scholarly journals Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

2021 ◽  
Vol 11 (17) ◽  
pp. 7788
Author(s):  
Noureddine Bencheikh ◽  
Mohamed Bouhrim ◽  
Ilyass Alami Merrouni ◽  
Salima Boutahiri ◽  
Loubna Kharchoufa ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Lipid Profile ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Antioxidant Activities ◽  
Bioactive Molecules ◽  
High Fat ◽  
Antioxidant Power ◽  
Albino Mice ◽  
Β Carotene

Ziziphus lotus (L.) Lam. (Z. lotus) is a medicinal plant species that is widely distributed throughout the Mediterranean basin. Moroccans traditionally use it to treat many illnesses thanks to its beneficial medicinal properties. The purpose of this study is to assess the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Z. lotus fruits (ZLF). The 2-2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the β-carotene bleaching test were used to determine the antioxidant activity of ZLF. The anti-hyperlipidemic effect of the aqueous extract of ZLF (200 and 400 mg/kg) was evaluated in albino mice exposed to the chronic high-fat diet, based on lipid profile, blood sugar, and changes in growth performance. The results showed that the aqueous extract of ZLF rich in flavonoids (2242.89 ± 25 µg QE (quercitin equivalent)/mg), and has a considerable antioxidant power against DPPH radicals (IC50 = 116 ± 0.02 µg/mL) and β-carotene oxidation. The aqueous extract of ZLF also showed a significant anti-hyperlipidemic effect by improving abnormal changes in lipid profile and blood glucose levels in albino mice exposed to a chronic high-fat diet. Our findings suggest that the anti-hyperlipidemic activities of ZLF aqueous extract are correlated with its flavonoid content and antioxidant activity. Therefore, the aqueous extract of ZLF could be an essential therapeutic candidate for hyperlipidemia patients, thanks to its richness in bioactive molecules.

scholarly journals Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Mohamed Bouhrim ◽  
Nour Elhouda Daoudi ◽  
Hayat Ouassou ◽  
Amina Benoutman ◽  
El Hassania Loukili ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Total Phenolic ◽  
High Fat ◽  
Albino Mice ◽  
Dpph Scavenging ◽  
Opuntia Dillenii

Opuntia dillenii (Ker-Gawl.) Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of O. dillenii seeds oil (ODSO), in vivo. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the Folin–Ciocalteu method were applied in this study to determine antioxidant activity and total phenolic content of ODSO, respectively. The antihyperlipidemic effect of the ODSO (2 ml/kg) was evaluated in the high-fat diet-fed albino mice, relying on lipid profile, blood glucose, and growth performance variations. Moreover, the preventive effect of ODSO was evaluated against alloxan monohydrate-induced diabetes in albino mice. ODSO had the highest total phenolic content (518.18 ± 14.36 mg EAC/kg) and DPPH scavenging activity (IC50 = 0.38 ± 0.08 mg/mL). Furthermore, ODSO showed a significant antidiabetogenic effect by reducing bodyweight loss, blood sugar level rise, and mortality rate caused by alloxan in albino mice. Then, ODSO has exhibited a significant antihyperlipidemic effect by improving the lipid profile disorder and glucose level rise in the blood, produced by the high-fat diet-fed albino mice. Results suggest that antidiabetogenic and antihyperlipidemic activities of ODSO correlate to the phenolic content and antioxidant activity of this oil. Hence, this plant could be a significant source of medically important critical compounds.

scholarly journals Palm Oil and Egusi Melon Oil Lower Serum and Liver Lipid Profile and Improve Antioxidant Activity in Rats Fed a High Fat Diet

2010 ◽  
Vol 8 (4) ◽  
pp. 154-158
Author(s):  
George O. Eidangbe ◽  
Godwin C. Ojieh ◽  
Blessing O. Idonije ◽  
Olarewaju M. Oluba
Keyword(s):  
Antioxidant Activity ◽  
Lipid Profile ◽  
Palm Oil ◽  
High Fat Diet ◽  
Liver Lipid ◽  
High Fat ◽  
Lower Serum

scholarly journals Chemical Profiling of Polysaccharides Present in Peels of Citrus limetta and Bioassay based Screening of in vitro Antioxidant Activities

2020 ◽  
Vol 32 (9) ◽  
pp. 2308-2314
Author(s):  
DIPAN ADHIKARI ◽  
TUHIN GHOSH
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Low Cost ◽  
Standard Procedure ◽  
Bioactive Molecules ◽  
Size Exclusion ◽  
Chemical Compositions ◽  
Antioxidant Power ◽  
Citrus Limetta

In this analyses, the chemical compositions of polysaccharides isolated from the peels of Citrus limetta had been studied and discussed its antioxidant activity of different active fractions. To emphasize the chemical structure of polysaccharides, a rhamnoglucan polysaccharide was identified with probable ester linked phenolic acid. The sugar composition and purification by size exclusion chromatography (SEC) has been presented. The antioxidant capacities of the extracts prepared from Citrus limetta peel powder were determined using well known in vitro systems and standard procedure for ferric reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH•), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid) (ABTS•+), hydroxyl radical (OH•), nitric oxide (NO) assay, total antioxidant activity (TAA) and metal chelation property. The rhamnoglucan (A) present exhibited the highest bioactivity potentiality succeeded by traces of uronic acid and galactan. From the investigation, it could be emphasized that water extracted polysaccharide, which brings forth potent pharmacological activities figures out the importance as alternative natural compounds as to-be-exploited leads for low-cost sources of efficient bioactive molecules with strong antioxidant activities in different pharmaceutical and cosmoceutical formulations.

