scholarly journals Influence of Serum Albumin on HbA1c and HbA1c-Defined Glycemic Status: A Retrospective Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaojing Feng ◽  
Yanyi Yang ◽  
Siqi Zhuang ◽  
Yiyuan Fang ◽  
Yufeng Dai ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Serum Albumin ◽  
Threshold Effect ◽  
Albumin Level ◽  
Diabetic Patients ◽  
Glycemic Status ◽  
Increased Risk ◽  
Routine Physical Examination ◽  
Diabetic Population ◽  
High Fasting Plasma Glucose

Background: Glycated hemoglobin (HbA1c) is commonly used in the diagnosis and evaluation of glycemic control in diabetes, and it may be influenced by several non-glycemic and glycemic factors, including albumin. This retrospective study investigated the influence of albumin on HbA1c and HbA1c-defined glycemic status.Methods: The demographic, hematological, and biochemical data were collected for 11,922 patients undergoing routine physical examination. Univariate and multivariate linear regression analyses, stratified analyses and interaction analyses, and multiple logistic regression were conducted to identify the association between albumin and HbA1c in people with different glycemic status.Results: HbA1c levels were inversely associated with serum albumin level (P < 0.0001) in all participants. Risk factors leading to the association included age > 45 years, high fasting plasma glucose (≥7.0 mmol/L), and anemia. The negative association between HbA1c and albumin was curved (P < 0.0001) and had a threshold effect in the HbA1c-defined diabetic population; the association was significantly stronger when the albumin level fell below 41.4 g/L (β: −0.31, 95% CI: −0.45 to −0.17, P < 0.0001). A 2 g/L increase in albumin reduced the odds of HbA1c-defined dysglycemia, diabetes, and poor glycemia control by 12% to 36%, after adjustment for all possible confounders.Conclusions: HbA1c was inversely associated with albumin level in all participants, and the association was significantly stronger in people with diabetes (defined by HbA1c criteria). For diabetic patients with lower albumin level, there was an increased risk of an erroneous HbA1c-based identification and management of glycemic status.

scholarly journals Influence of serum albumin on HbA1c and HbA1c-defined glycemic status: a retrospective study

2020 ◽  
Author(s):  
Xiao jing Feng ◽  
Yan yi Yang ◽  
Si qi Zhuang ◽  
Yi yuan Fang ◽  
Yu feng Dai ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Serum Albumin ◽  
Threshold Effect ◽  
Albumin Level ◽  
Diabetic Patients ◽  
Glycemic Status ◽  
Increased Risk ◽  
Routine Physical Examination ◽  
Diabetic Population ◽  
High Fasting Plasma Glucose

Abstract Backgound: Glycated hemoglobin (HbA1c) is commonly used in the diagnosis and evaluation of glycemic control in diabetes, and may be influenced by several non-glycemic and glycemic factors, including albumin. This retrospective study investigated the influence of albumin on HbA1c and HbA1c-defined glycemic status. Methods: The demographic, hematological, and biochemical data were collected for 11,922 patients undergoing routine physical examination. Univariate and multivariate linear regression analyses, stratified analyses and interaction analyses, and multiple logistic regression were conducted to identify the association between albumin and HbA1c in people with different glycemic status. Results: HbA1c levels were inversely associated with serum albumin level ( P < 0.0001) in all participants. Risk factors leading to the association included age >45 years, high fasting plasma glucose (≥7.0 mmol/L), and anemia. The negative association between HbA1c and albumin was curved ( P < 0.0001) and had a threshold effect in the HbA1c-defined diabetic population; the association was significantly stronger when the albumin level fell below 41.4 g/L (β: –0.31, 95% CI: –0.45 to –0.17, P < 0.0001). A 2 g/L increase in albumin reduced the odds of HbA1c-defined dysglycemia, diabetes, and poor glycemia control by 12% to 36%, after adjustment for all possible confounders. Conclusions: HbA1c was inversely associated with albumin level in all participants, and the association was significantly stronger in people with diabetes (defined by HbA1c criteria). For diabetic patients with lower albumin level, there was an increased risk of an erroneous HbA1c-based identification and management of glycemic status.

