scholarly journals U-Shaped Association Between Serum Uric Acid Level and Hypertensive Heart Failure: A Genetic Matching Case-Control Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongxuan Xu ◽  
Quan Wang ◽  
Yunqing Liu ◽  
Lingbing Meng ◽  
Huanyu Long ◽  
...  
Keyword(s):  
Heart Failure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Public Healthcare ◽  
Quadratic Term ◽  
Cross Sectional ◽  
Failure Group

Background: Heart failure (HF) is a global pandemic and lays an added burden on public healthcare. Previous studies indicated that high and low serum uric acid levels are associated with worse outcomes in many diseases. Reduced serum uric acid may not result in a better outcome.Methods: A comparative, matched cross-sectional study design was implemented. The matching variables were age, sex, BMI, BP, and histories of CKD, CVD, diabetes mellitus, stroke, hyperlipidemia. We reviewed the electronic medical records to identify patients diagnosed with hypertension or hypertensive heart failure (HHF) admitted to Beijing Hospital's cardiology department.Results: The median age of the two groups after matching are 71. There are 55.6% males in the hypertension group and 53.8% in the heart failure group. Univariate logistic regression analysis showed that UA's quadratic term is significant (OR = 1.00, 95% CI 1.00 to 1.00; P = 0.03), which indicated a u-shaped relationship between hypertension and HHF. FBS (OR = 0.22, 95% CI 0.05 to 0.95, p = 0.07) and HDL (OR = 1.23, 95% CI 1.00 to 1.54, P = 0.05) were not significant but close.Conclusion: Our results supported that both low and high uric acid levels were predictive of hypertensive heart failure. Besides, high-density lipoprotein cholesterol and fasting blood sugar were also associated with hypertensive heart failure. Low-density lipoprotein cholesterol was not associated with hypertensive heart failure.

scholarly journals Is the increase of uric acid associated with the components of the metabolic syndrome?

2020 ◽  
Vol 26 (1) ◽  
pp. 7-13
Author(s):  
Vaida Sudmantaitė ◽  
Jurgita Mikolaitytė ◽  
Jolita Badarienė ◽  
Alma Čypienė ◽  
Agnė Jucevičienė ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
The Metabolic Syndrome

Summary Objectives: There is increasing evidence that metabolic syndrome (MetS) may be associated with increased uric acid levels. Previous studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disorders. We sought to determine the association of serum uric acid (SUA) with MetS components and other cardiovascular risk factors among middle aged Lithuanians with MetS. Design and methods: A cross-sectional study was conducted in 2018. A total of 705 subjects aged 40 to 65 years with MetS diagnosed using NCEP ATP III criteria were included. None of the participants had previously diagnosed cardiovascular, cerebrovascular, peripheral artery or end-stage oncological disease. Blood tests and all anthropometric measurements were obtained using standard methods. Subjects were divided into 2 groups: with hyperuricaemia and without hyperuricaemia. Results: Hyperuricaemia was found in 33.3% of subjects. Mean serum uric acid level increased as the number of metabolic factors increased. Participants with hyperuricaemia had abnormal waist circumference (p < 0.001), higher systolic (p = 0.001) and diastolic blood pressure (p = 0.003), higher levels of triglycerides and, lower levels of high-density lipoprotein cholesterol (p < 0.001). Subjects in hyperuricaemia group were more likely to be alcohol users (p = 0.034), to have diabetes (p = 0.02) and higher body mass index (p < 0.001). Their creatinine levels were statistically significantly higher (p < 0.001). Conclusions: Our analysis showed that serum uric acid is associated with MetS and other cardiovascular risk factors. The study found a statistically significant association with the four out of five components of the MetS (excluding plasma glucose) as well as with alcohol consumption, and renal function indicators (creatinine, eGFR).

scholarly journals Uric acid levels are critical for non-alcoholic fatty liver disease

