scholarly journals Personality Traits in Burning Mouth Syndrome Patients With and Without a History of Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Trang Thi Huyen Tu ◽  
Motoko Watanabe ◽  
Takayuki Suga ◽  
Chaoli Hong ◽  
Chihiro Takao ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Burning Mouth Syndrome ◽  
Mcgill Pain Questionnaire ◽  
Psychiatric History ◽  
History Of ◽  
Personality Facets ◽  
Burning Mouth ◽  
Pain Symptoms ◽  
Depression History ◽  
History Of Depression

Objectives: So far, the strong link between neuroticism, chronic pain, and depression has been well-documented in literatures. Some suggested that they might share etiological factors, thus resulting in overlapping constructs. However, such effect has never been tested in burning mouth syndrome (BMS) patients, a complex phenomenon influenced by both neuropathic and psychopathological factors. We aim to clarify how personality affects individual's pain and pain-related experiences.Methods: Two hundred forty-eight patients with BMS provided demographic information and psychiatric history; completed Ten-Item Personality Inventory, a Visual Analog Scale of pain, and McGill Pain Questionnaire; and provided adequate parameters of depressive state, catastrophizing thinking, and central sensitization.Results: BMS patients with depression history suffered more severe clinical symptoms and scored higher in neuroticism and less in openness and extraversion than did those without psychiatric diagnoses. After age, sex, and duration of pain were controlled, neuroticism in BMS patients with depression correlates with affective dimension of pain. Instead, if psychiatric history is absent, neuroticism correlates with sensory dimension and pain intensity. In both groups, higher neuroticism, unlike other personality facets, contributed to a more severe clinical condition.Conclusion: Of the five traits, neuroticism appears to be the most crucial dimension associated with the pain symptoms and patient's conditions. This study implies that management of pain must extend beyond solely providing pain-relieving medication and must require a holistic and multidisciplinary approach.

Evaluation of serum neuron specific enolase levels among patients with primary and secondary burning mouth syndrome

Cephalalgia ◽  
2021 ◽  
pp. 033310242110466
Author(s):  
Jaimala Kishore ◽  
Fouzia Shaikh ◽  
Adnan Mustafa Zubairi ◽  
Sana Mirza ◽  
Montaser N Alqutub ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Spinal Cord Injuries ◽  
Clinical Symptoms ◽  
Neuron Specific Enolase ◽  
Burning Mouth Syndrome ◽  
Enzyme Linked Immunosorbent Assay ◽  
Painful Condition ◽  
Burning Mouth ◽  
A Minor ◽  
Serum Neuron Specific Enolase

Introduction Burning mouth syndrome is a painful condition of the oral cavity with ambiguous pathogenesis and diagnosis. Neuron-specific enolase is increased in several conditions including peripheral neuropathy of diabetes, ophthalmopathies, spinal cord injuries and tumors. Evidence on association of burning mouth syndrome and neuron-specific enolase is limited. Aim This study aims to evaluate neuron-specific enolase levels in primary and secondary burning mouth syndrome patients and compare the levels of neuron-specific enolase with associated conditions in secondary burning mouth syndrome. Methods One hundred and twenty-eight patients of more than 18 years of age with no gender predilection and having clinical symptoms of burning mouth syndrome and 135 healthy subjects were included. All the patients fulfilled Scala’s criteria for the diagnosis of burning mouth syndrome, including “primary” (idiopathic) and “secondary” (resulting from identified precipitating factors) burning mouth syndrome patients. Blood samples were obtained from burning mouth syndrome patients. Serum neuron-specific enolase was evaluated using enzyme-linked immunosorbent assay. To compare means and standard deviations, among primary and secondary burning mouth syndrome, data was analysed with analysis of variance and multiple comparisons test. Results The mean age of the study participants for burning mouth syndrome and healthy subjects was 53.30 and 51.6 years, respectively. Amongst the secondary burning mouth syndrome group, 32 (25%) of the patients had menopause, 15 (11.7%) had diabetes, eight (6.2%) of the patients had nutritional deficiency, seven (5.4%) had combined diabetes, menopause, and depression, six (4.6%) had combined diabetes and depression, four (3.1%) were diagnosed with Sjögren’s syndrome. A minor percentage of 2.3% (three) had gastroesophageal reflux disease, while the remaining three (2.3%) patients in the secondary burning mouth syndrome group were on anti-depressants. There was a statistically significant increase in the levels of neuron-specific enolase in primary burning mouth syndrome as compared to the secondary burning mouth syndrome and healthy groups. Among the subgroups of secondary burning mouth syndrome, diabetic individuals showed a significant increase in neuron-specific enolase level when compared with other conditions in the secondary burning mouth syndrome patients. Discussion and conclusion: The raised serum neuron-specific enolase levels in patients suffering from primary burning mouth syndrome highlight a possible neuropathic mechanism. It was also increased in the sub-group of secondary burning mouth syndrome patients having diabetes. Although it cannot be ascertained whether the deranged values in the diabetic group were due to burning mouth syndrome or due to diabetes, the raised quantity of neuron-specific enolase in the primary burning mouth syndrome group is a reliable diagnostic indicator. Future studies on the assessment of neuron-specific enolase levels as a diagnostic tool for onset and management of primary and secondary burning mouth syndrome are recommended.

