scholarly journals Robust Antibody Responses to the BNT162b2 mRNA Vaccine Occur Within a Week After the First Dose in Previously Infected Individuals and After the Second Dose in Uninfected Individuals

2021 ◽  
Vol 12 ◽  
Author(s):  
Yosuke Hirotsu ◽  
Kenji Amemiya ◽  
Hiroki Sugiura ◽  
Miyuki Shinohara ◽  
Mika Takatori ◽  
...  
Keyword(s):  
Health Care Workers ◽  
Protein A ◽  
Antibody Responses ◽  
Post Vaccination ◽  
Severity Of Disease ◽  
Care Workers ◽  
Before And After ◽  
Antibody Titres ◽  
Kinetics Of ◽  
Hourly Basis

BackgroundVaccines against severe acute respiratory syndrome coronavirus 2 can trigger acquired immunity in infection-naïve individuals and offer a path toward ending the coronavirus disease pandemic that began in 2019. However, the kinetics of early antibody responses in vaccinated individuals remain poorly understood.MethodWe followed BNT162b2 mRNA-vaccinated health care workers (HCWs, N=108) including 103 infection-naïve and five previously infected individuals. A total of 763 blood samples were collected weekly or hourly basis before and after vaccination. Serological analysis of anti-spike and anti-nucleocapsid antibodies was performed.ResultsSeroconversion occurred in all infection-naïve HCWs 3 weeks after the first dose (just before the second vaccination) and a marked boosting effect was observed at 4 weeks (1 week after the second dose). Among previously infected HCWs with pre-existing antibodies against the spike protein, a remarkable boosting effect was observed during the first week after vaccination, and a further increase in antibody titres was observed after the second dose. In one previously infected patient, daily blood sampling was conducted. Antibody titres began to increase 96 hours (4 days) after the first dose.ConclusionThe BNT162b2 mRNA vaccine remarkably enhanced antibody responses after the second dose in infection-naïve individuals and after the first dose in previously infected HCWs of all ages and genders. Antibody titres decreased slightly after the 5th week post-vaccination. The robust boosting effect of immunisation suggests that increased antibody titres following exposure to the virus may restrict viral replication, prolong the incubation period, or lessen the severity of disease.

scholarly journals Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers

2021 ◽  
pp. 074873042110593
Author(s):  
Wei Wang ◽  
Peter Balfe ◽  
David W. Eyre ◽  
Sheila F. Lumley ◽  
Denise O’Donnell ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Time Of Day ◽  
Antibody Responses ◽  
Post Vaccination ◽  
Host Immune Responses ◽  
Care Workers ◽  
Vaccine Type ◽  
Multiple Pathogens ◽  
Vaccination Time

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy.

scholarly journals kinetics of anti-SARS-CoV-2 antibodies over time. Results of 10 month follow up in over 300 seropositive Health Care Workers

2021 ◽  
Author(s):  
Jose Felipe Varona ◽  
Rodrigo Madurga ◽  
Francisco Peñalver ◽  
Elena Abarca ◽  
Cristina Almirall ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Care Workers ◽  
Kinetics Of ◽  
Over Time

Health-Care Workers’ Perception of Reimbursement for Complex Surgical Oncology Procedures

2020 ◽  
Vol 86 (2) ◽  
pp. 140-145
Author(s):  
Shoshana Levi ◽  
Emily Alberto ◽  
Dakota Urban ◽  
Nicholas Petrelli ◽  
Gregory Tiesi
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Online Survey ◽  
Surgical Oncology ◽  
Patient Perceptions ◽  
Cancer Center ◽  
Physician Reimbursement ◽  
Care Workers ◽  
Before And After ◽  
Fee Schedule

Perception of physician reimbursement for surgical procedures is not well studied. The few existing studies illustrate that patients believe compensation to be higher than in reality. These studies focus on patient perceptions and have not assessed health-care workers’ views. Our study examined health-care workers’ perception of reimbursement for complex surgical oncology procedures. An anonymous online survey was distributed to employees at our cancer center with descriptions and illustrations of three oncology procedures—hepatectomy, gastrectomy, and pancreaticoduodenectomy. Participants estimated the Medicare fee and gave their perceived value of each procedure. Participants recorded their perception of surgeon compensation overall, both before and after revealing the Medicare fee schedule. Most of the 113 participants were physicians (33.6%) and nurses (28.3%). When blinded to the Medicare fee schedules, most felt that reimbursements were too low for all procedures (60–64%) and that surgeons were overall undercompensated (57%). Value predictions for each procedure were discordant from actual Medicare fee schedules, with overestimates up to 374 per cent. After revealing the Medicare fee schedules, 55 per cent of respondents felt that surgeons were undercompensated. Even among health-care workers, a large discrepancy exists between perceived and actual reimbursement. Revealing actual reimbursements did not alter perception on overall surgeon compensation.

