scholarly journals Comment on the Determination of the Polar Anchoring Energy by Capacitance Measurements in Nematic Liquid Crystals

2021 ◽  
Vol 11 (16) ◽  
pp. 7387
Author(s):  
Patrick Oswald
Keyword(s):  
Sample Thickness ◽  
Dielectric Constants ◽  
Brilliant Yellow ◽  
Voltage Range ◽  
Capacitance Measurements ◽  
A Cell ◽  
Anchoring Energy ◽  
The One

Capacitance measurements have been extensively used to measure the anchoring extrapolation length L at a nematic–substrate interface. These measurements are extremely delicate because the value found for L often critically depends on the sample thickness and the voltage range chosen to perform the measurements. Several reasons have been proposed to explain this observation, such as the presence of inhomogeneities in the director distribution on the bounding plates or the variation with the electric field of the dielectric constants. In this paper, I propose a new method to measure L that takes into account this second effect. This method is more general than the one proposed in Murauski et al. Phys. Rev. E 71, 061707 (2005) because it does not assume that the anchoring angle is small and that the anchoring energy is of the Rapini–Papoular form. This method is applied to a cell of 8CB that is treated for planar unidirectional anchoring by photoalignment with the azobenzene dye Brilliant Yellow. The role of flexoelectric effects and the shape of the anchoring potential are discussed.

scholarly journals Comment on the Determination of the Polar Anchoring Energy by Capacitance Measurements in Nematic Liquid Crystals

2021 ◽  
Author(s):  
Patrick Oswald
Keyword(s):  
Liquid Crystals ◽  
Sample Thickness ◽  
Dielectric Constants ◽  
Brilliant Yellow ◽  
Voltage Range ◽  
Capacitance Measurements ◽  
A Cell ◽  
Anchoring Energy

Capacitance measurements have been extensively used to measure the anchoring extrapolation length L at a nematic-substrate interface. These measurements are extremely delicate because the value found for L often critically depends on the sample thickness and the voltage range chosen to perform the measurements. Several reasons have been proposed to explain this observation, such as the presence of inhomogeneities in the director distribution on the bounding plates or the variation with the electric field of the dielectric constants. In this paper I propose a new method to measure Lp that takes into account this second effect. This method is more general than that proposed in Murauski et al. Phys. Rev. E 71, 061707 (2005) because it does not assume that the anchoring angle is small and that the anchoring energy is of the Rapini-Papoular form. This method is applied to a cell of 8CB treated for planar unidirectional anchoring by photoalignment with the azobenzene dye Brilliant Yellow. The role of flexoelectric effects and the shape of the anchoring potential are discussed.

Ways of Applying Destination Management Concepts to the Development of Internal Tourism in Uzbekistan

2015 ◽  
pp. 172-190
Author(s):  
Bakhtiyor Navruz-Zoda ◽  
Nutfillo Ibragimov
Keyword(s):  
Supply And Demand ◽  
Tourism Industry ◽  
Location Selection ◽  
Tourism Management ◽  
Regional Management ◽  
Management Concepts ◽  
The One ◽  
Organic Combination

This chapter examines the role of the destination approach in the development of internal tourism in Uzbekistan. The trump-card of tourism in Uzbekistan is ancient cities like Tashkent, Samarkand, Shakhrisabz, Bukhara and Khiva. The chapter is focused on substantiation of destination model of tourism management, based on a junction of regional management and marketing theories. In order to reform the one-dimensional “package” system of tourism supply that operates in Uzbekistan to a multi-sided “integration” system it is recommended to run “creating destinations” policy in the tourism industry. That implies the creation process of integrated tourist destination based on organic combination of tourism supply and demand. The chapter describes seven stages of destination creating process: determination of purpose of visit in tourist location; selection of sights from destinations; clarification and analyzing destinations creating factors, explanation principles of creating destination; development criteria of creating destinations; creation of attractive destinations; arrangement of destination management system.

scholarly journals The Role of DNA Degradation in the Estimation of Post-Mortem Interval: A Systematic Review of the Current Literature

