scholarly journals Neuropsychological Sequelae, Quality of Life and Adaptive Behavior in Children and Adolescents with Anti-NMDAR Encephalitis: A Narrative Review

2021 ◽  
Vol 11 (11) ◽  
pp. 1387
Author(s):  
Samuela Tarantino ◽  
Roberto Averna ◽  
Claudia Ruscitto ◽  
Fabiana Ursitti ◽  
Michela Ada Noris Ferilli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Verbal Memory ◽  
Cognitive Skills ◽  
Motor Behavior ◽  
Young Patients ◽  
Recovery Phase ◽  
Neuropsychological Sequelae ◽  
Nmdar Encephalitis

Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a rare autoimmune illness characterized by a constellation of often severe, but treatable, psychiatric and neurological symptoms. Whereas symptoms such as psychosis and bizarre and abnormal motor behavior are common in adults, pediatric patients typically present with behavioral changes, irritability and sleep dysfunction. The recovery phase is usually slow and may be associated with longstanding adaptive, behavioral and neuropsychological problems. Very few studies explored the cognitive and adaptive sequelae in children with anti-NMDAR encephalitis. The present review article suggests that, although most children and adolescents return to their daily life and previous activities, they may have a low quality of life and show neuropsychological sequelae involving language, memory, especially verbal memory, and attentional resources, even after several months from the hospital discharge. In particular, the available results reveal difficulties in cognitive skills involving executive functions. This impairment is considered the “core” of the cognitive profile of young patients with anti-NMDAR encephalitis. On the other hand, some cognitive skills, such as general intelligence, show good overall recovery over time. Additional neuropsychological research evaluating larger samples, more homogenous methods and longitudinal studies is required.

A cross-sectional analysis of joint status and quality of life in children and adolescents with haemophilia in Romania

2017 ◽  
Vol 37 (S 01) ◽  
pp. S5-S8
Author(s):  
Delia Mihailov ◽  
Smaranda Arghirescu ◽  
Dan Poenaru ◽  
Jenel Patrascu ◽  
Cristina Ursu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Young Patients ◽  
Joint Damage ◽  
Health Condition ◽  
Joint Involvement ◽  
Age Group ◽  
International Consensus ◽  
Cross Sectional

Summary Background: Haemophilia is a congenital disorder of coagulation with high economic burden due to its requirement for an expensive, lifelong replacement therapy, with additional costs for the frequent complications and for the severe handicapping consequences. The objective of this cross-sectional study aimed at giving an insight into the health condition of young haemophiliacs in the absence of a regular prophylactic therapy. Methods: It was conducted on a heterogeneous group of 37 children and adolescents (4–24 years of age), with similar on demand therapeutic regimen, coming from the whole country, focusing on the joint status by using the Haemophila Joint Health Score (HJHS) system and on quality of life (QoL) by using the EQ-5D-3L-Y questionnaire. Results: The results revealed an impressive situation: 70.3 % with chronic arthropathy, 19 % with target joints, 69 % with multiple joint involvement, mainly elbow (41 %) and knee (34 %), joint damage starting in the age group 6–12 years (18.18 % arthropathy vs. 96 % in the age group above 12 years). Joint score (6.67 ± 7.92), gait score (0.75 ± 1.14) and HJHS (7.43 ± 8.78) were highly correlated (r = 0.7, p = 0.001) with the annualised bleeding rate ABR (16.2 ± 12.1). They impacted the QoL in all domains, also expressed by a VAS of 68.39 ± 21.6. Conclusion: We concluded that in the situation of an international consensus that prophylactic replacement can prevent cost-effectively and cost-efficiently the deleterious joint damages, our study is supporting the introduction even of secondary and tertiary prophylaxis in young patients in our country.

scholarly journals Positive Impact of Organized Physical Exercise on Quality of Life and Fatigue in Children and Adolescents With Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Filippo Spreafico ◽  
Francesco Barretta ◽  
Michele Murelli ◽  
Marco Chisari ◽  
Giovanna Gattuso ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Social Functioning ◽  
Positive Impact ◽  
Young Patients ◽  
Exercise Program ◽  
Well Being ◽  
Drop Out ◽  
Supervised Exercise

Background: Cancer and its treatment can cause serious health issues that impair physical and mental well-being in children and adolescents. Exercise may be a valid strategy for managing some symptoms, including fatigue. In the light of our experience, we provide further justification for including exercise as part of routine childhood cancer care.Methods: Forty-four children and adolescents who had solid cancers not contraindicating their movement were invited to join an in-hospital 6-week supervised exercise program, and asked afterwards to complete validated quality of life and fatigue scales. The program consisted of personalized workout sessions of aerobic, resistance and flexibility exercises. The results obtained on the scales were compared between 21 patients who engaged in the exercise program (GYM group) and 23 who refused (No-GYM group), examining the different dimensions of health-related quality of life (physical, emotional, cognitive, social) and fatigue (general, sleep/rest, cognitive) in the two groups.Results: Being diagnosed with cancer initially prompted all but one of the respondents to drop-out of previous routine exercise or sports although their continuation had not been contraindicated. After 6 weeks of exercise, the GYM group's scores for quality of life and fatigue showed a statistically significant better perceived emotional functioning, and a trend toward a better social functioning than in the No-GYM group.Conclusion: We suggest that exercise improves the satisfaction of children and adolescents with cancer with their physical, mental and social functioning. We would emphasize the potential benefits of general practitioners discussing and recommending exercise for their young patients with cancer.

