scholarly journals Association Between Neonatal Thyroid Function and Anogenital Distance from Birth to 48 Months of Age

2021 ◽  
Vol 12 ◽  
Author(s):  
Min Luan ◽  
Hong Liang ◽  
Guanghong Fang ◽  
Ziliang Wang ◽  
Xiujuan Su ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Birth Cohort ◽  
Thyroid Function ◽  
Life Stage ◽  
Plasma Concentrations ◽  
Reproductive Development ◽  
Anogenital Distance ◽  
Cord Plasma ◽  
Neonatal Thyroid Function

BackgroundEvidence from animal studies has indicated that neonatal thyroid function is vital for the reproductive development. Anogenital distance (AGD), a sensitive biomarker of the fetal hormonal milieu, can be used to predict adult reproductive disorders. However, few human studies have examined the association between neonatal thyroid function and AGD. We aimed to explore their associations in a birth cohort study.MethodsConcentrations of thyroid stimulating hormone (TSH) and thyroid hormones (THs), including total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) were measured in cord plasma in the Shanghai-Minhang Birth Cohort. The offspring AGD (AGDAP [anus–penis] and AGDAS [anus–scrotum] for boys and AGDAC [anus–clitoris] and AGDAF [anus–fourchette] for girls), body weight and anogenital index (AGI = AGD/weight [mm/kg]) were obtained at each follow-up visit. In total, 344 children (194 boys and 150 girls) with cord plasma concentrations of THs and TSH and at least one AGD measurement at birth and at 6, 12, and 48 months of age were included. Multiple linear regression and generalized estimating equation (GEE) models were used to examine the associations of cord plasma concentrations of THs and TSH with AGI.ResultsMultiple linear regression models showed inverse associations of TT4, FT3, and FT4 with female AGI, although statistical significance was only reached at birth, 6 and 48 months of age. These associations were also found in GEE models: higher TT4 and FT4 concentrations were associated with lower AGIAC (TT4: β = -0.27, 95% CI: -0.50, -0.03 for middle vs. lowest tertile; FT4: β = -0.38, 95% CI: -0.61, -0.16 for middle and β = -0.30, 95% CI: -0.55, -0.04 for highest vs. lowest tertile). Besides, girls with the highest tertile of FT3 concentrations had lower AGIAF than those with the lowest tertile (the highest vs. lowest tertile: β = -0.22, 95% CI: -0.36, -0.08). Positive associations between TSH and AGI at birth and at 12 months of age were observed in boys.ConclusionsThis study provides further evidence on the effects of neonatal thyroid function on reproductive development at an early life stage.

scholarly journals Thyroid Function Changes and Pubertal Progress in Females: A Longitudinal Study in Iodine-Sufficient Areas of East China

2021 ◽  
Vol 12 ◽  
Author(s):  
Yingying Wang ◽  
Dandan He ◽  
Chaowei Fu ◽  
Xiaolian Dong ◽  
Feng Jiang ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Thyroid Function ◽  
Pubertal Development ◽  
Thyroid Stimulating Hormone ◽  
East China ◽  
Regression Analyses ◽  
Free Triiodothyronine ◽  
Serum Tsh

BackgroundThe onset of puberty is influenced by thyroid function, and thyroid hormones (THs) fluctuate substantially during the period of pubertal development. However, it needs to be further clarified how THs change at specific puberty stages and how it influences pubertal development in girls. So far, longitudinal data from China are scarce.MethodsA cohort study was conducted among girls during puberty in iodine-sufficient regions of East China between 2017 to 2019. Serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were determined for each participant. Thyroid homeostasis structure parameters (THSPs), including the ratio of FT4 to FT3 (FT4/FT3), Jostel’s TSH index (TSHI), and thyroid feedback quantile-based index (TFQI), were calculated. Puberty category scores (PCS), calculated based on the Puberty Development Scale (PDS), was used to assess the stage of puberty. Girls were grouped into three categories according to PCS changes (△PCS) and six categories according puberty stage (BPFP: pre-pubertal at both baseline and follow-up; BPFL: pre-pubertal at baseline and late-pubertal at follow-up, respectively; BPFT: pre-pubertal at baseline and post-pubertal at follow-up, respectively; BLFL: late-pubertal at both baseline and follow-up; BLFT: late-pubertal at baseline and post-pubertal at follow-up, respectively; BTFT: post-pubertal at both baseline and follow-up). Multiple linear regression analyses were used to evaluate the associations of THs changes with pubertal progress.ResultsThe levels of serum TSH and FT3 decreased while serum FT4 increased during the study period (P<0.001). In multiple linear regression analyses, after adjustment for covariables, FT3 decreased by an additional 0.24 pmol/L (95% CI: -0.47 to -0.01) in the higher △PCS group than the lower △PCS group. Compared with the BLFL group, the BPFT group showed an additional decline in FT3 (β= -0.39 pmol/L, 95%CI: -0.73 to -0.04), the BTFT group showed a lower decline in TSH (β=0.50 mU/L, 95% CI: 0.21 to 0.80) and a lower decline in TSHI (β=0.24, 95%CI: 0.06 to 0.41), respectively. There was no association of △FT4 or △TFQI with △PCS or the puberty pattern.ConclusionsSerum TSH and FT3 decreased while serum FT4 increased among girls during puberty. Both the initial stage and the velocity of pubertal development were related to thyroid hormone fluctuations.