2020 ◽  
Vol 21 (10) ◽  
pp. 3540 ◽  
Author(s):  
Pamela Tozzo ◽  
Salvatore Scrivano ◽  
Matteo Sanavio ◽  
Luciana Caenazzo
Keyword(s):  
Analytical Techniques ◽  
Dna Degradation ◽  
Post Mortem ◽  
Post Mortem Interval ◽  
Target Organs ◽  
The One ◽  
Definition Of ◽  
Meta Analyses

The determination of the post-mortal interval (PMI) is an extremely discussed topic in the literature and of deep forensic interest, for which various types of methods have been proposed. The aim of the manuscript is to provide a review of the studies on the post-mortem DNA degradation used for estimating PMI. This review has been performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the PRISMA Guidelines. Several analytical techniques have been proposed to analyse the post-mortem DNA degradation in order to use it to estimate the PMI. Studies focused mainly on animal models and on particular tissues. The results have been mixed: while on the one hand literature data in this field have confirmed that in the post-mortem several degradation processes involve nucleic acids, on the other hand some fundamental aspects are still little explored: the influence of ante and post-mortem factors on DNA degradation, the feasibility and applicability of a multiparametric mathematical model that takes into account DNA degradation and the definition of one or more target organs in order to standardize the results on human cases under standard conditions.

The Crime of Aggression and the United Nations Security Council

2007 ◽  
Vol 20 (4) ◽  
pp. 867-894 ◽  
Author(s):  
NIELS BLOKKER
Keyword(s):  
Security Council ◽  
Criminal Court ◽  
United Nations Security Council ◽  
International Court Of Justice ◽  
International Court ◽  
The One ◽  
International Law Commission ◽  
Difficult Issue

This contribution is dedicated to Professor John Dugard. It discusses the most difficult issue to be resolved in the negotiations on the crime of aggression: the role of the Security Council in the exercise of jurisdiction over this crime by the International Criminal Court. The International Law Commission suggested a solution in the 1990s, but failing the required support and in the absence of subsequent agreement the 1998 Rome Conference could only prospectively give the Court jurisdiction over the crime of aggression. The post-Rome negotiations are characterized by, on the one hand, support from the five permanent members of the Security Council for the thesis that it should be exclusively for the Security Council to determine whether or not an act of aggression has been committed (as a precondition for the exercise of jurisdiction by the ICC) and, on the other hand, a rejection of this thesis combined with a search for alternatives by many other states. According to the analysis below, in relation to cases involving the crime of aggression the preferred way for the ICC to proceed is to exercise jurisdiction over this crime after a determination of state aggression has been made by the Security Council. Nevertheless, the view according to which such a determination could exclusively be made by the Council is rejected, on the basis of the rules of the Charter, the practice of the Security Council and the General Assembly, and decisions of the International Court of Justice. Finally, an alternative arrangement is suggested for the cases in which the Security Council is prevented from acting because of the use of the veto or because of lack of support from its members.

scholarly journals The cost of evolved constitutive lac gene expression is usually, but not always, maintained during evolution of generalist populations

2021 ◽  
Author(s):  
Kelly Phillips ◽  
Tim Cooper
Keyword(s):  
Lac Operon ◽  
Beneficial Mutation ◽  
General Adaptation ◽  
Genetic Perturbations ◽  
Compensatory Mutations ◽  
Escherichia Coli Bacteria ◽  
The One ◽  
The Cost

