scholarly journals Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors

2021 ◽  
Vol 15 ◽  
Author(s):  
Arthur Lefevre ◽  
Diego Benusiglio ◽  
Yan Tang ◽  
Quirin Krabichler ◽  
Alexandre Charlet ◽  
...  
Keyword(s):  
Signal To Noise Ratio ◽  
Brain Regions ◽  
Neuron Activity ◽  
Behavioral Context ◽  
Subcortical Structures ◽  
Social Brain ◽  
Social Stimuli ◽  
Anatomical Basis ◽  
Sensory Cortices ◽  
The Brain

Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and is known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. OT neurons thus project axons to various cortical and subcortical structures and activate neuronal subpopulations to increase the signal-to-noise ratio, and in turn, increases the saliency of social stimuli. Less is known about the origin of inputs to OT neurons, but recent studies show that cells projecting to OT neurons are often located in regions where the OT receptor (OTR) is expressed. Thus, we propose the existence of reciprocal connectivity between OT neurons and extrahypothalamic OTR neurons to tune OT neuron activity depending on the behavioral context. Furthermore, the latest studies have shown that OTR-expressing neurons located in social brain regions also project to other social brain regions containing OTR-expressing neurons. We hypothesize that OTR-expressing neurons across the brain constitute a common network coordinated by OT.

scholarly journals Genetic influences on brain representations of natural audiovisual experiences

2021 ◽  
Author(s):  
Satoshi Nishida ◽  
Shunsuke Toyoda ◽  
Chika Honda ◽  
Mikio Watanabe ◽  
Miina Ollikainen ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Brain Regions ◽  
Genetic Influence ◽  
Control Individual ◽  
Brain Response ◽  
Subcortical Structures ◽  
Movie Clip ◽  
Pattern Similarity ◽  
Sensory Cortices ◽  
The Brain

Abstract Natural sensory inputs in everyday situations induce unique experiences that vary between individuals, even when inputs are identical. This experiential uniqueness stems from the representations of sensory signals in each brain. We investigated whether genetic factors control individual differences in sensory representations in the brain by studying the brain representations of natural audiovisual signals in twin-pairs. We measured the brain response to natural movies in twins using functional magnetic resonance imaging and quantified the genetic influence on the multivoxel-pattern similarity of movie clip representations between each twin. The whole-brain analysis revealed a genetic influence on the multivoxel-pattern similarity in widespread brain regions, which included the occipitotemporal sensory cortices as well as the frontoparietal association cortices and subcortical structures. Our findings suggest that genetic factors exhibit an effect on natural audiovisual signaling by controlling audiovisual representations in the brain.

scholarly journals Genetic influences on brain representations of natural audiovisual experiences

2021 ◽  
Author(s):  
Satoshi Nishida ◽  
Shunsuke Toyoda ◽  
Chika Honda ◽  
Mikio Watanabe ◽  
Miina Ollikainen ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Brain Regions ◽  
Genetic Influence ◽  
Control Individual ◽  
Brain Response ◽  
Subcortical Structures ◽  
Movie Clip ◽  
Pattern Similarity ◽  
Sensory Cortices ◽  
The Brain

Abstract Natural sensory inputs in everyday situations induce unique experiences that vary between individuals, even when inputs are identical. This experiential uniqueness stems from the representations of sensory signals in each brain. We investigated whether genetic factors control individual differences in sensory representations in the brain by studying the brain representations of natural audiovisual signals in twin-pairs. We measured the brain response to natural movies in twins using functional magnetic resonance imaging and quantified the genetic influence on the multivoxel-pattern similarity of movie clip representations between each twin. The whole-brain analysis revealed a genetic influence on the multivoxel-pattern similarity in widespread brain regions, which included the occipitotemporal sensory cortices as well as the frontoparietal association cortices and subcortical structures. Our findings suggest that genetic factors exhibit an effect on natural audiovisual signaling by controlling audiovisual representations in the brain.

Sickness and the social brain: How the immune system regulates behavior across species

2021 ◽  
Author(s):  
Benjamin A. Devlin ◽  
Caroline J. Smith ◽  
Staci D. Bilbo
Keyword(s):  
Immune System ◽  
Social Behavior ◽  
Brain Regions ◽  
Behavior Changes ◽  
Social Brain ◽  
Evolutionary Origins ◽  
Immune Mediators ◽  
The Social ◽  
Sickness Behaviors ◽  
The Brain

Many instances of sickness critically involve the immune system. The immune system talks to the brain in a bi-directional loop. This discourse affords the immune system immense control, such that it can influence behavior and optimize recovery from illness. These behavioral responses to infection are called sickness behaviors and can manifest in many ways, including changes in mood, motivation, or energy. Fascinatingly, most of these changes are conserved across species, and most organisms demonstrate some form of sickness behaviors. One of the most interesting sickness behaviors, and not immediately obvious, is altered sociability. Here, we discuss how the immune system impacts social behavior, by examining the brain regions and immune mediators involved in this process. We first outline how social behavior changes in response to infection in various species. Next, we explore which brain regions control social behavior and their evolutionary origins. Finally, we describe which immune mediators establish the link between illness and social behavior, in the context of both normal development and infection. Overall, we hope to make clear the striking similarities between the mechanisms that facilitate changes in sociability in derived and ancestral vertebrate, as well as invertebrate, species.