scholarly journals Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study

BMC Urology ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Yongquan Tang ◽  
Zhihong Liu ◽  
Jiayu Liang ◽  
Ruochen Zhang ◽  
Kan Wu ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Serum Albumin ◽  
Kidney Cancer ◽  
Serum Albumin Level ◽  
Albumin Level

scholarly journals Perioperative serum albumin and its influence on clinical outcomes in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass: a multi-centre retrospective study

2019 ◽  
Vol 29 (06) ◽  
pp. 761-767 ◽  
Author(s):  
Brandon M. Henry ◽  
Santiago Borasino ◽  
Laura Ortmann ◽  
Mayte Figueroa ◽  
A.K.M. Fazlur Rahman ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Retrospective Study ◽  
Cardiopulmonary Bypass ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Critically Ill Children ◽  
Operative Morbidity ◽  
Neonates And Infants ◽  
Low Serum

AbstractHypoalbuminemia is associated with morbidity and mortality in critically ill children. In this multi-centre retrospective study, we aimed to determine normative values of serum albumin in neonates and infants with congenital heart disease, evaluate perioperative changes in albumin levels, and determine if low serum albumin influences post-operative outcomes. Consecutive eligible neonates and infants who underwent cardiac surgery with cardiopulmonary bypass at one of three medical centres, January 2012–August 2013, were included. Data on serum albumin levels from five data points (pre-operative, 0–24, 24–48, 48–72, 72 hours post-operative) were collected. Median pre-operative serum albumin level was 2.5 g/dl (IQR, 2.1–2.8) in neonates versus 4 g/dl (IQR, 3.5–4.4) in infants. Hypoalbuminemia was defined as &lt;25th percentile of these values. A total of 203 patients (126 neonates, 77 infants) were included in the study. Post-operative hypoalbuminemia developed in 12% of neonates and 20% of infants; 97% occurred in the first 48 hours. In multivariable analysis, perioperative hypoalbuminemia was not independently associated with any post-operative morbidity. However, when analysed as a continuous variable, lower serum albumin levels were associated with increased post-operative morbidity. Pre-operative low serum albumin level was independently associated with increased odds of post-operative hypoalbuminemia (OR, 3.67; 95% CI, 1.01–13.29) and prolonged length of hospital stay (RR, 1.40; 95% CI, 1.08–1.82). Lower 0–24-hour post-operative serum albumin level was independently associated with an increased duration of mechanical ventilation (RR, 1.35; 95% CI, 1.12–1.64). Future studies should further assess hypoalbuminemia in this population, with emphasis on evaluating clinically meaningful cut-offs and possibly the use of serum albumin levels in perioperative risk stratification models.

scholarly journals Association of admission vs. nadir serum albumin concentration with short-term treatment outcomes in patients with acute heart failure

2018 ◽  
Vol 46 (9) ◽  
pp. 3665-3674 ◽  
Author(s):  
Evan J. Peterson ◽  
Tien M. H. Ng ◽  
Komal A. Patel ◽  
Mimi Lou ◽  
Uri Elkayam
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Serum Albumin ◽  
Treatment Outcomes ◽  
Acute Heart Failure ◽  
Albumin Level ◽  
Albumin Concentration ◽  
Short Term ◽  
Short Term Treatment ◽  
Increased Risk