Beneficial mutations can become costly following an environmental change. Compensatory mutations can relieve these costs, while not affecting the selected function, so that the benefits are retained if the environment shifts back to be similar to the one in which the beneficial mutation was originally selected. Compensatory mutations have been extensively studied in the context of antibiotic resistance, responses to specific genetic perturbations and in the determination of interacting gene network components. Few studies have focused on the role of compensatory mutations during more general adaptation, especially as the result of selection in fluctuating environments where adaptations to different environment components may often involve tradeoffs. We examine if costs of a mutation in lacI, which deregulated expression of the lac operon in evolving populations of Escherichia coli bacteria, was compensated. This mutation occurred in multiple replicate populations selected in environments that fluctuated between growth on lactose, where the mutation was beneficial, and on glucose, where it was deleterious. We found that compensation for the cost of the lacI mutation was rare, but, when it did occur, it did not negatively affect the selected benefit. Compensation was not more likely to occur in a particular evolution environment. Compensation has the potential to remove pleiotropic costs of adaptation, but its rarity indicates that the circumstances to bring about the phenomenon may be peculiar to each individual or impeded by other selected mutations.

scholarly journals Morality and legality in Kant’s ethics

2020 ◽  
Vol 63 (2) ◽  
pp. 17-40
Author(s):  
Josip Guc
Keyword(s):  
Moral Law ◽  
Moral Feeling ◽  
The One ◽  
Kant's Ethics ◽  
Different Levels

Differentiation of morality and legality is one of the fundamental topoi of Kant?s ethics. However, alongside it is often interpreted in too simple (and also sometimes wrong) manner, this differentiation does not demonstrate the whole complexity of Kant?s understanding of moral correctness of certain types of will determination. Thus the goal of this paper is to point out different kinds of morally relevant actions (which are not limited to morality and legality), and then to explain to which extend each of them can be understood as morally correct. For that purpose we will thoroughly consider the issue of determination of will, and then also some of the problematic interpretations of legality and morality, where as a specific issue arises the one of equating morality with autonomy and legality with heteronomy (especially in domestic philosophical works). The issue of different levels of moral correctness of action will also be examined concerning the phenomenon of moral feeling. Particular attention will be given to the role of the kind of action that refer to having direct inclination toward morally correct action, even though it is not directly determined by the moral law. The analysis of these issues brings us to conclusion that legality is satisfied by an action which is outwardly done in a way it would be done by an autonomously determined will. Considering this, the determination of morality precedes the determination of legality. Other way around can be detected only in the process of education.

Assessment of autoantibodies against 21-hydroxylase in the diagnosis of primary autoimmune adrenal insufficiency

2020 ◽  
Author(s):  
Leila Sozaeva ◽  
Nadezhda Makazan ◽  
Larisa Nikankina ◽  
Natalya Malysheva ◽  
Ekaterina Kuvaldina ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Patient Survival ◽  
Adrenal Crisis ◽  
Primary Adrenal Insufficiency ◽  
Adrenal Steroidogenesis ◽  
Threatening Condition ◽  
Life Threatening ◽  
The One

Primary adrenal insufficiency is manifested by a deficiency of adrenal cortex hormones and can lead to a life-threatening condition. Early diagnosis is key to patient survival. Auto-antibodies to one of the adrenal steroidogenesis enzymes, 21-hydroxylase, are an immunological marker of autoimmune adrenal insufficiency. On the one hand, the study of antibodies to 21-hydroxylase is a method that helps establish the etiology of the disease the autoimmune genesis of adrenal gland damage. On the other hand, the determination of autoantibodies to 21-hydroxylase is the only prognostic factor of the risk of adrenal insufficiency, which makes it possible to prevent the development of acute adrenal crisis. The article provides a brief literature review on autoantibodies to 21-hydroxylase and the pathogenesis of autoimmune adrenal insufficiency, and a series of clinical cases that illustrates the significant role of autoantibodies to 21-hydroxylase in diagnosis of adrenal insufficiency.

scholarly journals The Role of Measurement in the Public Polls (Albanian Case)

2016 ◽  
Vol 1 (2) ◽  
pp. 357
Author(s):  
Fatbardha Doçi
Keyword(s):  
The Other ◽  
Gender Group ◽  
The Public ◽  
Margin Of Error ◽  
Systematic Sample ◽  
The One ◽  
The Right

