scholarly journals Biomaterials in Valvular Heart Diseases

2020 ◽  
Vol 8 ◽  
Author(s):  
Bita Taghizadeh ◽  
Laleh Ghavami ◽  
Hossein Derakhshankhah ◽  
Ehsan Zangene ◽  
Mahdieh Razmi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Disease ◽  
Heart Diseases ◽  
Low Cost ◽  
Surgical Approaches ◽  
Great Promise ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Valvular Heart Diseases

Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient’s quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach for VHD management is to replace or repair the injured valvular tissue with natural or synthetic biomaterials. Application of these biomaterials for cardiac valve regeneration and repair holds a great promise for treatment of this type of heart disease. The focus of the present review is the current use of different types of biomaterials in treatment of valvular heart diseases.

Symptoms, Hope, Self-Management Behaviors, and Quality of Life Among Chinese Preoperative Patient With Symptomatic Valvular Heart Diseases

2019 ◽  
Vol 31 (3) ◽  
pp. 284-293 ◽  
Author(s):  
Yongfeng Chen ◽  
Guifen Fu ◽  
Fang Liang ◽  
Jing Wei ◽  
Jing He ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rural Areas ◽  
Heart Diseases ◽  
Adult Population ◽  
Food Culture ◽  
Self Management ◽  
Valvular Heart Diseases ◽  
Loss Of Appetite ◽  
Management Behaviors

Introduction: More than 42 million people are estimated to suffer from valvular heart disease (VHD) worldwide with a prevalence of 5.3% to 7.7% in the Chinese adult population. The purpose of this study was to examine the associations between symptoms, hope, self-management behaviors, and quality of life (QOL) for preoperative patients with symptomatic VHD in a rural area of China. Method: This was a descriptive comparative study that took place in Nanning, China, between January 2015 and March 2016. The sample was 128 preoperative patients with symptomatic VHD. Data were collected using the Symptom Distress Questionnaire, Herth Hope Index, Self-Management Scale, and Minnesota Living with Heart Failure Questionnaire. Results: Data from 122 patients were included in the final analysis. Mean scores of hope, self-management, and QOL were 36.71, 55.27, and 55.56. Worse total scores of symptom severity ( r = 0.57 to 0.69, p < .001) and self-management behaviors ( r = −0.22 to −0.25, p < .05) were associated with poorer QOL. Fatigue, loss of appetite, and self-management behaviors explained 49.90% variance of QOL ( p < .001). Discussion: Fatigue, loss of appetite, and self-management influenced QOL of patients with symptomatic VHD. Interventions aimed at strengthening self-management and relieving symptoms should be tailored for patients with symptomatic VHD base on their traditional animist belief and food culture in rural areas of China such as the Zhuang Autonomous Region.

scholarly journals Socioeconomic characteristics and quality of life of urban and rural elderly people with heart disease

2015 ◽  
Vol 36 (3) ◽  
pp. 21-27 ◽  
Author(s):  
Darlene Mara dos Santos Tavares ◽  
Glendha Oliveira Arduini ◽  
Nayara Paula Fernandes Martins ◽  
Flavia Aparecida Dias ◽  
Lucia Aparecida Ferreira
Keyword(s):  
Quality Of Life ◽  
Heart Disease ◽  
Linear Regression ◽  
Social Relations ◽  
Urban Areas ◽  
Heart Diseases ◽  
Household Survey ◽  
Chi Square ◽  
Socioeconomic Characteristics

Objective: To compare the socioeconomic variables and quality of life scores (QOL) of elderly residents with heart diseases in urban and rural areas.Method: household survey with 829 urban and 220 rural elderlies. The data were collected using: Brazilian Questionnaire for Functional and Multidimensional Assessment, WHOQOL-BREF and WHOQOL-OLD. The collection in the urban area was from June to December of 2008 and, in the rural area, from June 2010 to March 2011. Chi-square, t-student and multiple linear regression (p <0.05) tests were used.Results: The proportion of women and elderlies with 75 years of age and over was higher in urban areas. Lower scores among urban elderlies physical and social relations were observed, and; facets autonomy, past, present and future activities and intimacy; for the rural elderlies, the environment, sensory abilities, death and dying.Conclusion: the urban elderlies showed a lower QOL score in most areas and facets compared to rural elderlies.

scholarly journals Quality of life of patients with congenital heart diseases

2011 ◽  
Vol 21 (6) ◽  
pp. 670-676 ◽  
Author(s):  
Ana M. Silva ◽  
Cláudia Vaz ◽  
Maria E. G. Areias ◽  
Daniela Vieira ◽  
Cidália Proença ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Negative Impact ◽  
Heart Diseases ◽  
Emotional Adjustment ◽  
Perception Of Quality

