scholarly journals The Potential of Calcium Phosphate Nanoparticles as Adjuvants and Vaccine Delivery Vehicles

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhe Sun ◽  
Wenyi Li ◽  
Jason C. Lenzo ◽  
James A. Holden ◽  
Michael J. McCullough ◽  
...  
Keyword(s):  
Immune Response ◽  
Calcium Phosphate ◽  
Vaccine Development ◽  
Vaccine Delivery ◽  
Vaccine Design ◽  
Cost Effective ◽  
Research Groups ◽  
Immunological Effects ◽  
Calcium Phosphate Nanoparticles ◽  
Delivery Vehicles

Vaccination is one of the most efficacious and cost-effective ways to protect people from infectious diseases and potentially cancer. The shift in vaccine design from disrupted whole pathogens to subunit antigens has brought attention on to vaccine delivery materials. For the last two decades, nanotechnology-based vaccines have attracted considerable attention as delivery vehicles and adjuvants to enhance immunogenicity, exemplified with the current COVID vaccines. The nanoparticle vaccines display unique features in protecting antigens from degradation, controlled antigen release and longer persisting immune response. Due to their size, shape and surface charge, they can be outstanding adjuvants to achieve various immunological effects. With the safety and biodegradable benefit of calcium phosphate nanoparticles (CaP NPs), they are an efficient carrier for vaccine design and adjuvants. Several research groups have studied CaP NPs in the field of vaccination with great advances. Although there are several reports on the overview of CaP NPs, they are limited to the application in biomedicine, drug delivery, bone regeneration and the methodologies of CaP NPs synthesis. Hence, we summarised the basic properties of CaP NPs and the recent vaccine development of CaP NPs in this review.

scholarly journals The CpG molecular structure controls the mineralization of calcium phosphate nanoparticles and their immunostimulation efficacy as vaccine adjuvants

Nanoscale ◽  
2020 ◽  
Vol 12 (17) ◽  
pp. 9603-9615 ◽  
Author(s):  
Razieh Khalifehzadeh ◽  
Hamed Arami
Keyword(s):  
Molecular Structure ◽  
Calcium Phosphate ◽  
Vaccine Delivery ◽  
Vaccine Adjuvants ◽  
Calcium Phosphate Nanoparticles

Effects of the CpG molecular structure on the mineralization and immunostimulation efficacy of calcium phosphate nanoparticles are explored for vaccine delivery applications.

scholarly journals Preparation of functional calcium phosphate nanoparticles for vaccine delivery

2016 ◽  
Vol 46 (9) ◽  
pp. 891-899
Author(s):  
Xinrong Liu ◽  
Qian Wang ◽  
Shaobing Zhou ◽  
Guihua Wei ◽  
Kang Wang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Vaccine Delivery ◽  
Calcium Phosphate Nanoparticles

scholarly journals Inflammatory and Autoimmune Reactions in Atherosclerosis and Vaccine Design Informatics

2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Michael Jan ◽  
Shu Meng ◽  
Natalie C. Chen ◽  
Jietang Mai ◽  
Hong Wang ◽  
...  
Keyword(s):  
Immune Response ◽  
Vaccine Development ◽  
Vaccine Design ◽  
Cardiovascular Morbidity ◽  
Bioinformatic Tools ◽  
High Affinity ◽  
The Past ◽  
Cardiovascular Morbidity And Mortality ◽  
Active Research ◽  
Positive Results

Atherosclerosis is the leading pathological contributor to cardiovascular morbidity and mortality worldwide. As its complex pathogenesis has been gradually unwoven, the regime of treatments and therapies has increased with still much ground to cover. Active research in the past decade has attempted to develop antiatherosclerosis vaccines with some positive results. Nevertheless, it remains to develop a vaccine against atherosclerosis with high affinity, specificity, efficiency, and minimal undesirable pathology. In this review, we explore vaccine development against atherosclerosis by interpolating a number of novel findings in the fields of vascular biology, immunology, and bioinformatics. With recent technological breakthroughs, vaccine development affords precision in specifying the nature of the desired immune response—useful when addressing a disease as complex as atherosclerosis with a manifold of inflammatory and autoimmune components. Moreover, our exploration of available bioinformatic tools for epitope-based vaccine design provides a method to avoid expenditure of excess time or resources.

