scholarly journals Swallow syncope: Clinical presentation, diagnostic criteria, and therapeutic options

2014 ◽  
Vol 20 (4) ◽  
pp. 207 ◽  
Author(s):  
Mohit Girotra ◽  
Stephen Glasser ◽  
SudhirK Dutta ◽  
Shashank Garg
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
Therapeutic Options

scholarly journals Relapsing Polychondritis: An Updated Review

Biomedicines ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 84 ◽  
Author(s):  
Francesco Borgia ◽  
Roberta Giuffrida ◽  
Fabrizio Guarneri ◽  
Serafinella Cannavò
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Features ◽  
Functional Impairment ◽  
Clinical Presentation ◽  
Systemic Disease ◽  
Relapsing Polychondritis ◽  
Review Article ◽  
Therapeutic Options ◽  
Immune Mediated ◽  
Specific Symptoms

Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and/or polyarthritis represent the most common clinical features, but potentially all types of cartilage may be involved. Because of the pleomorphic nature of the disease, with non-specific symptoms at the onset, the diagnosis of relapsing polychondritis is often delayed. In this review article we provide a comprehensive look into clinical presentation, laboratory and instrumental investigations, diagnostic criteria, and therapeutic options.

Swallow Syncope: Clinical Presentation, Diagnostic Criteria and Therapeutic Options

2012 ◽  
Vol 107 ◽  
pp. S258
Author(s):  
Shashank Garg ◽  
Mohit Girotra ◽  
Stephen Glasser ◽  
Sudhir Dutta
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
Therapeutic Options

scholarly journals INCIDENCE AND CLINICAL SIGNIFICANCE OF HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA IN TURP SPECIFIMENS

2020 ◽  
pp. 1-5
Author(s):  
B. Pavan Kumar ◽  
Imran Ali ◽  
Anwar Miya ◽  
Kishan Kishan
Keyword(s):  
Diagnostic Criteria ◽  
Prostatic Carcinoma ◽  
Invasive Carcinoma ◽  
Clinical Presentation ◽  
Intraepithelial Neoplasia ◽  
Diagnostic Techniques ◽  
Transurethral Resection Of Prostate ◽  
Low Grade ◽  
High Grade ◽  
Precancerous Condition

BACKGROUND : PIN is a well known precancerous condition of prostatic carcinoma. Transurethral resection of prostate has become the most prominent and the easiest way, to morphologically evaluate lesions of PIN. But clinicians are sometimes confused by the grading that is given in the report. So there is a need to define the diagnostic criteria and differential diagnosis of PIN using newer diagnostic techniques to assist in the better diagnosis and grading. AIMS AND OBJECTIVES: To evaluate whether the diagnostic criteria can be defined PIN and using newer techniques for PIN grading to improve the clinical management of patients with prostatic lesions. MATERIALS AND METHODS: This study will be done in the Department of Pathology MGM Hospitals, Warangal for a period of 2 years and includes consecutive cases of TURP specimens from the patients who present with obstructive symptoms as a major clinical presentation and correlated with PSA levels. INCLULSION CRITERIA: Patients who present with obstructive symptoms as a major clinical presentation. RESULTS: 1.160 cases of TURP specimens were studied out of which 53 (33.12%) cases are PIN. BPH -78 (48/74%), PC-15 (9.37%), SM-14 (8.75%) 2. Majority cases are low grade PIN 34 out of 53 cases (21.25%) High Grade PIN 19 out of 53cases. (11.87%) 3. High Grade PIN and prostatic Carcinoma shared increased incidence and severity with advancing age in the study. Majority of HG PIN cases in our study noted in (70-79 years of age) 4. The risk of carcinoma is more in cases of High Grade PIN (68.42%) than in low grade PIN (17.64%) 5. This warrants are need for repeat prostatic biopsies to diagnose the invasive carcinoma in patient with High grade PIN.