Delirium, depression, and long-term cognition

2021 ◽  
pp. 1-6
Author(s):  
Patricia S. Andrews ◽  
Jennifer Thompson ◽  
Rameela Raman ◽  
Chelsea Rick ◽  
Amy Kiehl ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Prior History ◽  
Depression Symptom ◽  
Neuropsychological Status ◽  
Beta Coefficient ◽  
History Of ◽  
Surgical Icu ◽  
Depression History ◽  
History Of Depression

ABSTRACT Objectives: We examined whether preadmission history of depression is associated with less delirium/coma-free (DCF) days, worse 1-year depression severity and cognitive impairment. Design and measurements: A health proxy reported history of depression. Separate models examined the effect of preadmission history of depression on: (a) intensive care unit (ICU) course, measured as DCF days; (b) depression symptom severity at 3 and 12 months, measured by the Beck Depression Inventory-II (BDI-II); and (c) cognitive performance at 3 and 12 months, measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) global score. Setting and participants: Patients admitted to the medical/surgical ICU services were eligible. Results: Of 821 subjects eligible at enrollment, 261 (33%) had preadmission history of depression. After adjusting for covariates, preadmission history of depression was not associated with less DCF days (OR 0.78, 95% CI, 0.59–1.03 p = 0.077). A prior history of depression was associated with higher BDI-II scores at 3 and 12 months (3 months OR 2.15, 95% CI, 1.42–3.24 p = <0.001; 12 months OR 1.89, 95% CI, 1.24–2.87 p = 0.003). We did not observe an association between preadmission history of depression and cognitive performance at either 3 or 12 months (3 months beta coefficient −0.04, 95% CI, −2.70–2.62 p = 0.97; 12 months 1.5, 95% CI, −1.26–4.26 p = 0.28). Conclusion: Patients with a depression history prior to ICU stay exhibit a greater severity of depressive symptoms in the year after hospitalization.

scholarly journals Co-occurrence of Pain Symptoms and Somatosensory Sensitivity in Burning Mouth Syndrome: A Systematic Review

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163449 ◽  
Author(s):  
Xavier Moisset ◽  
Valentina Calbacho ◽  
Pilar Torres ◽  
Christelle Gremeau-Richard ◽  
Radhouane Dallel
Keyword(s):  
Systematic Review ◽  
Burning Mouth Syndrome ◽  
Somatosensory Sensitivity ◽  
Burning Mouth ◽  
Pain Symptoms

scholarly journals Support Group as a Management Modality for Burning Mouth Syndrome: A Randomized Prospective Study

2021 ◽  
Vol 11 (16) ◽  
pp. 7207
Author(s):  
Talia Becker ◽  
Yafit Hamzani ◽  
Gavriel Chaushu ◽  
Shlomit Perry ◽  
Bahaa Haj Yahya
Keyword(s):  
Support Group ◽  
Clinical Symptoms ◽  
Medical Center ◽  
Life Quality ◽  
Burning Mouth Syndrome ◽  
Rank Test ◽  
Control Group ◽  
Before And After ◽  
Burning Mouth ◽  
Group Sessions

We aimed to investigate the effectiveness of a support group in the management of burning mouth syndrome (BMS). The cohort included 22 adult patients with BMS who attended the oral and maxillofacial department of a tertiary medical center in 2014–2019 and agreed to participate in the study. Eleven patients were assigned to a support group and took part in 90 min sessions held once weekly for 4 weeks (a total of 4 sessions), and the remainder continued their previous individual BMS management routine (control group). All patients completed a life-quality questionnaire before and 3 months after the group sessions. Scores for each group were compared between the two time points with a Wilcoxon signed-rank test. There was a significant decrease in scores for malaise (p = 0.041), total pain (p = 0.046), and difficulty enjoying food (p = 0.026) before and after the group sessions in the study group. No significant changes were found in the control group in any of the parameters examined. A group support can alleviate pain and other clinical symptoms of BMS. Further longer-term prospective studies are needed to corroborate our findings.

scholarly journals Reward learning deficits in Parkinson's disease depend on depression

