scholarly journals A Comparison of Micro-CT and Dental CT in Assessing Cortical Bone Morphology and Trabecular Bone Microarchitecture

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107545 ◽  
Author(s):  
Jui-Ting Hsu ◽  
Ying-Ju Chen ◽  
Jung-Ting Ho ◽  
Heng-Li Huang ◽  
Shun-Ping Wang ◽  
...  
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Rosmaliza Ramli ◽  
Mohd Fadhli Khamis ◽  
Ahmad Nazrun Shuid

Recent studies suggested thatEurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male. This study aimed to determine the effects ofEurycoma longifoliasupplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient osteoporosis model). Forty-eight-aged (10–12 months old)Sprague Dawleyrats were divided into six groups of sham-operated (SHAM), orchidectomised control (ORX), orchidectomised + 7 mg/rat testosterone enanthate (TEN) and orchidectomised +Eurycoma longifolia30 mg/kg (EL30), orchidectomised +Eurycoma longifolia60 mg/kg (EL60), orchidectomised +Eurycoma longifolia90 mg/kg (EL90). Rats were euthanized following six weeks of treatment. The left femora were used to measure the trabecular bone microarchitecture using micro-CT. Orchidectomy significantly decreased connectivity density, trabecular bone volume, and trabecular number compared to the SHAM group. Testosterone replacement reversed all the orchidectomy-induced changes in the micro-CT parameters. EL at 30 and 60 mg/kg rat worsened the trabecular bone connectivity density and trabecular separation parameters of orchidectomised rats. EL at 90 mg/kg rat preserved the bone volume. High dose of EL (90 mg/kg) may have potential in preserving the bone microarchitecture of orchidectomised rats, but lower doses may further worsen the osteoporotic changes.


2017 ◽  
Vol 177 (5) ◽  
pp. 409-420 ◽  
Author(s):  
Paula P B Silva ◽  
Fatemeh G Amlashi ◽  
Elaine W Yu ◽  
Karen J Pulaski-Liebert ◽  
Anu V Gerweck ◽  
...  

Context Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by microfinite element analysis (µFEA). Objective To elucidate both cortical and trabecular bone microarchitecture and estimated bone strength in men with active acromegaly or GHD compared to healthy controls. Design and subjects Cross-sectional study at a clinical research center, including 48 men (16 with acromegaly, 16 with GHD and 16 healthy controls). Outcome measures Areal bone mineral density (aBMD), cortical and trabecular bone microarchitecture and estimated bone strength (µFEA) at the radius and tibia. Results aBMD was not different between the 3 groups at any skeletal site. At the radius, patients with acromegaly had greater cortical area (P < 0.0001), cortical thickness (P = 0.0038), cortical pore volume (P < 0.0001) and cortical porosity (P = 0.0008), but lower trabecular bone density (P = 0.0010) compared to controls. At the tibia, patients with acromegaly had lower trabecular bone density (P = 0.0082), but no differences in cortical bone microstructure. Compressive strength and failure load did not significantly differ between groups. These findings persisted after excluding patients with hypogonadism. Bone microarchitecture was not deficient in patients with GHD. Conclusions Both cortical and trabecular microarchitecture are altered in men with acromegaly. Our data indicate that GH excess is associated with distinct effects in cortical vs trabecular bone compartments. Our observations also affirm the limitations of aBMD testing in the evaluation of patients with acromegaly.


Bone ◽  
2002 ◽  
Vol 30 (1) ◽  
pp. 191-194 ◽  
Author(s):  
H Jinnai ◽  
H Watashiba ◽  
T Kajihara ◽  
Y Nishikawa ◽  
M Takahashi ◽  
...  

Author(s):  
T. Christy Bobby ◽  
Shwetha V. ◽  
Vijaya Madhavi

The stability of a dental implant is one of the most important aspects that decide the success rate of implant treatment. The stability is considerably affected by the strength of trabecular bone present in maxilla and mandible. Thus, finding of trabecular bone strength is a key component for the success of dental implants. The trabecular bone strength is usually assessed by quantity of bone in terms of bone mineral density (BMD). Recently, it has been revealed that along with quantity of bone, strength of the bone also depends on quality features commonly referred as trabecular bone microarchitecture. Since the quality of the trabecular bone is varying across the maxilla and mandible, preoperative assessment of trabecular bone microarchitecture at sub-region of maxilla and mandible are essential for stable implant treatment. Thus, in this chapter, the authors inscribe the quantitative analysis of trabecular bone quality in maxilla and mandible using CBCT images by employing contourlet transform.


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