AbstractObjectivesTo assess the perception of the quality of life of adolescents and young adults with congenital heart disease and to examine the variables that have a negative impact on it and that add a resilience effect.MethodsA total of 22 male and 18 female patients, aged 12–26 years, of whom 27 were admitted to surgery and 13 were not, participated in this study. All patients had complete medical records and were interviewed once; demographic and clinical data were collected, and patients filled a questionnaire on quality of life, the WHOQOL-BREF, and underwent an interview on social support, educational style, self-image, functional limitations, and emotional adjustment.Results/ConclusionsOur patients showed a better perception of quality of life than did the general population, on the basis of psychological, social relationship and environment scales. Older patients hold a better perception of quality of life on the psychological scale. Cyanosis did not show any significant impact over perception of quality of life decay; however, the number of surgical procedures and the persistence of moderate-to-severe residual injuries had considerable detrimental effect. Social support had an impact on increasing resilience, promoting adjustment to illness. Several factors may play a role in adjustment to congenital heart disease, either improving the perception of quality of life or worsening it. We may conclude that some buffer variables on congenital heart disease may play roles in increasing the perception of quality of life of patients during their lifetime, social support probably explaining why the perception of quality of life is better than in the normal population. The number of surgeries and the moderate-to-severe residual injuries, however, reverted that effect.

scholarly journals Pruritus: still a challenge

2012 ◽  
Vol 87 (5) ◽  
pp. 735-741 ◽  
Author(s):  
Paulo Rowilson Cunha ◽  
Oswaldo Delfini Filho
Keyword(s):  
Quality Of Life ◽  
Histamine Release ◽  
Skin Diseases ◽  
Systemic Diseases ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Available Resources

Pruritus is a symptom that may be associated with a wide array of diseases - skin diseases, systemic diseases or even those without a defined cause. According to its severity and evolution, it may compromise the patients' quality of life in a significant way. New therapeutic approaches, in which histamine release is not the main event, are being described for pruritus control. Therefore, taking into account the origin of the mediators of pruritus, we conducted a review of the available resources emphasizing that, although very important, anti-histamines are not the answer for every kind of pruritus.

scholarly journals Melatonin’s Antineoplastic Potential Against Glioblastoma

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 599 ◽  
Author(s):  
Enrico Moretti ◽  
Gaia Favero ◽  
Luigi Fabrizio Rodella ◽  
Rita Rezzani
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Mechanisms Of Action ◽  
Therapeutic Approaches ◽  
Research Attention ◽  
Cancer Hallmarks ◽  
New Therapeutic Approaches ◽  
Number Of Patients ◽  
Intracellular Pathways

Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients’ expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties. Due to evidence demonstrating melatonin’s activity against several cancer hallmarks, there is growing interest in its use for preventing and treating cancer. In this review, we report on the potential effects of melatonin, alone or in combination with anticancer drugs, against GBM. We also summarize melatonin targets and/or the intracellular pathways involved. Moreover, we describe melatonin’s epigenetic activity responsible for its antineoplastic effects. To date, there are too few clinical studies (involving a small number of patients) investigating the antineoplastic effects of melatonin against GBM. Nevertheless, these studies described improvement of GBM patients’ quality of life and did not show significant adverse effects. In this review, we also report on studies regarding melatonin-like molecules with the tumor-suppressive properties of melatonin together with implemented pharmacokinetics. Melatonin effects and mechanisms of action against GBM require more research attention due to the unquestionably high potential of this multitasking indoleamine in clinical practice.

scholarly journals Neurorestoration after stroke

2016 ◽  
Vol 40 (5) ◽  
pp. E2 ◽  
Author(s):  
Tej D. Azad ◽  
Anand Veeravagu ◽  
Gary K. Steinberg
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Ischemic Stroke ◽  
Cell Biology ◽  
Clinical Implications ◽  
Stem Cell Biology ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Broad Overview

Recent advancements in stem cell biology and neuromodulation have ushered in a battery of new neurorestorative therapies for ischemic stroke. While the understanding of stroke pathophysiology has matured, the ability to restore patients' quality of life remains inadequate. New therapeutic approaches, including cell transplantation and neurostimulation, focus on reestablishing the circuits disrupted by ischemia through multidimensional mechanisms to improve neuroplasticity and remodeling. The authors provide a broad overview of stroke pathophysiology and existing therapies to highlight the scientific and clinical implications of neurorestorative therapies for stroke.

scholarly journals COMPARISON OF SEVERAL MODELS FOR CARDIOVASCULAR DISEASES PREDICTION

2020 ◽  
Vol 6 (6) ◽  
pp. 24-28
Author(s):  
Yue Wang ◽  
◽  
Lilia I. Voronova ◽  
Vyacheslav I. Voronov ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Chronic Diseases ◽  
Heart Diseases ◽  
Rapid Development ◽  
Science And Technology ◽  
Standard Of Living ◽  
Pace Of Life

Due to the rapid development of economy, science and technology, the pace of life of people has accelerated and their standard of living has increased. At the same time, the number of various chronic diseases, such as cardiovascular, cerebrovascular and chronic heart diseases, is increasing. These problems seriously affect people's quality of life. Therefore, the problem of predicting cardiovascular diseases has become extremely urgent. The article compares several models for predicting heart disease and evaluates quality of their prognosis.

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