scholarly journals Artificial Intelligence in Lung Cancer Pathology Image Analysis

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1673 ◽  
Author(s):  
Shidan Wang ◽  
Donghan M. Yang ◽  
Ruichen Rong ◽  
Xiaowei Zhan ◽  
Junya Fujimoto ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Lung Cancer ◽  
Image Analysis ◽  
Deep Learning ◽  
Digital Pathology ◽  
Diagnosis And Prognosis ◽  
Model Interpretation ◽  
Lung Cancer Diagnosis ◽  
Cancer Pathology ◽  
Pathology Image

Objective: Accurate diagnosis and prognosis are essential in lung cancer treatment selection and planning. With the rapid advance of medical imaging technology, whole slide imaging (WSI) in pathology is becoming a routine clinical procedure. An interplay of needs and challenges exists for computer-aided diagnosis based on accurate and efficient analysis of pathology images. Recently, artificial intelligence, especially deep learning, has shown great potential in pathology image analysis tasks such as tumor region identification, prognosis prediction, tumor microenvironment characterization, and metastasis detection. Materials and Methods: In this review, we aim to provide an overview of current and potential applications for AI methods in pathology image analysis, with an emphasis on lung cancer. Results: We outlined the current challenges and opportunities in lung cancer pathology image analysis, discussed the recent deep learning developments that could potentially impact digital pathology in lung cancer, and summarized the existing applications of deep learning algorithms in lung cancer diagnosis and prognosis. Discussion and Conclusion: With the advance of technology, digital pathology could have great potential impacts in lung cancer patient care. We point out some promising future directions for lung cancer pathology image analysis, including multi-task learning, transfer learning, and model interpretation.

scholarly journals ARTIFICIAL INTELLIGENCE AND NEXT GENERATION PATHOLOGY: TOWARDS PERSONALIZED MEDICINE

2021 ◽  
Vol 65 (2) ◽  
Author(s):  
Oleksandr Dudin ◽  
◽  
Ozar Mintser ◽  
Oksana Sulaieva ◽  
◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Image Analysis ◽  
Deep Learning ◽  
Personalized Medicine ◽  
Digital Pathology ◽  
Automated Image Analysis ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Wide Range

Introduction. Over the past few decades, thanks to advances in algorithm development, the introduction of available computing power, and the management of large data sets, machine learning methods have become active in various fields of life. Among them, deep learning possesses a special place, which is used in many spheres of health care and is an integral part and prerequisite for the development of digital pathology. Objectives. The purpose of the review was to gather the data on existing image analysis technologies and machine learning tools developed for the whole-slide digital images in pathology. Methods: Analysis of the literature on machine learning methods used in pathology, staps of automated image analysis, types of neural networks, their application and capabilities in digital pathology was performed. Results. To date, a wide range of deep learning strategies have been developed, which are actively used in digital pathology, and demonstrated excellent diagnostic accuracy. In addition to diagnostic solutions, the integration of artificial intelligence into the practice of pathomorphological laboratory provides new tools for assessing the prognosis and prediction of sensitivity to different treatments. Conclusions: The synergy of artificial intelligence and digital pathology is a key tool to improve the accuracy of diagnostics, prognostication and personalized medicine facilitation

scholarly journals Current Trends of Artificial Intelligence for Colorectal Cancer Pathology Image Analysis: A Systematic Review

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1884 ◽  
Author(s):  
Nishant Thakur ◽  
Hongjun Yoon ◽  
Yosep Chong
Keyword(s):  
Artificial Intelligence ◽  
Colorectal Cancer ◽  
Systematic Review ◽  
Image Analysis ◽  
State Of The Art ◽  
The State ◽  
Cochrane Library ◽  
Routine Practice ◽  
Cancer Pathology ◽  
Pathology Image

Colorectal cancer (CRC) is one of the most common cancers requiring early pathologic diagnosis using colonoscopy biopsy samples. Recently, artificial intelligence (AI) has made significant progress and shown promising results in the field of medicine despite several limitations. We performed a systematic review of AI use in CRC pathology image analysis to visualize the state-of-the-art. Studies published between January 2000 and January 2020 were searched in major online databases including MEDLINE (PubMed, Cochrane Library, and EMBASE). Query terms included “colorectal neoplasm,” “histology,” and “artificial intelligence.” Of 9000 identified studies, only 30 studies consisting of 40 models were selected for review. The algorithm features of the models were gland segmentation (n = 25, 62%), tumor classification (n = 8, 20%), tumor microenvironment characterization (n = 4, 10%), and prognosis prediction (n = 3, 8%). Only 20 gland segmentation models met the criteria for quantitative analysis, and the model proposed by Ding et al. (2019) performed the best. Studies with other features were in the elementary stage, although most showed impressive results. Overall, the state-of-the-art is promising for CRC pathological analysis. However, datasets in most studies had relatively limited scale and quality for clinical application of this technique. Future studies with larger datasets and high-quality annotations are required for routine practice-level validation.

