Elevations in Liver Transaminases in COVID-19: (How) Are They Related?

Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and inflammatory parameters in 209 adults with COVID-19. Demographic and clinical data, serum levels of inflammatory cytokines and liver aminotransferases were analyzed. Three groups were formed according to the liver transaminase abnormalities: (I) Normal transaminases, (II) Borderline transaminases elevation, and (III) Mild to severe transaminases elevation. Altered liver transaminases were directly related to disease severity, showing association with the NEWS2 score at admission and greater need for ICU or death. Moreover, higher levels of IL-2 and CRP were associated with borderline transaminases elevations, whereas higher levels of IL-10 and Neutrophil to Lymphocyte ratio were associated with mild to severe transaminases elevation. These results reinforce the importance of liver transaminases in patients with COVID-19 as a complementary marker for disease severity and also point to them as a parameter reflecting the continuous dynamics between viral infection and the immune response.

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Nail Involvement in Patients with Psoriatic Arthritis in Northern Iran

Autoimmune Diseases ◽

10.1155/2018/4608490 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

O. Zargari ◽

E. Kazemnezhad Leyli ◽

S. Z. Azimi

Keyword(s):

Psoriatic Arthritis ◽

Severe Disease ◽

Cross Sectional Study ◽

Joint Involvement ◽

Sectional Study ◽

Northern Iran ◽

Cross Sectional ◽

The Relationship ◽

Nail Involvement

Background. Psoriatic arthritis (PsA) results in an increased burden of psoriasis and impairs both quality of life and an individual’s functional capacity. The relationship between nail involvement and PsA in psoriasis is not fully characterized. Aim. To evaluate the frequency and characteristics of nail involvement in psoriatic patients and to assess the relationship with joint involvement. Methods. A total of 197 patients with moderate-to-severe psoriasis were consecutively invited to participate in this cross-sectional study. The patients are divided into two groups: those with and those without psoriatic arthritis. Results. 69.5% of psoriatic (137 out of 197) patients had nail involvement. The most common nail abnormality was onycholysis, followed by pitting and oil droplet changes. Nail involvement was more common in patients with psoriatic arthritis (82.1% versus 57.8%, p=0.001). Conclusion. Nail involvement is commonly associated with PsA. Onycholysis, splinter hemorrhage, and oil drop were significantly more common in the PsA group as opposed to patients with just skin findings. In general, psoriatic patients with arthritis had more severe disease.

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The Relationship between Dioxin-Like Polychlorobiphenyls and IGF-I Serum Levels in Healthy Adults: Evidence from a Cross-Sectional Study

PLoS ONE ◽

10.1371/journal.pone.0038213 ◽

2012 ◽

Vol 7 (5) ◽

pp. e38213 ◽

Cited By ~ 6

Author(s):

Octavio P. Luzardo ◽

Luis Alberto Henríquez-Hernández ◽

Pilar F. Valerón ◽

Pedro C. Lara ◽

Maira Almeida-González ◽

...

Keyword(s):

Serum Levels ◽

Cross Sectional Study ◽

Healthy Adults ◽

Sectional Study ◽

Cross Sectional ◽

Igf I ◽

The Relationship

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CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance

Journal of Diabetes Research ◽

10.1155/2016/5675739 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11 ◽

Cited By ~ 3

Author(s):

Milton-Omar Guzmán-Ornelas ◽

Marcelo Heron Petri ◽

Mónica Vázquez-Del Mercado ◽

Efraín Chavarría-Ávila ◽

Fernanda-Isadora Corona-Meraz ◽

...

Keyword(s):

Insulin Resistance ◽

Serum Levels ◽

Cross Sectional Study ◽

Cross Sectional ◽

Metabolic Markers ◽

Regulate Gene Expression ◽

Wild Type Phenotype ◽

Pcr Rflp ◽

Mexican Mestizos ◽

The Relationship

Genetic susceptibility has been described in insulin resistance (IR). Chemokine (C-C motif) ligand-2 (CCL2) is overexpressed in white adipose tissue and is the ligand of C-C motif receptor-2 (CCR2). TheCCL2G-2518A polymorphism is known to regulate gene expression, whereas the physiological effects of theCCR2Val64Ile polymorphism are unknown. The aim of the study is to investigate the relationship between these polymorphisms with soluble CCL2 levels (sCCL2), metabolic markers, and adiposity. In a cross-sectional study we included 380 Mexican-Mestizo individuals, classified with IR according to Stern criteria. Polymorphism was identified using PCR-RFLP/sequence-specific primers. Anthropometrics and metabolic markers were measured by routine methods and adipokines and sCCL2 by ELISA. The CCL2 polymorphism was associated with IR (polymorphicA+phenotype frequencies were 70.9%, 82.6%, in individuals with and without IR, resp.). Phenotype carriers CCL2 (A+) displayed lower body mass and fat indexes, insulin and HOMA-IR, and higher adiponectin levels. Individuals with IR presented higher sCCL2 compared to individuals without IR and was associated with CCR2 (Ile+) phenotype. The double-polymorphic phenotype carriers (A+/Ile+) exhibited higher sCCL2 than double-wild-type phenotype carriers (A−/Ile−). The present findings suggest that sCCL2 production possibly will be associated with the adiposity and polymorphic phenotypes ofCCL2andCCR2, in Mexican-Mestizos with IR.