Objectives Hypoalbuminemia occurs in 25% to 76% of patients hospitalized for acute heart failure (HF) and is associated with increased mortality. Hypoalbuminemia may predispose patients to intravascular volume depletion, hypotension, and acute worsening of renal function; however, its association with treatment outcomes during hospitalization is unknown. Methods This retrospective cohort study involved 414 adult patients hospitalized for HF requiring intravenous diuretics. Temporal changes in serum albumin and the association of hypoalbuminemia with urine output, renal function changes, blood pressure, use of intravenous vasoactive drugs, and short-term outcomes were assessed. Results Serum albumin decreased in most patients (72%) during hospitalization. Hypoalbuminemia was present in 29% and 50% of patients based on the mean admission and nadir serum albumin level, respectively. Hypoalbuminemia as assessed by the nadir albumin level was associated with an increased risk of acute worsening of renal function. A nadir albumin level of <3.0 g/dL remained significantly associated in the multivariate analyses. Conclusions Serum albumin commonly decreases during hospitalization for acute HF. Hypoalbuminemia assessed using the nadir level during hospitalization, not the admission level, was associated with an increased risk of acute worsening of renal function. The timing of serum albumin measurement may influence its utility as a biomarker.

scholarly journals Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective study

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
David Shaoen Sim ◽  
Suraya Zainul-Abidin ◽  
Eileen Yilin Sim ◽  
Chu Sheng Seng ◽  
Shern-En Evan Tan ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Surgical Treatment ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Femur Fractures

scholarly journals Impact of Diabetes on Extracellular Volume Status in Patients Initiating Peritoneal Dialysis

2017 ◽  
Vol 46 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Aniema Udo ◽  
Catriona Goodlad ◽  
Andrew Davenport
Keyword(s):  
Peritoneal Dialysis ◽  
Serum Albumin ◽  
Pulse Pressure ◽  
Extracellular Volume ◽  
Volume Overload ◽  
Glycated Haemoglobin ◽  
Diabetic Patients ◽  
Membrane Function ◽  
Arterial Blood ◽  
Increased Risk

Background: Recent reports have highlighted that diabetic patients with kidney failure are at increased risk of technique failure and transfer to haemodialysis within 90 days of initiating peritoneal dialysis (PD). We wished to determine whether there were differences between diabetic and non-diabetic patients within the first 3 months of starting PD. Methods: We reviewed results of corresponding bioimpedance and the 1st test of peritoneal membrane function (PET) in consecutive patients, 6-10 weeks after initiating PD electively. Results: Adult patients numbering 386 - 230 males (59.6%), 152 (39.4%) diabetic, 188 (48.7%) white, mean age 57.3 ±16.9 years - were studied. Although weight, residual renal function and peritoneal clearances were not different, diabetic patients had greater extracellular water to total body water (ECW/TBW; 40.4 ± 1.1 vs. 39.2 ± 1.4) and % ECW excess (9.6 [6.3-12.3] vs. 4.9 [0.7-8.9]), lower serum albumin (35.2 ± 4.7 vs. 37.8 ± 4.9 g/L), greater fat mass index (9.5 ± 4.2 vs. 7.7 ± 4.2), and although mean arterial blood pressure was similar, arterial pulse pressure was greater (66.9 ± 10.8 vs. 54.3 ± 17.3 mm Hg, all p < 0.001). On multivariate analysis, glycated haemoglobin was associated with pulse pressure (standardised β 0.24, p < 0.001), N terminal brain natriuretic peptide (β 0.24, p < 0.001), ECW/TBW (β 0.19, p = 0.012) and negatively with serum albumin (β -0.14, p = 0.033) and creatinine (β -0.18, p = 0.02). Conclusion: Diabetic patients electively starting PD were found to have greater ECW/TBW ratios and ECW excess 6-10 weeks after starting PD compared to non-diabetics, despite similar PET. Increased ECW could predispose diabetic patients to be at greater risk of volume overload.

scholarly journals Open-angle glaucoma in diabetic patients’ prevalence and risk factors: a cross-sectional study in Sudan

2020 ◽  
Vol 8 (6) ◽  
pp. 2205
Author(s):  
Omyma Abbas Banaga Salih ◽  
Ehab Hamed
Keyword(s):  
Risk Factors ◽  
Open Angle Glaucoma ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Diabetes Diagnosis ◽  
Open Angle ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Diabetic Population

