scholarly journals Effects of Feeding a Hypoallergenic Diet with a Nutraceutical on Fecal Dysbiosis Index and Clinical Manifestations of Canine Atopic Dermatitis

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2985
Author(s):  
Eleonora Elisa Alice Guidi ◽  
Alessandro Gramenzi ◽  
Paola Persico ◽  
Roberta Di Prinzio ◽  
Daniele Di Simone ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Gastrointestinal Tract ◽  
Multimodal Treatment ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Cutaneous Lesions ◽  
Dietary Regimen ◽  
Canine Atopic Dermatitis ◽  
Intestinal Dysbiosis ◽  
Allergic Skin

Background: an imbalance of the intestinal microbiota can cause health problems in the gastrointestinal tract and in other organs. Canine Atopic Dermatitis (CAD) is a genetically predisposed, inflammatory and pruritic allergic skin disease with multifactorial etiology and multimodal treatment. The aim of this study was to assess the effect of a nutraceutical product on Dysbiotic Index (DI) and the skin lesions of atopic dogs. Methods: a nutraceutical product was administered to 32 dogs with CAD. The product was associated with a standardized hypoallergenic diet for 60 days; the dietary regimen continued for 120 days, while ongoing therapies remained unchanged. Values of Visual Analogic Scale (VAS), Canine Atopic Dermatitis Lesional Index (CADLI) and DI were evaluated on day 0, 60, 120. Results: all the 32 dogs showed a statistically significant decrease (p < 0.001) to V60 of VAS and CADLI, which persisted and increased to V120 when diet alone was continued. The decrease in the DI value was also statistically significant (p < 0.001). Conclusion: the intake of nutraceutical associated with diet resulted in a decrease in the index of intestinal dysbiosis, with an improvement in the subjective severity of cutaneous lesions.

scholarly journals Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis

2021 ◽  
Vol 8 ◽  
Author(s):  
Ju-Yong Park ◽  
Seon-Myeong Kim ◽  
Jung-Hyun Kim
Keyword(s):  
Atopic Dermatitis ◽  
Relative Abundance ◽  
Barrier Function ◽  
Therapeutic Option ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Skin Microbiome ◽  
Canine Atopic Dermatitis ◽  
Allergic Skin

The management of canine atopic dermatitis, an allergic skin disorder, is challenging. To investigate the effect of phototherapy using a 308-nm excimer light as a topical treatment for canine atopic dermatitis, 10 dogs with canine atopic dermatitis and 10 with non-allergic skin were enrolled in this study. Phototherapy was applied every 7 days for a total of 2 months. The skin microbiome, skin barrier function, and clinical outcomes were evaluated after phototherapy. Phototherapy significantly changed the composition of the skin microbiome of dogs with atopic dermatitis and significantly increased the relative abundance of the phyla Actinobacteria and Cyanobacteria. It significantly alleviated the clinical signs of canine atopic dermatitis without serious adverse effects. Transepidermal water loss, as a measure of skin barrier function, significantly decreased after phototherapy. In addition, phototherapy increased microbial diversity and decreased the relative abundance of Staphylococcus pseudintermedius associated with the severity of canine atopic dermatitis. These results suggest that the excimer light therapy is a suitable and safe therapeutic option for canine atopic dermatitis, which is also a spontaneous animal model of atopic dermatitis.

The evaluation of Canine Atopic Dermatitis Extent and Severity Index (CADESI) test in dogs with Atopic Dermatitis (AD) treated with cyclosporine or prednisone

2010 ◽  
Vol 13 (4) ◽  
pp. 681-688 ◽  
Author(s):  
I. Taszkun
Keyword(s):  
Atopic Dermatitis ◽  
Severity Index ◽  
Skin Lesions ◽  
Clinical State ◽  
Point Scale ◽  
Canine Atopic Dermatitis ◽  
Group I ◽  
Oral Preparation ◽  
Sandimmun Neoral ◽  
Anti Inflammatory