2017 ◽  
Vol 47 (13) ◽  
pp. 2302-2311 ◽  
Author(s):  
M. H. M. Timmer ◽  
G. Sescousse ◽  
M. E. van der Schaaf ◽  
R. A. J. Esselink ◽  
R. Cools
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Reversal Learning ◽  
Learning Deficits ◽  
Medication Withdrawal ◽  
History Of ◽  
Depression History ◽  
Non Motor Symptoms ◽  
History Of Depression

BackgroundDepression is one of the most common and debilitating non-motor symptoms of Parkinson's disease (PD). The neurocognitive mechanisms underlying depression in PD are unclear and treatment is often suboptimal.MethodsWe investigated the role of striatal dopamine in reversal learning from reward and punishment by combining a controlled medication withdrawal procedure with functional magnetic resonance imaging in 22 non-depressed PD patients and 19 PD patients with past or present depression.ResultsPD patients with a depression (history) exhibited impaired reward v. punishment reversal learning as well as reduced reward v. punishment-related BOLD signal in the striatum (putamen) compared with non-depressed PD patients. No effects of dopaminergic medication were observed.ConclusionsThe present findings demonstrate that impairments in reversal learning from reward v. punishment and associated striatal signalling depend on the presence of (a history of) depression in PD.

scholarly journals Evaluating the Suitability and Potential Efficiency of Cannabis sativa Oil for Patients with Primary Burning Mouth Syndrome: A Prospective, Open-Label, Single-Arm Pilot Study

Pain Medicine ◽  
2020 ◽  
Author(s):  
Alessio Gambino ◽  
Marco Cabras ◽  
Evangelos Panagiotakos ◽  
Federico Calvo ◽  
Alessandra Macciotta ◽  
...  
Keyword(s):  
Pilot Study ◽  
Adverse Events ◽  
Pain Intensity ◽  
Cannabis Sativa ◽  
Burning Mouth Syndrome ◽  
Anxiety And Depression ◽  
Mcgill Pain Questionnaire ◽  
Placebo Control ◽  
Open Label ◽  
Burning Mouth

Abstract Objective To evaluate the use of a Cannabis sativa oil in the management of patients diagnosed with primary burning mouth syndrome (BMS). Design Prospective, open-label, single-arm pilot study. Setting University hospital. Subjects Seventeen patients with diagnosed BMS were included. Methods Subjects were treated for 4 weeks with a full cannabis plant extract, which was prepared from standardized plant material (cannabis flos) in specialized pharmacies by means of Romano-Hazekamp extraction and was diluted in oil (1 g of cannabis in 10 g of olive oil). The primary outcome was the change in pain intensity (assessed by the visual analog scale, Present Pain Intensity scale, McGill Pain Questionnaire, and Oral Health Impact Profiles) at the end of the protocol and during the succeeding 24 weeks; the neuropathic pain was also investigated with a specific interview questionnaire (DN4-interview [Douleur Neuropathique en 4 Questions]). Levels of anxiety and depression were considered as secondary outcomes, together with reported adverse events due to the specified treatment. Results Subjects showed a statistically significant improvement over time in terms of a clinical remission of the oral symptoms. Levels of anxiety and depression also changed statistically, displaying a favorable improvement. No serious reactions were detailed. None of the patients had to stop the treatment due to adverse events. Conclusions In this pilot evaluation, the C. sativa oil provided was effective and well tolerated in patients with primary BMS. Further bigger and properly defined randomized controlled trials, with different therapeutic approaches or placebo control, are needed, however.

scholarly journals Mediation model of comorbid anxiety disorders in late-life depression

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Chawisa Suradom ◽  
Nahathai Wongpakaran ◽  
Tinakon Wongpakaran ◽  
Peerasak Lerttrakarnnon ◽  
Surin Jiraniramai ◽  
...  
Keyword(s):  
Family History ◽  
Anxiety Disorders ◽  
Depressive Disorders ◽  
Psychiatric History ◽  
Depression Severity ◽  
Late Life Depression ◽  
Comorbid Anxiety ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression

Abstract Background A number of studies have been conducted on risk factors of comorbid anxiety disorders regarding late-life depression (LLD). This study investigated the associated factors and their relationship to comorbid anxiety disorders in LLD. Methods Participants included 190 elderly Thais (73.2% female, with a mean age of 68.39 ± 6.74 years) with depressive disorders, diagnosed according to DSM-IV Diagnosis Axis I disorders assessed by Mini-International Neuropsychiatric Interview. Demographic data, medical and psychiatric history, family psychiatric history, past depression, family history of depression, Neuroticism Inventory and 7-Item Hamilton Depression Rating Scale (HAMD-7) were analyzed for path analysis using Structural Equation Model framework. The bootstrapping method was used for testing indirect effects. Results Being female was associated with comorbid anxiety disorders with an indirect effect (β = − 0.032, P = 0.018) through neuroticism, depression severity, history and family history of depression. Family history of depression had no effect on comorbidity (P = 0.090). Neuroticism had an indirect effect on comorbid anxiety disorders (β = 0.075, P = 0.019) via depression severity as reflected by HAMD-7 score (β = 0.412, P =  < 0.001). Total variance explained from this model was 11%. This model had good-fit index with Chi-square > 0.05, CFI and TLI > 0.95 and RMSEA < 0.06. Conclusion Neuroticism mediates the effect of relationship between sex, family history and history of depressive disorders and comorbid anxiety disorders in LLD. Moreover, depression severity is a mediator for neuroticism and comorbid anxiety disorders. Longitudinal studies are warranted to indicate the importance of effective treatment of depression to lower the risk of developing comorbid anxiety disorders among depressed elderly.