Novel Cognitive Functions Arise at the Convergence of Macroscale Gradients

2021 ◽  
pp. 1-16
Author(s):  
Heejung Jung ◽  
Tor D. Wager ◽  
R. McKell Carter
Keyword(s):  
Brain Regions ◽  
Higher Order ◽  
Hierarchical Organization ◽  
Functional Modules ◽  
Cortical Areas ◽  
Future Space ◽  
Close Proximity ◽  
Sensory Cortices ◽  
Developmental Characteristics ◽  
The Brain

Abstract Functions in higher-order brain regions are the source of extensive debate. Although past trends have been to describe the brain—especially posterior cortical areas—in terms of a set of functional modules, a new emerging paradigm focuses on the integration of proximal functions. In this review, we synthesize emerging evidence that a variety of novel functions in the higher-order brain regions are due to convergence: convergence of macroscale gradients brings feature-rich representations into close proximity, presenting an opportunity for novel functions to arise. Using the TPJ as an example, we demonstrate that convergence is enabled via three properties of the brain: (1) hierarchical organization, (2) abstraction, and (3) equidistance. As gradients travel from primary sensory cortices to higher-order brain regions, information becomes abstracted and hierarchical, and eventually, gradients meet at a point maximally and equally distant from their sensory origins. This convergence, which produces multifaceted combinations, such as mentalizing another person's thought or projecting into a future space, parallels evolutionary and developmental characteristics in such regions, resulting in new cognitive and affective faculties.

Application of floating silicon-based linear multielectrode arrays for acute recording of single neuron activity in awake behaving monkeys

2014 ◽  
Vol 59 (4) ◽  
Author(s):  
Luca Bonini ◽  
Monica Maranesi ◽  
Alessandro Livi ◽  
Stefania Bruni ◽  
Leonardo Fogassi ◽  
...  
Keyword(s):  
Single Neuron ◽  
Signal To Noise Ratio ◽  
Brain Area ◽  
Cortical Layer ◽  
Neuron Activity ◽  
Multielectrode Arrays ◽  
Behaving Monkeys ◽  
Silicon Based ◽  
The Brain

AbstractOne of the fundamental challenges in behavioral neurophysiology in awake animals is the steady recording of action potentials of many single neurons for as long as possible. Here, we present single neuron data obtained during acute recordings mainly from premotor cortices of three macaque monkeys using a silicon-based linear multielectrode array. The most important aspect of these probes, compared with similar models commercially available, is that, once inserted into the brain using a dedicated insertion device providing an intermediate probe fixation by means of vacuum, they can be released and left floating in the brain. On the basis of our data, these features appear to provide (i) optimal physiological conditions for extracellular recordings, (ii) good or even excellent signal-to-noise ratio depending on the recorded brain area and cortical layer, and (iii) extreme stability of the signal over relatively long periods. The quality of the recorded signal did not change significantly after several penetrations into the same restricted cortical sector, suggesting limited tissue damage due to probe insertion. These results indicate that these probes offer several advantages for acute neurophysiological experiments in awake monkeys, and suggest the possibility to employ them for semichronic or even chronic studies.

scholarly journals Functional Neuroanatomy of Meaning Acquisition from Context

2008 ◽  
Vol 20 (12) ◽  
pp. 2153-2166 ◽  
Author(s):  
Anna Mestres-Missé ◽  
Estela Càmara ◽  
Antoni Rodriguez-Fornells ◽  
Michael Rotte ◽  
Thomas F. Münte
Keyword(s):  
Language Processing ◽  
Inferior Frontal Gyrus ◽  
Imaging Study ◽  
Brain Regions ◽  
Brain Network ◽  
Parahippocampal Gyrus ◽  
Middle Temporal Gyrus ◽  
Functional Neuroanatomy ◽  
Subcortical Structures ◽  
The Brain

An important issue in language learning is how new words are integrated in the brain representations that sustain language processing. To identify the brain regions involved in meaning acquisition and word learning, we conducted a functional magnetic resonance imaging study. Young participants were required to deduce the meaning of a novel word presented within increasingly constrained sentence contexts that were read silently during the scanning session. Inconsistent contexts were also presented in which no meaning could be assigned to the novel word. Participants showed meaning acquisition in the consistent but not in the inconsistent condition. A distributed brain network was identified comprising the left anterior inferior frontal gyrus (BA 45), the middle temporal gyrus (BA 21), the parahippocampal gyrus, and several subcortical structures (the thalamus and the striatum). Drawing on previous neuroimaging evidence, we tentatively identify the roles of these brain areas in the retrieval, selection, and encoding of the meaning.

