Immunomorphological features of chronic adenoiditis

2021 ◽  
Vol 27 (1) ◽  
pp. 12-20
Author(s):  
V.N. Krasnozhon ◽  
D.E. Cyplakov ◽  
E.M. Pokrovskaia ◽  
S.V. Khaliullina ◽  
E.F. Mannanova
Keyword(s):  
Chronic Adenoiditis

scholarly journals IMMUNOLOGIC RISK FACTORS OF DEVELOPMENT OTITIS MEDIA WITH EFFUSION IN CHILDREN SUFFERING FROM CHRONIC ADENOIDITIS

2013 ◽  
Vol 12 (3) ◽  
pp. 92-96
Author(s):  
N. V. Scherbik ◽  
A. V. Klimov ◽  
Ye. N. Kologrivova ◽  
O. V. Fyodorova ◽  
S. V. Komarova
Keyword(s):  
Risk Factors ◽  
Otitis Media ◽  
Mucosal Immunity ◽  
Otitis Media With Effusion ◽  
Clinical Group ◽  
Ifn Γ ◽  
Chronic Adenoiditis

There were 24 patients with chronic adenoiditis in the 1st group, another 24 patients with chronic adenoiditis in association with otitis media effusion (OME) were included in the 2d group. The study of mucosal immunity included assessment of SIgA, IL-6, IFN- and IL-10 levels in nasal washes. Decrease of SIgA content and increase of the number of IFN-γ-positive samples was revealed in children from the 2nd clinical group, which allows to regard these characteristics of the mucosal immunity as the risk factors for the development of otitis media with effusion.

Endogenous intoxication in chronic pathology of pharynx in children

2021 ◽  
Vol 20 (3) ◽  
pp. 94-101
Author(s):  
T. A. Mashkova ◽  
◽  
I. I. Chirkova ◽  
O. N. Yamshchikov ◽  
I. Yu. Revyakin ◽  
...  
Keyword(s):  
Biological Fluids ◽  
The Body ◽  
Chronic Tonsillitis ◽  
Palatine Tonsils ◽  
Immunological Markers ◽  
Decay Products ◽  
Endogenous Intoxication ◽  
Pathological Hypertrophy ◽  
Chronic Adenoiditis ◽  
Pharyngeal Tonsil

A review of scientific Russian and foreign articles devoted to the development of endogenous intoxication in chronic inflammatory pathology of the lymphoepithelial pharyngeal ring is carried out. Chronic tonsillitis and adenoiditis in children are one of the unsolved issues in otorhinolaryngology. Chronic tonsillitis is a chronic inflammation of the palatine tonsils characterized by recurrent exacerbations in the form of tonsillitis and a general toxic-allergic reaction. Adenoid vegetation is a pathological hypertrophy of the pharyngeal tonsil. Chronic adenoiditis is a chronic polyetiologic disease, which is based on a violation of the physiological immune processes of the pharyngeal tonsil. In children, one cannot talk about an isolated inflammation of the pharyngeal tonsil, since as a result of exposure to antigens, an immune response arises, which involves all structures of the lymphoepithelial pharyngeal ring in the process, therefore some authors distinguish the term «adenotonsillitis». With pronounced activation of microflora in the nasopharynx and oropharynx, the body’s resistance to pathogenic microorganisms decreases, as a result of which decay products and toxins damage the vascular endothelium, disrupt their permeability and, penetrating through the epithelial barrier, contribute to the development of chronic intoxication and sensitization of the body. Endogenous intoxication is a polyetiologic and polypathogenetic syndrome characterized by the accumulation of endogenous toxins in tissues and biological fluids. Diagnostics of the endogenous intoxication severity includes a number of clinical and laboratory indicators and immunological markers. But, despite the constant improvement of the research methods, the issue of endotoxicosis diagnosis in chronic tonsillitis and adenoiditis remains insufficiently studied. As a result of the inadequate diagnosis, there is often a simultaneous removal of the pharyngeal and palatine tonsils, which in turn can lead to irreversible consequences.

Tactics of conservative treatment of chronic adenoiditis in children

2019 ◽  
Vol 84 (2) ◽  
pp. 36
Author(s):  
G. S. Maltseva ◽  
M. V. Drozdova ◽  
S. V. Ryazantsev ◽  
G. P. Zakharova ◽  
S. B. Bezshapochny
Keyword(s):  
Conservative Treatment ◽  
Chronic Adenoiditis

Analysis of the Microorganism’s Sensitivity in Patients with Chronic Adenoiditis to Pharmacotherapy with Antibacterial Drugs

2020 ◽  
Vol 17 (9) ◽  
pp. 4741-4745
Author(s):  
Leontiy V. Druzhikin ◽  
Elena S. Druzhikina ◽  
Sergey A. Alekhin ◽  
Elena B. Artyushkova ◽  
Alexander A. Dolzhikov ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Upper Respiratory Tract ◽  
Negative Consequences ◽  
Antibacterial Drugs ◽  
Pharmacological Agents ◽  
Microbial Association ◽  
Hospital Units ◽  
Gram Staining ◽  
Number Of Patients ◽  
Chronic Adenoiditis

