scholarly journals A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1480
Author(s):  
Elisa Rodrigues Sousa ◽  
Eugenio Zoni ◽  
Sofia Karkampouna ◽  
Federico La Manna ◽  
Peter C. Gray ◽  
...  
Keyword(s):  
Bibliometric Analysis ◽  
Scientific Literature ◽  
Stem Cell Differentiation ◽  
Tissue Growth ◽  
Growth And Remodeling ◽  
Comprehensive Overview ◽  
Critical Knowledge ◽  
Physiological Processes ◽  
First Time ◽  
Glucose Regulated Protein

Cripto is a small glycosylphosphatidylinisitol (GPI)-anchored and secreted oncofetal protein that plays important roles in regulating normal physiological processes, including stem cell differentiation, embryonal development, and tissue growth and remodeling, as well as pathological processes such as tumor initiation and progression. Cripto functions as a co-receptor for TGF-β ligands such as Nodal, GDF1, and GDF3. Soluble and secreted forms of Cripto also exhibit growth factor-like activity and activate SRC/MAPK/PI3K/AKT pathways. Glucose-Regulated Protein 78 kDa (GRP78) binds Cripto at the cell surface and has been shown to be required for Cripto signaling via both TGF-β and SRC/MAPK/PI3K/AKT pathways. To provide a comprehensive overview of the scientific literature related to Cripto, we performed, for the first time, a bibliometric analysis of the biological roles of Cripto as reported in the scientific literature covering the last 10 years. We present different fields of knowledge in comprehensive areas of research on Cripto, ranging from basic to translational research, using a keyword-driven approach. Our ultimate aim is to aid the scientific community in conducting targeted research by identifying areas where research has been conducted so far and, perhaps more importantly, where critical knowledge is still missing.

scholarly journals Osteopathic empirical research: a bibliometric analysis from 1966 to 2018

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chantal Morin ◽  
Isabelle Gaboury
Keyword(s):  
Bibliometric Analysis ◽  
Empirical Research ◽  
Scientific Literature ◽  
Case Reports ◽  
Empirical Studies ◽  
Body Part ◽  
The United States ◽  
Mesh Terms ◽  
Research Designs ◽  
System Body

Abstract Background Despite the increasing use of osteopathy, a manipulative complementary and alternative medicine therapy, in the general population, its efficacy continues to be debated. In this era of evidence-based practice, no studies have previously reviewed the scientific literature in the field to identify published knowledge, trends and gaps in empirical research. The aims of this bibliometric analysis are to describe characteristics of articles published on the efficacy of osteopathic interventions and to provide an overall portrait of their impacts in the scientific literature. Methods A bibliometric analysis approach was used. Articles were identified with searches using a combination of relevant MeSH terms and indexing keywords about osteopathy and research designs in MEDLINE and CINAHL databases. The following indicators were extracted: country of primary author, year of publication, journals, impact factor of the journal, number of citations, research design, participants’ age group, system/body part addressed, primary outcome, indexing keywords and types of techniques. Results A total of 389 articles met the inclusion criteria. The number of empirical studies doubled every 5 years, with the United States, Italy, Spain, and United Kingdom being the most productive countries. Twenty-three articles were cited over 100 times. Articles were published in 103 different indexed journals, but more than half (53.7%) of articles were published in one of three osteopathy-focused readership journals. Randomized control trials (n = 145; 37.3%) and case reports (n = 142; 36.5%) were the most common research designs. A total of 187 (48.1%) studies examined the effects of osteopathic interventions using a combination of techniques that belonged to two or all of the classic fields of osteopathic interventions (musculoskeletal, cranial, and visceral). Conclusion The number of osteopathy empirical studies increased significantly from 1980 to 2014. The productivity appears to be very much in sync with practice development and innovations; however, the articles were mainly published in osteopathic journals targeting a limited, disciplinary-focused readership.

scholarly journals Bibliometric Analysis of Global Scientific Literature on effects of COVID-19 Pandemic on Mental Health

2021 ◽  
pp. 102753
Author(s):  
Tosin Yinka Akintunde ◽  
Taha Hussein Musa ◽  
Hassan Hussein Musa ◽  
Idriss Hussein Musa ◽  
Chen Shaojun ◽  
...  
Keyword(s):  
Mental Health ◽  
Bibliometric Analysis ◽  
Scientific Literature