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Immunoinflammatory Biomarkers in Serum Are Associated with Disease Severity in Atopic Dermatitis

Dermatology ◽

10.1159/000514503 ◽

2021 ◽

pp. 1-8

Author(s):

Jesper Grønlund Holm ◽

Guillem Hurault ◽

Tove Agner ◽

Maja Lisa Clausen ◽

Sanja Kezic ◽

...

Keyword(s):

Atopic Dermatitis ◽

Disease Severity ◽

Predictive Models ◽

Severe Disease ◽

Serum Levels ◽

Disease Characteristics ◽

Immunological Markers ◽

Chemokine Ligand ◽

Serum Total Ige ◽

The Relationship

Background: A growing body of evidence links various biomarkers to atopic dermatitis (AD). Still, little is known about the association of specific biomarkers to disease characteristics and severity in AD. Objective: To explore the relationship between various immunological markers in the serum and disease severity in a hospital cohort of AD patients. Methods: Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, were divided into groups based on disease severity (SCORAD). Serum levels of a preselected panel of immunoinflammatory biomarkers were tested for association with disease characteristics. Two machine learning models were developed to predict SCORAD from the measured biomarkers. Results: A total of 160 patients with AD were included; 53 (33.1%) with mild, 73 (45.6%) with moderate, and 34 (21.3%) with severe disease. Mean age was 29.2 years (range 6–70 years) and 84 (52.5%) were females. Numerous biomarkers showed a statistically significant correlation with SCORAD, with the strongest correlations seen for CCL17/thymus and activation-regulated chemokine (chemokine ligand-17/TARC) and CCL27/cutaneous T cell-attracting-chemokine (CTACK; Spearman R of 0.50 and 0.43, respectively, p < 0.001). Extrinsic AD patients were more likely to have higher mean SCORAD (p < 0.001), CCL17 (p < 0.001), CCL26/eotaxin-3 (p < 0.001), and eosinophil count (p < 0.001) than intrinsic AD patients. Predictive models for SCORAD identified CCL17, CCL27, serum total IgE, IL-33, and IL-5 as the most important predictors for SCORAD, but with weaker associations than single cytokines. Conclusions: Specific immunoinflammatory biomarkers in the serum, mainly of the Th2 pathway, are correlated with disease severity in patients with AD. Predictive models identified biomarkers associated with disease severity but this finding warrants further investigation.

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The Relationship Between Adma and Anthropometric, Glucose, Lipid, and Inflammatory Parameters in Obese

Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI) ◽

10.32734/jetromi.v1i1.1111 ◽

2019 ◽

Vol 1 (1) ◽

Author(s):

Dharma Lindarto ◽

Brama Ihsan Sazli

Keyword(s):

Cardiovascular Risk ◽

Asymmetric Dimethylarginine ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Inflammatory Parameters ◽

Obese Subjects ◽

Hs Crp ◽

Risk Parameters ◽

The Relationship

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxideproduction and involved in various pathological processes, especially processes involvingcardiovascular risk. The purpose of this study was to analyze the correlation betweenADMA and anthropometric, glucose, lipid, and inflammatory parameters. The study wasanalyzed by a cross-sectional study of 45 obese subjects at H. Adam Malik Hospital. Bloodtests were carried out after 8-10 hours of fasting against cardiovascular risk: anthropometry(body weight, BMI, and WC), glucose (FPS, PPS, HbA1C, Fasting Insulin, and HOMA-IR), lipid (LDL-C, HDL-C, TG, and sd-LDL), and inflammation (ApoB and hs-CRP)parameters. The results showed of the 45 subjects, the average age was 41.69 ± 5.69 yearsold, and the average BMI was 33.09 ± 5.05 (Obesity I). ADMA was also found to becorrelated significantly with FPG, HBA1c, and TG parameters [r=-0.506, p=0.001; r=-0.334, p=0.013, dan r = -0.315. p=0.017, respectively]. In obesity, ADMA correlatedsignificantly with cardiovascular risk parameters: FPG, HbA1C, and TG.

