scholarly journals The Chemical Exposome of Human Aging

2020 ◽  
Vol 11 ◽  
Author(s):  
Biswapriya B. Misra
Keyword(s):  
Healthy Aging ◽  
Single Cells ◽  
Well Being ◽  
Model Organisms ◽  
Human Aging ◽  
Human Beings ◽  
Chronological Aging ◽  
Chemical Exposures ◽  
Disease Predisposition ◽  
Endogenous Metabolites

Aging is an inevitable biological phenomenon displayed by single cells and organs to entire organismal systems. Aging as a biological process is characterized as a progressive decline in intrinsic biological function. Understanding the causative mechanisms of aging has always captured the imagination of researchers since time immemorial. Although both biological and chronological aging are well defined and studied in terms of genetic, epigenetic, and lifestyle predispositions, the hallmarks of aging in terms of small molecules (i.e., endogenous metabolites to chemical exposures) are limited to obscure. On top of the endogenous metabolites leading to the onset and progression of healthy aging, human beings are constantly exposed to a natural and anthropogenic “chemical” environment round the clock, from conception till death, affecting one’s physiology, health and well-being, and disease predisposition. The research community has started gaining sizeable insights into deciphering the aging factors such as immunosenescence, nutrition, frailty, inflamm-aging, and diseases till date, without much input from their interaction with exogenous chemical exposures. The “exposome” around us, mostly, accelerates the process of aging by affecting the internal biological pathways and signaling mechanisms that result in the deterioration of human health. However, the entirety of exposome on human aging is far from established. This review intends to catalog the known and established associations of the exposome from past studies focusing on aging in humans and other model organisms. Further discussed are the current technologies and informatics tools that enable the study of aging exposotypes, and thus, provide a window of opportunities and challenges to study the “aging exposome” in granular details.

Prospective Memory Development Across the Lifespan

2020 ◽  
Vol 25 (3) ◽  
pp. 162-173 ◽  
Author(s):  
Sascha Zuber ◽  
Matthias Kliegel
Keyword(s):  
Prospective Memory ◽  
Healthy Aging ◽  
Present Model ◽  
Current Knowledge ◽  
Well Being ◽  
The Elderly ◽  
Cognitive Factors ◽  
Everyday Functioning ◽  
Integrative Framework

Abstract. Prospective Memory (PM; i.e., the ability to remember to perform planned tasks) represents a key proxy of healthy aging, as it relates to older adults’ everyday functioning, autonomy, and personal well-being. The current review illustrates how PM performance develops across the lifespan and how multiple cognitive and non-cognitive factors influence this trajectory. Further, a new, integrative framework is presented, detailing how those processes interplay in retrieving and executing delayed intentions. Specifically, while most previous models have focused on memory processes, the present model focuses on the role of executive functioning in PM and its development across the lifespan. Finally, a practical outlook is presented, suggesting how the current knowledge can be applied in geriatrics and geropsychology to promote healthy aging by maintaining prospective abilities in the elderly.

Persons Together

2018 ◽  
Author(s):  
Alan L. Mittleman
Keyword(s):  
Human Nature ◽  
Well Being ◽  
Image Of God ◽  
Jewish Tradition ◽  
The Political ◽  
Human Beings ◽  
Human Flourishing ◽  
Political Dimensions ◽  
Market Relations ◽  
The Image Of God

This chapter moves into the political and economic aspects of human nature. Given scarcity and interdependence, what sense has Judaism made of the material well-being necessary for human flourishing? What are Jewish attitudes toward prosperity, market relations, labor, and leisure? What has Judaism had to say about the political dimensions of human nature? If all humans are made in the image of God, what does that original equality imply for political order, authority, and justice? In what kinds of systems can human beings best flourish? It argues that Jewish tradition shows that we act in conformity with our nature when we elevate, improve, and sanctify it. As co-creators of the world with God, we are not just the sport of our biochemistry. We are persons who can select and choose among the traits that comprise our very own natures, cultivating some and weeding out others.

scholarly journals Connecting Climate and Communicable Disease to Penta Helix Using Hierarchical Likelihood Structural Equation Modelling

Symmetry ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 657
Author(s):  
Rezzy Eko Caraka ◽  
Maengseok Noh ◽  
Rung-Ching Chen ◽  
Youngjo Lee ◽  
Prana Ugiana Gio ◽  
...  
Keyword(s):  
Latent Variables ◽  
Structural Equation ◽  
Healthy Lifestyle ◽  
Communicable Disease ◽  
Well Being ◽  
Equation Modeling ◽  
Human Beings ◽  
The Sustainable Development ◽  
Healthcare Facilities ◽  
Hierarchical Likelihood