Possible Causes in Breaking of Dental Implants Research

2017 ◽  
Vol 907 ◽  
pp. 104-118
Author(s):  
Maria Stoicănescu ◽  
Eliza Buzamet ◽  
Dragos Vladimir Budei ◽  
Valentin Craciun ◽  
Roxana Budei ◽  
...  
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Scientific Literature ◽  
Surface Characteristics ◽  
Raw Material ◽  
New Materials ◽  
Materials Used ◽  
Type Of Failure ◽  
First Time ◽  
Consequent Increase

Dental implants are becoming increasingly used in current dental practice. This increased demand has motivated manufacturers to develop varieties of product through design, but also looking for new materials used to improve surface characteristics in order to obtain a better osseointegration. But the increase in the use of implants goes to a consequent increase in the number of failures. These failures are caused either by treatment complications (peri-implantitis), by fatigue breakage under mechanical over-stress, by defective raw material, or due to errors during the insertion procedures. Although they are rare, these complications are serious in dentistry. Before to market a dental implant to clinical practitioners, the product is validated among other determinations in number of biocompatibility research. Raw material issues, details about its structure and properties are less published by the scientific literature, but all this are subject of a carefully analysis of the producers. Breaking of dental implants during surgical procedures, during the prosthetic procedures or during use (chewing, bruxism, accidents, etc.), is the second most common cause of loss of an implant after consecutive peri-implantitis rejection. Although the frequency of this type of failure for a dental implant is much smaller than those caused by the peri-implantitis, a detailed study of broken implants can explain possible causes. The use of scanning electron microscopy (SEM) in the study of the cleave areas explain the production mechanism of cleavages, starting from micro-fissures in the alloy used for the production of dental implants. These micro-fissures in weak areas of the implant (anti-rotational corners of the polygons, etc.) could generate a serious risk of cleavage first time when a higher force is applied.

scholarly journals Propiedades psicométricas de la Escala de Interacción en las Clases Dirigidas (EICD)

2016 ◽  
Vol 12 (3) ◽  
pp. 840 ◽  
Author(s):  
Adrián Pastor-Barceló ◽  
Vicente Prado-Gascó ◽  
Pilar Bustillo-Casero
Keyword(s):  
Design Methodology ◽  
Scientific Literature ◽  
Small Sample ◽  
Improve Quality ◽  
Validity And Reliability ◽  
Final Version ◽  
First Time ◽  
To Receive ◽  
Insight Into

Purpose: This research focuses on the construction and validation of a scale designed to assess the quality of the supervised classes: Interaction on Supervised Classes Scale (ISCS).Design/methodology/approach: This is a descriptive correlational study. For the construction of the scale three phases were performed in which different experts assessed the adequacy of the items. Finally, the psychometric properties of the final version were studied in a sample of 314 consumers (69.1% women) aged between 18 and 77 with an average of 39.33 years (SD=12.25).Findings: The scale presents adequate validity and reliability, being a useful tool for measuring the interaction in Supervised Classes.Research limitations/implications: The sampling, non-probabilistic or convenience, have taken the sample of a unique sports facility and the small sample size.Practical implications: The ISCS allows managers to receive better feedback, allowing them to obtain deeper insight into the quality and satisfaction of the service. According to its results, the managers may implement different strategies to improve quality in a key service within sports centers.Originality/value: For the first time the interaction between customers and between customers and employees is evaluated both inside and outside the center, a topic that had not yet been studied in the scientific literature. The scale can be applied to any type of directed activity, and will allow a greater understanding of the quality of service.

scholarly journals Redescription of Centronia melanitis Hübner, 1818 (Lepidoptera: Arctiinae: Arctiini: Ctenuchina) with notes on androconial organs

2021 ◽  
Vol 3 ◽  
pp. ec03029
Author(s):  
Juan Grados ◽  
Karla Mantilla
Keyword(s):  
Scientific Literature ◽  
Sexual Attraction ◽  
Museum Collections ◽  
First Time

The Neotropical genus Centronia Hübner, 1818 is monotypic and represented by the species Centronia melanitis Hübner, 1818. Individuals of this species display diurnal habits and are attracted by plant bait of Heliotropium sp.. Specimens of Centronia are very rare in museum collections. The present study, notes are provided for the male specimens and the first time the female is mentioned in the scientific literature. The presence of androconial organs in Centronia melanitis and other species of Ctenuchina is hypothesized to be related to the visits to pyrrolizidine sources and their role in the pheromones production and the sexual attraction for mating.