scholarly journals Neuropsychiatric Aspects in a Patient Diagnosed with Frontotemporal Dementia: Clinical Case of Low Incidence and Prevalence Disease in Colombia

2021 ◽  
pp. 451-463
Author(s):  
Juliana Vergel Hernández ◽  
María Eugenia Barrera Robledo ◽  
Carlos Alberto Hurtado González ◽  
Carlos Steven Marmolejo Escobar ◽  
Sebastián Ospina Otalvaro ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Frontotemporal Dementia ◽  
Verbal Memory ◽  
Clinical Case ◽  
Motor Behavior ◽  
Neurocognitive Deficits ◽  
Neurobehavioral Disorders ◽  
Low Incidence ◽  
The Individual

Frontotemporal dementia (FTD) is a neuropsychiatric pathology characterized by dysfunctions in the frontal lobe of the brain, especially in planning, execution, and inhibition tasks, with an inability to make decisions and handle different sequences, also affecting the temporal lobe. The patient presents alterations to store, consolidate, and recall information. These neurocognitive deficits are accompanied by neurobehavioral disorders such as depression, anxiety, and apathy that contribute to the worsening of the quality of life, with a high impact on the individual, social, and family level. To identify the neurobehavioral disorders and neurocognitive deterioration that present a patient diagnosed with FTD: clinical case of low incidence and prevalence disease in Colombia. A 40-year-old man, with progressive deterioration of his immediate verbal memory, low verbal fluency, aberrant motor behavior, sexual impulsivity, alterations in his executive functions, especially in planning tasks, decision-making, and inhibition was found to have a lesser degree of affectation in his visuospatial functioning and visuoconstructive abilities. It was found that the patient presents a severe dysexecutive syndrome associated with a clinical picture of FTD, correlated with an inability to process and recall information, accompanied by disorders such as depression, anxiety, and apathy. It is necessary to generate a functional neurorehabilitation plan that aims to improve the quality of life in these patients. In the same way, it is necessary to create new lines of research and intervention that have the purpose to create a greater field of heuristics or new questions in this type of neurodegenerative pathologies.

scholarly journals Health-Related Quality of Life of Children and Adolescents With Congenital Hyperinsulinism – A Scoping Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaja Kristensen ◽  
Julia Quitmann ◽  
Stefanie Witt
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Scoping Review ◽  
Young Patients ◽  
Congenital Hyperinsulinism ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

IntroductionDespite improvements in diagnosis and therapeutic advances in treatment, congenital hyperinsulinism (CHI) remains a severe disease with high patient impairment. We aimed to review the literature on Health-related Quality of Life in children and adolescents with congenital hyperinsulinism and summarize the findings.Materials and MethodsFor this scoping review, a literature search was conducted in PubMed and Web of Science in May 2021. Inclusion and exclusion criteria for the selection of articles were defined a priori.ResultsTwo hundred and forty-five (245) articles were identified through the search and screened on the basis of title and abstract. The full texts of forty articles were then assessed. Finally, four articles (published 2012-2020) describing Health-related Quality of Life in children and adolescents with congenital hyperinsulinism were included. The study designs were heterogeneous and included cross-sectional observational studies (n=2), clinical trials (n =1), and case reports (n=1) with different sample sizes. Three studies were conducted in European countries and one in Japan. The results for Health-related Quality of Life revealed inconsistencies.ConclusionThere are only a few studies looking at Health-related Quality of Life in children and adolescents with congenital hyperinsulinism. To gain a comprehensive understanding of the impact of congenital hyperinsulinism on Health-related Quality of Life in children and adolescents, it is necessary to use both generic and condition-specific instruments to measure Health-related Quality of Life of young patients in larger samples, to collect longitudinal data, and to consider qualitative research approaches.

Particularities of tinnitus in children and adolescents

ORL ro ◽  
2016 ◽  
Vol 4 (1) ◽  
pp. 40-42
Author(s):  
Alexandra Boloș ◽  
Sebastian Cozma ◽  
Andreea Silvana Szalontay
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Children And Adolescents ◽  
Psychological Factors ◽  
Ambient Noise ◽  
Psychological Consequences ◽  
Therapeutic Approaches

Tinnitus is a common otologic symptom and probably the most troublesome. Tinnitus causes a number of physical and psychological consequences, that interfere with the quality of life of the patient. Many authors believe that the presence of tinnitus in children is a matter of lesser importance than in adults because it is met less frequently and would be a fleeting symptom, inoffensive for them (Graham, 1981). In addition, the prevalence of tinnitus during adolescence and even in young adults is increasing, possibly as a consequence of the increased ambient noise (Bulbul SF, Shargorodsky J). Various therapeutic approaches have generated different results, which led us to consider the role of psychological factors, hence the need to underline the particularities of this symptom in childhood.  

Impact of the COVID-19 Pandemic on the Mental Health and Quality of Life of Children and Adolescents

2020 ◽  
Author(s):  
Ulrike Ravens-Sieberer ◽  
Anne Wüstner ◽  
Christiane Otto ◽  
Michael Erhart ◽  
Janine Devine ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Children And Adolescents
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