scholarly journals Lifetime Prevalence and Risk Factors for Perinatal Depression in a Large Cohort of Women with Depression

2021 ◽  
Author(s):  
Jacqueline Kiewa ◽  
Samantha Meltzer-Brody ◽  
Jeanette Milgrom ◽  
Elizabeth Bennett ◽  
Tracey Mackle ◽  
...  
Keyword(s):  
Risk Factors ◽  
Depressive Symptoms ◽  
Emotional Abuse ◽  
Perinatal Depression ◽  
Lifetime Prevalence ◽  
European Ancestry ◽  
Secondary Outcome ◽  
History Of ◽  
Depression History ◽  
History Of Depression

Abstract ObjectivesAmongst women with a history of depression, this study sought to identify risk factors associated with reporting perinatal depression (PND)). Lifetime prevalence, length and severity of PND were evaluated, as well as the effect of PND onset either after previous depression episodes, or as the first episode of depression.SettingThe Australian Genetics of Depression Study (AGDS), an online case cohort study of the etiology of depression.ParticipantsIn a large sample of parous women who met DSM criteria for major depressive disorder (MDD) (n=7,182), we identified two subgroups of PND cases (Edinburgh Postnatal Depression Scale score >= 13) with and without prior depression history (n=2,261; n=878 respectively). For a range of risk factors, both subgroups were compared to women with MDD who did not report depressive symptoms in the perinatal period (non-perinatal depression (NPD) cases). PND cases with prior depression history were compared to NPD cases with depression onset before their first pregnancy (n=672). PND cases without prior depression history were compared to all NPD cases (n=2,124).Primary and secondary outcome measuresDescriptive measures reported lifetime prevalence, length, and severity of PND. Logistic regression compared a range of characteristics of PND cases to those of the comparison group of NPD cases.ResultsOf women who experienced depression prior to first pregnancy, PND cases were significantly more likely to report more episodes of depression (OR=1.1 per additional depression episode, CI=[1.1-1.1], P=1.9e-13), non-European ancestry (OR=1.5, CI=[1.0-2.1], P=3.4e-02), severe nausea during pregnancy (OR=1.3, CI=[1.1-1.6], P=6.6e-03) and emotional abuse (OR=1.4, CI=[1.1-1.7], P=5.3e-03). Women without any depression before their first perinatal episode were significantly more likely to report emotional abuse (OR=1.3, CI=[1.1-1.6], P=1.0e-02) than women with NPD.ConclusionsThe majority of parous women in this study experienced PND, associated with more complex, severe depression. Results highlight the importance of perinatal assessments of depressive symptoms, particularly for women with a history of depression or childhood adverse experiences.

scholarly journals Reward learning deficits in Parkinson’s disease depend on depression

2016 ◽  
Author(s):  
Monique H.M. Timmer ◽  
Guillaume Sescousse ◽  
Marieke E. van der Schaaf ◽  
Rianne A.J. Esselink ◽  
Roshan Cools
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Reversal Learning ◽  
Learning Deficits ◽  
Medication Withdrawal ◽  
History Of ◽  
Depression History ◽  
Non Motor Symptoms ◽  
History Of Depression

AbstractBackgroundDepression is one of the most common and debilitating non-motor symptoms of Parkinson’s disease (PD). The neurocognitive mechanisms underlying depression in PD are unclear and treatment is often suboptimal.MethodsWe investigated the role of striatal dopamine in reversal learning from reward and punishment by combining a controlled medication withdrawal procedure with functional magnetic resonance imaging (fMRI) in 22 non-depressed PD patients and 19 PD patients with past or present PD-related depression.ResultsPD patients with a PD-related depression (history) exhibited impaired reward versus punishment reversal learning as well as reduced reward versus punishment-related BOLD signal in the striatum (putamen) compared with non-depressed PD patients. No effects of dopaminergic medication were observed.ConclusionsThe present findings demonstrate that impairments in reversal learning from reward versus punishment and associated reward-related striatal signalling depend on the presence of (a history of) depression in PD.

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