scholarly journals Could Modifying the Skin Microbiome, Diet, and Lifestyle Help with the Adverse Skin Effects after Stopping Long-Term Topical Steroid Use?

Allergies ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 1-15
Author(s):  
Christopher Wallen-Russell ◽  
Anja Gijsberts-Veens ◽  
Samuel Wallen-Russell
Keyword(s):  
Adverse Effects ◽  
Topical Steroid ◽  
Skin Condition ◽  
Small Sample ◽  
Main Question ◽  
Skin Microbiome ◽  
Steroid Use ◽  
Depth Analysis ◽  
Preliminary Study

We set up this preliminary study to begin to evaluate one main question: could strengthening the microbiome have potential benefits for the skin condition of patients suffering with adverse effects after stopping long-term topical steroid use? We aim to turn it into a much larger study if the results show the interventions might help. After commonly being prescribed for eczema, cessation of topical steroid use, especially after long periods of inappropriate use, can leave lasting adverse effects on the body and skin, known by some as topical steroid withdrawal (TSW). This preliminary study involved seven human participants suffering with skin problems associated with TSW who approached Dr. Anja Gijsberts-Veens of their own volition because they were interested in more natural recovery methods. Five completed the study in full. Progress in skin condition was tracked by self-assessed symptom severity questionnaires filled out at the beginning and end of the five-month study. The skin microbiome was addressed by using a 100% natural product shown in previous work to significantly increase skin microbiome biodiversity. Three participants implemented dietary changes and supplementation in response to guidance after fecal sample analysis, with the aim of improving gut microbiome health. The average improvement in skin symptoms for all participants was 40%, and average symptom improvement ranged from 14% for Patient 5 to 92% for Patient 1. On average, the participants saw an improvement in 85% of their symptoms and stagnation or regression in 11% and 4%, respectively. Our results suggest that the interventions used might improve the skin condition of TSW patients, but the small sample size and the lack of a control group mean that more definitive conclusions should be reserved for our follow-up work, which addresses these issues. We also aim to swab the skin of participants to assess the effect on the skin microbiome from skin and gut treatments, as well as including a more in-depth analysis of skin and gut microbiomes.

Group-Based Interventions and Test-Taking Anxiety in Male College Students of Varied Ethnicities

2020 ◽  
Vol 12 (1) ◽  
pp. 13-27
Author(s):  
Sylvia Lindinger-Sternar ◽  
◽  
Chelsie Dollar ◽  
Sachin Jain ◽  
Jared Roberts
Keyword(s):  
College Students ◽  
Panic Disorder ◽  
Small Sample Size ◽  
Small Sample ◽  
Panic Attacks ◽  
Caffeine Intake ◽  
Test Taking ◽  
Male College ◽  
Preliminary Study

