scholarly journals Continuous Hydrogenation: Triphasic System Optimization at Kilo Lab Scale Using a Slurry Solution

2021 ◽  
Vol 3 ◽  
Author(s):  
Florian Salique ◽  
Ancuta Musina ◽  
Marc Winter ◽  
Nedelec Yann ◽  
Philippe M. C. Roth
Keyword(s):  
Process Development ◽  
Flow Reactor ◽  
Process Intensification ◽  
System Optimization ◽  
Hydrogenation Reaction ◽  
Phase System ◽  
Hydrogenation Reactions ◽  
Influential Parameters ◽  
Continuous Hydrogenation ◽  
Intrinsic Safety

Despite their widespread use in the chemical industries, hydrogenation reactions remain challenging. Indeed, the nature of reagents and catalysts induce intrinsic safety challenges, in addition to demanding process development involving a 3-phase system. Here, to address common issues, we describe a successful process intensification study using a meso-scale flow reactor applied to a hydrogenation reaction of ethyl cinnamate at kilo lab scale with heterogeneous catalysis. This method relies on the continuous pumping of a catalyst slurry, delivering fresh catalyst through a structured flow reactor in a continuous fashion and a throughput up to 54.7 g/h, complete conversion and yields up to 99%. This article describes the screening of equipment, reactions conditions and uses statistical analysis methods (Monte Carlo/DoE) to improve the system further and to draw conclusions on the key influential parameters (temperature and residence time).

scholarly journals Boosting the Productivity of H2-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H2 From Water Electrolysis

2021 ◽  
Vol 3 ◽  
Author(s):  
Barnabas Poznansky ◽  
Sarah E. Cleary ◽  
Lisa A. Thompson ◽  
Holly A. Reeve ◽  
Kylie A. Vincent
Keyword(s):  
Continuous Flow ◽  
Room Temperature ◽  
Immobilized Enzyme ◽  
Flow Reactor ◽  
Process Intensification ◽  
Water Electrolysis ◽  
Turnover Frequency ◽  
Batch Mode ◽  
Hydrogenation Reactions ◽  
Redox Biocatalysis

Translation of redox biocatalysis into a commercial hydrogenation flow reactor, with in-built electrolytic H2 generation, was achieved using immobilized enzyme systems. Carbon-supported biocatalysts were first tested in batch mode, and were then transferred into continuous flow columns for H2-driven, NADH-dependent asymmetric ketone reductions. The biocatalysts were thus handled comparably to heterogeneous metal catalysts, but operated at room temperature and 1–50 bar H2, highlighting that biocatalytic strategies enable implementation of hydrogenation reactions under mild–moderate conditions. Continuous flow reactions were demonstrated as a strategy for process intensification; high conversions were achieved in short residence times, with a high biocatalyst turnover frequency and productivity. These results show the prospect of using enzymes in reactor infrastructure designed for conventional heterogeneous hydrogenations.

Catalytic asymmetric hydrogenation reaction by in situ formed ultra-fine metal nanoparticles in live thermophilic hydrogen-producing bacteria

Nanoscale ◽  
2021 ◽  
Author(s):  
Wei Bing ◽  
Faming Wang ◽  
Yuhuan Sun ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Metal Nanoparticles ◽  
Catalytic Hydrogenation ◽  
Asymmetric Hydrogenation ◽  
Environmentally Friendly ◽  
Hydrogenation Reaction ◽  
Highly Efficient ◽  
Hydrogenation Reactions ◽  
Live Bacteria ◽  
Catalytic Asymmetric Hydrogenation

An environmentally friendly biomimetic strategy has been presented and validated for the catalytic hydrogenation reaction in live bacteria. In situ formed ultra-fine metal nanoparticles can realize highly efficient asymmetric hydrogenation reactions.

scholarly journals Immobilization of an Iridium(I)-NHC-Phosphine Catalyst for Hydrogenation Reactions under Batch and Flow Conditions

Catalysts ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 656
Author(s):  
Henrietta Kovács ◽  
Krisztina Orosz ◽  
Gábor Papp ◽  
Ferenc Joó ◽  
Henrietta Horváth
Keyword(s):  
Catalytic Activity ◽  
Ion Exchange ◽  
Heterogeneous Catalyst ◽  
Aqueous Phase ◽  
Levulinic Acid ◽  
Flow Reactor ◽  
High Catalytic Activity ◽  
Flow Conditions ◽  
Hydrogenation Reactions ◽  
Excellent Selectivity

Na2[Ir(cod)(emim)(mtppts)] (1) with high catalytic activity in various organic- and aqueous-phase hydrogenation reactions was immobilized on several types of commercially available ion-exchange supports. The resulting heterogeneous catalyst was investigated in batch reactions and in an H-Cube flow reactor in the hydrogenation of phenylacetylene, diphenylacetylene, 1-hexyne, and benzylideneacetone. Under proper conditions, the catalyst was highly selective in the hydrogenation of alkynes to alkenes, and demonstrated excellent selectivity in C=C over C=O hydrogenation; furthermore, it displayed remarkable stability. Activity of 1 in hydrogenation of levulinic acid to γ-valerolactone was also assessed.