The evaluation of Canine Atopic Dermatitis Extent and Severity Index (CADESI) test in dogs with Atopic Dermatitis (AD) treated with cyclosporine or prednisone The purpose of this study was to assess the clinical state of dogs with atopic dermatitis (AD) by use of CADESI test in own modification during the first visit in the Dermatology Consult Room as well as during the treatment. The study was performed in two groups (I-E and II-C) of 20 dogs in each group. In dogs which were qualified to the I-E group, as antiallergic, anti-inflammatory and antipruritic treatment, prednisone (oral preparation Encorton - Polfa Pabianice) at dose 0.5 mg/kg b.w./day was administered, while in dogs qualified to the II-C group - cyclosporine (oral preparation Sandimmun Neoral - Novartis Pharma) at a dose of 5 mg/kg b.w./day; the treatment was continued for 6 weeks in both groups. During the study, skin lesions were assessed in 15 specified body areas using 4 parameters and 5-point scale. In group I-E and II-C the amount of received points in CADESI test was decreased by 82.26% and by 83% respectively, after the treatment. Statistical analyses of the results obtained revealed no statistically significant (P=0.05) differences between means of I-E and II-C groups in consecutive examinations, which indicates comparable clinical efficacy of both drugs. Statistically significant differences (P=0.05) of the parameters assessed were found after secondary dermatoses treatment, and after every two weeks of antipruritic and anti-inflammatory treatment.

scholarly journals Influence of intestinal microbiota on the immunopathogenesis of atopic dermatitis in children

2021 ◽  
pp. 4-11
Author(s):  
Alexander Viktorovich Zhestkov ◽  
Olga Olegovna Pobezhimova
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Intestinal Microbiota ◽  
Intestinal Microflora ◽  
Dynamic Equilibrium ◽  
Clinical Manifestations ◽  
Factors Affecting ◽  
Intestinal Dysbiosis ◽  
Human Intestinal Microbiota ◽  
Th1 Cytokines

Particular attention is paid to atopic dermatitis (AD) as one of the earliest and most frequent clinical manifestations of allergy in children. AD is a multifactorial disease, the development of which is closely related to genetic defects in the immune response and adverse environmental influences. It was found that the action of these factors determines the rate of development of AD, especially in young children. One of these factors is a violation of the intestinal microbiota, which plays an essential role in the development of the child's immune system and has a protective effect in the formation of atopy. It has been shown that 80-95% of patients with AD have intestinal dysbiosis, while, along with a deficiency of lactobacilli and bifidobacteria, there is an excessive growth of Staphilococcus. The use of modern molecular genetics technologies made it possible to obtain a fairly complete understanding of the number, genetic heterogeneity and complexity of the bacterial components of the intestinal microbiota, while clinical studies have shown the importance of its interactions with the host organism in the formation of various forms of pathology. It has been established that the human intestinal microbiota is an evolutionary set of microorganisms that exists as a balanced microecological system in which the symbiotic microflora is in dynamic equilibrium, forms microbial associations that occupy a certain ecological niche in it, and is one of the most important factors affecting human health. The gut microbiota plays an important role in the pathogenesis of atopic dermatitis, which causes immunosuppression, but the exact mechanism of its action is still unclear. It is widely known that probiotics act on the immune system. These are living microorganisms with immunomodulatory effects that stimulate Th1 cytokines and suppress Th2 responses, which are being investigated for the treatment of several diseases. The most commonly used probiotics are part of the intestinal microflora such as lactobacilli, bifidobacteria and enterococci. The purpose of this article: to systematize the information available today on the influence of the composition of the intestinal microflora on the immunopathogenesis of atopic dermatitis.

scholarly journals IDENTIFICATION OF MALASSEZIA SPECIES AND ITS ASSOCIATION WITH CLINICAL MANIFESTATIONS OF ATOPIC DERMATITIS

2021 ◽  
Vol 506 (1-2) ◽  
Author(s):  
Tran Cam Van ◽  
Nguyen Van Hieu
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Manifestations ◽  
Morphological Characteristics ◽  
Skin Lesions ◽  
Common Species ◽  
Atopic Dermatitis Patient ◽  
Inflammatory Skin Disease ◽  
Direct Examination ◽  
National Hospital ◽  
Malassezia Species