You are here: Home › Abstracts › Abstracts – Volume 12, Number 1, May 2020 › Group-Based Interventions and Test-Taking Anxiety in Male College Students of Varied Ethnicities doi 10.9769/EPJ.2020.12.1.SLS Sylvia Lindinger-Sternart, University of Providence, Great Falls,Montana, USA Chelsie Dollar, Great Falls, Montana, USA Sachin Jain, University of Providence, Montana, USA Jared Roberts, University of Providence, Montana, USA Abstract Purpose: Panic disorder is a disabling condition associated with reduced quality of life and impaired functioning. It is one of the most common mental health conditions in the United States and several European countries, and causes a significant burden of disease on impacted families. Typically, women have double the prevalence rate of anxiety-related disorders as compared to men. This preliminary study aimed to explore whether Emotional Freedom Techniques (EFT) offers potential as a treatment to reduce fear of future panic attacks in women who suffer from panic attacks. Eight women participated in the study. Outcomes were measured using the Subjective Units of Distress(SUD) scale and the Panic and Agoraphobia Scale(PAS). Results indicated reductions in both SUD and PAS scores at pre- and post-intervention, though not statistically significant, likely due to the small sample size. Nonetheless, the findings of this study support preliminary evidence that EFT may offer potential as a treatment for women with panic disorder. Further research to confirm statistical significance and long-term impacts of EFT needs to be conducted. Method: The current preliminary study adopted a one-group pre test, post test quasi-experimental A-B-A design, using the subjects themselves as their own control group. Results: The participants ranged from 35 to 53 years of age with a mean age of 43.75 years (SD 5.82) and median of 44 years, which is consistent with the literature that anxiety and panic encompasses all age brackets (Flint & Gagnon, 2003; Smoller et al., 2003; Yonkers, Bruce, Dyck, & Keller, 2003; Yonkers et al., 1998). Eight participants completed the demographic questionnaire, which included medications taken daily. Although all the participants were on medications, only five participants took medication for anxiety. Several different types of medicines or supplements were used by participants such as SSRIs, benzodiazepines, and magnesium, which is consistent with standards and guidelines for treating anxiety and panic disorders (Faria et al., 2012; Flint & Gagnon, 2003; Van Apeldoorn et al., 2014). Among the treatments besides medications, the most popular intervention was yoga and deep breathing. Participants reported an average caffeine intake of 1.125 cups per day (SD 1.13) with a range of 0 to 3 cups per day and median of 1 cup per day. Participants’ caffeine intake was similar to consumption patterns of the general population and can be eliminated as a variable that may influence this study’s results. This approach is consistent with the literature from the American Psychiatric Association (2013). Conclusion: To date, this is the first research study completed to determine whether EFT can assist with the reduction of fear of future panic attacks in women. The results showed a decrease in the PAS scores from the first day to the last day after four 60-minute sessions of group EFT. In addition, the SUD scores also showed a decrease not only from start of each session to end of each session but also from the first EFT session to the end of the last session, indicating the participants’ fear of having a future panic attack decreased from the first session to the last session. Statistically significant results were not obtained, however, likely due to the small sample size and high participant attrition rate. Nonetheless, this study offers preliminary support for the conducting of larger clinical trials to confirm the efficacy of EFT for treating fear of future panic attacks in women, as well as long-term impacts of EFT treatment on panic.

scholarly journals Acute red eye following the use of steroid eye drops by patients seen at the eye clinic, department of ophthalmology, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital Amaku – Awka, South Eastern Nigeria: Case series

2021 ◽  
Vol 2 (1) ◽  
pp. 01-07
Author(s):  
Ochiogu Bernard Chukwunonyerem ◽  
Udeaja Anthonia Chinyelu ◽  
Ughachukwu Peter Olisa
Keyword(s):  
Adverse Effects ◽  
Topical Steroid ◽  
Case Series ◽  
University Teaching ◽  
Eye Drops ◽  
Steroid Use ◽  
Important Group ◽  
Red Eye ◽  
Department Of Ophthalmology ◽  
Eye Clinic

Five cases (one male, four females aged between 32-65 years) of acute painful red eye following application of steroid eye drops have been presented. Their presentation followed a similar trend viz: sudden painful eyes, redness, tearing, photophobia, tenderness, and blepharospasm following topical steroid eye use. There was immediate relief within an hour of instillation of atropine 1% eye drop and full recovery after two weeks of presentation following further treatment with atropine 1% eye drop, tablet paracetamol, chloramphenicol eye drop and flurbiprofen eye drop. Steroids are important group of drugs that are employed in the management of many medical conditions. When used properly, they bring good results most of the time. Acute red eye was observed in this case series following topical steroid use on the eyes and the patients need to be educated on the proper use of this group of drugs so as to reduce its adverse effects.