scholarly journals S93. ADHD SYMPTOMS AND DAILY SMOKING AT AGE 15–16 YEARS AND PSYCHOTIC DISORDER IN EARLY ADULTHOOD. FINDINGS FROM THE NORTHERN FINLAND BIRTH COHORT 1986 STUDY

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S69-S69
Author(s):  
Solja Niemelä ◽  
Teemu Peltonen ◽  
Jari Koskela ◽  
Antti Mustonen ◽  
Jouko Miettunen ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Psychiatric Disorders ◽  
Birth Cohort ◽  
Psychotic Disorder ◽  
Psychiatric Diagnosis ◽  
Daily Smoking ◽  
P Value ◽  
Adhd Symptoms ◽  
Self Medication

Abstract Background Association between smoking with both ADHD(1) and psychosis(2) has been explained by self-medication of ADHD and psychotic symptoms with nicotine use(3). Persons with psychosis also share impairments with persons with ADHD: e.g. inattention is a feature of both of these disorders(3). Aim of this study was to investigate the association between ADHD symptoms and adolescent smoking in relation to psychotic disorder in young adulthood. Methods The Northern Finland Birth Cohort 1986 Study includes 99% of all births (n=9432) in the region. Participants with information on ADHD symptoms and daily smoking at age 15–16 years were included (n=5858, 48,7% male, 62.1% of the original study population). ADHD symptoms were evaluated by parents, who filled in the Strengths and Weaknesses of ADHD Symptoms and Normal Behaviors (SWAN) questionnaire. SWAN comprises ADHD symptoms (inattention, hyperactive-impulsive, combined) rated from 3 (far below average) to -3 (far above average). Information on psychiatric diagnoses was collected from four national registries until the end of year 2016. Associations between daily smoking and ADHD symptoms were analyzed using multiple linear regression. Sex, family structure, frequent alcohol intoxication, illicit drug use, and psychotic experiences at age 15–16 years were used as covariates. Analyses were done separately according to the psychiatric diagnosis status at age 30–31 years: no psychiatric diagnosis; any psychiatric diagnosis other than psychosis; any psychotic disorder. Results Among participants with psychotic disorder (n=119), daily smokers had higher inattention mean scores compared to non-smokers (-6.5 vs. 0.03, p-value=0.001, effect size (es)=0.8). Among those without psychiatric disorders (n=4618), daily smokers had higher scores in all SWAN domains compared to non-smokers: inattention (-8.9 vs. -3.6, p-value<0.001, es=0.6); hyperactive-impulsive (-13.3 vs. -8.8, p<0.001, es=0.5); and combined (-22.2 vs. -12.5, p<0.001, es=0.6). Respectively, also daily smokers with any psychiatric disorder other than psychosis (n=1121) had higher scores in all SWAN domains: inattention (-7.0 vs. -2.1, p<0.001, es=0.5); hyperactive-impulsive (-11.6 vs. -7.0, p<0.001, es=0.5); and combined (-18.6 vs. 9.1, p<0.001, es=0.5). Within psychosis group, daily smoking associated only with inattention symptoms (standardized beta-coefficient (sbc)=0.38 p=0.004) in the multiple linear regression. Among those without psychiatric disorders, and among those with psychiatric disorders other than psychosis, daily smoking associated with all SWAN symptom domains. The respective figures were for inattention (sbc=0.14, p<0.001; sbc=0.12, p=0.001); for hyperactive-impulsive (sbc=0.11, p<0.001; sbc=0.12, p=0.001); and for combined (sbc=0.14, p<0.001; sbc=0.13, p<0.001). Discussion In adolescence, the relationship between inattention problems and daily smoking was remarkable among participants with subsequent psychotic disorder. Vulnerability to smoking among adolescents at risk for psychosis may be explained by self-medication related to inattention problems. References