scholarly journals Review: The Effects of Supersonic Aviation on Ozone and Climate

Aerospace ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 41
Author(s):  
Sigrun Matthes ◽  
David S. Lee ◽  
Ruben Rodriguez De De Leon ◽  
Ling Lim ◽  
Bethan Owen ◽  
...  
Keyword(s):  
Emission Scenario ◽  
Scientific Literature ◽  
Global Climate ◽  
Comprehensive Overview ◽  
Climate Effect ◽  
Regulatory Issues ◽  
Future Studies ◽  
Climate Effects ◽  
Supersonic Transport ◽  
Quantitative Estimates

When working towards regulation of supersonic aviation, a comprehensive understanding of the global climate effect of supersonic aviation is required in order to develop future regulatory issues. Such research requires a comprehensive overview of existing scientific literature having explored the climate effect of aviation. This review article provides an overview on earlier studies assessing the climate effects of supersonic aviation, comprising non-CO2 effects. An overview on the historical evaluation of research focussing on supersonic aviation and its environmental impacts is provided, followed by an overview on concepts explored and construction of emission inventories. Quantitative estimates provided for individual effects are presented and compared. Subsequently, regulatory issues related to supersonic transport are summarised. Finally, requirements for future studies, e.g., in emission scenario construction or numerical modelling of climate effects, are summarised and main conclusions discussed.

scholarly journals The growth of interest for astronomical X-ray polarimetry

2018 ◽  
Author(s):  
Frédéric Marin
Keyword(s):  
Quantitative Assessment ◽  
Supernova Remnant ◽  
Scientific Literature ◽  
High Energy ◽  
X Ray ◽  
Highly Sensitive ◽  
In The Beginning ◽  
First Time

Astronomical X-ray polarimetry was first explored in the end of the 60's by pioneering rocket instruments. The craze arising from the first discoveries on stellar and supernova remnant X-ray polarization led to the addition of X-ray polarimeters on-board of early satellites. Unfortunately, the inadequacy of the diffraction and scattering technologies required to measure polarization with respect to the constraints driven by X-ray mirrors and detectors, coupled to long integration times, slowed down the field for almost 40 years. Thanks to the development of new, highly sensitive, compact X-ray polarimeters in the beginning of the 2000's, the possibility to observe astronomical X-ray polarization is rising again and scientists are now ready to explore the high energy sky thanks to modern X-ray polarimeters. In the forthcoming years, several X-ray missions (both rockets, balloons and satellites) will open a new observational windows. A wind of renewal blows over the area of X-ray polarimetry and this paper presents for the first time a quantitative assessment, all based on scientific literature, of the growth of interest for astronomical X-ray polarimetry.

scholarly journals Identification and functional characterization of the Piezo1 channel pore domain

2020 ◽  
pp. jbc.RA120.015905
Author(s):  
Elena D Nosyreva ◽  
David Thompson ◽  
Ruhma Syeda
Keyword(s):  
Functional Characterization ◽  
Functional Study ◽  
Heat Sensation ◽  
Physiological Processes ◽  
Structural Details ◽  
Functional Understanding ◽  
And Function ◽  
Downstream Processes ◽  
Pore Domain ◽  
First Time

Mechanotransduction is the process by which cells convert physical forces into electro-chemical responses. On a molecular scale these forces are detected by mechanically activated ion channels, which constitute the basis for hearing, touch, pain, cold and heat sensation amongst other physiological processes. Exciting high-resolution structural details of these channels are currently emerging that will eventually allow us to delineate the molecular determinants of gating and ion permeation. However, our structural-functional understanding across the family remains limited. Piezo1 is one of the largest and least understood of these channels, with various structurally identified features within its trimeric assembly. This study seeks to determine the modularity and function of Piezo1 channels by constructing deletion proteins guided by cryo EM structural knowledge. Our comprehensive functional study identified, for the first time, the minimal amino acid sequence of the full-length Piezo1 that can fold and function as the channel’s pore domain between E2172 and the last residue E2547. While, the addition of an anchor region has no effect on permeation properties. The Piezo1 pore domain is not pressure sensitive and the appending of Piezo Repeat-A did not restore pressure-dependent gating, hence the sensing module must exist between residues 1-1952. Our efforts delineating the permeation and gating regions within this complex ion channel have implications in identifying small molecules that exclusively regulate the activity of the channel’s pore module to influence mechanotransduction and downstream processes.

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