Design: Health issues throughout the sustainable development goals have also been integrated into one ultimate goal, which helps to ensure a healthy lifestyle as well as enhances well-being for any and all human beings of all social level. Meanwhile, regarding the clime change, we may take urgent action to its impacts. Purpose: Nowadays, climate change makes it much more difficult to control the pattern of diseases transmitted and sometimes hard to prevent. In line with this, Centres for Disease Control (CDC) Taiwan grouped the spread of disease through its source in the first six main groups. Those are food or waterborne, airborne or droplet, vector-borne, sexually transmitted or blood-borne, contact transmission, and miscellaneous. According to this, academics, government, and the private sector should work together and collaborate to maintain the health issue. This article examines and connects the climate and communicable aspects towards Penta-Helix in Taiwan. Finding: In summary, we have been addressing the knowledge center on the number of private companies throughout the health care sector, the number of healthcare facilities, and the education institutions widely recognized as Penta Helix. In addition, we used hierarchical likelihood structural equation modeling (HSEMs). All the relationship variables among climate, communicable disease, and Penta Helix can be interpreted through the latent variables with GoF 79.24%.

scholarly journals The Value of Recreational Ecosystem Services in India

2020 ◽  
Vol 3 (1) ◽  
pp. 80
Author(s):  
Muniyandi Balasubramanian
Keyword(s):  
Ecosystem Services ◽  
National Park ◽  
Economic Value ◽  
Consumer Surplus ◽  
Well Being ◽  
Vital Role ◽  
Human Beings ◽  
Forest Ecosystem Services ◽  
The Individual ◽  
Mental Well Being

Forest ecosystem services have played a vital role in human well-being. Particularly, recreational ecosystem services are creating physical and mental well-being for human beings. Therefore, the main objective of the paper is to estimate the economic value of recreational ecosystem services provides by recreational sites such as Nandi Hills and Nagarhole National Park based on the individual travel cost method in Karnataka, India. This study has used a random sampling method for 300 tourist visitors to recreational sites. The present study has also estimated the consumer surplus of the visitors. The results of the study have found that (i) economic value of two creational sites has been estimated at US $323.05 million, (ii) the consumer surplus has been estimated for Nandi Hills at US $7.45 and Nagarhole National Park at US $3.16. The main implication of the study is to design the entry fees for the recreational site and sustainable utilization of recreational ecosystem services for the present and future generations.

scholarly journals Findings From the Understanding Patterns of Healthy Aging Among Men Who Have Sex With Men Project

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 823-824
Author(s):  
Mark Brennan-Ing ◽  
Michael Plankey ◽  
Deborah Gustafson
Keyword(s):  
Los Angeles ◽  
Urban Areas ◽  
Healthy Aging ◽  
Research Policy ◽  
Disease Risk ◽  
Well Being ◽  
Hiv Status ◽  
Gay Community ◽  
Regulatory Strategies ◽  
Sex With Men

Abstract In 1984, the Multicenter AIDS Cohort Study (MACS) was started to identify factors in the HIV epidemic related to disease risk and treatment progression among gay, bisexual, and other men who have sex with men (MSM) in four urban areas in the US: Baltimore, MD/Washington, D.C.; Chicago, IL; Pittsburgh, PA, and Los Angeles, CA. MACS participants complete biannual study visits involving HIV testing, biometric screenings, and psychosocial data collection. In 2015 a MACS sub-study, the Understanding Patterns of Healthy Aging among MSM Project (HAMSM), was started to better understand resiliencies promoting well-being among MSM age 40 and older, including those with HIV. HAMSM has helped us to understand aging trajectories among MSM, and provides a unique combination of physiological and psychosocial data that can inform efforts to support MSM in healthy aging. This symposium will present emerging findings from the HAMSM study. Our first paper examines the relationships between psychological connection to the gay community (PSOC) and developmental regulatory strategies associated with health behaviors and more positive self-appraisals. The second paper examines how PSOC is related to HIV risk reduction behaviors, and if there are differences in such behaviors based on HIV status. Our third paper considers how self-perceptions of aging (age discrepancy, aging satisfaction) are related to frailty and frailty transitions, and if these relationships differ by HIV status. The final paper examines the relationship of social support to frailty among MSM by HIV status. Implications of these findings for research, policy, and programs targeting MSM will be discussed.

scholarly journals Resilient Aging: Psychological Well-Being and Social Well-Being as Targets for the Promotion of Healthy Aging