2020 ◽  
Author(s):  
Guanqun Chao ◽  
Yue Zhu ◽  
Lizheng Fang
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Risk Factor ◽  
Fatty Liver ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Density Lipoprotein ◽  
Diagnostic Threshold

Abstract Background: To clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors.Methods: Datas were obtained from subjects who underwent health examination in the Health promotion centre of Sir Run Run Shaw hospital of Zhejiang University from January 2016 to December 2017.The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines.Statistical analyses were performed using R software.Results: 79492 subjects were analyzed. 56680(71.3%) participants did not have NAFLD, 22812(28.7%) participants had NAFLD. Male, age, BMI, high blood pressure, central obesity, high glycosylated hemoglobin, high serum uric acid, high triglyceride, high total cholesterol, high low density lipoprotein cholesterol (LDL-C), abnormal liver function were risk factors of NAFLD, however, low high-density lipoprotein cholesterol (HDL-C) level was another risk factor of NAFLD.OR value suggested serum uric acid was a robust risk factor for NAFLD in all subgroups.In male group, AUC was 0.656 (95%CI: 0.651-0.661), the optimal diagnostic threshold was 395.5 mol/L, the sensitivity was 61.9%, the specificity was 61.1%, and the yoden index was 0.23. In female group, AUC was 0.716 (95%CI: 0.708-0.724), the optimal diagnostic threshold was 294.5 mol/L, sensitivity was 67.7%, specificity was 64.5%, and the Jordan index was 0.32.Conclusions: Our study suggested that there was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.Contributions to the literature：1. The purpose of this study was to clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors in the physical examination population.2. There was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.3. The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.

Abstract 20287: Cardiac MIBG Imaging Predicts Cardiac Death in Patients With Chronic Heart Failure , Irrespective of Hyperuricemia

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Satoshi Takahashi ◽  
Takahisa Yamada ◽  
Takashi Morita ◽  
Yoshio Furukawa ◽  
Shunsuke Tamaki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Uric Acid ◽  
Chronic Heart Failure ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Cardiac Death ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Washout Rate ◽  
Mibg Imaging

Background: Elevated uric acid level is associated with an increased risk of adverse outcome in patients with chronic heart failure (CHF). On the other hand, cardiac metaiodobenzylguanidine (MIBG) imaging provides prognostic information in patients with CHF. However, there is no information available on the prognostic value of cardiac MIBG imaging in CHF patients, relating to hyperuricemia. Methods: We enrolled 113 CHF outpatients (NYHA2.0±0.6, ischemic origin 48%) with radionuclide LVEF <40%(30±8%). The cardiac MIBG washout rate (WR) was calculated from the chest anterior view images obtained at 20 and 200 min after isotope injection. Abnormal WR was defined as >27% as reported previously. At the entry, we measured serum uric acid level and hyperuricemia was define as >7.0mg/dl. The primary end point was cardiac death. Reults: At the entry, 59 and 51 of 113 patients had abnormal WR and hyperuricemia, respectively. Serum uric acid level was significantly higher in patients with than without abnormal WR (7.3±1.8 vs 6.3±2.0 mg/dl, p=0.007). During the follow up period of 7.6±4.3 years, 35 patients had cardiac death. Cardiac death was significantly more often observed in patients with than without abnormal WR (47% vs 13%, p<0.001) and hyperuricemia (42% vs 23%, p=0.034). At multivariate Cox analysis, abnormal WR and hyperuricemia were significantly independently associated with cardiac death (p=0.02 and p=0.03, respectively). Patients with abnormal WR had a significantly greater risk of cardiac death than those with normal WR in group with hyperuricemia (p=0.004, harard ratio: 6.5, 95%CI 1.8 to 23.4) and without hyperuricemia(p=0.001, hazard ratio: 4.4, 95%CI 1.5 to 13.2). Conclusion: Cardiac MIBG imaging provides the additional information to hyperuricemia in CHF.

scholarly journals Serum Uric Acid level in the severity of Congestive Heart Failure (CHF)