Effect of Lactobacillus helveticus CD6 on serum lipid profile and indicators of liver function in high-fat diet fed Swiss albino mice

3 Biotech ◽  
2021 ◽  
Vol 11 (6) ◽  
Author(s):  
Mahesh P. Patil ◽  
Jayesh J. Ahire ◽  
Ulhas K. Patil ◽  
Bharat Bhushan ◽  
Bhushan L. Chaudhari
Keyword(s):  
Liver Function ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Lactobacillus Helveticus ◽  
Serum Lipid Profile ◽  
High Fat ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Antihyperlipidemic and hypolipidemic properties of Tacca leontopetaloides (L.) Kuntze (Dioscoreales: Dioscoreaceae) tuber’s aqueous extracts in the rats

2017 ◽  
Vol 4 (7) ◽  
pp. 67-80 ◽  
Author(s):  
Doubla Sali Aissatou ◽  
Josiane Thérèse Ngatchic Metsagang ◽  
Celestin Dongmo Sokeng ◽  
Nicolas Yanou Njintang
Keyword(s):  
Lipid Profile ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Biochemical Parameters ◽  
Coconut Oil ◽  
Hdl Cholesterol ◽  
Normal Diet ◽  
Histopathological Study ◽  
Aqueous Extracts ◽  
High Fat

Tubers of Tacca leontopetaloides (L.) Kuntze (Dioscoreales: Dioscoreaceae) play an important role in food substitution during the periods of food shortage in occidental and central Africa. It is also used in traditional medicine for the treatment of the diarrhea, dysentery, stomach evil, viral hepatitis and the infection of guinea worn. This study attempted to evaluate the antihyperlipidemic and hypolipidemic properties of aqueous extracts of the tubers of T. leontopetaloides in rats. For this experimentation, two tests were done: antihyperlipidemic and hypolipidemic tests. Hyperlipidemia was induced in rats with High Fat Diet containing 300 g of egg yolk, 2 g of cholesterol, 250 g of coconut oil and 50 g of soya oil. The group of rats on which the antihyperlipidemic test was done was fed with High Fat Diet and supplemented with T. leontopetaloides aqueous extract at 27.34 mg/kg, and 54.68 mg/kg; after 21 days of experimentation, the different groups of rats were sacrificed. The lipid profile and some biochemical parameters were evaluated. Organs like kidneys, liver and stomach were taken for histopathological evaluation. For the hypolipidemic test, after three weeks of induction of hyperlipidemia, the diet was changed to normal diet and aqueous extract of tubers was given to rats during 21 days at doses of 3.41 mg/kg and 13.67 mg/kg. The animals were sacrificed after 21 days of experimentation. The lipid profile, some biochemical parameters and histopathology of organs were evaluated. The antihyperlipidemic and hypolipidemic tests of aqueous extract of the tubers of T. leontopetaloides induced reduction in total cholesterol, triglyceride, LDL-cholesterol and an increase in HDL-cholesterol significantly (p < 0.05); decreasing activities of ALAT and ASAT enzymes, levels of creatinin remained no changed. Histopathological study revealed that extracts did not repair the destructions of liver cells and glomerules of kidneys caused by High Fat Diet. Aqueous extract of tubers of T. leontopetaloides exhibits antihyperlipidemic and hypolipidemic activities; hence it could be important in the management of cardiovascular diseases.

Antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Ramalingam Sripradha ◽  
Magadi Gopalakrishna Sridhar ◽  
Nachimuthu Maithilikarpagaselvi
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Antioxidant Activities ◽  
Ethanolic Extract ◽  
High Fat ◽  
Polyphenol Content ◽  
Total Polyphenol ◽  
Garcinia Cambogia ◽  
Antioxidant Power ◽  
Total Polyphenol Content