Introduction: The prevalence of chronic pathology of the pharyngeal lymphatic system in preschool children reaches 45% and is mainly manifested by hypertrophy of adenoid vegetations, which in half of cases are combined with chronic inflammation, which, with repeated periods of exacerbation, leads to the development of severe chronic pathology of the upper respiratory tract. The role of microorganisms toleranceto pharmacological agents is widely proven in formation of chronic inflammatory disorders and demand correction of therapeutic schemes. Research tasks: The aim of this research was to study the microbial landscape of oropharynx in children who received surgical for adenoiditis and determine the sensitivity of the identified microorganisms to the pharmacotherapy with antibiotics. Material and Methods: We conducted a study of 1577 children aged from 1 year to 17 years and 11 months who received inpatient treatment at the otorhinolaryngological Department of the OO “Scientific and clinical multidisciplinary center named after Z. I. Kruglaya” in the city of Oryol in the period from 2015 to 2017 for hypertrophy of adenoid vegetations. The patients were divided into three groups based on the years of the study. The study of the oropharyngeal microbial association was performed by preparing a smear followed by Gram staining and bacterioscopy. Determination of the sensitivity of microorganisms to antibacterial drugs was performed by discdiffusion method. Results: We found in patients oropharynx microbial landscape with hypertrophy of chronic vegetation in dynamics over the period from 2015 to 2017, an increase in the number of opportunistic saprophytic flora was detected, which was observed against the background of a clear increase in the number of patients with this pathology an increase in the number of cases associated with saprophytic MRCA flora, represented mainly by Staphylococcus aureus, leads to a decrease in the effectiveness of conservative treatment of chronic adenoiditis, which is expressed in an increase in the number of adenotomies. Conclusion: The study revealed negative consequences of uncontrolled use of antibiotic therapy at the pre-hospital stage and irrational schemes of chemotherapy in hospital units, which is manifested in the growing resistance of microorganisms to both “old” antibacterial drugs and a decrease in sensitivity to pharmacotherapy with the latest generation of antibiotics and requires active revision of the schemes of antibiotic therapy and prevention.

scholarly journals Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis

IDCases ◽  
2016 ◽  
Vol 4 ◽  
pp. 56-58 ◽  
Author(s):  
Cheshil Dixit ◽  
Lance E. Keller ◽  
Jessica L. Bradshaw ◽  
D. Ashley Robinson ◽  
Edwin Swiatlo ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Chronic Adenoiditis

scholarly journals Etiological aspects of chronic pathology of the lymphepithelial pharyngeal ring in children at the present stage

2021 ◽  
pp. 100-105
Author(s):  
Yu. S. Preobrazhenskaya ◽  
M. V. Drozdova ◽  
S. V. Ryazantsev
Keyword(s):  
Present Stage ◽  
Adequate Treatment ◽  
Treatment Regimens ◽  
Wide Range ◽  
Common Problems ◽  
Chronic Adenoiditis ◽  
Immunomodulating Drugs ◽  
Positive Effect ◽  
Selection Of ◽  
Pharyngeal Tonsil

The lymphoepithelial pharyngeal ring is located in the entrance gate and is constantly exposed to infectious agents. Currently, chronic pathology of the lymphoepithelial pharyngeal ring remains one of the most common problems in the practice of a pediatric doctor. Hypertrophy of the pharyngeal tonsil, chronic adenoiditis, which occurs in 35.3% of children under the age of 7 years, and chronic tonsillitis, which occurs in 15-63% of cases, are among the most common diseases of childhood. Taking into account the wide range of infectious microbiota that contributes to the development of chronic pathology of the lymphoepithelial pharyngeal ring, the issue of differential diagnosis of the etiology of the disease and the selection of adequate treatment regimens remains relevant. In most cases, at the present stage, the approach to the treatment of patients with chronic inflammation of the lymphoid ring of the pharynx in children is reduced to replacing the surgical method with a conservative one with the appointment of immunocorrective and immunomodulatory drugs. The lack of a positive effect of the ongoing conservative treatment, clinical and laboratory signs of persistent streptococcal infection say us about the need for surgical treatment. At the same time, a group of frequently ill children requires special attention with the development of new regimens of the immunocorrecting and immunomodulating drugs usage.

scholarly journals Assessment of size of adenoid-comparison of adenoidal nasopharyngeal ratio and nasal endoscopy in children with chronic adenoiditis

2019 ◽  
Vol 7 (3) ◽  
pp. 776
Author(s):  
Sunaina Binth Hamza ◽  
Ranjith V. T.
Keyword(s):  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Lateral View ◽  
Nasal Endoscopy ◽  
X Rays ◽  
Cross Sectional ◽  
Gold Standard Method ◽  
X Ray ◽  
Grade 3 ◽  
Chronic Adenoiditis

Background: Adenoid hypertrophy (AH) is a common cause of upper airway obstruction in paediatric patients and can have a significant influence on the health of the child. Children who have hypertrophic adenoids often exhibit nasal obstruction, snoring, sleep apnea, otitis media with effusion and craniofacial abnormalities. The main objective of this study was to know the association between size of adenoids and occurrence of otitis media with effusion (OME) and to correlate the grades of AH by lateral nasopharyngeal radiograph and nasal endoscope.Methods: This was an observational cross-sectional study of 100 children who were diagnosed as chronic adenoiditis were studied clinically with relevant investigations. The digital X-ray nasopharynx lateral view and nasal endoscopic results of all the patients were analyzed and graded.Results: Mean Adenoidal-nasopharyngeal ratio for which OME was present was 0.72 which corresponds to X-ray grade 2. It was also found that 80.6% of X-ray grade 3 adenoids had OME and 100% of cases of endoscopic grade 4 adenoids had OME in either or both ears.  36 cases with grade 3 X-rays, 69% were in endoscopic grade 3 and 19.4% cases were shown to have complete choanal obstruction (grade 4).Conclusions: There is significant association between the size of adenoids and OME. The X-ray nasopharynx provides a more convenient method and nasal endoscopy is the gold standard method for determining whether the AH is clinically significant or not.

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