scholarly journals Management of Brucellosis

1970 ◽  
Vol 3 (1) ◽  
pp. 16-20
Author(s):  
MA Samad Talukder ◽  
ARE Mohamed ◽  
MM Madkour ◽  
Thur Y Albaage
Keyword(s):  
Saudi Arabia ◽  
High Temperature ◽  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
High Titre ◽  
Agglutination Test ◽  
Joint Involvement ◽  
Slow Response ◽  
Adequate Therapy

Experiences with management of 140 (82 males and 58 females) patients of brucellosis is presented. The diagnostic criteria was based on clinical presentation (fever, joint pains) and high titre positive brucella agglutination test. Forty-four (31.4%) patients responded in 2-9 days as evidenced by high temperature coming to normal on receipt of adequate therapy by tetracycline alone or in combination with streptomycin or other drugs. Inappropriate antibiotic in inappropriate doses was given to 23 (16.4%) patients resulting in a slow response. More than half 73 (52%) were not treated as they did not attend for follow up for result of investigation or misdiagnosis. The complications were bone and joint involvement and endocarditis. To give adequate therapy and avoid complications any patient with pyrexia in Saudi Arabia should be investigated for brucellosis.DOI: http://dx.doi.org/10.3329/bjms.v3i1.8222BJMS 1996; 3(1): 16-20

Stiff Person Syndrome

2013 ◽  
Author(s):  
Aaron E. Miller ◽  
Teresa M. DeAngelis
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Features ◽  
Therapeutic Options ◽  
Stiff Person Syndrome ◽  
Muscular Rigidity ◽  
Unexplained Pain ◽  
Electrophysiological Tests

Stiff person syndrome is an important autoimmune mediated disorder to consider in patients with unexplained pain and muscular rigidity. We review the proposed diagnostic criteria, common clinical features, and important serologic and electrophysiological tests to aid in diagnosis as well as medical and rehabilitative therapeutic options. In addition, we discuss the identification and management of possible paraneoplastic presentations.

scholarly journals Differential Diagnosis of Pediatric Multiple Sclerosis

Children ◽  
2019 ◽  
Vol 6 (6) ◽  
pp. 75 ◽  
Author(s):  
Maria Milagros Galardi ◽  
Cristina Gaudioso ◽  
Saumel Ahmadi ◽  
Emily Evans ◽  
Laura Gilbert ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Differential Diagnosis ◽  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
Correct Diagnosis ◽  
Acute Disseminated Encephalomyelitis ◽  
Test Results ◽  
Pediatric Multiple Sclerosis ◽  
Ancillary Test ◽  
Spectrum Disorders

The differential diagnosis of pediatric multiple sclerosis (MS) can be broad and pose diagnostic challenges, particularly at initial presentation. Among demyelinating entities, neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibodies (MOG-ab) associated disorders, and acute disseminated encephalomyelitis (ADEM) are now well-known as unique disease processes and yet continue to overlap with MS in regards to clinical presentation and imaging. In non-inflammatory entities, such as metabolic disorders and leukodystrophies, an erroneous diagnosis of MS can be made even while applying appropriate diagnostic criteria. Knowing the epidemiology, typical clinical presentation, diagnostic criteria, and ancillary test results in each disease, can aid in making the correct diagnosis by contrasting these features with those of pediatric MS. Determining the correct diagnosis early, allows for efficient and effective treatment as well as appropriate prognostication.

