scholarly journals Serum Total Bilirubin and Progression of Chronic Kidney Disease and Mortality: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 7 ◽  
Author(s):  
Jia Li ◽  
Dongwei Liu ◽  
Zhangsuo Liu
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Dose Response ◽  
Lower Risk ◽  
Large Scale ◽  
Protective Factor ◽  
Total Bilirubin ◽  
Meta Analysis ◽  
Serum Total Bilirubin ◽  
Physiological Range

Background: Previous studies have suggested that serum total bilirubin (STB) levels are associated with heightened chronic kidney disease (CKD) and mortality in both the general population and nephropathy patients. However, these results remain inconsistent. The aim of our study was to investigate whether STB was a predictor for progression of CKD and mortality by meta-analysis.Methods: We performed a systematic literature search in PubMed, Web of Science, MEDLINE, EMBASE, Google Scholar, and Cochrane Library's database up to June 30, 2019. Pooled risk ratios (RR) and corresponding 95% confidence intervals (CI) were extracted for the highest vs. lowest category STB levels within the physiological range, and a random-effects model was applied to calculate the dose–response relationships. A pooled hazard ratio (HR) was used to investigate the association between STB levels and mortality in dialysis patients.Results: A total of 16 studies, wherein participants were followed from 21 months to 7 years, were eligible for inclusion in the study. For the categorized STB, 11 studies with 41,188 participants were identified and analyzed. Patients with the highest STB levels were associated with a lower risk of CKD (RR = 0.64; 95% CI 0.55–0.73) compared to those with the lowest STB levels. Furthermore, based on seven studies, a pooled RR of 0.89, 95% CI (0.80–0.99) was observed for the continuous STB levels (per 0.2 mg/dL increase). Four studies that included 51,764 participants illustrated that there was no association between STB levels and all-cause mortality (HR = 0.77; 95% CI 0.42–1.41). A prominent negative linear relationship (X2 = 14.70; P = 0.0001) was found between STB levels and risk of CKD. Subgroup analyses showed that there were no significant differences in the subgroup adjustment factor except for sample size.Conclusions: Elevated STB levels within a physiological range are associated with lower risk of CKD regardless of the study characteristics and coincide with a liner dose–response relationship. However, whether high STB levels are a protective factor against mortality remains inconclusive. Large-scale randomized controlled trails are needed to target STB levels for predicting renal outcomes.

scholarly journals Dietary patterns and chronic kidney disease risk: a systematic review and updated meta-analysis of observational studies

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Ling-Qiong He ◽  
Xu-Hong Wu ◽  
Yi-Qian Huang ◽  
Xiao-Yan Zhang ◽  
Long Shu
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Lower Risk ◽  
Observational Studies ◽  
Meta Analysis ◽  
Drinking Pattern ◽  
Healthy Dietary Pattern

Abstract Background A number of studies have reported the association between dietary patterns and the risk of chronic kidney disease (CKD), however a consistent perspective hasn’t been established to date. Herein, we conducted this systematic review and meta-analysis of observational studies to assess the association between dietary patterns and CKD. Methods MEDLINE, EBSCO and references from eligible studies were searched for relevant articles published up to 9 May 2020 that examined the association of common dietary patterns and CKD. The heterogeneity among studies was assessed by Cochran’s Q test and I2 methods. Results Seventeen eligible studies, involving 149,958 participants, were included in our systematic review and meta-analysis. The highest compared with the lowest category of healthy dietary pattern was significantly associated with a lower risk of CKD (OR=0.69; CI: 0.57, 0.84; P=0.0001). A higher risk of CKD was shown for the highest compared with the lowest categories of Western-type dietary pattern (OR=1.86; CI: 1.21, 2.86; P=0.005). There were evidence of a lower risk of CKD in the highest compared with the lowest categories of light-moderate drinking pattern (OR=0.76; CI: 0.71, 0.81; P< 0.0001) and heavy drinking pattern (OR=0.67; CI: 0.56, 0.80; P< 0.0001). Conclusions The results of this systematic review and meta-analysis show that a healthy dietary pattern and alcohol drinking were associated with lower risk of CKD, whereas a Western-type dietary pattern was associated with higher risk of CKD.

scholarly journals Association of physical activity with chronic kidney disease: a systematic review and dose-response meta-analysis

Aging ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 19221-19232
Author(s):  
Yongjian Zhu ◽  
Yongjun Bu ◽  
Guofu Zhang ◽  
Shibin Ding ◽  
Desheng Zhai ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Dose Response ◽  
Meta Analysis

scholarly journals Relationship between birth weight and chronic kidney disease: an integrative analysis of observational studies and causal inference through genetic approaches

