scholarly journals Targeting Adipokines in Obesity-Related Tumors

2021 ◽  
Vol 11 ◽  
Author(s):  
Xi Pu ◽  
Deyu Chen
Keyword(s):  
Lipid Metabolism ◽  
Endocrine Cells ◽  
Independent Risk Factor ◽  
Specific Treatment ◽  
Global Epidemic ◽  
Inflammatory Conditions ◽  
Glucose And Lipid Metabolism ◽  
The Relationship ◽  
Insulin Like Growth Factors

Obesity, a global epidemic, is an independent risk factor for the occurrence and development of a variety of tumorigenesis, such as breast cancer, pancreatic cancer, ovarian cancer and colorectal cancer. Adipocytes are important endocrine cells in the tumor microenvironment of obesity-related tumors, which can secrete a variety of adipokines (such as leptin, adiponectin, estrogen, resistin, MIF and MCP-1, etc.), among which leptin, adiponectin and estrogen are the most in-depth and valuable ones. These adipokines are closely related to tumorigenesis and the progression of tumors. In recent years, more and more studies have shown that under chronic inflammatory conditions such as obesity, adipocytes secrete more adipokines to promote the tumorigenesis and development of tumors. However, it is worth noting that although adiponectin is also secreted by adipocytes, it has an anti-tumor effect, and can cross-talk with other adipokines (such as leptin and estrogen) and insulin to play an anti-tumor effect together. In addition, obesity is the main cause of insulin resistance, which can lead to the increase of the expression levels of insulin and insulin-like growth factor (IGF). As important regulators of blood glucose and lipid metabolism, insulin and IGF also play an important role in the progress of obesity related tumors. In view of the important role of adipokines secreted by adipocytes and insulin/IGF in tumors, this article not only elaborates leptin, adiponectin and estrogen secreted by adipocytes and their mechanism of action in the development of obesity- related tumors, but also introduces the relationship between insulin/IGF, a regulator of lipid metabolism, and obesity related tumors. At the same time, it briefly describes the cancer-promoting mechanism of resistin, MIF and MCP-1 in obesity-related tumors, and finally summarizes the specific treatment opinions and measures for various adipokines and insulin/insulin-like growth factors in recent years.

scholarly journals Gormony zhirovoy tkani i funktsional'nayaaktivnost' shchitovidnoy zhelezy

2010 ◽  
Vol 7 (4) ◽  
pp. 8-11 ◽  
Author(s):  
N A Petunina ◽  
N E Al'tshuler ◽  
N G Rakova ◽  
L V Trukhina
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
The Impact ◽  
The Relationship ◽  
Tissue Hormones

The review presents a recent data from the literature on the physiologic and pathophysiologic role of adipose tissue hormones (adiponectin, resistin, leptin). The article details the role of adipocytokines in atherogenesis. It also presents the results of studies depicting the relationship between subclinical hypothyroidism, lipid metabolism and insulin resistance as well as the impact of thyroid dysfunction upon the secretion of adipocytokines.

scholarly journals ROLE OF GUT MICROBIOTA IN LIPID METABOLISM

2018 ◽  
Vol 11 (4) ◽  
pp. 4 ◽  
Author(s):  
Khrystyna Kvit ◽  
Viacheslav Kharchenko
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Blood Lipids ◽  
Published Data ◽  
Long Time ◽  
Lipid Balance ◽  
The Relationship

 Researchers have studied the connection between cholesterol and microbiota for a long time. The results of widely published data demonstrate that the relationship between the lipid balance of the blood and the composition of the intestinal microbiota is apparent. The oblective of this study was, we tried to find the path through which this connection is carried out. Furthermore, the aim was to analyze the studies, which demonstrate the decrease of blood lipids as the result of different prebiotics and probiotics prescribtion. Also, the screening of different data from previous years was done for comparing the changes in the pathogenesis.

scholarly journals Role of bone morphogenetic protein‐9 in the regulation of glucose and lipid metabolism

