scholarly journals Immunohistochemical Differences in Squamous Precancerous and Cancerous Lesions of the Oral Cavity and the Larynx: Preliminary Data

2021 ◽  
Vol 11 (5) ◽  
pp. 2048
Author(s):  
Piero Luigi Aló ◽  
Miriam Cicciarelli ◽  
Francesca De Felice ◽  
Claudia Quintiliani ◽  
Alessandro Corsi ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Squamous Cell ◽  
Immune Cell ◽  
Invasive Squamous Cell Carcinoma ◽  
Qualitative And Quantitative ◽  
Programmed Death ◽  
Preinvasive Lesions ◽  
Cancerous Lesions ◽  
Near Future ◽  
Immunohistochemical Analyses

The aim of this study is to assess immune cell populations in squamous precancerous (preinvasive) and cancerous lesions of the oral cavity and larynx. Qualitative and quantitative immunohistochemical analyses were performed to determine the expressions of CD4, CD8, CD15, CD57 and CD68. The expressions of programmed death-ligand 1 (PD-L1), p16 and Ki67 were also assessed. Squamous cell lesions from forty-one patients were included in the study. Sixteen samples were categorized as precancerous (preinvasive) lesions and twenty-five as invasive squamous cell carcinoma. Invasive lesions showed a negative correlation with CD57+ cells (ρ = −0.69) and a positive correlation with Ki67 (ρ = 0.61). The amount of CD4+ lymphocytes was higher in invasive lesions. There were no differences in PD-L1 and p16 immunoreactivity. Our analysis showed differences in the immunohistochemical profile between preinvasive and invasive squamous cell lesions. In the near future, this study should be useful in driving treatment strategy in both preinvasive and invasive squamous cell lesions of the oral cavity and larynx. However, studies on larger series of patients focusing on site-specific lesions are required.

Invasive squamous cell carcinoma arising in an inverted papilloma involving oral cavity

2020 ◽  
Vol 36 (2) ◽  
pp. 209-214
Author(s):  
Nagihan Koç ◽  
Hatice Boyacıoğlu ◽  
Nihal Avcu ◽  
Şafak Parlak ◽  
Tuğba Taşkın Türkmenoğlu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inverted Papilloma ◽  
Invasive Squamous Cell Carcinoma

“A HISTOPATHOLOGICAL STUDY OF TUMORS OF ORAL CAVITY”

2021 ◽  
pp. 1-5
Author(s):  
P.V. Kala Chandra Sekhar ◽  
B. victor Paul
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Squamous Cell ◽  
Tobacco Consumption ◽  
Histopathological Study ◽  
Invasive Squamous Cell Carcinoma ◽  
College Hospital ◽  
Oral Cancers ◽  
Associated Risk Factors ◽  
Oral Cavity Neoplasms

Background: The incidence of oral cavity neoplasms in the population has increased manifold over the years. Oral cancer is one of the common cancers in the world, common in India, and also in Bangladesh, Srilanka and Pakistan. Oral cancer is one of the few cancers, whose cause were known and hence it is possible to prevent. The real challenge in oral cancer lies in its prevention and early diagnosis. Objectives: 1.To study the morphological spectrum of neoplasms in oral cavity. 2.To study the age and gender incidence of various neoplasms. 3.To study the commonest sites of various neoplasms. 4.To evaluate or analyse the associated risk factors. Materials and methods: This is a prospective study of the cases attended to Government General Hospital, Vijayawada or Government Dental College Hospital Vijayawada, of oral cavity neoplasms. The biopsy of the tissues was carried out at the Department of Pathology, Siddhartha Medical College, Vijayawada. The study period was from June 2011 to August 2013 over a period of two years and three months. Results: The Study comprises a total of 74 surgical biopsies from oral cavity neoplasms received in the Department of Pathology, 52 of these were malignant lesions and 20 were benign tumour and 2 were premalignant conditions. The invasive squamous cell carcinoma was the most frequent histological type of oral cavity neoplasms. Among the oral cancers, peak age th th incidence was the 5 and 6 decade of life. There was signicant male preponderance. Tongue was the most common site involved. Smokeless tobacco consumption was the commonest associated habit which leads to malignancy. Conclusion:In thisa study we observed that among the oral cavity neoplasms, high incidence of carcinomas are seen, among these squamous cell carcinomas are predominant.

scholarly journals Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma

2009 ◽  
Vol 23 (6) ◽  
pp. 415-419 ◽  
Author(s):  
Tan Attila ◽  
Anna Fu ◽  
Nanda Gopinath ◽  
Catherine J Streutker ◽  
Norman E Marcon
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Course ◽  
Rare Condition ◽  
Invasive Squamous Cell Carcinoma ◽  
Endoscopic Biopsies ◽  
Potential Development ◽  
Associated Malignancy

Esophageal papillomatosis is a very rare condition that is believed to have a benign clinical course. Recent reports underscore the potential development of a malignancy in association with squamous papillomatosis of the esophagus. A case of esophageal papillomatosis complicated by the development of esophageal invasive squamous cell carcinoma diagnosed after esophagectomy, despite multiple nondiagnostic endoscopic biopsies, is described. The patient also developed squamous cell carcinoma in the oral cavity and pyloric channel. The finding of extensive esophageal papillomatosis and unremitting dysphagia symptoms should prompt investigations into an underlying associated malignancy.

