scholarly journals Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection

2021 ◽  
Vol 27 ◽  
Author(s):  
Huai Wang ◽  
Jiankang Yang
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Viral Entry ◽  
Colon Adenocarcinoma ◽  
The Novel ◽  
Aberrant Expression ◽  
Systematic Analysis ◽  
More Care ◽  
Novel Coronavirus ◽  
Colorectal Cancer Patients

The epidemic of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in the world pose a global health emergency. Cancer has been identified as a risk factor for the novel Coronavirus disease 2019 (COVID-19). The ACE2 and TMPRSS2 have been implicated in SARS-CoV-2 infection for mediating viral entry into the host cell. However, a systematic analysis of aberrant expression of ACE2 and TMPRSS2 was not yet reported in multiple human cancers. Here, we analyzed gene expression of ACE2 and TMPRSS2 across 31 types of tumors. Notably, overexpression of ACE2 and TMPRSS2 have been observed in colorectal cancer including colon adenocarcinoma (COAD), and rectum adenocarcinoma (READ). In addition, the colorectal tumors with upregulated gene expressing presented with decreased DNA methylation levels. DNA methylation might be one of the reasons for abnormal expression of ACE2 and TMPRSS2. Conclusively, colorectal cancer was the only cancer with the upregulated expression of ACE2 and TMPRSS2. More care of colorectal cancer patients is needed in multiple cancers affected by the COVID-19 outbreak.

Clinical Relevance of Plasma DNA Methylation in Colorectal Cancer Patients Identified by Using a Genome-Wide High-Resolution Array

2014 ◽  
Vol 22 (S3) ◽  
pp. 1419-1427 ◽  
Author(s):  
Pei-Ching Lin ◽  
Jen-Kou Lin ◽  
Chien-Hsing Lin ◽  
Hung-Hsin Lin ◽  
Shung-Haur Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
High Resolution ◽  
Cancer Patients ◽  
Clinical Relevance ◽  
Plasma Dna ◽  
Genome Wide ◽  
A Genome ◽  
Colorectal Cancer Patients

Su1892 Sept9 DNA Methylation in Healthy, Adenoma and Colorectal Cancer Patients: A Comparison Between Tissue and Plasma Specimens

2012 ◽  
Vol 142 (5) ◽  
pp. S-528-S-529
Author(s):  
Kinga Tóth ◽  
Orsolya Galamb ◽  
Ferenc Sipos ◽  
Katalin Leiszter ◽  
Gabor Valcz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

scholarly journals P-192 DNA methylation profile of APC and DKK2 genes as biomarkers in colorectal cancer patients

2015 ◽  
Vol 26 ◽  
pp. iv55 ◽  
Author(s):  
T. da Silva ◽  
V. Vidigal ◽  
A. Felipe ◽  
R. Artigiani Neto ◽  
S. Saad ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Cancer Patients ◽  
Methylation Profile ◽  
Dna Methylation Profile ◽  
Colorectal Cancer Patients

Abstract A30: DNA methylation field defects in colorectal cancer patients.

2012 ◽  
Vol 5 (11 Supplement) ◽  
pp. A30-A30
Author(s):  
Ling Li ◽  
Yulan Cheng ◽  
Saliat Ibrahim ◽  
Stephen Meltzer ◽  
Yuriko Mori
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Cancer Patients ◽  
Colorectal Cancer Patients ◽  
Field Defects

scholarly journals Aberrant expression of miRNAs predicts recurrence and survival in stage-II colorectal cancer patients from Egypt

2017 ◽  
Vol 37 (1) ◽  
Author(s):  
Abeer A. Bahnassy ◽  
Mohammad El-Sayed ◽  
Nasr M. Ali ◽  
Ola Khorshid ◽  
Marwa M. Hussein ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Stage Ii ◽  
Aberrant Expression ◽  
Stage Ii Colorectal Cancer ◽  
Colorectal Cancer Patients

scholarly journals Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV

2020 ◽  
Author(s):  
Yanyan Zhu ◽  
Miaomiao Jiang ◽  
Liang Gao ◽  
Xiaoyun Huang
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Cell Types ◽  
Cell Entry ◽  
The Novel ◽  
Cell Analysis ◽  
Systematic Analysis ◽  
Proximal Tubule Cells ◽  
Putative Receptor ◽  
Novel Coronavirus

ACE2, the putative receptor for the novel coronavirus (2019-nCoV), played an important role in cell entry of 2019-nCoV. However, it is not yet clear what cell types within the human body express ACE2. Here, a systematic analysis was undertaken using published single cell datasets. In total, our study analyzed 229652 cells, from five different organs, derived from 88 donors. The top ACE2 expressing cells include proximal tubule cells in the kidney and enterocytes in the intestine. Other major ACE2 expressing cells in the kidney include podocytes, intercalated cells and endothelial cells. Our results offer a comprehensive atlas of ACE2 expression at the single cell level and unravel the enormous potential targets of 2019-nCoVinfection beyond the lung.

scholarly journals Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patients

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Daniel Castellano-Castillo ◽  
Sonsoles Morcillo ◽  
Ana B. Crujeiras ◽  
Lidia Sánchez-Alcoholado ◽  
Mercedes Clemente-Postigo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Visceral Adipose Tissue ◽  
Global Dna Methylation ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Colorectal Cancer Patients ◽  
Visceral Adipose

scholarly journals Multiple gene promoter methylation and clinical stage in adjacent normal tissues: Effect on prognosis of colorectal cancer in Taiwan

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chih-Hsiung Hsu ◽  
Cheng-Wen Hsiao ◽  
Chien-An Sun ◽  
Wen-Chih Wu ◽  
Tsan Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Tumor Tissue ◽  
Clinical Stage ◽  
Methylation Status ◽  
Aberrant Methylation ◽  
Event Free Survival ◽  
Free Survival ◽  
Normal Tissues ◽  
Colorectal Cancer Patients

AbstractThis study provide an insight that the panel genes methylation status in different clinical stage tended to reflect a different prognosis even in matched normal tissues, to clinical recommendation. We enrolled 153 colorectal cancer patients from a medical center in Taiwan and used the candidate gene approach to select five genes involved in carcinogenesis pathways. We analyzed the relationship between DNA methylation with different cancer stages and the prognostic outcome. There were significant trends of increasing risk of 5-year time to progression and event-free survival of subjects with raising number of hypermethylation genes both in normal tissue and tumor tissue. The group with two or more genes with aberrant methylation in the advanced cancer stages (Me/advanced) had lower 5-year event-free survival among patients with colorectal cancer in either normal or tumor tissue. The adjusted hazard ratios in the group with two or more genes with aberrant methylation with advanced cancer stages (Me/advanced) were 8.04 (95% CI, 2.80–23.1; P for trend <0.01) and 8.01 (95% CI, 1.92–33.4; P for trend <0.01) in normal and tumor tissue, respectively. DNA methylation status was significantly associated with poor prognosis outcome. This finding in the matched normal tissues of colorectal cancer patients could be an alternative source of prognostic markers to assist clinical decision making.

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