Background: Diabetic patients are at increased risk of glaucoma compared to the general population. Risk factors for glaucoma that is specific to diabetic patients include increased IOP, retinopathy and neovascular changes and years since diagnosis of diabetes. This cross-sectional study aims to report on the prevalence of glaucoma in diabetic patients in community diabetes centre in Sudan and examine associations with previously reported risk factors.Methods: A cross-sectional study was carried out in Omdurman specialised diabetic healthcare centre in Sudan. A total of 300 patients consented to participation. All patients filled in a survey for both demographics and diabetic disease history then had an assessment for glaucoma by an ophthalmologist. The assessment included examination of the anterior segment, optic nerve assessment and fundus examination using a stereoscopic slit lamp, intraocular pressure (IOP) measurement using tonometry, peripheral anterior chamber configuration and depth assessments using gonioscopy and central visual field assessment using perimetry.Results: Prevalence of open-angle glaucoma diagnosis was 2.8% among diabetic patients who were included in this study. Family history for glaucoma was significantly associated with increased risk of open-angle glaucoma (OR 5.67, 95% CI 1.74-18.45). Retinopathy was also associated with an increased risk of developing the condition (OR 3.1, 95% CI 1.11-8.51). Gender, years since diabetes diagnosis and medications did not have significant associations.Conclusions: Patients with diabetes are at increased risk of developing open-angle glaucoma, but the prevalence among the diabetic population attending community diabetes centre in Sudan remains low. Among different clinical determinants, diabetic retinopathy and genetic determinants may explain the increased risk in the diabetic population.

scholarly journals Prognostic Value of Fibrinogen in Patients With Coronary Artery Disease and Prediabetes or Diabetes Following Percutaneous Coronary Intervention: Five-year Findings From a Large Cohort Study

2021 ◽  
Author(s):  
Deshan Yuan ◽  
Ping Jiang ◽  
Pei Zhu ◽  
Sida Jia ◽  
Ce Zhang ◽  
...  
Keyword(s):  
Fasting Blood Glucose ◽  
Coronary Intervention ◽  
Diabetic Patients ◽  
Cardiac Mortality ◽  
Glycemic Status ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Large Cohort Study ◽  
Artery Disease

Abstract Background: Fibrinogen (FIB) is an independent risk factor for mortality and cardiovascular events in the general population. However, the relationship between FIB and long-term mortality among CAD patients undergoing PCI remains unclear, especially in individuals complicated with diabetes mellitus (DM) or prediabetes (Pre-DM). Methods: 6,140 patients with CAD undergoing PCI were included in the study and subsequently divided into three groups according to FIB levels (FIB-L, FIB-M, FIB-H). These patients were further grouped by glycemic status [normoglycemia (NG), Pre-DM, DM]. The primary endpoint was all-cause mortality. The secondary endpoint was cardiac mortality. Results: FIB was positively associated with hemoglobin A1c (HbA1c) and fasting blood glucose (FBG) in CAD patients with and without DM (P <0.001). During a median follow-up of 5.1 years, elevated FIB was significantly associated with long-term all-cause mortality (adjusted HR: 1.86; 95% CI: 1.28-2.69; P=0.001) and cardiac mortality (adjusted HR: 1.82; 95% CI: 1.15-2.89; P=0.011). Similarly, patients with DM, but not Pre-DM, had increased risk of all-cause and cardiac mortality compared with NG group (all P<0.05). When grouped by both FIB levels and glycemic status, diabetic patients with medium and high FIB levels had higher risk of mortality [(adjusted HR: 2.57; 95% CI: 1.12-5.89), (adjusted HR: 3.04; 95% CI: 1.35-6.82), all P<0.05]. Notably, prediabetic patients with high FIB also had higher mortality risk (adjusted HR: 2.27; 95% CI: 1.01-5.12). Conclusions: FIB was strongly associated with long-term all-cause and cardiac mortality among CAD patients undergoing PCI, especially in those with DM and Pre-DM. FIB test may help to identify high-risk individuals in this specific population.

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