scholarly journals Biomarker Studies in Stress Biology: From the Gene to Population, from the Organism to the Application

Biology ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1340
Author(s):  
Marco F. L. Lemos

Endpoints assessed at the population or community level are most often the result of the sum of effects on individuals, arising from the effects at the cellular and molecular levels. Within this framework, these lower biological level endpoints are more responsive at an early stage of exposure, making them potential toolboxes to be used as early-warning markers to address stress. Given this, by linking responses and understanding organisms’ metabolism and physiology, the possibilities for the use of biomarkers in stress biology are vast. Here, biomarker comprehensive examples are given to enlighten the need to link levels of biological organization, and their usefulness for a myriad of fields and applications is presented and discussed.

Author(s):  
Wijitbusaba Marome ◽  
Rajib Shaw

Thailand has been affected by COVID-19, like other countries in the Asian region at an early stage, and the first case was reported as early as mid-January 2020. Thailand’s response to the COVID-19 pandemic has been guided by the “Integrated Plan for Multilateral Cooperation for Safety and Mitigation of COVID-19”. This paper analyses the health resources in the country and focuses on the response through community-level public health system and legislative measures. The paper draws some lessons on future preparedness, especially with respect to the four priorities of Sendai Framework for Disaster Risk Reduction. At the end, the paper puts some key learning for future preparedness. While Thailand’s response to COVID-19 has been effective in limiting the spread of the disease, it falls short at being able to address the multiple dimensions of the crisis such as the economic and social impacts. The socioeconomic sectors have been hardest hit, with significant impact on tourism sectors. Sociopolitical system also plays an important role in governance and decision-making for pandemic responses. The analysis suggests that one opportunity for enhancing resilience in Thailand is to strive for more multilevel governance that engages with various stakeholders and to support grassroots and community-level networks. The COVID-19 pandemic recovery is a chance to recover better while leaving no one behind. An inclusive long-term recovery plan for the various impacted countries needs to take a holistic approach to address existing gaps and work towards a sustainable society. Furthering the Health Emergency Disaster Risk Management (HEDRM) Framework may support a coordinated response across various linked sectors rather than straining one particular sector.


Author(s):  
Ning Huan ◽  
Enjian Yao ◽  
Binbin Li

Recently, surges of passengers caused by large gatherings, temporary traffic control measures, or other abnormal events have frequently occurred in metro systems. From the standpoint of the operation managers, the available information about these outside events is incomplete or delayed. Unlike regular peaks of commuting, those unforeseen surges pose great challenges to emergency organization and safety management. This study aims to assist managers in monitoring passenger flow in an intelligent manner so as to react promptly. Compared with the high cost of deploying multisensors, the widely adopted automated fare collection (AFC) system provides an economical solution for inflow monitoring from the application point of view. In this paper, a comprehensive framework for the early warning mechanism is established, including four major phases: data acquisition, preprocessing, off-line modeling, and on-line detection. For each station, passengers’ tapping-on records are gathered in real time, to be further transformed into a dynamic time series of inflow volumes. Then, a sequence decomposition model is formulated to highlight the anomaly by removing its inherent disturbances. Furthermore, a novel hybrid anomaly detection method is developed to monitor the variation of passenger flow, in which the features of inflow patterns are fully considered. The proposed method is tested by a numerical experiment, along with a real-world case study of Guangzhou metro. The results show that, for most cases, the response time for detection is within 5 min, which makes the surge phenomenon observable at an early stage and reminds managers to make interventions appropriately.


2019 ◽  
Vol 19 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Jian Huang ◽  
Theodoor Wouterus Johannes van Asch ◽  
Changming Wang ◽  
Qiao Li

Abstract. Gully-type debris flow induced by high-intensity and short-duration rainfall frequently causes great loss of properties and causalities in mountainous regions of southwest China. In order to reduce the risk by geohazards, early warning systems have been provided. A triggering index can be detected in an early stage by the monitoring of rainfall and the changes in physical properties of the deposited materials along debris flow channels. Based on the method of critical pore pressure for slope stability analysis, this study presents critical pore pressure threshold in combination with rainfall factors for gully-type debris flow early warning. The Wenjia gully, which contains an enormous amount of loose material, was selected as a case study to reveal the relationship between the rainfall and pore pressure by field monitoring data. A three-level early warning system (zero, attention, and warning) is adopted and the corresponding judgement conditions are defined in real time. Based on this threshold, there are several rainfall events in recent years have been validated in Wenjia gully, which prove that such a combined threshold may be a reliable approach for the early warning of gully-type debris flow to safeguard the population in the mountainous areas.