In Albania reality are made a lot of surveys to predict the result of elections. It is so important to have the exactly result of the election of another items to predict. A prestigious company has done the survey in Albania reality, but they have “Forgotten“ that the Albania reality is different from the reality, because they have used the same questionnaires in Albania reality.It is so important to have the right measurement and to have the reliability and the validity of the survey. So we have types of measurement and in my research I have used one of them. If we used the right measurement, we can have a small margin of error and the result of the surveys should be the reliability than the other cases. I have decided to make the survey in Albanian reality lot of survey in two different realities. One of them I have used two kinds of sample, when one of them is systematic sample and another is quota sample. A comparison between two surveys is made providing the same questionnaire (with delicate questions) in the same place and time. The only difference was in the last step of the sample: one of the surveys has made the interviews based on the quota (gender, group age), whereas the other has used the systematic schema (with step – door by door). The margin decided by this way included also the one produced by the used of the quota. The expectation was a determination of differences between answers by this distinction.

THE GENESIS OF LEGAL SUPPORT OF ACADEMIC VIRTUE

2020 ◽  
pp. 36-39
Author(s):  
I. Shopina
Keyword(s):  
Higher Education ◽  
Educational Activity ◽  
Ethical Values ◽  
The Third ◽  
Academic Responsibility ◽  
Third Stage ◽  
The One ◽  
Definition Of

The article is dedicated to the determination of the peculiarity of stages of legal support of academic virtue in Ukraine.It has been proven that the first stage for development of legal support to academic virtue has started in 2004, when the all-European processes of increasing the role of universities within a society have been initiated as well as the transformation ofrequirements to the participants of educational activity. This stage has been characterized by the acceptance of a Bucharestdeclaration on ethical values and principles of higher education in the European region (2-5 September 2004) and its result has been the establishment of an overall European discourse of academic virtue which included pedagogical, ethical and legalaspects of the phenomenon under research.It has been pointed out, that the third stage of legal support to academic virtue is related with stipulating in 2011 within aNational framework, the qualifications of adherence to proper academic virtue as the one that is considered to be necessary toinitiate, plan, implement and correct the subsequent process of a thorough scientific research of the level of basic skills andabilities. From this moment on there’s an active development of the terminological core dedicated to the issue of academicvirtue, there’s a preparation of suggestions to be implemented to the legislation on education, particularly, by determining thelegal definition of academic virtue, the forms and types of academic responsibility, and also the active reaffirming of ethicalrequirements on the academic virtues of teachers, scientists and individuals obtaining education in the codes of academicvirtues, approved in the course of gatherings of working teams or the scientific councils of universities.

Role of Immunocytochemistry in the Cytological Diagnosis of Pulmonary Tumors

2019 ◽  
Vol 64 (1-2) ◽  
pp. 16-29 ◽  
Author(s):  
Jasna Metovic ◽  
Luisella Righi ◽  
Luisa Delsedime ◽  
Marco Volante ◽  
Mauro Papotti
Keyword(s):  
Predictive Marker ◽  
Needle Aspiration ◽  
Lung Cancer Patients ◽  
Bronchial Brushing ◽  
A Cell ◽  
Cytological Specimen ◽  
Pulmonary Tumors

Pulmonary cytology is a challenging diagnostic tool, and it is usually evaluated considering medical history and radiological findings in order to reach an accurate diagnosis. Since the majority of lung cancer patients have an advanced stage at diagnosis, a cytological specimen is frequently the only material available for diagnosis and further prognostic/predictive marker determination. Several types of specimens can be obtained from the respiratory system (including sputum, bronchoalveolar lavage, bronchial brushing, fine needle aspiration, and pleural fluid) with different technical preclinical management protocols and different diagnostic yields. Immunocytochemistry (ICC) has a pivotal role in the determination of diagnostic, prognostic, and predictive markers. Therefore, limited cytology samples are to be used with a cell-sparing approach, to allow both diagnostic ICC evaluation as well as predictive marker assessment by ICC or specific molecular assays. In this review, we describe the most common ICC markers used for the diagnosis and prognostic/predictive characterization of thoracic tumors in different cytological specimens.

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