Current Practice of Therapeutic Hypothermia for Mild Hypoxic Ischemic Encephalopathy

2019 ◽  
Vol 34 (7) ◽  
pp. 402-409 ◽  
Author(s):  
Chia L. Saw ◽  
Abhijeet Rakshasbhuvankar ◽  
Shripada Rao ◽  
M Bulsara ◽  
Sanjay Patole
Keyword(s):  
Adverse Effects ◽  
Therapeutic Hypothermia ◽  
Meta Analysis ◽  
Significant Proportion ◽  
Small Sample ◽  
Hypoxic Ischemic Encephalopathy ◽  
Cochrane Library ◽  
Short And Long Term ◽  
Ischemic Encephalopathy

Context: Therapeutic hypothermia is the recommended treatment for neonates with moderate or severe hypoxic ischemic encephalopathy (HIE). There is an increasing trend to use therapeutic hypothermia even in infants with mild hypoxic ischemic encephalopathy, even though there is little evidence to support/refute this. Objective: To estimate the incidences of mild hypoxic ischemic encephalopathy among infants who received therapeutic hypothermia, and its short- and long-term outcomes. Data Sources and Study Selection: PubMed, Embase, CINAHL, and Cochrane library were searched to identify observational studies reporting on therapeutic hypothermia in term and near-term infants with mild hypoxic ischemic encephalopathy. The JBI (Joanna Briggs Institute) tools were used to assess the risk of bias in the included studies. Random effects meta-analysis was conducted to find out the percentage of cooled infants who had only mild hypoxic ischemic encephalopathy. Results: A total of 3590 citations were screened, of which 13 were included. Of the 2783 infants who received therapeutic hypothermia, 573 had mild hypoxic ischemic encephalopathy. Meta-analysis found that 22% of the infants who underwent therapeutic hypothermia had only mild hypoxic ischemic encephalopathy (95% confidence interval: 16%-27%; I2 statistic = 90.5%). Five studies provided information on adverse effects of therapeutic hypothermia in mild hypoxic ischemic encephalopathy. The reported adverse effects were extreme hypothermia, bradycardia, hypoglycemia, sepsis, skin necrosis, pulmonary hypertension, and systemic hypotension. Limitation: The limitations included relatively small sample size and the lack of data for short- and long-term neurodevelopmental outcome. Conclusions: A significant proportion of infants who received therapeutic hypothermia had mild hypoxic ischemic encephalopathy. Randomized trials are urgently needed to evaluate the efficacy and safety of therapeutic hypothermia in infants with mild hypoxic ischemic encephalopathy.

A Qualitative Study Exploring the Views and Experiences of Adults Who Decided to Cease Long-term Topical Steroid Use

Dermatitis ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Belinda Sheary ◽  
Chloe Tyson ◽  
Mark Fort Harris
Keyword(s):  
Qualitative Study ◽  
Topical Steroid ◽  
Steroid Use

Ultrastructural observations of the aorta of calves implanted with a mechanical left ventricular assist device

1990 ◽  
Vol 48 (3) ◽  
pp. 834-835
Author(s):  
J P Cassella ◽  
V Salih ◽  
T R Graham
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Aortic Tissue ◽  
Assist Device ◽  
Ventricular Assist ◽  
Transmission Electron ◽  
Left Ventricular Assist ◽  
Preliminary Study

Left ventricular assist systems are being developed for eventual long term or permanent implantation as an alternative to heart transplantation in patients unsuitable for or denied the transplant option. Evaluation of the effects of these devices upon normal physiology is required. A preliminary study was conducted to evaluate the morphology of aortic tissue from calves implanted with a pneumatic Left Ventricular Assist device-LVAD. Two 3 month old heifer calves (calf 1 and calf 2) were electively explanted after 128 days and 47 days respectively. Descending thoracic aortic tissue from both animals was removed immediately post mortem and placed into karnovsky’s fixative. The tissue was subsequently processed for transmission electron microscopy (TEM). Some aortic tissue was fixed in neutral buffered formalin and processed for routine light microscopy.