scholarly journals Incidence of COVID-19 Infection in Hospital Workers From March 1, 2020 to May 31, 2021 Routinely Tested, Before and After Vaccination With BNT162B2

2021 ◽  
Author(s):  
Francesca Larese Filon ◽  
Francesca Rui ◽  
Federico Ronchese ◽  
Paola Michieli ◽  
Corrado Negro
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Hospital Workers ◽  
Factors Associated ◽  
Care Workers ◽  
Before And After ◽  
Polymerase Chain ◽  
Incident Rate ◽  
Rate Ratios ◽  
Monthly Incidence

Abstract Objective To evaluate the incidence of COVID-19 infection in health care workers from the start of COVID-19 pandemic in NE of Italy, to the vaccination with BNT162b2. Materials and methods This was a retrospective cohort study. Health care workers were routinely tested for SARS-CoV-2 infections using real-time polymerase chain reaction tests in nasopharyngeal swabs. Logistic regression was used to calculate incident rate ratios (IRRs) of factors associated to COVID-19. Results A total of 4251 workers were followed-up and an annual incidence of COVID-19 of 13.6% was found. In March 2021 the incidence of infection was 4.88 and 103.55 cases for 100.000 person-days in vaccinated and non-vaccinated workers, respectively, with an adjusted IRRs of 0.05 (95% CI 0.02–0.08). Conclusions Our study evaluated the monthly incidence in health care workers in Trieste hospitals before and after the vaccination finding the protective effect of BNT162B2 vaccine in 95% of health care workers routinely tested.

scholarly journals Standardised, quantitative neutralisation responses to SARS-CoV-2 Variants of Concern by convalescent anti-sera from first wave infections of UK Health Care Workers and Patients

2021 ◽  
Author(s):  
Diego Cantoni ◽  
Martin Mayora-Neto ◽  
Angalee Nadesalingam ◽  
David A. Wells ◽  
George W. Carnell ◽  
...  
Keyword(s):  
Health Care Workers ◽  
Healthcare Workers ◽  
World Health Organisation ◽  
World Health ◽  
Care Centre ◽  
International Standard ◽  
Care Workers ◽  
The World ◽  
Antibody Titres ◽  
The Uk

One of the defining criteria of Variants of Concern (VOC) is their ability to evade pre-existing immunity, increased transmissibility, morbidity and/or mortality. Here we examine the capacity of convalescent plasma, from a well defined cohort of healthcare workers (HCW) and Patients infected during the first wave from a national critical care centre in the UK, to neutralise B.1.1.298 variant and three VOCs; B.1.1.7, B.1.351 and P.1. Furthermore, to enable lab to lab, country to country comparisons we utilised the World Health Organisation (WHO) International Standard for anti-SARS-CoV-2 Immunoglobulin to report neutralisation findings in International Units. These findings demonstrate a significant reduction in the ability of first wave convalescent plasma to neutralise the VOCs. In addition, Patients and HCWs with more severe COVID-19 were found to have higher antibody titres and to neutralise the VOCs more effectively than individuals with milder symptoms. Widespread use of the WHO International Standard by laboratories in different countries will allow for cross-laboratory comparisons, to benchmark and to establish thresholds of protection against SARS-CoV-2 and levels of immunity in different settings and countries.

Healthcare Workers’ Mobile Phones as a Possible Vehicle of Nosocomial Pathogens and the Role of Different Disinfectants in their Decontamination

2021 ◽  
Vol 30 (3) ◽  
pp. 29-36
Author(s):  
Rana E. Elgabeery ◽  
Radwa A. Eissa ◽  
Sohair M. Soliman ◽  
Naglaa F. Ghoname
Keyword(s):  
Health Care ◽  
Mobile Phones ◽  
Health Care Workers ◽  
Healthcare Workers ◽  
Colony Count ◽  
Drug Resistant ◽  
University Hospitals ◽  
Care Workers ◽  
Before And After

Background: As Mobile Phones (MPs) aren’t cleaned routinely and have been touched during patient’s examination, they may become contaminated with hospital pathogens. Objectives: Screen MPs of Health care workers (HCWs) for pathogens and verify the effect of disinfectants in their decontamination. Methods: A questionnaire was submitted by 160 HCWs in Tanta University Hospitals. Samples were taken from their MPs and subjected to pour plate counting before and after disinfection. Standard identification and antibiotic susceptibility of isolates were done. Results: Colony count was greater in MPs used while caring for patients or inside restroom, and was less in regularly cleaned MPs. All tested disinfectants reduced the colony count significantly. Pathogens were isolated from 84.38% of samples and 36.25% of them were Multi-Drug Resistant Organisms (MDROs). Conclusion: Using MPs at critical care areas and restroom may contribute to their contamination with pathogens. Regular disinfection of MPs can reduce this contamination.