scholarly journals Intelligence neurocircuitry: cortical and subcortical structures

2017 ◽  
Vol 34 (03) ◽  
pp. 123-129 ◽  
Author(s):  
D. Damiani ◽  
L. Pereira ◽  
D. Damiani ◽  
A. Nascimento
Keyword(s):  
Cognitive Processes ◽  
Insular Cortex ◽  
Brain Regions ◽  
Learning Disorders ◽  
Functional Magnetic Resonance ◽  
Subcortical Structures ◽  
Cerebral Lesions ◽  
Conventional Models ◽  
Functional Areas ◽  
The Brain

AbstractThe authors describe the brain regions involved in the process of intelligence using as a basis, the models of the theory of frontoparietal integration (P-FIT Model). They also correlate the model described with functional areas of Brodmann, integrating them into the tertiary brain areas and address the subcortical structures involved in cognitive processes, including the memory. The studies performed by functional magnetic resonance, also unmask various regions related with intelligence, neither previously described by Brodmann nor even in conventional models of learning. The anterior insular cortex presents itself as the most recent tertiary area to be considered. Subcortical structures, when injured, mimick injuries to the cerebral cortex, demonstrating their great participation in cognition. The topographies of aphasia and the functioning mechanisms of the bearers of learning disorders, including dyslexic, dysgraphia and dyscalculic should be reconsidered. A better understanding of this topographic anatomy may clarify the mechanisms used in those individuals with cerebral lesions.

Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle Based Targeted Drug Delivery System

2020 ◽  
Vol 21 ◽  
Author(s):  
Sayed Md Mumtaz ◽  
Gautam Bhardwaj ◽  
Shikha Goswami ◽  
Rajiv Kumar Tonk ◽  
Ramesh K. Goyal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Drug Delivery System ◽  
Delivery System ◽  
Genetic Disorder ◽  
Drug Regimen ◽  
Brain Regions ◽  
Radio Therapy ◽  
Novel Drug ◽  
The Brain

: The Glioblastoma Multiforme (GBM; grade IV astrocytoma) exhort tumor of star-shaped glial cell in the brain. It is a fast-growing tumor that spreads to nearby brain regions specifically to cerebral hemispheres in frontal and temporal lobes. The etiology of GBM is unknown, but major risk factors are genetic disorder like neurofibromatosis and schwanomatosis which develop the tumor in the nervous system. The management of GBM with chemo-radio therapy leads to resistance and current drug regimen like Temozolomide (TMZ) is less efficacious. The reasons behind failure of drugs are due to DNA alkylation in cell cycle by enzyme DNA guanidase and mitochondrial dysfunction. Naturally occurring bio-active compounds from plants known as phytochemicals, serve as vital sources for anti-cancer drugs. Some typical examples include taxol analogs, vinca alkaloids such as vincristine, vinblastine, podophyllotoxin analogs, camptothecin, curcumin, aloe emodin, quercetin, berberine e.t.c. These phytochemicals often act via regulating molecular pathways which are implicated in growth and progression of cancers. However the challenges posed by the presence of BBB/BBTB to restrict passage of these phytochemicals, culminates in their low bioavailability and relative toxicity. In this review we integrated nanotech as novel drug delivery system to deliver phytochemicals from traditional medicine to the specific site within the brain for the management of GBM.

Neuro-Clinical Signatures of Language Impairments: A Theoretical Framework for Function-to-structure Mapping in Clinics

2020 ◽  
Vol 20 (9) ◽  
pp. 800-811 ◽  
Author(s):  
Ferath Kherif ◽  
Sandrine Muller
Keyword(s):  
Brain Mapping ◽  
Theoretical Framework ◽  
Brain Regions ◽  
Language Impairments ◽  
Structure Mapping ◽  
Language Functions ◽  
The Past ◽  
Language Recovery ◽  
The Brain ◽  
Bow Tie

In the past decades, neuroscientists and clinicians have collected a considerable amount of data and drastically increased our knowledge about the mapping of language in the brain. The emerging picture from the accumulated knowledge is that there are complex and combinatorial relationships between language functions and anatomical brain regions. Understanding the underlying principles of this complex mapping is of paramount importance for the identification of the brain signature of language and Neuro-Clinical signatures that explain language impairments and predict language recovery after stroke. We review recent attempts to addresses this question of language-brain mapping. We introduce the different concepts of mapping (from diffeomorphic one-to-one mapping to many-to-many mapping). We build those different forms of mapping to derive a theoretical framework where the current principles of brain architectures including redundancy, degeneracy, pluri-potentiality and bow-tie network are described.

Sign in / Sign up

Export Citation Format

Share Document