Introduction: Atopic dermatitis is a chronic, recurrent inflammatory skin disease that is characterized by an eczematous reaction. Few studies have investigated fungi in the pathogenesis of atopic dermatitis, however, there are different about distribution of Malassezia species. Objectives: To indentificate of Malassezia species and its asociation with clinical manifestations in Vietnamese atopic dermatitis patient. Methods: 178 patients who were diagnosed with atopic dermatitis and had a postitive direct examination of Malassezia at the National hospital of dermatology and venereology between July 2019 and June 2020.  Specimens were taken with cellotape, then stained in 20% of potassium hydroxit combined with ParkerTM blue black ink.  All patient who had postive test were cultured on SDA and mDixon. For fungal samples, we selected pure colonies with morphological characteristics of yeast as follows about 1cm in diameter, round, cream or milky in color, smooth and glossy to detect the species. Results: From the samples of atopic dermatitis patients, we cultured and idenfified 41 cases. 5 species were found, in which M. globosa was the most common species, accounting for 39%, followed by M. restricta (19.5%), M. dermatis (17.1%),  M. furfur (17.1%) and M. sympodialis (2.4%). Conclusion: On the skin lesions of Vietnamese patients with atopic dermatitis, M. globosa was the most common species with 39.0%.

Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs

2014 ◽  
Vol 25 (2) ◽  
pp. 77-e25 ◽  
Author(s):  
Thierry Olivry ◽  
Manolis Saridomichelakis ◽  
Tim Nuttall ◽  
Emmanuel Bensignor ◽  
Craig E. Griffin ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Severity Index ◽  
Skin Lesions ◽  
Severity Scale ◽  
Canine Atopic Dermatitis

scholarly journals Peculiarities of the clinical course of allergic dermatoses in children (literature review)

2020 ◽  
pp. 58-63
Author(s):  
O.M. Mochulska ◽  
◽  
K.T. Hlushko ◽  
Keyword(s):  
Skin Diseases ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Skin Lesions ◽  
Stevens Johnson Syndrome ◽  
Clinical Criteria ◽  
Johnson Syndrome ◽  
Allergic Skin ◽  
Allergic Contact

The prevalence of allergic diseases is constantly growing around the world. According to WHO forecasts, most of the world's population will suffer from various allergies by 2050, at the same time any substance can be an allergen, and the XXI century will be the era of allergies. In the structure of allergic diseases in children the leading place is occupied by allergic skin lesions — allergic dermatoses, which are characterized by pronounced clinical polymorphism, acute or chronic stage with the development of concomitant pathological changes in many systems of the growing child's body. Allergic dermatoses are a large group of skin diseases, including: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome), toxicodermias, as well as less common dermatoses, in the pathogenesis of which are leading allergic reactions. Purpose — to describe clinical criteria for the differential diagnosis of allergodermatoses in children in order to increase its effectiveness. Conclusions. Allergodermatoses in children are characterized by polymorphism of clinical manifestations, which depends on the specific nosology. There is a tendency to increase the frequency of allergic skin diseases in children, especially severe forms with recurrent course, resistant to traditional pharmacotherapy. Comprehensive detailed study of clinical manifestations of allergic dermatoses in children will contribute to the development of differential diagnostic criteria for allergic dermatoses in children, to verify accurate diagnosis and to prescribe the pathogenesis-based treatment for various allergic skin diseases in time. No conflict of interest was declared by the authors. Key words: children, allergy, allergic dermatoses, clinical criteria.

scholarly journals The Role of Staphylococcus aureus in Secondary Infections in Patients with Atopic Dermatitis (AD)

2016 ◽  
Vol 65 (3) ◽  
pp. 253-259 ◽  
Author(s):  
Jacek Międzobrodzki
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Skin Lesions ◽  
Skin Condition ◽  
Staphylococcal Infection ◽  
Secondary Infections ◽  
Allergic Skin ◽  
Atopic Skin ◽  
Favorable Conditions