2019 ◽  
Author(s):  
Xinghao Yu ◽  
Zhongshang Yuan ◽  
Haimiao Chen ◽  
Jiaji Yang ◽  
Yixin Gao ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Birth Weight ◽  
Kidney Disease ◽  
Instrumental Variables ◽  
Observational Studies ◽  
Large Scale ◽  
Causal Effect ◽  
Meta Analysis ◽  
Likelihood Method ◽  
Inverse Association

ABSTRACTObjectiveAlthough many observational studies have shown that there was an inverse association between birth weight and chronic kidney disease (CKD) in adults, whether such association is causal remains largely unclear.MethodsWe first conducted a systematic review and meta-analysis to investigate the association between birth weight and CKD. Then using a set of valid instrumental variables for birth weight, we performed a two-sample Mendelian randomization (MR) to evaluate its causal effect on CKD based on summary association statistics available from large scale genome-wide association study (GWAS) (up to 143,677 individuals for birth weight and 118,147 individuals for CKD). We further validated the MR results with extensive sensitive analyses.ResultsThe results of meta-analysis showed that individuals with low birth weight have about 76% (95% CI 36∼126%) higher risk of CKD in late life compared with those with normal birth weight. Depending on 26 instrumental variables, the inverse variance weighted MR showed that the odds ratio per one SD increase of birth weight on CKD was estimated to be 0.91 (95% CI 0.72∼1.14, p=0.396). The similar null association between birth weight and CKD is also observed using the weighted median method and maximum likelihood method as well as the Egger regression. Such non-significant association is robust against potential instrumental outliers and pleiotropic effects.ConclusionOur study identifies an inverse association between birth weight and adult CKD in observational studies, while it is not supportive of the causal role of birth weight on CKD based on our MR analysis.

Association of serum total bilirubin with renal outcome in Japanese patients with stages 3–5 chronic kidney disease

Metabolism ◽  
2015 ◽  
Vol 64 (9) ◽  
pp. 1096-1102 ◽  
Author(s):  
Teppei Sakoh ◽  
Masaru Nakayama ◽  
Shigeru Tanaka ◽  
Ryota Yoshitomi ◽  
Yoriko Ura ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Total Bilirubin ◽  
Japanese Patients ◽  
Renal Outcome ◽  
Serum Total Bilirubin

scholarly journals Hepatic Steatosis Index and Chronic Kidney Disease among Middle-Aged Individuals: A Large-Scale Study in Japan

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Hirotaka Ochiai ◽  
Takako Shirasawa ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Ken Sakamoto ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Hepatic Steatosis ◽  
Dose Response ◽  
Large Scale ◽  
Early Stage ◽  
Response Relationship ◽  
Middle Aged ◽  
Dose Response Relationship ◽  
Hepatic Steatosis Index

Background. Though nonalcoholic fatty liver disease (NAFLD) is related to chronic kidney disease (CKD), it is unclear whether the hepatic steatosis index (HSI), a screening tool for NAFLD, is related to CKD. The present study investigated the relationship between HSI and CKD among middle-aged individuals in Japan. Methods. Subjects were adults (aged 40–64 years) who received an annual health checkup in Japan between April 2013 and March 2014. Height and weight were measured, and venous blood samples were obtained to determine alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine levels. HSI was calculated by the following formula: HSI = 8 × ALT / AST   ratio + body   mass   index (+2, if diabetes; +2, if female). CKD was defined as an estimated glomerular filtration rate < 60   mL / min / 1.73   m 2 and/or urinary protein of ≥ (+). Logistic regression analysis was performed to estimate the odds ratio (OR) and its 95% confidence interval (CI) for CKD. Results. Data of 94,893 adults were analyzed. Compared with men with an HSI < 30 , men with 30 ≤ HSI ≤ 36 (OR: 1.50, 95% CI: 1.40–1.61) and HSI > 36 (OR: 2.14, 95% CI: 1.99–2.31) had significantly higher ORs for CKD. Moreover, there was a significant dose-response relationship between HSI and CKD ( P for trend < 0.001 ). Even after adjusting for confounders, the significant results persisted. These findings in men were similar to those in women. Conclusions. This study showed that the HSI was associated with CKD among middle-aged adults in Japan. Additionally, a dose-response relationship of HSI to CKD was observed. The present study suggested that it might be useful to monitor the HSI among middle-aged individuals to detect CKD at an early stage.

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