Clinical characteristics and therapeutic options in hypnic headache

Cephalalgia ◽  
2010 ◽  
Vol 30 (12) ◽  
pp. 1435-1442 ◽  
Author(s):  
Dagny Holle ◽  
Steffen Naegel ◽  
Sarah Krebs ◽  
Zaza Katsarava ◽  
Hans-Christoph Diener ◽  
...  
Keyword(s):  
Side Effects ◽  
Effective Treatment ◽  
Diagnostic Criteria ◽  
Clinical Characteristics ◽  
Motor Behavior ◽  
International Headache Society ◽  
Treatment Options ◽  
Therapeutic Options ◽  
Individual Treatment ◽  
Hypnic Headache

Background: Hypnic headache (HH) is a rare primary headache disorder that is characterized by exclusively sleep-related headache attacks. Because of its low prevalence, clinical features and therapeutic options are widely unknown or under discussion. Methods: Twenty patients with HH were examined and interviewed using a standardized questionnaire in regard to their clinical characteristics and effective treatment regimens. Data were evaluated according to current International Headache Society (IHS) diagnostic criteria. Individual treatment history and effective treatment options were compared with expected efficacy based on current literature. Results: In conflict to current IHS criteria, 15% of patients reported trigemino-autonomic symptoms. All patients showed distinct motor behavior during their headache attacks. In acute pain attacks caffeine was most effective. Lithium, topiramate, melatonin, amitriptyline and indomethacin were sometimes useful prophylactic treatment options but were often associated with side effects. Conclusions: Our results underline the need for modification of the IHS diagnostic criteria of HH to better reflect the actual clinical characteristics of this headache. Caffeine should be considered as first-line acute therapy. Prophylactic medical treatment should be carefully evaluated in regard to side effects in this aged patient population, as this seems to be a major concern of patients apart from pure pain reduction.

Midcavitary Tako-Tsubo syndrome in cancer patients.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e14011-e14011 ◽  
Author(s):  
Dana Ionescu ◽  
Danielle Stone ◽  
James Stone ◽  
Jean-Bernard Durand ◽  
Juan Lopez-Mattei ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Patients ◽  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
Laboratory Data ◽  
Left Ventricular ◽  
Cardiac Biomarkers ◽  
Cancer Center ◽  
Published Data ◽  
Left Ventriculography

e14011 Background:Variants of the classic Tako-tsubo syndrome or stress induced cardiomyopathy (SC) includes mid ventricular or basal left ventricular wall motion abnormalities. Midcavitary dyskinesia and ballooning is considered a unique presentation, and there is no published data showing midcavitary involvement in cancer patients. Methods: All cancer patients who fulfilled the diagnostic criteria for SC at MD Anderson Cancer Center over a 6–year period were included in the study. We selected and retrospectively reviewed the medical records of 8 patients who had midcavitary SC. Clinical presentation, ECG, laboratory data, transthoracic echocardiogram and left ventriculography results were reviewed. Results: Out of30 cancer patients who fulfilled the diagnostic criteria for SC, 8 patients (26.7%) (4 females, 4 men, mean age 57.37 yo) had midcavitary SC. 62,5 % patients were diagnosed with a solid malignancy. Trigger factors for midcavitary SC were: systemic infection (3 patients with neutropenia), emotional stress (2 patients), chemotherapy (1 patient undergoing treatment with Ibrutinib), and surgical interventions (3 patients). Clinical presentation included chest pain (37.5%), shortness of breath (50%) and non specific symptoms (12.5%). T wave inversion was the most common electrocardiographic presentation (37.5 %), followed by ST elevation (25 %). All patients had changes of the cardiac biomarkers (BNP mean 2224. 4 pg/dl, TN I mean 2. 8 ng/dl, CK-MB mean 14 ng/dl) and significant LV dysfunction (LVEF < 50%). All patients underwent coronary angiography which showed no obstructive CAD; left ventriculography identified basilar and apical hyperkinesis and midventricular hypokinesia. Cancer therapy was interrupted; aspirin and beta blockers were initiated in all patients. The most common complications of midcavitary SC were: respiratory failure requiring intubation (37, 5%), pulmonary edema (25%), and hypotension (25%). No cardiac deaths were registered. None of the patients experienced recurrence of SC. Conclusions: Mid cavitary SC remains a rare entity, and raises further questions about the causal association between the mid cavitary involvement and cancer, and its impact on cancer therapy and overall survival in this cohort of patients.

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