2019 ◽  
Vol 12 (3) ◽  
pp. 291-310
Author(s):  
Daniel Hagemann ◽  
Monika Wohlmann

Purpose The global financial and economic crisis resulting from the US housing crisis has shown that house prices can have far-reaching consequences for the real economy. For macroprudential supervision, it is, therefore, necessary to identify house price bubbles at an early stage to counteract speculative price developments and to ensure financial market stability. This paper aims to develop an early warning system to signal speculative price bubbles. Design/methodology/approach The results of explosivity tests are used to identify periods of excessive price increases in 18 industrialized countries. The early warning system is then based on a logit and an ordered logit regression, in which monetary, macroeconomic, regulatory, demographic and private factors are used as explanatory variables. Findings The empirical results show that monetary developments have the highest explanatory power for the existence of house price bubbles. Further, the study reveals currently emerging house price bubbles in Norway, Sweden and Switzerland. Practical implications The results implicate a new global housing boom, particularly in those countries that did not experience a major price correction during the global financial crisis. Originality/value The ordered logit model is an advanced approach that offers the advantage of being able to differentiate between different phases of a house price bubble, thereby allowing a multi-level assessment of the risk of speculative excesses in the housing market.


2011 ◽  
Vol 480-481 ◽  
pp. 841-844
Author(s):  
Dong Xing Wang ◽  
Su Chen

The most commonly used indoor fire extinguishing systems are automatic sprinkling fire extinguishing systems. However, such systems have disadvantages of difficult to maintenance and low in reliability. The design of a composite indoor fire distinguishing system has been proposed, which consists of a fixed fire early warning subsystem and a moveable fire detecting and extinguishing subsystem. The moveable fire detecting and extinguishing subsystem is established on an automated guided vehicle. The system is fully autonomic, robust, and easy to maintenance. In addition, it can promptly and precisely detect fire in its early stage, and extinguish it in time. Experiments have demonstrated that the system is applicable.


2006 ◽  
Vol 21 (S3) ◽  
pp. s62-s78 ◽  
Author(s):  

AbstractIntroduction:This Supplement is a Report of the Conference convened by the Regional Office for South East Asia (SEARO) of the World Health Organization (WHO). The Conference was a follow-up to the WHO Conference of May 2005 in Phuket, Thailand on the Earthquake and Tsunami of 26 December 2004. The invitational meeting brought together representatives of 11 countries impacted by the events. The goal of the Conference was to produce a plan of action that meets the specific needs of the countries and ensure that the countries of the Region will be better equipped to cope with any future event.Objectives:The objectives of the Conference were to: (1) identify gaps in the health needs of the affected and vulnerable populations for preparedness, responses, recovery, and rehabilitation; (2) determine the next steps in addressing these gaps; and (3) develop benchmarks and a corresponding framework for action that must be achieved to solidify the capacities and capabilities of the health sector to meet emergencies.Methods:Presentations of background papers, panel discussions, and Working Groups were used. Based, in part, on the materials presented, the Working Groups drafted benchmarks that could mark the progress in achieving the overall goal and proposed strategies that could be used to reach the benchmarks. Representatives of the participating countries summarized the current status of their respective countries relative to each of the defined benchmarks.Results:The benchmarks relate to: (1) legal framework for preparedness and response; (2) national disaster plan for preparedness and response; (3) budget; (4) rules of engagement for external actors; (5) community plan based on risk identification and vulnerability assessment; (6)community-based capacities; (7) local capacity for provision of essential services and supplies; (8) awareness and advocacy programs; (9) identification of hazards, risks, and vulnerabilities; (10) education and training; (11) “safe” health facilities; and (12) surveillance and early warning systems.There exists a wide range in the levels of preparedness at all levels in the affected countries particularly at the community level. The country representatives agreed that community-level preparedness, legal frameworks, local and national disaster plans, surveillance and early warning systems, and advocacy and awareness programs demand more attention.The strategies and mechanisms that will facilitate achievement of the benchmarks were grouped into seven categories: (1) monitoring, evaluation, surveillance, and assessments; (2) education and training (human resource development); (3) information and communications; (4) legislation, policies, and authority; (5) funding; (6) planning and preparedness; and (7) coordination and control. Any or all of the strategies suggested could be implemented by the countries in the Region.Conclusion:The Conference delivered an important set of benchmarks and strategies that, when implemented, will facilitate the countries and the communities within them reaching better levels of preparedness and response to future events. Attaining the benchmarks will decrease the number of lives lost and minimize the pain and suffering associated with such events.


2020 ◽  
Author(s):  
Pengbo Liu ◽  
Makoto Ibaraki ◽  
Jamie VanTassell ◽  
Kelly Geith ◽  
Matthew Cavallo ◽  
...  

ABSTRACTSARS-CoV-2 is a respiratory virus but it is also detected in a significant proportion of fecal samples of COVID-19 cases. Recent studies have shown that wastewater surveillance can be a low-cost tool for management of COVID-19 pandemic and tracking COVID-19 outbreaks in communities but most studies have been focusing on sampling from wastewater treatment plants. Institutional level of wastewater surveillance may serve well for early warning purposes since cases can be tracked and immediate action can be executed in the event of positive signal. In this study, a novel Moore swab method was developed and used for wastewater surveillance of COVID-19 at institutional level. Among the 219 swab samples tested, 28 (12.8%) swabs collected from the three campuses and two buildings were positive for SARS-CoV-2. Further individual clinical diagnosis validated the wastewater results and indicated that this method was sensitive enough to detect 1-2 cases in a building. In addition, comparison between grab and Moore swab methods from the hospital sewage line indicated that Moore swab method was more sensitive than the grab sampling method. These results suggest that the Moore swab is a sensitive, practical, and easy to use early warning tool for COVID-19 surveillance especially in low-resource settings and at an early stage of infection in communities.