S100A2 expression as a predictive marker for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral cavity

2005 ◽  
Author(s):  
Fumiyuki Suzuki ◽  
Nobuhiko Oridate ◽  
Akihiro Homma ◽  
Yuji Nakamaru ◽  
Tatsumi Nagahashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Marker ◽  
Stage I ◽  
Invasive Squamous Cell Carcinoma ◽  
Cervical Metastasis

scholarly journals Squamous cell carcinoma of the tongue in Sprague-Dawley rats using 4-nitroquinoline 1-oxide model

2016 ◽  
Vol 28 (1) ◽  
Author(s):  
Erni Erfan ◽  
Nafrialdi N. ◽  
Puspita Ekawuyung
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Induction Time ◽  
Water Soluble ◽  
Invasive Squamous Cell Carcinoma ◽  
Sprague Dawley ◽  
Histological Changes ◽  
Carcinoma Of Tongue

Background. 4-nitroquinoline 1-oxide (4NQO) is a water soluble carcinogen which is often used to induce cancer in oral cavity. Objective. The purpose of this study was to know the incidence of histopathological lesions in the tongue of rats after administration of 4-nitroquinoline 1-oxide (4NQO) for a model of oral carcinogenesis in the animal experimental laboratory. Materials and Methods. This study was conducted in the Department of  Pathological Anatomy, Faculty of Medicine, University of Indonesia (FMUI). 4NQO (30 ppm) was administered by drinking water ad libitum to the Sprague Dawley (SD) rats during different time inductions (4-9 and 36-46 weeks). The present of tumor in oral cavity of the 4NQO-treated rats were observed macroscopically and microscopically. Tumor volume were measured based on the formula established by G. Carlsson. The degree of histological changes was determined according to observation towards their Hematoxylin and Eosin (HE) staining results. Results. Dysplasia and invasive squamous cell carcinoma (SCC) were respectively found in the tongue of the group given 4NQO for 4-9 and 36-46 weeks. The tongue from rats (4NQO for 36-46 weeks) exhibited whitish protuberant nodular lesions with the longest diameter was 17 mm. The histopathological lesion incidences for dysplasia and invasive SCC respectively were 25% (5/20) and 75% (15/20). The rats had tumor in their tongues with variation of degree alteration which proportional to the induction time. The extension of 4NQO induction time increasing the degree of change in the tumor. Conclusion. 4NQO represents a good model of carcinoma of tongue and gives consistence results with histological changes degree being related to duration of exposure.

scholarly journals Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral cavity and oropharynx

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Andrew P. South ◽  
Nicoline Y. den Breems ◽  
Tony Richa ◽  
Uche Nwagu ◽  
Tingting Zhan ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Cell Fate ◽  
Dna Adducts ◽  
Squamous Cell ◽  
Tobacco Smoke ◽  
Immune Cell ◽  
Tobacco Smoke Exposure ◽  
Proliferation Index ◽  
Driver Gene ◽  
Tobacco Carcinogen

AbstractSquamous cell carcinomas of the head and neck (HNSCC) arise from mucosal keratinocytes of the upper aero-digestive tract. Despite a common cell of origin and similar driver-gene mutations which divert cell fate from differentiation to proliferation, HNSCC are considered a heterogeneous group of tumors categorized by site of origin within the aero-digestive mucosa, and the presence or absence of HPV infection. Tobacco use is a major driver of carcinogenesis in HNSCC and is a poor prognosticator that has previously been associated with poor immune cell infiltration and higher mutation numbers. Here, we study patterns of mutations in HNSCC that are derived from the specific nucleotide changes and their surrounding nucleotide context (also known as mutation signatures). We identify that mutations linked to DNA adducts associated with tobacco smoke exposure are predominantly found in the larynx. Presence of this class of mutation, termed COSMIC signature 4, is responsible for the increased burden of mutation in this anatomical sub-site. In addition, we show that another mutation pattern, COSMIC signature 5, is positively associated with age in HNSCC from non-smokers and that larynx SCC from non-smokers have a greater number of signature 5 mutations compared with other HNSCC sub-sites. Immunohistochemistry demonstrates a significantly lower Ki-67 proliferation index in size matched larynx SCC compared with oral cavity SCC and oropharynx SCC. Collectively, these observations support a model where larynx SCC are characterized by slower growth and increased susceptibility to mutations from tobacco carcinogen DNA adducts.

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