculation of their body composition. Group 1 comprised a group of six moderately fat ewes (fat content < 25% body weight), and group 2 four very fat ewes (fat content >40% body weight). The ewes were undernourished by feeding progressively diminishing quantities of a mixture of lucerne chaff and oats (1:1) until group 1 had lost 38.7 and group 2 33.7% of their initial weight in 150–200 days. Feed intakes and wool growth of the sheep were recorded and calculations were made of the body composition in terms of total body water, fat, protein, and ash as undernutrition progressed. Thiocyanate spaces, haematocrit values, and plasma, blood, and red cell volumes were also measured. Generally the ewes in group 1 exhibited a starvation syndrome which was characterized by the gradual depletion of the fat and protein reserves of the body until fat reserves had been almost completely used. Thiocyanate spaces in these ewes expanded relative to body weight, and the circulatory parameters showed a progressive shrinkage of the red cell volume while plasma volume was maintained. The ewes in group 2 differed markedly in their reaction to undernutrition in that three out of the four passed, after a time, into a phase of inappetence and died while still in a very fat condition.


2020 ◽  
pp. 193229682095210
Author(s):  
Claudio Tubili ◽  
Daniela Pollakova ◽  
Maria Rosaria Nardone ◽  
Ugo Di Folco

Aim: Sensor-augmented pumps with predictive low glucose suspend function (PLGS-SAP) help patients avoid hypoglycemia and improve quality of life: in this retrospective study, we investigated long-term effects of PLGS-SAP on metabolic outcomes, acute and chronic diabetic complications, in particular cardiovascular events. Materials and Methods: One hundred thirty-nine adults with type 1 diabetes (T1D) treated for more than 10 years with continuous subcutaneous insulin infusion (CSII) were followed for 5 years; 71 (Group 1) started to use PLGS-SAP, and 68 (Group 2) maintained on their non-PLGM insulin pump. Glucose control measures (hemoglobin A1c [HbA1c], acute diabetic complications), clinical outcomes (body mass index [BMI], arterial hypertension, dyslipidemia), chronic diabetes-related complications, and device utilization (continuous glucose monitoring utilization, use of temporary basal rates or special boluses, carbohydrate counting usage) were assessed. Results: The reduction of HbA1c was significant in Group 1 (from 7.5% ± 1.1% to 7.0% ± 1.0%, P = .02), while in Group 2 it did not reach statistical significance (from 7.5% ± 1.1% to 7.4% ± 0.9%, P = .853). BMI increased significantly in Group 2 (from 25.3 ± 2.8 to 25.7 ± 3.4, P < .001), but not in Group 1 (from 25.2 ± 3.5 to 25.2 ± 2.8, P = .887). There were no statistically significant differences in occurrence of acute diabetes complications, other clinical outcomes, prevalence of diabetes-related complications, or device utilization between the groups. Conclusions: In our five-year follow-up experience with T1D CSII users, PLGS-SAP has resulted efficient in improving metabolic control and maintaining the body weight.


Author(s):  
A. A. Jakovenko ◽  
O. Y. Shestopalova ◽  
A. Sh. Rumyantsev ◽  
V. M. Somova

The aim of the study. Compare the efficiency of the use of dual-energy x-ray absorptiometry (DRA) and bioimpedansometry (BIM) in the evaluation of the body composition of hemodialysis patients.Patients and methods. 67 patients on hemodialysis, among which 23 men and 44 women aged 54±14,4 years. BIM and DRA were used to evaluate the body composition.Results. The results of determining the total muscle mass of the body obtained by the results of DFA and BIM were compared with the use of the Bland-Altman method. The correlation coefficient between the indices was R=0,994, p<0,0001, delta (M±s) was –0,48±0,91 kg, CI 95% (–0,71)…(–0,26) kg.Conclusion. DRA does not have significant advantages over tetrapolar multifrequency BIM when assessing the body composition in hemodialysis patients. 