Pengaruh Motivasi Kerja Terhadap Kinerja Pegawai Kantor Sekretariat Daerah Kabupaten Gunungkidul

2017 ◽  
Vol 23 (2) ◽  
pp. 121-137
Author(s):  
Ary Sutrischastini ◽  
Agus Riyanto
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Sampling Method ◽  
Work Motivation ◽  
Probability Sampling ◽  
Random Probability

This paper will discuss the effect of work motivation (incentives, motives and expectations) on the performance of the staff of the Regional Secretariat Gunungkidul. The purpose of this paper is: 1) Determine the effect of incentives on the performance of the staff of the Regional Secretariat Gunungkidul, 2) Determine the effect of motive on the performance of the staff of the Regional Secretariat Gunungkidul, 3) To know the effect of expectations on the performance of the staff of the Regional Secretariat Gunungkidul, 4)To know the effect of incentives, motives and expectations on the performance of the staff of the Regional Secretariat Gunungkidul.Research sites in the Regional Secretariat Gunungkidul and the population is 162entire employee in the Regional Secretariat Gunungkidul. Samples amounted to 116 respondents taken with simple random probability sampling method. Data were analyzed using multiple linear regression. Results obtained: (1) incentives positive and significant effect on the performance of, (2) motif positive and significant effect on the performance of, (3) expectations positive and significant impact on the performance of , and (4) incentives, motives and expectations of positive and significant impact on the performance of the staff of the Regional Secretariat Gunungkidul.

PENGARUH FAKTOR-FAKTOR INTERNAL PERBANKAN TERHADAP NON PERFORMING FINANCING PADA BANK UMUM SYARIAH

2019 ◽  
Vol 6 (2) ◽  
pp. 115-130
Author(s):  
Eka Ambara Harci Putranta ◽  
Lilik Ambarwati
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Capital Adequacy ◽  
Annual Reports ◽  
Regression Methods ◽  
Capital Adequacy Ratio ◽  
Negative Effect ◽  
Independent Variable

The study aims to analyze the influence of internal banking factors in the form of: Capital Adequency Ratio (CAR), Financing to Deposit Ratio (FDR) and Total Assets (TA) to Non Performing Financing at Sharia Banks. This research method used multiple linear regression analysis with the help of SPSS 16.00 software which is used to see the influence between the independent variables in the form of Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR) and Total Assets (TA) to Non Performing Financing. The sample of this study was 3 Islamic Commercial Banks, so there were 36 annual reports obtained through purposive sampling, then analyzed using multiple linear regression methods. The results showed that based on the F Test, the independent variable had an effect on the NPF, indicated by the F value of 17,016 and significance of 0,000, overall the independent variable was able to explain the effect of 69.60%. While based on the partial t test, showed that CAR has a significant negative effect, Total assets have a significant positive effect with a significance value below 0.05 (5%). Meanwhile FDR does not affect NPF.

Faktor-Faktor Yang Mempengaruhi Keputusan Mahasiswa Memilih Program Studi Kebidanan STIKES Muhammadiyah Ciamis Tahun 2016

2018 ◽  
Vol 5 (1) ◽  
pp. 69-82
Author(s):  
Evi Mariana
Keyword(s):  
Data Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Random Sampling ◽  
Sampling Method ◽  
Marketing Mix ◽  
Stratified Random Sampling ◽  
Price Promotion ◽  
F Test ◽  
Physical Evidence

