scholarly journals Mechanism of Improving Aspirin Resistance: Blood-Activating Herbs Combined With Aspirin in Treating Atherosclerotic Cardiovascular Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Yixi Zhao ◽  
Shengjie Yang ◽  
Min Wu
Keyword(s):  
Genetic Polymorphism ◽  
Cardiovascular Diseases ◽  
Cardiovascular Events ◽  
Hot Spot ◽  
Aspirin Resistance ◽  
High Morbidity ◽  
Potential Mechanism ◽  
Primary And Secondary Prevention ◽  
Holistic View ◽  
Atherosclerotic Cardiovascular Diseases

Atherosclerotic thrombotic disease continues to maintain a high morbidity and mortality rate worldwide at present. Aspirin, which is reckoned as the cornerstone of primary and secondary prevention of atherosclerotic cardiovascular diseases (ASCVDs), has been applied in clinics extensively. However, cardiovascular events continue to occur even though people utilize aspirin appropriately. Therefore, the concept of aspirin resistance (AR) was put forward by scholars, which is of great significance for the prediction of the clinical outcome of diseases. The pathogenesis of AR may be incorporated with low patient compliance, insufficient dose, genetic polymorphism, increased platelet transformation, inflammation, and the degenerative changes and calcification of platelets. The improvement of AR in the treatment of ASCVDs has gradually become a research hot spot in recent years. Traditional Chinese medicine (TCM) regards individuals as a whole and treats them from a holistic view, which has been found to have advantages in clinical studies on the treatment of AR. Many kinds of blood-activating TCM have the effect of improving AR. The potential mechanism for the improvement of AR by blood-activating herbs combined with aspirin was explored. The combination of blood-activating herbs and aspirin to improve AR is likely to turn into a hot topic of research in the future.

scholarly journals MicroRNAs Expression Profiles in Cardiovascular Diseases

2014 ◽  
Vol 2014 ◽  
pp. 1-23 ◽  
Author(s):  
Elsa Bronze-da-Rocha
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular Events ◽  
Expression Profiles ◽  
High Morbidity ◽  
Circulating Mirnas ◽  
Regulate Gene Expression ◽  
Cardiovascular Pathologies ◽  
Artery Disease ◽  
New Biomarkers ◽  
Posttranscriptional Level

The current search for new markers of cardiovascular diseases (CVDs) is explained by the high morbidity and mortality still observed in developed and developing countries due to cardiovascular events. Recently, microRNAs (miRNAs or miRs) have emerged as potential new biomarkers and are small sequences of RNAs that regulate gene expression at posttranscriptional level by inhibiting translation or inducing degradation of the target mRNAs. Circulating miRNAs are involved in the regulation of signaling pathways associated to aging and can be used as novel diagnostic markers for acute and chronic diseases such as cardiovascular pathologies. This review summarizes the biogenesis, maturation, and stability of miRNAs and their use as potential biomarkers for coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF).

scholarly journals Prevalence of metabolic syndrome within hypertensive population and the risk of developing atherosclerotic cardiovascular diseases

2015 ◽  
Vol 10 (2) ◽  
pp. 187-194
Author(s):  
Gabriel Cristian BEJAN ◽  
◽  
Dumitru MATEI ◽  
Adela IANCU ◽  
◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Urban Areas ◽  
Cardiovascular Events ◽  
Insulin Resistance Syndrome ◽  
Major Cardiovascular Events ◽  
Hypertensive Population ◽  
Increased Risk ◽  
Atherosclerotic Cardiovascular Diseases

Metabolic syndrome, also called insulin resistance syndrome or excess of catecholamines, is represented by several cardiometabolic factors that result in increased incidence of cardiovascular disease and type 2 diabetes. Due to sedentary lifestyle and hypercaloric food, with a high percent of saturated fats and carbohydrates, that characterize modern lifestyle of the population, especially in urban areas, the prevalence of metabolic syndrome recorded an ascending slope that makes it a very topical issue for the medical world. During the years 2013-2014 we conducted an observational study on a sample of 111 hypertensive patients without major cardiovascular events such as myocardial infarction or stroke, with age between 48 and 83 years, in whom we determined the prevalence of metabolic syndrome and cardiovascular disease. The survey results showed an increased prevalence of metabolic syndrome, considering that we related to a hypertensive population, and an increased risk of non-fatal atherosclerotic cardiovascular diseases in men and fatal cardiovascular events in next 10 years especially for women.

scholarly journals Bilirubin and cardiovascular risk

2021 ◽  
Vol 26 (9) ◽  
pp. 4511
Author(s):  
O. M. Drapkina ◽  
A. Ya. Kravchenko ◽  
A. V. Budnevsky ◽  
A. V. Kontsevaya ◽  
M. S. Ryaskina ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Collateral Circulation ◽  
Cardiovascular Events ◽  
Left Ventricular ◽  
Ischemic Damage ◽  
Endogenous Antioxidant ◽  
Atherosclerotic Cardiovascular Diseases

This literature review demonstrates the results of experimental and clinical studies, as well as data from meta-analyzes on the effect of bilirubin levels on cardiovascular system. Recent studies provided a new look at the role of bilirubin in cardiovascular disease. Modern concepts consider bilirubin as a powerful endogenous antioxidant with anti-inflammatory effects, capable of influencing the course of atherosclerotic cardiovascular diseases and reducing ischemic damage. The change in bilirubin levels affects the coronary blood flow, the development of collateral circulation and the morphology of coronary plaques. A low bilirubin level is associated with an increase in left ventricular mass and a decrease in its contractility, which, in turn, leads to heart failure and increases the risk of rehospitalizations. Taking into account the above effects of bilirubin, there was interest in assessing the effect of its blood level on the risk of atherosclerotic cardiovascular diseases. Recent studies have attempted to create risk stratification models for adverse cardiovascular events based on bilirubin levels.

Cumulative prevalence of risk factors for atherosclerotic cardiovascular diseases in Iranian adolescents: IHHP-HHPC

2005 ◽  
Vol 81 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Roya Kelishadi ◽  
Gholamhossein Sadri ◽  
Ali Akbar Tavasoli ◽  
Manijeh Kahbazi ◽  
Hamid Reza Roohafza ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Atherosclerotic Cardiovascular Diseases ◽  
Cumulative Prevalence

scholarly journals Structural Design of Vascular Stents: A Review

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 770
Author(s):  
Chen Pan ◽  
Yafeng Han ◽  
Jiping Lu
Keyword(s):  
Cardiovascular Diseases ◽  
Hot Spot ◽  
Coronary Intervention ◽  
Patient Specific ◽  
Vascular Stent ◽  
Vascular Stents ◽  
Stent Restenosis ◽  
Percutaneous Coronary ◽  
Representative Unit Cell ◽  
Volume Unit

Percutaneous Coronary Intervention (PCI) is currently the most conventional and effective method for clinically treating cardiovascular diseases such as atherosclerosis. Stent implantation, as one of the ways of PCI in the treatment of coronary artery diseases, has become a hot spot in scientific research with more and more patients suffering from cardiovascular diseases. However, vascular stent implanted into vessels of patients often causes complications such as In-Stent Restenosis (ISR). The vascular stent is one of the sophisticated medical devices, a reasonable structure of stent can effectively reduce the complications. In this paper, we introduce the evolution, performance evaluation standards, delivery and deployment, and manufacturing methods of vascular stents. Based on a large number of literature pieces, this paper focuses on designing structures of vascular stents in terms of “bridge (or link)” type, representative volume unit (RVE)/representative unit cell (RUC), and patient-specific stent. Finally, this paper gives an outlook on the future development of designing vascular stents.

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