2020 ◽  
Author(s):  
Sazzad Hossain ◽  
Hannah Cloke ◽  
Andrea Ficchì ◽  
Elisabeth Stephens

<p>There is high temporal variability in the occurrence of the monsoon floods in Bangladesh during the South Asian summer monsoon. Detailed flood forecast information about flood timing and duration can play a vital role in flood preparedness decisions. The objective of this study is to understand different stakeholder perceptions about existing forecasting tools and data, and how these can support preparedness and response activities. Forecast users can be divided into three broad categories-national, sub-national and community level. The stakeholders working at national level are involved in policy making while the sub-national level involved in implementation of policies.  In order to identify the appropriate lead-time for better flood preparedness and the challenges in communicating probabilistic forecasts to users, semi-structured interviews with key stakeholders involved in various sectors of flood disaster management at national and sub-national level, community level household surveys, focus group discussions and a national consultation workshop were undertaken during the 2019 monsoon.</p><p>It was found all major stakeholders working at national and sub-national levels are aware of the availability of forecasts and receive flood forecasts from the Flood Forecasting and Warning Centre (FFWC). However, about 40% of the respondents at the community do not receive forecast information. Before the flood event, policy level stakeholders need to know the availability of resources and preparedness at the sub-national level for better response activities. On the other hand, sub-national level stakeholders of different government agencies act as a bridge between policy level and the local community. Existing short-range forecasts cannot provide information about the potential flood duration which is essential for resources assessment, mobilization and preparedness activities.</p><p>People living in the floodplain are aware about the flood seasons as it is an annual phenomenon. However, they can anticipate floods events only 2 to 3 days beforehand based on the available early warning and their risk knowledge. This short-range forecast can be used for some basic household level response activities such as protecting household equipment or moving their livestock to a safer place. It is essential to know the actual duration and flood extent for their agricultural decisions such as understanding when to transplant young crops into the field. The study found that all stakeholders need forecast information with a lead-time between 15 to 20 days for better flood preparedness decisions. People are likely to have seen deterministic forecasts so far and are not used to probabilistic forecasts with multiple scenarios for a same event. However, national forecast bulletins may include probability of flooding events based on a threshold known as flood danger level. Capacity development of the local community is necessary to improve understanding of the probabilistic forecast and overcome communication challenges.</p><p> </p><p> </p>


Author(s):  
Michael Schorr ◽  
Klaas Kole ◽  
Ferdinand Foessing

Abstract For pipelines in the oil, gas, and mining industry, movement of pipelines is one of the main integrity hazards. This movement in most cases is caused by landslides instigated by heavy rain, earthquakes or volcanic activities. If the pipeline movement remains undetected at an early stage, it can lead to the need for costly repairs to prevent, remove, or repair potential or actual damage. Moreover, if the movements stay undetected for too long, these lines may fail and lead to catastrophic events. This paper will illustrate what a fast and cost-effective solution to avoid these threats at an early stage looks like and how it works. It will explain the process and demonstrate the full power of this technology on the basis of a case study. The standard solution for pipelines without a permanent position monitoring system at the time of installation includes the use of intelligent tools that are able to detect even the slightest changes in the trajectory. These inspection tools are quite expensive to run, especially when multiple screening runs are required throughout a year, e.g. before and after the rainy season or after a seismic event. Other monitoring solutions are either limited to only a specific area where the movement has already been detected at an earlier stage or lack the precision required to serve as an early warning system, such as LIDAR or satellite image comparison. Over the years, ROSEN has developed a technology that can bridge the gap between frequent measurements and cost-effective service. It is based on an electronic gyroscope that is commonly used in Inline Inspection tools but can also be installed in readily available cleaning tools. When first run in a pipeline, it records the whole pipeline trajectory, leaving no segment undocumented. The next step is to compare these recorded pipeline routing measurements with already existing trajectory baseline data, recorded earlier by any ILI tool with an optical gyro or similar. This comparison will reveal any deviation between both trajectories and precisely determine any pipeline movement. A case study will demonstrate how the comparison is achieved. When performing repetitive inspections, this screening comparison enables the operators to detect the onset of movements and monitor the progress of any known pipeline movement. It allows them to distinguish between stable areas from dynamic ground movements and keeps close track of changes in the pipe course. Through regular repetitions, any further development of the movement is tracked, and appropriate reactive measures can be scheduled in a timely manner. This new service provides a cost-effective and powerful early warning tool for geological pipeline integrity threats that can lead to loss of integrity, the asset, or — worst-case scenario — loss of life or environmental contamination, while at the same time, it reduces the necessity of pipeline intervention that will affect production.


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