2017 ◽  
Vol 33 (2) ◽  
Author(s):  
Adnan Khan ◽  
Mohammad Hassan Shah ◽  
Sarbiland Khan ◽  
Umama Shamim ◽  
Sanan Arshad
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level

scholarly journals Serum uric acid level in Bangladeshi adults with essential hypertension

2020 ◽  
Vol 7 (7) ◽  
pp. 1136
Author(s):  
SK. Kabir Ahammed ◽  
A. B. M. Kamrul Hasan ◽  
Mohammed Ruhul Kabir ◽  
Gunosindhu Paul ◽  
Shishir Kumar Basak ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Cross Sectional ◽  
Hypertensive Group ◽  
Positive Correlations

Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN).  The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.

Association Between Serum Uric Acid and Prediabetes in the Korean General Population

2019 ◽  
Vol 31 (8) ◽  
pp. 719-727
Author(s):  
Ryoung Jin Park ◽  
Min Gu Kang
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Hemoglobin A1c ◽  
Multiple Logistic Regression Analysis ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Activity Level ◽  
Cross Sectional ◽  
Increased Risk

The purpose of this study is to examine the relation of serum uric acid with prediabetes in Korea. We conducted a cross-sectional study in 4633 individuals aged 20 to 81 years who participated in the 2016 Korean National Health and Nutrition Examination Survey. Participants are considered to have prediabetes if they have one or more of the following: impaired fasting glucose (fasting blood glucose levels between 5.6 and 6.9 mmol/L); impaired hemoglobin A1c (hemoglobin A1c ranges of 5.7% to 6.4% [39-46 mmol/mol]). Multiple logistic regression analysis was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). Prediabetes was more prevalent in the hyperuricemia group compared with the normal-range group among men (OR = 1.51; 95% CI = 1.11-2.05; P < .01) and women (OR = 1.84; 95% CI = 1.01-3.37; P = .04) after adjustment for age, body mass index, abdominal obesity, blood pressure, triglyceride, high-density lipoprotein cholesterol, renal function, alcohol consumption, smoking, and physical activity level. For a standard deviation increment in uric acid, the odds of having prediabetes as compared with that of not having prediabetes increased about 114% in men ( P = .05) and 116% in women ( P = .01). Higher levels of uric acid were associated with an increased risk of prediabetes among the general Korean population.

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan

2015 ◽  
Vol 41 (2) ◽  
pp. 138-146 ◽  
Author(s):  
Minako Wakasugi ◽  
Junichiro James Kazama ◽  
Ichiei Narita ◽  
Tsuneo Konta ◽  
Shouichi Fujimoto ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Kidney Function ◽  
Serum Uric Acid Level ◽  
Kidney Injury ◽  
Population Based ◽  
Guidance System ◽  
Sensitivity Analyses ◽  
Cross Sectional ◽  
Reduced Kidney Function

Background: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dl, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. Methods: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study using data from the Specific Health Checkups and Guidance System in Japan. Logistic analysis was used to examine the relationship between hypouricemia and reduced kidney function, defined as estimated glomerular filtration rate <60 ml/min/1.73 m2. Results: Among 90,710 men (mean age, 63.8 years) and 136,935 women (63.7 years), 193 (0.2%) and 540 (0.4%) were identified as having hypouricemia, respectively. The prevalence of hypouricemia decreased with age in women (p for trend <0.001), but not in men (p for trend = 0.24). Hypouricemia was associated with reduced kidney function in men (odds ratio, 1.83; 95% confidence interval, 1.23-2.74), but not in women (0.61; 0.43-0.86), relative to the reference category (i.e., serum uric acid levels of 4.1-5.0 mg/dl) after adjusting for age, drinking, smoking, diabetes, hypertension, hypercholesterolemia, obesity, and history of renal failure. Sensitivity analyses stratified by diabetic status yielded similar results. Conclusions: This study is the first to provide evidence that hypouricemia is associated with reduced kidney function in men. Further research will be needed to determine the long-term prognosis of individuals with hypouricemia.

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