The Effects of Long-Term Topical Intranasal Steroid Use on Nasal Bacterial Flora

2008 ◽  
Vol 1 (1) ◽  
pp. 17-22
Author(s):  
Turgut KARLIDAĞ ◽  
Ahmet KİZİRLİGİL ◽  
Erol KELEŞ ◽  
Hayrettin Cengiz ALPAY ◽  
İrfan KAYGUSUZ ◽  
...  
Keyword(s):  
Bacterial Flora ◽  
Steroid Use

scholarly journals Erythema Gyratum Repens in Long-Term Smoker

2019 ◽  
Vol 11 (3) ◽  
pp. 268-272
Author(s):  
Andrew P. Sauvageau ◽  
Jacob Mojeski ◽  
Thomas W. Fiorica ◽  
Craig C. Miller
Keyword(s):  
Female Patient ◽  
Skin Condition ◽  
Morbidity And Mortality ◽  
Cancer Growth ◽  
Internal Malignancy ◽  
Adenocarcinoma Of The Lung

Erythema gyratum repens (EGR) is a rare paraneoplastic skin condition characterized by the eruption of expanding, concentric, erythematous patches and plaques. The condition may precede a symptomatic appearance of internal malignancy, and therefore provides a unique opportunity to prevent additional morbidity and mortality secondary to undetectable cancer growth. We report the case of a 71-year-old female patient clinically diagnosed with EGR and subsequently diagnosed with otherwise asymptomatic adenocarcinoma of the lung.

Oil pollution and fisheries

1982 ◽  
Vol 297 (1087) ◽  
pp. 401-411 ◽  
Keyword(s):  
Water Quality ◽  
Adverse Effects ◽  
Oil Pollution ◽  
Coastal Areas ◽  
Short Term ◽  
Fish Stocks ◽  
Local Impacts ◽  
Reduced Water ◽  
Long Term Adverse Effects

The term ‘pollution’ is taken in its broadest sense and effects are recognized to be due to interference, tainting and toxicity. Each of these types of impact is discussed and assessed. It is concluded that no long-term adverse effects on fish stocks can be attributed to oil but that local impacts can be extremely damaging in the short term and that produce from specific localities can be tainted and unmarketable for long periods. In some coastal areas oil can be one among several contributors to reduced water quality, and the implications of this are discussed.

Capabilities of Bottom of the Pyramid Organizations

2021 ◽  
pp. 000765032110018
Author(s):  
Farley Simon Nobre ◽  
Rodrigo L. Morais-da-Silva
Keyword(s):  
Business Model ◽  
Integrative Review ◽  
Responsible Innovation ◽  
Future Research ◽  
Bottom Of The Pyramid ◽  
Main Question ◽  
Responsible Management ◽  
Responsible Consumption ◽  
Short And Long Term

Bottom of the Pyramid (BoP) organizations are the ones that develop a set of capabilities that contribute to create short- and long-term sustainability values inside and outside the boundaries of BoP ecosystems. Capabilities have an important role in BoP organizations’ strategies that aim to solve BoP issues. Notwithstanding its developments, BoP research still lacks theoretical contributions for the analysis of organizations. We suggest special attention to the need of advancing knowledge on capabilities of BoP organizations because this field is scattered and fragmented, misinterpreted, and still underdeveloped in the literature. We oriented our research formulating and seeking answers to our main question on what are the capabilities needed to enable organizations to create sustainability values in BoP ecosystems? We conducted an integrative review of BoP research for the period from 1998 to 2019, and we found 22 key capabilities of BoP organizations. We organized the capabilities into four major categories including BoP Responsible Consumption, BoP Responsible Business Model, BoP Responsible Management, and BoP Responsible Innovation. We advanced propositions and discussions regarding the capabilities and major categories’ popularity, interdependence and combination, short- and long-term temporal functions, sustainability roles, and effectiveness to address BoP issues. Our article organizes the field of capabilities of BoP organizations; advances contributions and implications for management, organizations, and policymaking; and opens fruitful avenues for future research.

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