scholarly journals Cellular Composition and Differentiation Signaling in Chicken Small Intestinal Epithelium

Animals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 870
Author(s):  
Haihan Zhang ◽  
Dongfeng Li ◽  
Lingbin Liu ◽  
Ling Xu ◽  
Mo Zhu ◽  
...  
Keyword(s):  
Intestinal Epithelium ◽  
Intestinal Development ◽  
Cell Culture Model ◽  
Proliferation Zone ◽  
Small Intestinal Epithelium ◽  
Culture Model ◽  
Different Types ◽  
Development And Differentiation ◽  
Small Intestinal

The small intestine plays an important role for animals to digest and absorb nutrients. The epithelial lining of the intestine develops from the embryonic endoderm of the embryo. The mature intestinal epithelium is composed of different types of functional epithelial cells that are derived from stem cells, which are located in the crypts. Chickens have been widely used as an animal model for researching vertebrate embryonic development. However, little is known about the molecular basis of development and differentiation within the chicken small intestinal epithelium. This review introduces processes of development and growth in the chicken gut, and compares the cellular characteristics and signaling pathways between chicken and mammals, including Notch and Wnt signaling that control the differentiation in the small intestinal epithelium. There is evidence that the chicken intestinal epithelium has a distinct cellular architecture and proliferation zone compared to mammals. The establishment of an in vitro cell culture model for chickens will provide a novel tool to explore molecular regulation of the chicken intestinal development and differentiation.

scholarly journals Use of Collagen Gel as an Alternative Extracellular Matrix for the In Vitro and In Vivo Growth of Murine Small Intestinal Epithelium

2013 ◽  
Vol 19 (12) ◽  
pp. 961-969 ◽  
Author(s):  
Ziyad Jabaji ◽  
Connie M. Sears ◽  
Garrett J. Brinkley ◽  
Nan Ye Lei ◽  
Vaidehi S. Joshi ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Intestinal Epithelium ◽  
Collagen Gel ◽  
Small Intestinal Epithelium ◽  
Small Intestinal ◽  
In Vivo Growth

scholarly journals Effects of ingested nanocellulose and nanochitosan materials on carbohydrate digestion and absorption in an in vitro small intestinal epithelium model

2021 ◽  
Author(s):  
Zhongyuan Guo ◽  
Glen DeLoid ◽  
Xiaoqiong Cao ◽  
Dimitrios Bitounis ◽  
Kaarunya Sampathkumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intestinal Epithelium ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Small Intestinal Epithelium ◽  
Surface Areas ◽  
Small Intestinal ◽  
Drug Delivery Applications ◽  
Carbohydrate Digestion

Nanoscale materials derived from natural biopolymers like cellulose and chitosan have many potentially useful agri-food and oral drug delivery applications. Because of their large and potentially bioactive surface areas and...

Toxicity, uptake, and nuclear translocation of ingested micro-nanoplastics in an in vitro model of the small intestinal epithelium

2021 ◽  
pp. 112609
Author(s):  
Glen M. DeLoid ◽  
Xiaoqiong Cao ◽  
Dimitrios Bitounis ◽  
Dilpreet Singh ◽  
Paula Montero Llopis ◽  
...  
Keyword(s):  
Intestinal Epithelium ◽  
In Vitro Model ◽  
Nuclear Translocation ◽  
Small Intestinal Epithelium ◽  
Small Intestinal ◽  
Vitro Model

scholarly journals Metabolism of Caprine Milk Carbohydrates by Probiotic Bacteria and Caco-2:HT29–MTX Epithelial Co-Cultures and Their Impact on Intestinal Barrier Integrity

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 949 ◽  
Author(s):  
Alicia Barnett ◽  
Nicole Roy ◽  
Adrian Cookson ◽  
Warren McNabb
Keyword(s):  
Intestinal Epithelium ◽  
Carbon Sources ◽  
Intestinal Barrier ◽  
Probiotic Bacteria ◽  
Mrna Levels ◽  
Barrier Integrity ◽  
Small Intestinal Epithelium ◽  
Caprine Milk ◽  
Culture Model ◽  
Small Intestinal

The development and maturation of the neonatal intestine is generally influenced by diet and commensal bacteria, the composition of which, in turn, can be influenced by the diet. Colonisation of the neonatal intestine by probiotic Lactobacillus strains can strengthen, preserve, and improve barrier integrity, and adherence of probiotics to the intestinal epithelium can be influenced by the available carbon sources. The goal of the present study was to examine the role of probiotic lactobacilli strains alone or together with a carbohydrate fraction (CF) from caprine milk on barrier integrity of a co-culture model of the small intestinal epithelium. Barrier integrity (as measured by trans epithelial electrical resistance (TEER)), was enhanced by three bacteria/CF combinations (Lactobacillus rhamnosus HN001, L. plantarum 299v, and L. casei Shirota) to a greater extent than CF or bacteria alone. Levels of occludin mRNA were increased for all treatments compared to untreated co-cultures, and L. plantarum 299v in combination with CF had increased mRNA levels of MUC4, MUC2 and MUC5AC mucins and MUC4 protein abundance. These results indicate that three out of the four probiotic bacteria tested, in combination with CF, were able to elicit a greater increase in barrier integrity of a co-culture model of the small intestinal epithelium compared to that for either component alone. This study provides additional insight into the individual or combined roles of microbe–diet interactions in the small intestine and their beneficial contribution to the intestinal barrier.

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