scholarly journals The Inducible Role of Ambient Particulate Matter in Cancer Progression via Oxidative Stress-Mediated Reactive Oxygen Species Pathways: A Recent Perception

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2505 ◽  
Author(s):  
Chiang-Wen Lee ◽  
Thi Thuy Tien Vo ◽  
Ching-Zong Wu ◽  
Miao-Ching Chi ◽  
Chieh-Mo Lin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Cancer Progression ◽  
Fine Particulate Matter ◽  
Small Diameter ◽  
Premature Death ◽  
Fine Particulate ◽  
Underlying Mechanisms ◽  
The Relationship

Cancer is one of the leading causes of premature death and overall death in the world. On the other hand, fine particulate matter, which is less than 2.5 microns in aerodynamic diameter, is a global health problem due to its small diameter but high toxicity. Accumulating evidence has demonstrated the positive associations between this pollutant with both lung and non-lung cancer processes. However, the underlying mechanisms are yet to be elucidated. The present review summarizes and analyzes the most recent findings on the relationship between fine particulate matter and various types of cancer along with the oxidative stress mechanisms as its possible carcinogenic mechanisms. Also, promising antioxidant therapies against cancer induced by this poison factor are discussed.

scholarly journals Fine Particulate Matter Leads to Unfolded Protein Response and Shortened Lifespan by Inducing Oxidative Stress in C. elegans

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Yunli Zhao ◽  
Ling Jin ◽  
Yuxin Chi ◽  
Jing Yang ◽  
Quan Zhen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Metabolic Enzyme ◽  
C Elegans ◽  
Unfolded Protein ◽  
Fine Particulate ◽  
Underlying Mechanisms ◽  
Protein Response ◽  
Phenylbutyric Acid

Oxidative stress has been proven as one of the most critical regulatory mechanisms involved in fine Particulate Matter- (PM2.5-) mediated toxicity. For a better understanding of the underlying mechanisms that enable oxidative stress to participate in PM2.5-induced toxic effects, the current study explored the effects of oxidative stress induced by PM2.5 on UPR and lifespan in C. elegans. The results implicated that PM2.5 exposure induced oxidative stress response, enhanced metabolic enzyme activity, activated UPR, and shortened the lifespan of C. elegans. Antioxidant N-acetylcysteine (NAC) could suppress the UPR through reducing the oxidative stress; both the antioxidant NAC and UPR inhibitor 4-phenylbutyric acid (4-PBA) could rescue the lifespan attenuation caused by PM2.5, indicating that the antioxidant and moderate proteostasis contribute to the homeostasis and adaptation to oxidative stress induced by PM2.5.

Role of oxidative stress and DNA hydroxymethylation in the neurotoxicity of fine particulate matter

Toxicology ◽  
2017 ◽  
Vol 380 ◽  
pp. 94-103 ◽  
Author(s):  
Hongying Wei ◽  
Yan Feng ◽  
Fan Liang ◽  
Wei Cheng ◽  
Xiaomeng Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Dna Hydroxymethylation ◽  
Fine Particulate

scholarly journals Effects of ambient PM2.5and 9-nitroanthracene on DNA damage and repair, oxidative stress and metabolic enzymes in the lungs of rats

2017 ◽  
Vol 6 (5) ◽  
pp. 654-663 ◽  
Author(s):  
Ruijin Li ◽  
Lifang Zhao ◽  
Li Zhang ◽  
Minghui Chen ◽  
Jing Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Dna Damage ◽  
Particulate Matter ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Fine Particulate Matter ◽  
Complex Mixture ◽  
Dna Damage And Repair ◽  
Fine Particulate

Ambient fine particulate matter (PM2.5) is a complex mixture associated with lung cancer risk.

The relationship between fine particulate matter (PM2.5) and schizophrenia severity

2018 ◽  
Vol 91 (5) ◽  
pp. 613-622 ◽  
Author(s):  
Rika Eguchi ◽  
Daisuke Onozuka ◽  
Kouji Ikeda ◽  
Kenji Kuroda ◽  
Ichiro Ieiri ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate ◽  
The Relationship
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