Process intensification of continuous starch hydrolysis with a Couette–Taylor flow reactor

2013 ◽  
Vol 91 (11) ◽  
pp. 2259-2264 ◽  
Author(s):  
Hayato Masuda ◽  
Takafumi Horie ◽  
Robert Hubacz ◽  
Naoto Ohmura
Keyword(s):  
Flow Reactor ◽  
Process Intensification ◽  
Starch Hydrolysis ◽  
Taylor Flow

Intensification of the Production of 2-Ethyl-Hexyl Acrylate: Batch Kinetics and Reactive Distillation

2018 ◽  
Vol 16 (7) ◽  
Author(s):  
Vivek D. Talnikar ◽  
Onkar A. Deorukhkar ◽  
Amit Katariya ◽  
Yogesh S. Mahajan
Keyword(s):  
Kinetic Model ◽  
Acrylic Acid ◽  
Process Development ◽  
Reactive Distillation ◽  
Batch Reactor ◽  
Process Intensification ◽  
Complete Conversion ◽  
Reaction Conditions ◽  
Batch Mode ◽  
Batch Kinetics

Abstract The reaction of acrylic acid and 2-ethyl-1 hexanol was explored in this work with the intent of process intensification. In order to assess the effect of important parameters on the course of reaction, this work initially conducted batch reactor experiments. Reaction conditions in the batch reactor for a specific conversion (~ 30 %) were obtained. A kinetic model was then obtained through regression to arrive at a rate expression that is later used in process development. Experiments were performed in the reactive distillation (RD) environment in batch mode, which showed substantial increase in conversion (~ 80 %) indicating the applicability of RD. Further, this work performed simulation in the RD environment to assess process intensification. Simulations show that it is possible to obtain complete conversion of the acid.

Continuous hydrogenation reactions in a tube reactor packed with Pd/C

2005 ◽  
pp. 40 ◽  
Author(s):  
Nungruethai Yoswathananont ◽  
Kohei Nitta ◽  
Yumi Nishiuchi ◽  
Masaaki Sato
Keyword(s):  
Tube Reactor ◽  
Hydrogenation Reactions ◽  
Continuous Hydrogenation

scholarly journals Ni–Zn–Al-Based Oxide/Spinel Nanostructures for High Performance, Methane-Selective CO2 Hydrogenation Reactions

2019 ◽  
Vol 150 (6) ◽  
pp. 1527-1536
Author(s):  
T. Rajkumar ◽  
András Sápi ◽  
Marietta Ábel ◽  
Ferenc Farkas ◽  
Juan Fernando Gómez-Pérez ◽  
...  
Keyword(s):  
High Performance ◽  
Consumption Rate ◽  
Hydrogenation Reaction ◽  
Reaction Conditions ◽  
Metal Support Interaction ◽  
Metal Support ◽  
Hydrogenation Reactions ◽  
Oxide Spinel ◽  
Methane Selectivity ◽  
Spinel Structures

Abstract In the present study, NiO modified ZnAl2O4 and ZnO modified NiAl2O4 spinel along with pure Al2O3, ZnAl2O4 and NiAl2O4 for comparison in the CO2 hydrogenation reaction have been investigated. It was found that NiAl2O4, NiO/ZnAl2O4 and ZnO/NiAl2O4 catalysts exhibited outstanding activity and selectivity towards methane even at high temperature compared to similar spinel structures reported in the literature. NiO/ZnAl2O4 catalyst showed CO2 consumption rate of ~ 19 μmol/g·s at 600 °C and ~ 85% as well as ~ 50% of methane selectivity at 450 °C and 600 °C, respectively. The high activity and selectivity of methane can be attributed to the presence of metallic Ni and Ni/NiO/ZnAl2O4 interface under the reaction conditions as evidenced by the XRD results. Graphic Abstract High performance Ni–Zn–Al-based oxide/spinel nanostructures is synthesized and NiO/ZnAl2O4 catalyst exhibited higher catalytic activity in the CO2 hydrogenation reaction due to the presence of metal support interaction between Ni and ZnAl2O4 support.

scholarly journals Sustainable Production of 5-Hydroxymethylfurfural from Pectin-Free Sugar Beet Pulp in a Simple Aqueous Phase System-Optimization with Doehlert Design

Energies ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 5649
Author(s):  
Hanna Pińkowska ◽  
Małgorzata Krzywonos ◽  
Paweł Wolak ◽  
Przemysław Seruga ◽  
Agata Górniak ◽  
...  
Keyword(s):  
Sugar Beet ◽  
Subcritical Water ◽  
Batch Reactor ◽  
Hydrothermal Process ◽  
System Optimization ◽  
Holding Time ◽  
Sugar Beet Pulp ◽  
Free Sugar ◽  
Phase System ◽  
Beet Pulp

Waste solid residue from the hydrothermal extraction of pectin derived from sugar beet pulp was used as feedstock in the production of 5-hydroxymethylfurfural (5-HMF). The depolymerization of pectin-free sugar beet pulp (PF-SBP) to monosaccharides and their dehydration to 5-HMF were conducted in subcritical water using a batch reactor. The experimental design methodology was used in order to model the hydrothermal process and to optimize the operational parameters of the reaction, namely temperature and holding time. These parameters are required to achieve the highest yield of 5-HMF. The model predicts, in good agreement with experimental results (R2 = 0.935), an optimal yield of 5-HMF (of approximately 38% in relation to the cellulosic fraction content in the PF-SBP) at a temperature of 192.5 °C and a holding time of about 51.2 min. 5-HMF was successfully isolated from the reaction mixture using the liquid–liquid extraction method. The results are suitable for industrial upscaling and may become an incentive to introduce a new, environmentally friendly, uncomplicated, and efficient waste treatment method. The method would be used to treat products from the sugar refining industry, the treatment of which has proven to be problematic until now.

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