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The Association of 25 (OH) Vitamin D Levels and Severity and Outcome of COVID-19: A Cross-sectional Study

10.21203/rs.3.rs-141034/v1 ◽

2021 ◽

Author(s):

Maryam Vasheghani ◽

Nasrin Jannati ◽

Parvaneh Baghaei ◽

Mitra Rezaei ◽

Majid Marjani

Keyword(s):

Vitamin D ◽

Severe Disease ◽

Serum Levels ◽

Multivariate Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Icu Admission ◽

Vitamin D Levels ◽

25 Oh Vitamin D

Abstract BackgroundCoronavirus disease 2019 (COVID-19) is a pandemic disease. Experiments with influenza and severe acute respiratory syndrome (SARS) have shown supplemental vitamin D can reduce the risk of infection and death.AimThis study was performed to evaluate the relationship between vitamin D levels and the severity and outcome of admitted patients with COVID-19.Material and MethodsThis cross-sectional study was performed on COVID-19 cases diagnosed by examining RT-PCR assay for SARS-CoV-2 or a set of symptoms and typical findings in lung CT scan. Based on clinical and radiologic characteristics, the patients were categorized as mild, moderate, severe, and critical. Calcium, phosphorus, albumin, creatinine, and serum 25 hydroxy vitamin D were measured and their correlation with the severity and outcome were analyzed.ResultsFrom May 1 to June 31, 2020, 508 patients ((442 patients in general wards and 66 patients in intensive care unit (ICU)) were included in this study. The participants were 56±17 years old (mean ±SD) (range from 14 to 95 years) and 52% were male. According to the past medical history, 190 (37.4%) of them had comorbidity. Concerning severity, 13.2%, 42.3%, 35.4%, and 9.1% had the mild, moderate, severe, and critical disease, respectively. The in-hospital mortality rate was 10.8%. In the multivariate regression analysis, age had a positive correlation and use of vitamin D supplement, serum level of 25 OH vitamin D, calcium, and albumin had a negative correlation with disease severity and admission to ICU. Poor outcome was inversely related to serum levels of vitamin D, calcium, albumin, and renal function. Vitamin D deficiency increased the rate of ICU admission by 2.7 times (95%CI=1.288-5.91, P=0.009).ConclusionIn patients who are hospitalized due to COVID-19, low 25-hydroxyvitamin D, hypocalcemia, and hypoalbuminemia are associated with severe disease, ICU admission, and an increase in mortality.

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Relationship between Serum Levels of OPG and TGF-βwith Decreasing Rate of BMD in Native Chinese Women

International Journal of Endocrinology ◽

10.1155/2013/727164 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8

Author(s):

Xi-Yu Wu ◽

Yi-Qun Peng ◽

Hong Zhang ◽

Hui Xie ◽

Zhi-Feng Sheng ◽

...

Keyword(s):

Lumbar Spine ◽

Linear Regression ◽

Chinese Women ◽

Serum Levels ◽

Cross Sectional Study ◽

Distal Forearm ◽

Sectional Study ◽

Cross Sectional ◽

The Relationship ◽

Positive Determinant

The objective of this study was to investigate the relationship between serum levels of OPG, TGF-β1, and TGF-β2 and BMD decrease rate (BDR) in native Chinese women. This cross-sectional study was performed on 465 healthy native Chinese women aged 35–80 years. Serum levels of OPG, TGF-β1, and TGF-β2 were determined. BDR was measured by DXA at the posteroanterior spine, hip, and distal forearm. At all skeletal sites tested, there was a negative correlation between BDR and serum levels of both OPG (r=−0.122to –0.230, allP= 0.007–0.000) and TGF-β2 (r=−0.100to –0.173, allP= 0.029–0.000) and a positive correlation between BDR and serum TGF-β1 (r=0.245−0.365, allP=0.000). After adjustment for age and BMI, there were no statistically significant correlations between serum levels of OPG or TGF-β2 and BDR. However, statistically significant correlations between serum TGF-β1 and BDR at the lumbar spine and ultradistal forearm remained. Multiple linear regression stepwise analysis showed that serum OPG could explain 1.4–3.7% of BDR variation. Serum TGF-β1 was a positive determinant of BDR and could explain 5.3–13.3% of BDR variation.

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Evaluation of the Relationship Between Vitamin D Levels and Related Serum Markers as Well as Disease Activity in Patients With Rheumatoid Arthritis: A Cross-sectional Study in Western Iran

10.21203/rs.3.rs-125995/v2 ◽

2020 ◽

Author(s):

