scholarly journals Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications

2021 ◽  
Vol 12 ◽  
Author(s):  
Jin-Yu Sun ◽  
Rui Wu ◽  
Jiang Xu ◽  
Hui-Ying Xue ◽  
Xiao-Jie Lu ◽  
...  
Keyword(s):  
Immune System ◽  
Organ Transplantation ◽  
Immune Tolerance ◽  
Immune Rejection ◽  
Tolerance Strategy ◽  
Maternal Tolerance ◽  
Transplanted Organs ◽  
The Relationship ◽  
Transplantation Outcomes ◽  
Maternal Fetal Interface

The immune system recognizes and attacks non-self antigens, making up the cornerstone of immunity activity against infection. However, during organ transplantation, the immune system also attacks transplanted organs and leads to immune rejection and transplantation failure. Interestingly, although the embryo and placenta are semi-allografts, like transplanted organs, they can induce maternal tolerance and be free of a vigorous immune response. Also, embryo or placenta-related antibodies might adversely affect subsequent organ transplantation despite the immune tolerance during pregnancy. Therefore, the balance between the immune tolerance in maternal-fetal interface and normal infection defense provides a possible desensitization and tolerance strategy to improve transplantation outcomes. A few studies on mechanisms and clinical applications have been performed to explore the relationship between maternal-fetal immune tolerance and organ transplantation. However, up to now, the mechanisms underlying maternal-fetal immune tolerance remain vague. In this review, we provide an overview on the current understanding of immune tolerance mechanisms underlying the maternal-fetal interface, summarize the interconnection between immune tolerance and organ transplantation, and describe the adverse effect of pregnancy alloimmunization on organ transplantation.

Paternal priming of maternal tissues to optimise pregnancy success

2018 ◽  
Vol 30 (1) ◽  
pp. 50 ◽  
Author(s):  
John J. Bromfield ◽  
Jason A. Rizo ◽  
Laila A. Ibrahim
Keyword(s):  
Immune System ◽  
Immune Tolerance ◽  
New Paradigm ◽  
Fetal Tissues ◽  
Maternal Immune System ◽  
The Face ◽  
Specific Antigens ◽  
Maternal Tolerance ◽  
Specific Tolerance ◽  
Fetal Antigen

The question of ‘how does the allogeneic fetus survive gestation in the face of the maternal immune system?’ has yet to be definitively answered. Several acceptable mechanisms exist to facilitate survival of the semi-allogeneic fetus in various species; paramount is the immunological separation of maternal and fetal tissues during gestation. However, keen observation of the maternal immune system during pregnancy has noted maternal immune tolerance to paternal-specific antigens. A mechanism by which the maternal immune system tolerates specific paternal antigens expressed on the fetus would be far more beneficial than the previously proposed immune indolence that would leave the mother susceptible to infection. In species like human or rodent, implantation occurs days after fertilisation and, as such, the mechanisms to establish antigen-specific tolerance must be initiated very early during pregnancy. We and others propose that these mechanisms are initiated at the time of insemination when paternal antigens are first introduced to the maternal immune system. Indeed, a new paradigm demonstrating the importance of paternal–maternal communication at the time of insemination is becoming evident as it relates to maternal tolerance to fetal antigen and ultimately pregnancy success.

Corrigendum to: Paternal priming of maternal tissues to optimise pregnancy success

2018 ◽  
Vol 30 (2) ◽  
pp. 415
Author(s):  
John J. Bromfield ◽  
Jason A. Rizo ◽  
Laila A. Ibrahim
Keyword(s):  
Immune System ◽  
Immune Tolerance ◽  
New Paradigm ◽  
Fetal Tissues ◽  
Maternal Immune System ◽  
The Face ◽  
Specific Antigens ◽  
Maternal Tolerance ◽  
Specific Tolerance ◽  
Fetal Antigen