The potential of porous silicon particles for multi-epitopic vaccine development

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
G. Navarro-Tovar ◽  
A. Wong-Arce ◽  
M. Campos-Portillo ◽  
G. Palestino ◽  
S. Rosales-Mendoza
Keyword(s):  
Porous Silicon ◽  
Vaccine Development ◽  
Vaccine Delivery ◽  
Subunit Vaccines ◽  
Convenient Approach ◽  
Delivery Vehicles ◽  
Potential Vaccine ◽  
And Control ◽  
Vaccine Delivery Vehicle ◽  
Silicon Particles

AbstractVaccination is a crucial approach to eradicate and control amyriad of infectious and non-communicable diseases. Subunit vaccines are considered the most convenient approach for vaccine formulation; however, the development of new adjuvants and vaccine delivery vehicles to improve the immunogenicity of such formulations is needed. The authors of this review describe the recent application of porous silicon particles (PSiP) as both a potential vaccine delivery vehicle and adjuvant. PSiP are attractive for this application due to its safety, biodegradability and compatibility for functionalization. Herein, the development of multi-epitope cancer vaccines is discussed as an example on how PSiP are promising materials for the development of innovative vaccines.

scholarly journals Evaluation of Synergistic Effect of Cytosine-Phosphodiesterbond-Guanosin-Oligodeoxynucleotide 7909, and Protamine on Transfection Process Mediated by Calcium Phosphate Nanoparticles

2020 ◽  
Vol 10 (01) ◽  
pp. 52-59
Author(s):  
Ghassaq T. Al-Ubaidi ◽  
Ahmed A. Abbas ◽  
Ali A. Taha ◽  
Qasim S. Sharhan ◽  
Israa W. Ahmed ◽  
...  
Keyword(s):  
Immune Response ◽  
Calcium Phosphate ◽  
Cellular Immune Response ◽  
Sandwich Elisa ◽  
Interleukin 12 ◽  
Monocytic Cell ◽  
Monocytic Cell Line ◽  
Partial Protection ◽  
Calcium Phosphate Nanoparticles ◽  
Cellular Immune

Bacille Calmette-Guerin (BCG) still the only authenticated vaccine against tuberculosis. Due to its drawbacks, a need for a new formula has emerged. The implication of “Nanovaccinology” is one of the possible alternatives. The non-viral vectors have a low transfection ability. In the context, this work aims to add two adjuvants to a calcium phosphate nanoparticles (CPNPs) functionalized with early secreted antigenic target 6-kilo dalton ( ESAT-6) cloned pcDNA3.1(+) plasmid. ESAT-6 gene is specific to mycobacterium tuberculosis complex (MTC) and encodes a T-cell antigen. The adjuvants in practice are Herring protamine and cytosine-phosphodiester bond-guanosine-oligodeoxynucleotide 7909 ( CpG-ODN 7909). Each has a different strategy in enhancing immune response; protamine is particulate adjuvant while CpG is an immunopotentiator substance. Nano complex was transfected into THP-1 monocytic cell line after its activation to a macrophage via 100nM PMA. Cellular immune response, interleukin-12 (IL-12), and tumor necrosis factor –alfa (TNF-ɑ) also ESAT-6 protein production were assayed via the Sandwich ELISA technique. Results revealed that CPNPs offer only partial protection to the adsorbed plasmid against enzymatic degradation. Nano complex formula with two adjuvants resulted in significantly higher cellular immune response comparing to formula carrying one adjuvant. In conclusion, the implication of CPNPs in gene delivery accompanied with two adjuvants each possess different strategy, will result in partial protection to the delivered gene with upsurge cellular immune response.

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