Relationship Of Pneumocystis KEX1 Antibody Responses To Pneumocystis Colonization In Health Care Workers

2010 ◽  
Author(s):  
Jan Kristoff ◽  
Serena Fong ◽  
Renuka Tipirneni ◽  
Leah Jarlsberg ◽  
Laurence Huang ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Antibody Responses ◽  
Care Workers ◽  
Relationship Of

scholarly journals The implementation of the choice on termination of pregnancy act: some empirical findings

Curationis ◽  
2000 ◽  
Vol 23 (2) ◽  
Author(s):  
MC Engelbrecht ◽  
AJ Pelser ◽  
Charles Ngwena ◽  
HCJ Van Rensburg
Keyword(s):  
Social Workers ◽  
Health Care Workers ◽  
Health Professionals ◽  
Service Providers ◽  
Considerable Proportion ◽  
Abortion Law ◽  
Care Workers ◽  
Before And After ◽  
Trained Staff ◽  
Do So

The Choice on Termination o f Pregnancy Act o f 1996substantially liberalised abortion law. Whilst a substantial number of terminations of pregnancies (TOPs) have already been performed in terms of the new Act, it has also surfaced that an array of factors of various kinds may impede its further implementation and operation. A study was undertaken to determine the nature and extent of any such impediments to the implementation of the Choice on Termination o f Pregnancy Act. More specifically a survey was conducted amongst a sample of 75 women who had undergone a TOP since the implementation of the Act; health professionals and social workers who provide TOP services (n=16); and health professionals and social workers who are in a position to refer women to TOP facilities (n=63). Overall, the clients were well treated at the TOP facilities, and were satisfied with the service given to them. However, post-counselling and to a lesser extent pre-counselling, is lacking. Counselling is important as a considerable proportion of the clients suffered from emotional feelings usually associated with depression and/or self-reproach before and after the termination procedure. Furthermore these clients did not usually discuss their termination with family members. TOP service providers were dissatisfied with the TOP facilities, especially the insufficient number of consultation and counselling rooms. Health care workers in a position to refer clients to TOP facilities were not always willing to do so, thereby obstructing the referral system. In the main, it is recommended that the entire TOP procedure should be done at clinics/hospitals so that clients will not have to do inductions at home, more trained staff should be available, facilities should be adequate and accessible, and there should be psychological support for staff.

Understanding the Predictors that Contribute to Liberian Health Care Workers Feeling Protected From Ebola While at Work

2020 ◽  
pp. 1-6
Author(s):  
Kayla Enriquez ◽  
Kanagasabai Udhayashankar ◽  
Michelle Niescierenko
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Ebola Virus ◽  
Virus Disease ◽  
Infection Prevention And Control ◽  
Care Workers ◽  
Before And After ◽  
Returning To Work ◽  
Care Worker ◽  
And Control

ABSTRACT Objective: To assess Liberian health care workers’ feelings around safety in returning to work in the setting of the Ebola virus disease outbreak of 2014–2015 after receiving infection prevention and control (IPC) training. Methods: Academic Consortium Combating Ebola in Liberia (ACCEL) training surveys were done at 21 public, Liberian hospitals to understand health care workers’ attitudes surrounding Ebola and whether they felt safe while at work based on multiple factors. Logistic regression was used for analysis. Results: We found that health care workers feeling safe at work during the Ebola outbreak was primarily predicted by the number of IPC/Ebola trainings received pre-ACCEL interventions. Health care workers felt increasingly safer and motivated to return to work as trainings approached 3 (OR 8, p-value < 0.001); however, more than 3 trainings resulted in decreased safety and motivation. In addition, health care workers who reported washing their hands before and after patient contact were 3.4 times more likely to understand how to protect themselves from Ebola. Conclusions: These results help to better understand the utility of repeated trainings on health care worker practice attitudes and the importance of IPC policies within hospitals, such as hand hygiene promotion and education, when coordinating humanitarian efforts.

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