The purpose of this study was to analyze the factors that influence the decisionof the students chose to study in Obstetrics Prodi STIKES Muhammadiyah Ciamis and analyze the factors that most influence the decision of the students chose to study in Obstetrics Prodi STIKES Muhammadiyah Ciamis. Collecting data in this study was conducted using a survey by questionnaire to 114 students by stratified random sampling method. Methods of data analysis using multiple linear regression, F test and test T. The result is a marketing mix that significantly is the product, place, and physical evidence. And that does not affect the marketing mix is price, promotion, place, and processes

ANALISIS PENGARUH INFLASI, KURS DAN IHSG TERHADAP RETURN REKSA DANA SAHAM PT NIKKO SECURITIES INDONESIA PERIODE 2014-2017

2019 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
Muhammad Rois Rois ◽  
Manarotul Fatati Fatati ◽  
Winda Ihda Magfiroh
Keyword(s):  
Regression Analysis ◽  
Exchange Rate ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Stock Price ◽  
Price Index ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Equity Fund ◽  
Stock Price Index

This study aims to determine the effect of Inflation, Exchange Rate and Composite Stock Price Index (IHSG) to Return of PT Nikko Securities Indonesia Stock Fund period 2014-2017. The study used secondary data obtained through documentation in the form of PT Nikko Securities Indonesia Monthly Net Asset (NAB) report. Data analysis is used with quantitative analysis, multiple linear regression analysis using eviews 9. Population and sample in this research are PT Nikko Securities Indonesia. The result of multiple linear regression analysis was the coefficient of determination (R2) showed the result of 0.123819 or 12%. This means that the Inflation, Exchange Rate and Composite Stock Price Index (IHSG) variables can influence the return of PT Nikko Securities Indonesia's equity fund of 12% and 88% is influenced by other variables. Based on the result of the research, the variables of inflation and exchange rate have a negative and significant effect toward the return of PT Nikko Securities Indonesia's equity fund. While the variable of Composite Stock Price Index (IHSG) has a negative but not significant effect toward Return of Equity Fund of PT Nikko Securities Indonesia

FAKTOR-FAKTOR YANG MEMPENGARUHI KUALITAS AUDIT

2019 ◽  
Vol 5 (1) ◽  
pp. 50-63
Author(s):  
Heru Heryanto ◽  
Nur Laela ◽  
Riana R Dewi
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Audit Quality ◽  
Positive Influence ◽  
T Test ◽  
Coefficient Of Determination ◽  
Analysis Tool ◽  
Validity And Reliability ◽  
Test Analysis ◽  
Analysis Technique

This study aims to determine the significance of the influence of competence, independence, professionalism, auditor experience, accountability, and auditor's knowledge of audit quality. This study uses a questionnaire with a population and sample, namely all auditors who work at the Public Accounting Office (KAP) in the Special Region of Yogyakarta and Surakarta. Sampling techniques using Convenience Sampling with a sample of 61 respondents. The data used in this study is a questionnaire using a Likert scale 1 to 5. The data analysis technique used in this study is multiple linear regression using the SPSSprogram for Windows. The analysis tool in this study using validity and reliability, the classical assumption (normality test, multicollinearity, heteroscedasticity test and autocorrelation test) while the data were analyzed using multiple linear regression test, t test, F test and the coefficient of determination (R2).Based on the results of the t-test analysis performed, it shows that there is a positive influence of competence, independence, professionalism, auditor experience, accountability, and auditor's knowledge of audit quality and simultaneously competency, independence, professionalism, auditor experience, accountability, and auditor knowledge variables affect quality audit

Analisis Pengaruh Kepemimpinan dan Komunikasi Terhadap Motivasi dan Kinerja Pegawai (Satuan Polisi Pamong Praja Kota Surabaya)

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Muhammad Rodhiyallah ◽  
Amiartuti Kusmaningtyas ◽  
Hendro Tjahjono
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Sampling Technique ◽  
Employee Motivation ◽  
Leadership Communication ◽  
Dominant Effect ◽  
And Performance

The aim of the study was to analyze and determine the influence of leadership and communication, on employee motivation and performance at Satuan Polisi Pamong Praja Kota Surabaya. Branch, as many as 100 persons. Sampling technique samples (Slovin) data was analyzed with multiple linear regression with SPSS for windows program. The result of the research indicated that leadership, communication, and motivation simultaneously have significant effect on employees’ performances with determination value of 0,424 or 4,24%. Leadership, communication and motivation partially has significant effect on performance. Communication itself has dominant effect on employee’s performance.

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