2021 ◽  
Vol 7 ◽  
pp. 233372142110029
Author(s):  
Eric S. Kim ◽  
Rifky Tkatch ◽  
David Martin ◽  
Stephanie MacLeod ◽  
Lewis Sandy ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Population Aging ◽  
Well Being ◽  
The United States ◽  
Treatment Programs ◽  
Response Effort ◽  
Psychological Well Being ◽  
Social Trends ◽  
Functional Quality ◽  
Prevention And Treatment

Population aging is one of the most important social trends of the 21st century and in the United States, the number of people aged ≥65 is projected to increase by nearly 50% in the next 15 years. Most biomedical and public health efforts have focused on reducing harmful risk factors when targeting chronic disease—an approach that has contributed greatly to prevention and treatment programs. However, evidence suggests that the number of years lost to disability is increasing and historic gains we have made in life expectancy are eroding, and even reversing in some groups. As our society ages and grapples with these issues, expanding the focus to include resilience, as well as psychosocial assets in our prevention and treatment programs might help inform the multidisciplinary response effort we need. Here we synthesize research evaluating associations between different dimensions of psychological well-being (e.g., purpose in life, optimism, life satisfaction) and social well-being (e.g., structural, functional, quality) with chronic conditions. We also evaluate evidence around three biopsychosocial pathways hypothesized to underlie these associations. These factors are meaningful, measurable, and potentially modifiable; thus, further pursuing this line of inquiry might unveil innovative paths to enhancing the health of our rapidly aging society.

tenet of ubuntu in South (African) ethics

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Vhumani Magezi ◽  
Clement Khlopa
Keyword(s):  
Pastoral Care ◽  
South African ◽  
Moral Theory ◽  
Well Being ◽  
Christian Ethics ◽  
African Philosophy ◽  
Human Beings ◽  
African Ethics ◽  
Contemporary Christian ◽  
African Worldview

The notion of ubuntu as a moral theory in the South African and African contexts presents attractive norms of an African worldview that can be articulated and applied to contemporary Christian ethics. The proponents of ubuntu perceive it as an African philosophy based on the maxim, “a person is a person through other persons”, whereby the community prevails over individual considerations. It is not merely an empirical claim that our survival or well-being is causally dependent on others but is in essence capturing a normative account of what we ought to be as human beings. However, ubuntu has shortcomings that make it an impractical notion. Despite its shortcomings, ubuntu has natural ethic potential that enforces and engenders hospitality, neighbourliness, and care for all humanity. This article contributes to further conceptualisation and understanding of the notion of ubuntu and its relationship with hospitality in order to retrieve some principles that can be applied to effective and meaningful pastoral care. The principles drawn from ubuntu are juxtaposed with Christian principles and pastoral care to encourage embodiment of God by pastoral caregivers.

scholarly journals Cardiac Vagus and Exercise

Physiology ◽  
2019 ◽  
Vol 34 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Alexander V. Gourine ◽  
Gareth L. Ackland
Keyword(s):  
Heart Rate ◽  
Healthy Aging ◽  
Exercise Physiology ◽  
Experimental Studies ◽  
Genomic Data ◽  
Well Being ◽  
Vagal Activity ◽  
Physiological Modeling ◽  
Resting Heart Rate ◽  
Molecular Neuroscience

Lower resting heart rate and high autonomic vagal activity are strongly associated with superior exercise capacity, maintenance of which is essential for general well-being and healthy aging. Recent evidence obtained in experimental studies using the latest advances in molecular neuroscience, combined with human exercise physiology, physiological modeling, and genomic data suggest that the strength of cardiac vagal activity causally determines our ability to exercise.

scholarly journals Explorative healthy aging approaches fostering social innovation: thematizing life course narratives of older women participating in a documentary film

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Susie Riva-Mossman ◽  
Henk Verloo
Keyword(s):  
Older Women ◽  
Healthy Aging ◽  
Social Innovation ◽  
Well Being ◽  
Learning Processes ◽  
Exploratory Research ◽  
Relational Networks ◽  
Important Concern ◽  
The Social ◽  
Social Learning Processes

The transformative process of investigating life stories and their impact on healthy aging has only recently been explored. The relationship between hope and individual healthy aging strategies is still an under-researched area. This study contributes to filling the knowledgeability gap. The authors examine senior stories of hope and the experience of self-determination and well-being. The study documents the social learning processes of older people as they narratively search for solutions and imagine a hopeful future of healthy aging. A group of four older women participated in a semi-structured filmed interview, questioned by an academic expert. Healthy aging emerged as an important concern among all participants, confirming the need to actively learn how to age well. This exploratory research brought forth thematic clusters, orienting shared value solutions to demographic change. Qualitative research methods reinforce lifelong, collaborative learning processes that not only produce scientific literature, but also put in place relational networks that can grow and endure over time, generating social innovation. The film documented the role of hope and resilience in healthy aging.

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