1994 ◽  
Vol 8 (4) ◽  
pp. 239-245
Author(s):  
G Bédard ◽  
A Pellicano ◽  
R Ste-Marie

During the course of esophageal motility studies, short zones of elevated esophageal baseline pressure are occasionally noticed. The aim of this study is to determine their frequency and their cause. Among 77 consecutive esophageal manometries (group 1), 17 cases (22%) of ‘esophageal high pressure zones’ (EHPZs) were recorded. Thirty-three additional patients (group 2) were evaluated and 18 other cases of EHPZ were found; in the latter group, a miniature sound microphone was positioned on a carotid artery. When a high pressure zone was identified, the manometric catheter was immobilized; the patient underwent a chest x-ray, with the radiopaque marker imbedded in the catheter used to locate the thoracic structures adjacent to EHPZs. In both groups, indentations (pressure spikes) over the high pressure zones occurred synchronously with the patients’ radial or carotid pulse. Results suggest that EHPZs are caused by the compression and pulsations of vascular or cardiac periesophageal structures; the aortic arch is responsible for the manometric EHPZ when it is found between 10 and 14 cm above the lower esophageal sphincter whereas the left auricle is the cause of the EHPZ if it is located between 4 and 7 cm above the lower esophageal sphincter.


2018 ◽  
Vol 28 (2) ◽  
pp. 46-51
Author(s):  
Martin Hashemi ◽  
Miglė Mackevičiūtė

Today it is more and more preferred to preserve teeth with promising prognosis rather than to extract them. The efficiency and the precision of retreatment files to remove filling material are important factors of successful treatment. The aim of this study was to evaluate the efficiency of MaxWire® alloy file in removing root canal filling material after retreatment with endodontic retreatment instruments. Distal roots of twenty human mandibular molars with single and straight canals were selected for this study. All canals were instrumented up to #40/.04 with Bio-race system and apical preparation was finished with Kfile #50/.02. Obturation was performed using lateral condensation technique with ADSEAL sealer. Radiographs were performed in buccolingual and mesiodistal directions with periapical X-ray after obuturation. Teeth were randomly divided into two groups with ten teeth in each. Group 1: removal of root canal filling material was performed using D-race system. Group 2: removal of root canal filling material was performed using D-race system following XP endo Finisher R instrument. Radiographs were performed after retreatment. Residual material was calculated in percentage left in canals. Statistical significance between the two groups were analyzed with t-test. Remnants of root canal filling material was observed in both groups: 38.90% in Group 1 and 13.71% in Group 2, respectively. There was a significant difference between the groups in term of the total root canal filling material (p&amp;lt;0.05). MaxWire® alloy file significantly increased the amount of removed root canal filling material after retreatment with endodontic retreatment instruments.


2022 ◽  
Vol 4 (1) ◽  
pp. 1-4
Author(s):  
Hatice Kilic ◽  
Habibe Hezer ◽  
Berker Ozturk ◽  
Muhammed Sait Besler ◽  
Huseyin Cetin ◽  
...  

Purpose: Chest radiography is normal in approximately 20-40% of acute pulmonary embolism (PE) patients without cardiopulmonary disease. The aim of this study was to determine whether there is any difference between the patients with normal chest X-ray and those with pathological findings in terms of clinical severity and prognosis. Methods: 178 of PE patients were included in the study. 110 patients had no parenchymal pathology, whereas group 1 (n = 110); group 2 (n = 68) had various pathological parenchymal findings in 68 patients. Clinical and radiological parameters were compared between these groups. Following the diagnosis of PE, the cases were recorded in the fifth year. Results: In 178 participants; those with normal chest X-ray (group 1), with parenchymal pathological findings on the chest X-ray (group 2); echocardiographic systolic pulmonary artery pressure (sPAP) (p = 0.68), gender (p = 0.9) and thrombus type (p = 0.41) were similar. The patients in group 1 were not different in terms of central thrombus detected in computed tomography pulmonary angiogram compared to the patients in group 2; however, the chest radiograph of the patients in group 1 had no parenchymal pathology. Central thrombus group 1, group 2, respectively; 97 (89.0%), 53 (77.9%), p = 0.07. There was no significant difference between the two groups in terms of mortality which was followed up in fifth year (p > 0.05). Conclusions: Normal chest X-ray in PE can determine mortality and may involve increased risk of massive PE.