Abstract: The study investigated the antihyperlipidemic and antioxidant activities of the ethanolic extract of: The phytochemical constituents, total polyphenol content and ferric reducing antioxidant power (FRAP) were estimated in the: The analyses revealed the presence of carbohydrates, proteins, sterols, tannins, flavonoids and saponins in GE. The total polyphenol content and FRAP of GE were 82.82±7.64 mg of gallic acid equivalents and 260.49±10.18 µM FRAP per gram of the GE. High-fat feeding elevated plasma total cholesterol (TC), triacylglycerol (TAG), non-high-density lipoprotein-cholesterol (non-HDL-C), malondialdehyde (MDA), reduced HDL-C and blood antioxidants, glutathione (GSH), glutathione peroxidase (GPx), catalase. Increase in total oxidant status (TOS), oxidative stress index (OSI) and decrease in the total antioxidant status (TAS) were observed in plasma, liver and kidney of fat-fed rats. Administration of GE decreased food intake, plasma TC, TAG, non HDL-C, MDA, increased HDL-C and blood antioxidants GSH, GPx, catalase. GE also reduced TOS, OSI and elevated TAS in plasma and liver of fat-fed rats. Renal OSI was significantly reduced upon GE treatment.: Our study demonstrated that GE is effective in ameliorating high-fat-diet-induced hyperlipidemia and oxidative stress.

Investigation of Nutritional Contents, Antioxidant and Immunostimulatory Activities of Aqueous Extract from Laguncularia racemosa Leaves

2020 ◽  
Vol 10 ◽  
Author(s):  
Dayane Kelly Dias do Nascimento Santos ◽  
Cristiane Moutinho Lagos de Melo ◽  
Elivânia Maria da Silva ◽  
Vanessa Silva de Almeida ◽  
Iranildo José da Cruz Filho ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Antioxidant Activities ◽  
Folk Medicine ◽  
Proliferation Index ◽  
Laguncularia Racemosa ◽  
High Concentration ◽  
Popular Medicine ◽  
Biological Tests ◽  
Phytochemical Profile

Background: One of the four most incident species in mangrove is the Laguncularia racemosa, plant widely used in popular medicine against inflammation and fever. Objective: Here, L. racemosa was investigated in relation to their phytochemical profile, antioxidant activity, citotoxicity, antimicrobial and immunostimulatory effect. Method: Aqueous extract was obtained from leaves of plant, its phytochemical profile was investigated through UPLC method, the antioxidant assays performed were TAA, DPPH, ABTS, nitrite and lipid peroxidation assay. Antimicrobial assays were made using standard strains. For all biological tests were used mice splenocytes and from these cell cultures were measured cytotoxicity, proliferation index and cytokines production. Results: Laguncularia racemosa leaves showed the presence of ions, proteins, carbohydrates, vitamins and high concentration of phenolic compounds. Antioxidant activities were promoted by aqueous extract, especially in DPPH and NO assays. Extract in 6 µg/mL did not induce significant cell death, stimulated the cell proliferation and the IL-4 production. Moreover, decreases of proinflammatory cytokines IFN-γ, TNF-α and IL-6 were found. Conclusion: The presence of essential nutrients, significant antioxidant activity and immune stimulation confirm the use of this plant in folk medicine against inflammation.

scholarly journals Antioxidant Evaluation of the Aqueous Extract of Hulls of Campsiandra laurifolia in Colitis Induced by Acetic Acid in Wistar Rats

2021 ◽  
Vol 41 (02) ◽  
pp. 138-144
Author(s):  
Lucas Petitemberte de Souza ◽  
Henrique Sarubbi Fillmann ◽  
Sandielly Rebeca Benitez da Fonseca ◽  
Marilda da Silva Brasil ◽  
Norma Anair Possa Marroni ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Phenolic Compounds ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Experimental Colitis ◽  
Anal Pressure ◽  
Antioxidant Power ◽  
Significance Level ◽  
Sphincter Anal

AbstractDue to the ethnopharmacological use of Campsiandra laurifolia (Fabaceae), popularly known as Acapurana, to treat wounds and ulcers, associated with the lack of alternative treatments for intestinal inflammations such as ulcerative colitis (UC), the present work sought to characterize its phytochemical and antioxidant activities, and to evaluate remedial action in experimental colitis with acetic acid. Phytochemical analyzes were performed through qualitative and quantitative colorimetric tests of the main secondary metabolites. In the colitis model, 24 male Wistar rats aged ± 60 days old were used, divided into 4 groups: Control (CO) control + aqueous extract of C. laurifolia 50 mg/kg (CO + A50); Colitis (CL); and Colitis + aqueous extract of C. laurifolia 50 mg/kg (CL + A50). Measurement of sphincter anal pressure and histological tests of the large intestine, lipoperoxidation (LPO), enzyme activity of superoxide dismutase (SOD), and levels of glutathione (GSH) were performed. For statistical analysis, the oxidative stress (OS) results were expressed as means ± standard error, adopting a significance level of p < 0.05. The screening indicated the presence of flavonoids, saponins and tannins in the extract, with high levels of phenolic compounds and tannins, and was related to high antioxidant capacity. In the histological analysis, the CL group presented loss of the crypts, edema and inflammatory infiltrate. The use of C. laurifolia extract restructured the crypts, decreased edema and increased sphincter anal pressure, with a decrease in LPO, SOD, and an increase in GSH. It is suggested that the use of C. laurifolia extract reduces OS due to its antioxidant power conferred by the phenolic compounds present in the extract.

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