Staphylococcus aureus colonizes the mucous membrane of the nasal vestibule of a significant number of healthy people. These microorganisms are opportunistic pathogens, that in favorable conditions, may cause infections of various course, location or manifestation. Secondary infections emerge in cases when other risk factors contribute to such a change. One of the diseases during which S. aureus changes its saprophytic character to a pathogenic one is atopic dermatitis (AD), an allergic skin condition of a chronic and recurrent nature. Patients with AD are highly predisposed to secondary staphylococcal infections due to active S. aureus colonization of the stratum corneum, damage of the skin barrier or a defective immune response. Microorganisms present in skin lesions destroy the tissue by secreting enzymes and toxins, and additionally stimulate secondary allergic reactions. The toxins secreted by strains of S. aureus also act as superantigens and penetrate the skin barrier contributing to a chronic inflammation of the atopic skin lesions. The S. aureus species also releases proinflammatory proteins, including enzymes that cause tissue damage. When initiating treatment it is particularly important to properly assess that the onset of the secondary bacterial infection is caused by S. aureus and thus justifying the inclusion of antibiotic therapy. Depending on the severity and extent of the staphylococcal infection, topical antibiotics are used, usually mupirocin or fusidic acid, or general antibiotic treatment is introduced. Another therapeutic strategy without antibiotics has given a positive effect in patients.

scholarly journals Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Mojgan Sanjari ◽  
Mohammadreza Shakibi ◽  
Moeinadin Safavi
Keyword(s):  
Clinical Manifestations ◽  
Skin Lesions ◽  
Small Vessel Vasculitis ◽  
Iga Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Cutaneous Lesions ◽  
Radioiodine Ablation ◽  
Antithyroid Agents ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Graves’ disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch–Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch–Schönlein purpura (IgA vasculitis) as a side effect. The patient was a 31-year-old woman with a chief complaint of tremor and significant weight loss who contracted pruritic palpable purpura during her disease course. Then, she underwent the treatment of hyperthyroidism by methimazole which intensified her cutaneous lesions. The diagnosis of Henoch–Schönlein purpura (IgA vasculitis) was confirmed after skin biopsy. Finally, she was treated with colchicine, prednisolone, and radioiodine ablation, which caused her lesions to disappear. The temporal priority of pruritic palpable skin lesions to hyperthyroidism treatment with methimazole suggested that Henoch–Schönlein purpura (IgA vasculitis) was related to hyperthyroidism and was intensified by antithyroid agents in this patient.

scholarly journals CLINICAL AND DIAGNOSTIC VALUE OF DETERMINATION OF NEOPTERIN IN ATOPIC DERMATITIS IN CHILDREN

2018 ◽  
Vol 25 (3) ◽  
pp. 24-27
Author(s):  
M. M. BEN ◽  
E. YU. YANCHEVSKAYA ◽  
O. A. MESNYANKINA
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Laboratory Method ◽  
Control Group ◽  
Allergic Skin ◽  
Monitoring And Forecasting

Aim. To improve the diagnosis of allergic skin diseases in childrenMaterials and methods. 135 children aged from 2 to 6 with atopic dermatitis were examined during exacerbation. They were on inpatient treatment in the skin and venereologic department of the Regional skin and venereologic dispensary and the Department of Allergology of the Regional children's clinical hospital. At the same time, 103 people (the main group) had uncomplicated course of the disease, 32 patients had complications of atopic dermatitis in the form of secondary infection. The control group consisted of 29 children aged 2 to 6. Neopterin in serum was determined by enzyme-linked immunosorbent analysis using test kits "Neopterin ELISA" (Germany). Statistical reliability of the obtained data was evaluated using The Student's test.Results. Atopic dermatitis in children, regardless of clinical manifestations, is accompanied by an increase in the content of neopterin in serum. The nature of the increase in the level of neopterin is determined by the duration of the disease, while its highest values are characteristic of the prolonged course of the process (over 4 years).Conclusion. The determination of neopterin in children with atopic dermatitis is a promising laboratory method for assessing the severity of dermatosis, monitoring and forecasting the further course of the process, as well as evaluating the effectiveness of therapeutic measures.

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