scholarly journals Risk of Urinary Bladder Cancer in Patients With Inflammatory Bowel Diseases: A Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhihua Geng ◽  
Qing Geng
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Meta Analysis ◽  
Urinary Bladder Cancer ◽  
Immunosuppressive Drugs ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Weak Trend

A systematic search of the PubMed, Cochrane, Embase, and Web of Science databases was conducted to investigate the risk of urinary bladder cancer (BC) in patients with inflammatory bowel disease (IBD). We identified 168 articles, of which 11 met the inclusion and exclusion criteria. Our analysis included 165,176 patients with IBD, 491 of whom had BC. Overall, the pooled standardized incidence ratio (SIR) was 0.99 (95% CI: 0.87–1.12; I2 = 0%). Further subgroup analysis showed that BC risk was neither statistically higher for Crohn's disease (CD) (SIR: 1.19; 95% CI: 0.94–1.44; I2 = 0%) nor for patients with ulcerative colitis (UC) (SIR: 0.92; 95% CI: 0.77–1.06; I2 = 0%). In the analysis of two case-control studies providing data on BC in UC and CD combined, IBD patients seemed to have a higher risk of BC than non-IBD patients (relative risk: 1.25; 95% CI: 0.77–2.03; I2 = 37.5%). Although the overall risk of BC was not significantly increased among patients with IBD, there was a weak trend for the risk to be elevated in CD patients, indicating marginal significance. These findings may primarily be explained by the opposite effects of smoking on CD and UC as well as the immunosuppressive drugs these patients often take.

scholarly journals Association between the TACC3 rs798766 Polymorphism and Risk of Urinary Bladder Cancer: A Synthesis Based on Current Evidence

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Xiang-Yu Meng ◽  
Ming-Jun Shi ◽  
Jia-Feng Chen ◽  
Yi Liao ◽  
Bang-Wang Hu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Population Attributable Risk ◽  
Urinary Bladder Cancer ◽  
Current Evidence ◽  
Bladder Cancer Risk ◽  
Search Terms ◽  
Increased Risk

Background. A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision. Methods. EMBASE, PubMed, Google Scholar, and Wanfang Data were searched. “rs798766” and “urinary bladder cancer” were used as the search terms. A total of 6 eligible studies were identified, in which 8194 cases and 50,165 controls were investigated. Meta-analysis was performed using extracted data. Subgroup analysis by ethnicity was also performed. Population attributable risk (PAR) was calculated. Results. We found a significant association between rs798766[T] and increased risk of bladder cancer, allelic[T] OR=1.27, 95%CI=1.20–1.33. Subgroup analysis by ethnicity revealed similar results, allelic[T] OR=1.24, 95%CI=1.17–1.32 in Caucasian subjects and allelic[T] OR=1.33, 95%CI=1.21–1.46 in Asian subjects. PAR based on pooled allelic ORs and the frequency of the risk allele in control subjects was 4.63% in the overall population and 3.92% in Asians and 4.36% in Caucasians. Conclusion. rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found.

Clinical value of FDG PET or PET/CT in urinary bladder cancer: A systemic review and meta-analysis

2012 ◽  
Vol 81 (9) ◽  
pp. 2411-2416 ◽  
Author(s):  
Yu-Yu Lu ◽  
Jin-Hua Chen ◽  
Ji-An Liang ◽  
Hsin-Yi Wang ◽  
Cheng-Chieh Lin ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Urinary Bladder Cancer ◽  
Systemic Review ◽  
Clinical Value ◽  
Pet Ct

scholarly journals Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Liu ◽  
Lingxin Xiong ◽  
Yan Zhou ◽  
Bingzhen Zheng ◽  
Tongjun Liu ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Meta Analysis ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Case Control Studies ◽  
Single Nucleotide ◽  
Precise Estimation ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Hereditary Susceptibility

Background. It has been found that single-nucleotide polymorphisms (SNPs) of microRNA might be involved in the development of inflammatory bowel diseases (IBDs). However, the related retrospective research has not been reported. In this work, we performed a meta-analysis to derive a more precise estimation of the associated relationship. Methods. We searched the studies on the association of SNPs of microRNA with the hereditary susceptibility of IBD in PubMed and Embase; eligible research was selected by screening the abstract and full text. The meta-analysis was performed based on the statistical software Stata 14.0, and besides, the odds ratio and 95% confidence interval were calculated to evaluate the strength of the association. Results. 159 papers were acquired from the PubMed and Embase databases, and five eligible articles containing nine case-control studies were selected. In the study, we first found that the association between miRNA-196a2 rs11614913 and IBD was insignificant. Then, the susceptibility of miRNA-146a rs2910146 to IBD increased significantly in allelic comparison, homozygote model, heterozygote model, and dominant model. Moreover, a positive relationship between miRNA-499 rs3746444 and IBD was identified in the homozygote model. Conclusion. Our findings demonstrated that miRNA-146a rs2910146 (G>C) polymorphism was associated with the susceptibility to IBD and miRNA-196a2 rs11614913 (T>C) and miRNA-499 rs3746444 (A>G) did not reveal an obvious relationship with the IBD susceptibility.

Diagnostic value of [18F] FDG-PET and PET/CT in urinary bladder cancer: a meta-analysis

Tumor Biology ◽  
2015 ◽  
Vol 36 (5) ◽  
pp. 3209-3214 ◽  
Author(s):  
Huojun Zhang ◽  
Wei Xing ◽  
Qinqin Kang ◽  
Chao Chen ◽  
Linhui Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Urinary Bladder Cancer ◽  
Diagnostic Value ◽  
Pet Ct ◽  
18F Fdg

TNF-α gene polymorphisms and risk of urinary bladder cancer – A case-control study and meta-analysis

Meta Gene ◽  
2021 ◽  
pp. 100848
Author(s):  
Prashant Tripathi ◽  
Rajender Singh ◽  
Alok Raghav ◽  
Satya Narayan Sankhwar ◽  
Sandeep Kumar Bansal ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Meta Analysis ◽  
Urinary Bladder Cancer ◽  
Case Control ◽  
Tnf Α ◽  
Control Study
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