2019 ◽  
Vol 33 (9) ◽  
pp. 10077-10088 ◽  
Author(s):  
Min Yang ◽  
Zerong Liang ◽  
Mengliu Yang ◽  
Yanjun Jia ◽  
Gangyi Yang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Bone Morphogenetic Protein ◽  
Glucose And Lipid Metabolism ◽  
Morphogenetic Protein ◽  
Bone Morphogenetic Protein 9

scholarly journals Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases

2018 ◽  
Vol 127 ◽  
pp. 108-115 ◽  
Author(s):  
Jia-Qiang Huang ◽  
Ji-Chang Zhou ◽  
Yuan-Yuan Wu ◽  
Fa-Zheng Ren ◽  
Xin Gen Lei
Keyword(s):  
Lipid Metabolism ◽  
Glutathione Peroxidase ◽  
Glutathione Peroxidase 1 ◽  
Glucose And Lipid Metabolism

scholarly journals Fibroblast growth factor 21: a regulator of metabolic disease and health span

2017 ◽  
Vol 313 (3) ◽  
pp. E292-E302 ◽  
Author(s):  
Ting Xie ◽  
Po Sing Leung
Keyword(s):  
Lipid Metabolism ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Metabolic Diseases ◽  
Scientific Basis ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Glucose And Lipid Metabolism ◽  
Care Guidelines

Fibroblast growth factor 21 (FGF21) is a potent endocrine regulator with physiological effects on glucose and lipid metabolism and thus garners much attention for its translational potential for the management of obesity and related metabolic syndromes. FGF21 is mainly expressed in several metabolically active tissue organs, such as the liver, adipose tissue, skeletal muscle, and pancreas, with profound effects and therapeutic relevance. Emerging experimental and clinical data point to the demonstrated metabolic benefits of FGF21, which include, but are not limited to, weight loss, glucose and lipid metabolism, and insulin sensitivity. In addition, FGF21 also acts directly through its coreceptor β-klotho in the brain to alter light-dark cycle activity. In this review, we critically appraise current advances in understanding the physiological actions of FGF21 and its role as a biomarker of various metabolic diseases, especially type 2 diabetes mellitus. We also discuss the potentially exciting role of FGF21 in improving our health and prolonging our life span. This information will provide a fuller understanding for further research into FGF21, as well as providing a scientific basis for potentially establishing health care guidelines for this promising molecule.

scholarly journals Time Averaged Uric Acid Is Associated With the Prognosis of IgAN in Females

2021 ◽  
Author(s):  
Quan Zhang ◽  
Luyao Dong ◽  
Hongling Han
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
General Hospital ◽  
Independent Risk Factor ◽  
Glomerular Diseases ◽  
Progression Of Disease ◽  
Medical University ◽  
The Relationship ◽  
Worse Prognosis

Abstract Background IgA Nephropathy (IgAN) is one of the most common glomerular diseases. However, the effect of uric acid on the prognosis of IgAN is still unclear, especially between males and females. Therefore, the present study aimed to explore the role of hyperuricemia in IgAN patients and the differences in gender. Consequently, the study conducted a retrospective analysis of the prognosis of IgAN in patients from the General Hospital of Tianjin Medical University. Methods: A total of 1,022 patients with primary IgAN, diagnosed through renal biopsy were enrolled from the Department of Nephrology, General Hospital of Tianjin Medical University. However, after applying the exclusion criteria, only 463 patients remained and were regularly followed up in the hospital. In addition, the relationship between Time Average Uric Acid (TA-UA) and prognosis of IgAN was analyzed. Results: The findings showed that TA-UA was an independent risk factor for the prognosis of IgAN in the 463 patients studied (OR=1.752，95%CI=1.348-2.277，p＜0.001). Additionally, higher TA-UA values were associated with a faster progression of disease and worse prognosis (p < 0.05). Elevated TA-UA was also shown to be an independent risk factor for the progression of disease in female patients but not in their male counterparts (women: HR=1.998，95%CI=1.398-2.854，p＜0.001，men: HR=1.405，95%CI=0.869-2.274, p=0.166). Conclusion: Increased TA-UA is an independent risk factor for the progression of IgAN, especially in women.

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