The question of ‘how does the allogeneic fetus survive gestation in the face of the maternal immune system?' has yet to be definitively answered. Several acceptable mechanisms exist to facilitate survival of the semi-allogeneic fetus in various species; paramount is the immunological separation of maternal and fetal tissues during gestation. However, keen observation of the maternal immune system during pregnancy has noted maternal immune tolerance to paternal-specific antigens. A mechanism by which the maternal immune system tolerates specific paternal antigens expressed on the fetus would be far more beneficial than the previously proposed immune indolence that would leave the mother susceptible to infection. In species like human or rodent, implantation occurs days after fertilisation and, as such, the mechanisms to establish antigen-specific tolerance must be initiated very early during pregnancy. We and others propose that these mechanisms are initiated at the time of insemination when paternal antigens are first introduced to the maternal immune system. Indeed, a new paradigm demonstrating the importance of paternal–maternal communication at the time of insemination is becoming evident as it relates to maternal tolerance to fetal antigen and ultimately pregnancy success.

Influence of the Intestinal Microbiota on Diabetes Management

2020 ◽  
Vol 21 (15) ◽  
pp. 1603-1615
Author(s):  
Eva Alvarez-Vieites ◽  
Arora López-Santamarina ◽  
José M. Miranda ◽  
Alicia del Carmen Mondragón ◽  
Alexandre Lamas ◽  
...  
Keyword(s):  
Immune System ◽  
Intestinal Microbiota ◽  
Diabetes Management ◽  
Scientific Evidence ◽  
Focused Attention ◽  
Economic Implications ◽  
Experimental Animals ◽  
Low Intensity ◽  
New Treatments ◽  
The Relationship

In recent decades, there has been a very rapid increase in the prevalence of diabetes globally, with serious health and economic implications. Although today there are several therapeutic treatments for this disease, these do not address the causes of the disease and have serious side effects, so it is necessary to seek new treatments to replace or complement the existing ones. Among these complementary treatments, a strong link between the intestinal microbiota and diabetes has been demonstrated, which has focused attention on the use of biotherapy to regulate the function of the intestinal microbiota and, thus, treat diabetes. In this way, the main objective of this work is to provide a review of the latest scientific evidence on diabetes, gathering information about new trends in its management, and especially, the influence of the intestinal microbiota and microbiome on this pathology. It is possible to conclude that the relationship between the intestinal microbiota and diabetes is carried out through alterations in energy metabolism, the immune system, changes in intestinal permeability, and a state of low-intensity systemic inflammation. Although, currently, most of the experimental work, using probiotics for diabetes management, has been done on experimental animals, the results obtained are promising. Thus, the modification of the microbiota through biotherapy has shown to improve the symptoms and severity of diabetes through various mechanisms related to these alterations.

scholarly journals Psychoneuroimmunology: stress effects on pathogenesis and immunity during infection.

1994 ◽  
Vol 7 (2) ◽  
pp. 200-212 ◽  
Author(s):  
J F Sheridan ◽  
C Dobbs ◽  
D Brown ◽  
B Zwilling
Keyword(s):  
Infectious Disease ◽  
Immune System ◽  
Disease Susceptibility ◽  
Stress Effects ◽  
Response To Stress ◽  
Specific Receptors ◽  
Sympathetic Nervous ◽  
Effects Of Stress ◽  
The Relationship ◽  
Pituitary Adrenal Axis

The mammalian response to stress involves the release of soluble products from the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. Cells of the immune system respond to many of the hormones, neurotransmitters, and neuropeptides through specific receptors. The function of the immune system is critical in the mammalian response to infectious disease. A growing body of evidence identifies stress as a cofactor in infectious disease susceptibility and outcomes. It has been suggested that effects of stress on the immune system may mediate the relationship between stress and infectious disease. This article reviews recent psychoneuroimmunology literature exploring the effects of stress on the pathogenesis of, and immune response to, infectious disease in mammals.

scholarly journals Relationship of Depression, Aging and Immune System During Covid-19 Pandemic: A Review

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Farah Iylia Binti Fauzi ◽  
Siti Fatimah Binti Salleh ◽  
Mohammad Shahadat Hossen
Keyword(s):  
Mental Health ◽  
Immune System ◽  
Elderly People ◽  
Social Isolation ◽  
Mental Health Problems ◽  
Preventive Measures ◽  
Coping Mechanisms ◽  
Depression And Anxiety ◽  
Relationship Of ◽  
The Relationship