Nasrin Moghimi ◽

Ali Faridfar ◽

Reza Shahriarirad ◽

Mohsen Nikandish ◽

Amirhossein Salimi ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Levels ◽

Cross Sectional Study ◽

Serum Marker ◽

Sectional Study ◽

Cross Sectional ◽

Vitamin D Levels ◽

The Relationship

Abstract Introduction: Many studies have reported the role of vitamin D in rheumatoid arthritis (RA) which is related to several serum autoantibodies such as RF and Anti CCP. It also has been shown that vitamin D deficiency affect the DAS28 and VAS score inversely. Therefore, we aim to assess the relationship between vitamin D deficiency and RA-related autoantibodies including Anti CCP and RF levels and also evaluate the association between these parameters and the severity of disease.Methods: In this cross-sectional study, RA patients over 16 years of age were enrolled. The severity of diseases was assessed via the DAS28 scoring system. Serum levels of 25(OH) vitamin D were determined by the ELISA method, along with other rheumatoid related laboratory evaluations including Anti CCP, RF and CRPResults: A total of 100 patients with a mean age of 45.27± 14.14 were included and evaluated; of them, 75% were female and 77% lived in the city. Most of the patients (66%) had moderate DAS28 levels; however, no substantial relationship was observed between DAS28 and vitamin D levels. A significant positive relation between serum 25(OH)D level and disease duration, as well as the level of education, was observed. There was also no significant correlation between RA-related autoantibodies and inflammatory serum marker with 25(OH)D.Conclusion: Due to vitamin deficiency in the majority of cases (73%) and the relationship between serum 25(OH)D levels and the duration of disease, it can be concluded that vitamin D levels should be checked in those patients.

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Association between VEGF -2578 C> A Polymorphism with VEGF Serum Levels in Gastritis with Helicobacter Pylori

International Journal of Research and Review ◽

10.52403/ijrr.20210823 ◽

2021 ◽

Vol 8 (8) ◽

pp. 171-175

Author(s):

Tara Rizvira Monica ◽

Gontar Alamsyah Siregar ◽

Taufik Sungkar

Keyword(s):

Serum Levels ◽

Mucosal Damage ◽

Cross Sectional Study ◽

Endoscopic Examination ◽

Chain Reaction ◽

Cross Sectional ◽

Excess Production ◽

Polymerase Chain ◽

H Pylori ◽

The Relationship

Mucosal damage in people with gastritis causes the production of VEGF. VEGF is a neoangiogenesis function to repair damaged tissue. Excess production can cause cancer risk. VEGF genotype polymorphisms are thought to affect the production of serum VEGF levels. The aim of this study was to determine the relationship between VEGF - 2578 C> A polymorphism and serum VEGF levels in H. pylori gastritis. Method: cross-sectional study was conducted at H. Adam Malik General Hospital and Network Hospital with 100 samples. Endoscopic examination was performed to assess the gastric mucosa and a tissue biopsy was performed. The urea breath test (UBT) test and the Campylobacter like organism (CLO) test to determine H. pylori infection. VEGF - 2578 C> A was checked by Polymerase Chain Reaction (PCR). The data will be analyzed by univariate and bivariate. Result: One hundred people with gastritis, of which 59 people were infected with H. pylori. In this study, H. pylori infection did not have a significant relationship with VEGF levels. VEGF - 2578 C> A polymorphisms also had no relationship to serum VEGF levels. Conclusion: There is no correlation between VEGF - 2578 C> A polymorphism with VEGF serum levels (p> 0.05). Keywords: VEGF polymorphisms, VEGF - 2578 CA, H. pylori, Gastritis.

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The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality

Scientific Reports ◽

10.1038/s41598-021-97017-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Maryam Vasheghani ◽

Nasrin Jannati ◽

Parvaneh Baghaei ◽

Mitra Rezaei ◽

Roqayeh Aliyari ◽

...

Keyword(s):

Mortality Rate ◽

Severe Disease ◽

Multivariate Logistic Regression Analysis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

Severity Of Disease ◽

25 Hydroxyvitamin D ◽

General Wards ◽

The Relationship

AbstractSupplemental vitamin D can reduce the risk and mortality of viral pneumonia. The relationship between 25 hydroxyvitamin D [25(OH)D] levels and the severity and mortality of Coronavirus disease 2019 (COVID-19) was evaluated. In this cross-sectional study, the admitted patients with COVID-19 were categorized as mild, moderate, severe, and critical based on clinical and radiologic characteristics. Calcium, phosphorus, albumin, creatinine, and serum 25(OH)D were measured and their correlation with the severity of disease and mortality were analyzed. During 2 months, 508 patients (442 patients in general wards and 66 patients in the intensive care unit (ICU)) were included. The participants were 56 ± 17 years old (52% male, 37% with comorbidity). Concerning severity, 13%, 42%, 36%, and 9% had mild, moderate, severe, and critical diseases, respectively. The mortality rate was 10.8%. Admission to ICU, severity of disease and mortality decreased significantly across quartiles of 25(OH)D. According to multivariate logistic regression analysis, disease mortality had a positive correlation with age and had a negative correlation with the serum level of 25(OH)D, calcium, and albumin. In hospitalized patients with COVID-19, low 25(OH)D was associated with severe disease and increased ICU admission and mortality rate.

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