Author(s):  
Anna Pieczyńska ◽  
Ewa Zasadzka ◽  
Tomasz Trzmiel ◽  
Małgorzata Pyda ◽  
Mariola Pawlaczyk

Ageing is inevitably associated with body composition changes, such as loss of muscle mass, increase in the total fat mass, and unfavorable reduction of subcutaneous fat. Physical activity exerts significant effects on the body composition. The aim of the study was to investigate the effects of two different weekly doses of resistance-aerobic training on the body composition in older people. The study consisted in a retrospective data analysis of fitness club members aged ≥60. The trainees participated in resistance-aerobic training sessions two or three times/week for a minimum of two months. A body composition analysis was performed before and after the training sessions. Group 1 (36 subjects) and Group 2 (28 subjects) had two and three training sessions/week, respectively. A higher skeletal muscle mass was found in Group 1 and lower waist-hip-ratio indices were observed in Group 2. No statistically significant differences were found in the body mass, skeletal muscle mass, fat mass, total body water, lean mass, body mass index, visceral fat area between both groups. The number of training session/week proved to be statistically insignificant for all investigated variables. Resistance-aerobic training with two sessions/week may be as effective in maintaining proper body composition in older people as the same training at the dose of three sessions/week.


VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 381-386 ◽  
Author(s):  
Christian Uhl ◽  
Thomas Betz ◽  
Andrea Rupp ◽  
Markus Steinbauer ◽  
Ingolf Töpel

Abstract. Summary: Background: This pilot study was set up to examine the effects of a continuous postoperative wound infusion system with a local anaesthetic on perioperative pain and the consumption of analgesics. Patients and methods: We included 42 patients in this prospective observational pilot study. Patients were divided into two groups. One group was treated in accordance with the WHO standard pain management protocol and in addition to that received a continuous local wound infusion treatment (Group 1). Group 2 was treated with analgesics in accordance with the WHO standard pain management protocol, exclusively. Results: The study demonstrated a significantly reduced postoperative VAS score for stump pain in Group 1 for the first 5 days. Furthermore, the intake of opiates was significantly reduced in Group 1 (day 1, Group 1: 42.1 vs. Group 2: 73.5, p = 0.010; day 2, Group 1: 27.7 vs. Group 2: 52.5, p = 0.012; day 3, Group 1: 23.9 vs. Group 2: 53.5, p = 0.002; day 4, Group 1: 15.7 vs. Group 2: 48.3, p = 0.003; day 5, Group 1 13.3 vs. Group 2: 49.9, p = 0.001). There were no significant differences between the two groups, neither in phantom pain intensity at discharge nor postoperative complications and death. Conclusions: Continuous postoperative wound infusion with a local anaesthetic in combination with a standard pain management protocol can reduce both stump pain and opiate intake in patients who have undergone transfemoral amputation. Phantom pain was not significantly affected.


2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Jerzy Stanek

AbstractShort CommunicationsEXIT (ex-utero intrapartum treatment) procedure is a fetal survival-increasing modification of cesarean section. Previously we found an increase incidence of fetal vascular malperfusion (FVM) in placentas from EXIT procedures which indicates the underlying stasis of fetal blood flow in such cases. This retrospective analysis analyzes the impact of the recently introduced CD34 immunostain for the FVM diagnosis in placentas from EXIT procedures.Objectives and MethodsA total of 105 placentas from EXIT procedures (48 to airway, 43 to ECMO and 14 to resection) were studied. In 73 older cases, the placental histological diagnosis of segmental FVM was made on H&E stained placental sections only (segmental villous avascularity) (Group 1), while in 32 most recent cases, the CD34 component of a double E-cadherin/CD34 immunostain slides was also routinely used to detect the early FVM (endothelial fragmentation, villous hypovascularity) (Group 2). 23 clinical and 47 independent placental phenotypes were compared by χ2 or ANOVA, where appropriate.ResultsThere was no statistical significance between the groups in rates of segmental villous avascularity (29 vs. 34%), but performing CD34 immunostain resulted in adding and/or upgrading 12 more cases of segmental FVM in Group 2, thus increasing the sensitivity of placental examination for FVM by 37%. There were no other statistically significantly differences in clinical (except for congenital diaphragmatic hernias statistically significantly more common in Group 2, 34 vs 56%, p=0.03) and placental phenotypes, proving the otherwise comparability of the groups.ConclusionsThe use of CD34 immunostain increases the sensitivity of placental examination for FVM by 1/3, which may improve the neonatal management by revealing the increased likelihood of the potentially life-threatening neonatal complications.


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