scholarly journals Using Micro-CT Derived Bone Microarchitecture to Analyze Bone Stiffness – A Case Study on Osteoporosis Rat Bone

2015 ◽  
Vol 6 ◽  
Author(s):  
Yuchin Wu ◽  
Samer Adeeb ◽  
Michael R. Doschak
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Rosmaliza Ramli ◽  
Mohd Fadhli Khamis ◽  
Ahmad Nazrun Shuid

Recent studies suggested thatEurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male. This study aimed to determine the effects ofEurycoma longifoliasupplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient osteoporosis model). Forty-eight-aged (10–12 months old)Sprague Dawleyrats were divided into six groups of sham-operated (SHAM), orchidectomised control (ORX), orchidectomised + 7 mg/rat testosterone enanthate (TEN) and orchidectomised +Eurycoma longifolia30 mg/kg (EL30), orchidectomised +Eurycoma longifolia60 mg/kg (EL60), orchidectomised +Eurycoma longifolia90 mg/kg (EL90). Rats were euthanized following six weeks of treatment. The left femora were used to measure the trabecular bone microarchitecture using micro-CT. Orchidectomy significantly decreased connectivity density, trabecular bone volume, and trabecular number compared to the SHAM group. Testosterone replacement reversed all the orchidectomy-induced changes in the micro-CT parameters. EL at 30 and 60 mg/kg rat worsened the trabecular bone connectivity density and trabecular separation parameters of orchidectomised rats. EL at 90 mg/kg rat preserved the bone volume. High dose of EL (90 mg/kg) may have potential in preserving the bone microarchitecture of orchidectomised rats, but lower doses may further worsen the osteoporotic changes.


Author(s):  
Wan Muhammad Luqman Sazali ◽  
Sahriza Salwani Md Shah ◽  
M Zuhaili Kashim ◽  
Budi Priyatna Kantaatmadja ◽  
Lydia Knuefing ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107545 ◽  
Author(s):  
Jui-Ting Hsu ◽  
Ying-Ju Chen ◽  
Jung-Ting Ho ◽  
Heng-Li Huang ◽  
Shun-Ping Wang ◽  
...  

2018 ◽  
Vol 76 (5) ◽  
pp. 972-981
Author(s):  
Carolina Cintra Gomes ◽  
Deborah Queiroz Freitas ◽  
Amanda Maria Medeiros Araújo ◽  
Laura Ricardina Ramírez-Sotelo ◽  
Fernanda Paula Yamamoto-Silva ◽  
...  

Materials ◽  
2020 ◽  
Vol 13 (16) ◽  
pp. 3606
Author(s):  
Armin Rashidi ◽  
Tina Olfatbakhsh ◽  
Bryn Crawford ◽  
Abbas S. Milani

X-ray computed tomography provides qualitative and quantitative structural and compositional information for a broad range of materials. Yet, its contribution to the field of advanced composites such as carbon fiber reinforced polymers is still limited by factors such as low imaging contrast, due to scarce X-ray attenuation features. This article, through a review of the state of the art, followed by an example case study on Micro-computed tomography (CT) analysis of low X-ray absorptive dry and prepreg carbon woven fabric composites, aims to highlight and address some challenges as well as best practices on performing scans that can capture key features of the material. In the case study, utilizing an Xradia Micro-CT-400, important aspects such as obtaining sufficient contrast, an examination of thin samples, sample size/resolution issues, and image-based modeling are discussed. The outcome of an optimized workflow in Micro-CT of composite fabrics can assist in further research efforts such as the generation of surface or volume meshes for the numerical modeling of underlying deformation mechanisms during their manufacturing processes.


Author(s):  
Jenny Tan ◽  
Agatha Labrinidis ◽  
Ruth Williams ◽  
Mustafa Mian ◽  
Peter J. Anderson ◽  
...  

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