Deep learning in digital pathology image analysis: a survey

2020 ◽  
Vol 14 (4) ◽  
pp. 470-487
Author(s):  
Shujian Deng ◽  
Xin Zhang ◽  
Wen Yan ◽  
Eric I-Chao Chang ◽  
Yubo Fan ◽  
...  
Keyword(s):  
Image Analysis ◽  
Deep Learning ◽  
Digital Pathology ◽  
Pathology Image

Research on CT Scan Image of Lung Cancer Based on Deep Learning Method in Artificial Intelligence Field

2020 ◽  
Vol 10 (4) ◽  
pp. 934-939
Author(s):  
Xiaochen Yi ◽  
Zongze Sun ◽  
Baolong Yu ◽  
Munan Yang ◽  
Zhuo Zhang
Keyword(s):  
Artificial Intelligence ◽  
Lung Cancer ◽  
Deep Learning ◽  
Cancer Diagnosis ◽  
Lung Nodule ◽  
Three Dimensional ◽  
Image Data ◽  
Heat Map ◽  
Lung Cancer Diagnosis ◽  
Nodule Detection

Cancer is one of the diseases with high mortality in the 21st century, and lung cancer ranks first in all cancer morbidity and mortality. In recent years, with the rise of big data and artificial intelligence, lung cancer-assisted diagnosis based on deep learning has gradually become A popular research topic. Computer-aided lung cancer diagnosis technology is mainly the process of processing and analyzing the lung image data obtained by medical instrument imaging. The process is summarized into four steps: medical image data preprocessing, lung parenchymal segmentation, lung Nodule detection and segmentation, as well as lesion diagnosis. In order to solve the problem that the two-dimensional image model is not applicable to three-dimensional images, this paper proposes a three-dimensional convolutional neural network model suitable for lung cancer diagnosis. The model consists of two parts. The first part is a three-dimensional deep nodule detection network (FCN) model, which generates a heat map of the lung nodules. We can locate the locations of those malignant nodules through the heat map. According to the heat map generated in the first part, the second part selects those malignant nodules that are likely to be large, and then fuses the features of these selected nodules into one feature vector, showing the whole lung scan. Finally, we use this feature to classify and determine whether we have lung cancer.

Computer-Aided Lung Cancer Diagnosis Approaches Based on Deep Learning

2018 ◽  
Vol 30 (1) ◽  
pp. 90 ◽  
Author(s):  
Peng Zhang ◽  
Xinnan Xu ◽  
Hongwei Wang ◽  
Yuanli Feng ◽  
Haozhe Feng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Deep Learning ◽  
Cancer Diagnosis ◽  
Lung Cancer Diagnosis ◽  
Computer Aided

Future of biomarker evaluation in the realm of artificial intelligence algorithms: application in improved therapeutic stratification of patients with breast and prostate cancer

2021 ◽  
pp. jclinpath-2020-207351
Author(s):  
Jenny Fitzgerald ◽  
Debra Higgins ◽  
Claudia Mazo Vargas ◽  
William Watson ◽  
Catherine Mooney ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Artificial Intelligence ◽  
Patient Outcome ◽  
Image Analysis ◽  
High Throughput Screening ◽  
Personalised Medicine ◽  
Digital Pathology ◽  
Disease Stage ◽  
Breast And Prostate Cancer ◽  
Biomarker Evaluation

Clinical workflows in oncology depend on predictive and prognostic biomarkers. However, the growing number of complex biomarkers contributes to costly and delayed decision-making in routine oncology care and treatment. As cancer is expected to rank as the leading cause of death and the single most important barrier to increasing life expectancy in the 21st century, there is a major emphasis on precision medicine, particularly individualisation of treatment through better prediction of patient outcome. Over the past few years, both surgical and pathology specialties have suffered cutbacks and a low uptake of pathology specialists means a solution is required to enable high-throughput screening and personalised treatment in this area to alleviate bottlenecks. Digital imaging in pathology has undergone an exponential period of growth. Deep-learning (DL) platforms for hematoxylin and eosin (H&E) image analysis, with preliminary artificial intelligence (AI)-based grading capabilities of specimens, can evaluate image characteristics which may not be visually apparent to a pathologist and offer new possibilities for better modelling of disease appearance and possibly improve the prediction of disease stage and patient outcome. Although digital pathology and AI are still emerging areas, they are the critical components for advancing personalised medicine. Integration of transcriptomic analysis, clinical information and AI-based image analysis is yet an uncultivated field by which healthcare professionals can make improved treatment decisions in cancer. This short review describes the potential application of integrative AI in offering better detection, quantification, classification, prognosis and prediction of breast and prostate cancer and also highlights the utilisation of machine learning systems in biomarker evaluation.

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