COVID-19 is a highly contagious virus that first appeared in China in December 2019. It has affected over 157 million people and killed over 3.2 million. The paper reviews the function of the immune system for COVID-19 prevention, depression, and anxiety due to COVID-19 and their effects on the immune system and the relationship of aging with the immune system and depression and anxiety. It has been found that several elderly people lack the coping mechanisms required to deal with the stress caused by COVID-19. Hence, identifying the factors and mechanisms that lead to this resilience will aid in the development of preventive measures for certain elderly people and groups with more severe mental health problems. Additionally, it would be beneficial to understand how technology could be leveraged to accomplish this goal. During the pandemic, various steps such as social isolation, quarantine, and self-isolation are needed to be implemented properly to slow the spread of the virus. Meanwhile, to help halt the pandemic, everybody must be vaccinated as soon as possible until any bans on social gatherings and social isolation can be removed, allowing other sectors such as schooling, social activities, and life to resume normalcy.

scholarly journals When the past informs our future

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Abigail LaBella
Keyword(s):  
Immune System ◽  
The Past ◽  
Healthy Pregnancy ◽  
Maternal Fetal Interface

Comparing the genes expressed at the maternal-fetal interface in different species helps to pinpoint those that contribute to a healthy pregnancy by regulating the activity of the immune system.

scholarly journals The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Sophie Docherty ◽  
Rachael Harley ◽  
Joseph J. McAuley ◽  
Lindsay A. N. Crowe ◽  
Carles Pedret ◽  
...  
Keyword(s):  
Immune System ◽  
Physiological Stress ◽  
Innate Immune ◽  
Physiological Effects ◽  
Emotional Wellbeing ◽  
Musculoskeletal Health ◽  
Exercise Induced ◽  
Musculoskeletal Systems ◽  
Response To Exercise ◽  
The Relationship

AbstractThe physiological effects of physical exercise are ubiquitously reported as beneficial to the cardiovascular and musculoskeletal systems. Exercise is widely promoted by medical professionals to aid both physical and emotional wellbeing; however, mechanisms through which this is achieved are less well understood. Despite numerous beneficial attributes, certain types of exercise can inflict significant significant physiological stress. Several studies document a key relationship between exercise and immune activation. Activation of the innate immune system occurs in response to exercise and it is proposed this is largely mediated by cytokine signalling. Cytokines are typically classified according to their inflammatory properties and evidence has shown that cytokines expressed in response to exercise are diverse and may act to propagate, modulate or mitigate inflammation in musculoskeletal health. The review summarizes the existing literature on the relationship between exercise and the immune system with emphasis on how exercise-induced cytokine expression modulates inflammation and the immune response.

scholarly journals Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Ranferi Ocaña-Guzman ◽  
Luis Vázquez-Bolaños ◽  
Isabel Sada-Ovalle
Keyword(s):  
Immune System ◽  
Cell Lines ◽  
Immune Tolerance ◽  
Defense Mechanisms ◽  
Macrophage Activation ◽  
Immunological Tolerance ◽  
Innate Defense ◽  
Activation Mechanisms ◽  
Monocytes And Macrophages ◽  
Inhibitory Molecules

A variety of receptors perform the function of attenuating or inhibiting activation of cells in which they are expressed. Examples of these kinds of receptors include TIM-3 and PD-1, among others that have been widely studied in cells of lymphoid origin and, though to a lesser degree, in other cell lines. Today, several studies describe the function of these molecules as part of the diverse mechanisms of immune tolerance that exist in the immune system. This review analyzes the function of some of these proteins in monocytes and macrophages and as well as their participation as inhibitory molecules or elements of immunological tolerance that also act in innate defense mechanisms. We chose the receptors TIM-3, PD-1, CD32b, and CD200R because these molecules have distinct functional characteristics that provide examples of the different regulating mechanisms in monocytes and macrophages.

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