scholarly journals The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5933
Author(s):  
Marta Puzzono ◽  
Alessandro Mannucci ◽  
Simone Grannò ◽  
Raffaella Alessia Zuppardo ◽  
Andrea Galli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Young Adults ◽  
Early Onset ◽  
Current Evidence ◽  
Exogenous Factors ◽  
Diet And Lifestyle ◽  
Early Onset Colorectal Cancer

The incidence of early-onset colorectal cancer, defined as colorectal cancer occurring in young adults under the age of 50, is increasing globally. Knowledge of the etiological factors in young adults is far from complete. Questionable eoCRCs’ exogenous factors are represented by processed meat, sugary drinks, alcohol, Western dietary pattern, overweight and obesity, physical inactivity, and smoking, though with heterogeneous results. Therefore, we performed a systematic review to summarize the current evidence on the role of diet and lifestyle as eoCRC risk factors. We systematically searched PubMed, Scopus, and EMBASE up to July 2021, for original studies evaluating diet, alcohol, physical activity, BMI, and smoking in eoCRC and included twenty-six studies. Indeed, the exogenous factors could represent modifiable key factors, whose recognition could establish areas of future interventions through public health strategies for eoCRC primary prevention. Additionally, we discussed the role of additional non-modifiable risk factors, and of epigenetic regulation and microbiota as mediators of the eoCRC triggered by diet and lifestyle.

Risk Factors for Early-Onset Colorectal Cancer: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Dylan E. O’Sullivan ◽  
R. Liam Sutherland ◽  
Susanna Town ◽  
Kristian Chow ◽  
Jeremy Fan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Early Onset ◽  
Meta Analysis ◽  
Early Onset Colorectal Cancer

Mo1607 Role of Environmental Risk Factors on Early-Onset Colorectal Cancer Risk

2012 ◽  
Vol 142 (5) ◽  
pp. S-640
Author(s):  
Aung Ko Win ◽  
Sergio A. Taunde ◽  
Joanne P. Young ◽  
Daniel D. Buchanan ◽  
Driss Ait Ouakrim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Risk ◽  
Environmental Risk ◽  
Early Onset ◽  
Environmental Risk Factors ◽  
Colorectal Cancer Risk ◽  
Early Onset Colorectal Cancer

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women

Gut ◽  
2021 ◽  
pp. gutjnl-2020-323450
Author(s):  
Jinhee Hur ◽  
Ebunoluwa Otegbeye ◽  
Hee-Kyung Joh ◽  
Katharina Nimptsch ◽  
Kimmie Ng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Early Onset ◽  
Cox Proportional Hazards ◽  
Adolescents And Young Adults ◽  
Health Study ◽  
Birth Cohorts ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage ◽  
Early Onset Colorectal Cancer

ObjectiveSugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined.DesignIn the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake in adulthood and adolescence with EO-CRC risk among 95 464 women who had reported adulthood beverage intake using validated food frequency questionnaires (FFQs) every 4 years. A subset of 41 272 participants reported beverage intake at age 13–18 years using a validated high school-FFQ in 1998. Cox proportional hazards models were used to estimate relative risks (RRs) with 95% CIs.ResultsWe documented 109 EO-CRC cases. Compared with individuals who consumed <1 serving/week of SSBs in adulthood, women who consumed ≥2 servings/day had a more than doubled risk of EO-CRC (RR 2.18; 95% CI 1.10 to 4.35; ptrend=0.02), with a 16% higher risk (RR 1.16; 95% CI 1.00 to 1.36) per serving/day increase. Each serving/day increment of SSB intake at age 13–18 years was associated with a 32% higher risk of EO-CRC (RR 1.32; 95% CI 1.00 to 1.75). Replacing each serving/day of adulthood SSB intake with that of artificially sweetened beverages, coffee, reduced fat milk or total milk was associated with a 17%–36% lower risk of EO-CRC.ConclusionHigher SSB intake in adulthood and adolescence was associated with a higher risk of EO-CRC among women. Reduction of SSB consumption among adolescents and young adults may serve as a potential strategy to alleviate the growing burden of EO-CRC.

982 – Risk Factors for Early-Onset Colorectal Cancer in a Sample of 68,067 US Veterans Undergoing Colonoscopy 1999-2014

2019 ◽  
Vol 156 (6) ◽  
pp. S-207-S-208
Author(s):  
Eric Low ◽  
Joshua Demb ◽  
Lin Liu ◽  
Ashley Earles ◽  
Ranier Bustamante ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Early Onset ◽  
Us Veterans ◽  
Early Onset Colorectal Cancer

Su1728 - Risk Factors for Early Onset Colorectal Cancer: A Retrospective Analysis

2018 ◽  
Vol 154 (6) ◽  
pp. S-568-S-569
Author(s):  
Valerie Gausman ◽  
David Dornblaser ◽  
Sanya Anand ◽  
Kelli O'Connell ◽  
Mengmeng Du ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Retrospective Analysis ◽  
Early Onset ◽  
Early Onset Colorectal Cancer

scholarly journals Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer

2012 ◽  
Vol 57 (11) ◽  
pp. 709-716 ◽  
Author(s):  
Jérémie H Lefevre ◽  
Carolina Bonilla ◽  
Chrystelle Colas ◽  
Bruce Winney ◽  
Elaine Johnstone ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Rare Variants ◽  
Adenomatous Polyposis ◽  
Early Onset Colorectal Cancer

Risk factors and clinical characteristics of early-onset colorectal cancer vs. late-onset colorectal cancer

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Milena Di Leo ◽  
Raffaella A. Zuppardo ◽  
Marta Puzzono ◽  
Ilaria Ditonno ◽  
Alessandro Mannucci ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Early Onset ◽  
Clinical Characteristics ◽  
Late Onset ◽  
Early Onset Colorectal Cancer

scholarly journals Risk Factors Associated With Early-Onset Colorectal Cancer

2020 ◽  
Vol 18 (12) ◽  
pp. 2752-2759.e2 ◽  
Author(s):  
Valerie Gausman ◽  
David Dornblaser ◽  
Sanya Anand ◽  
Richard B. Hayes ◽  
Kelli O'Connell ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Early Onset ◽  
Factors Associated ◽  
Early Onset Colorectal Cancer

scholarly journals Social Determinants Associated with the Rising Incidence of Early-Onset Colorectal Cancer in the U.S.: A PRISMA Systematic Review

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 302-302
Author(s):  
Laura Amweg ◽  
Laura Hayman
Keyword(s):  
Physical Activity ◽  
Colorectal Cancer ◽  
United States ◽  
Young Adults ◽  
Early Onset ◽  
The United States ◽  
Literature Study ◽  
Funding Sources ◽  
Prospective Longitudinal ◽  
Early Onset Colorectal Cancer

Abstract Objectives To examine the behavioral, socioeconomic, clinical and systemic characteristics of colorectal cancer (CRC) in young adults (19–49 years of age) in the United States (U.S). Methods A systematic literature review was performed using PRISMA methodology. Eleven electronic databases were searched for the extant literature. Study eligibility criteria included colorectal cancer patients in the United States aged 19–49 years. Articles published in peer-reviewed journals in English between January 2009-April 2019 were included. Results Diet, smoking, low physical activity, and gut microbiome changes were identified as modifiable risk factors associated with early-onset colorectal cancer (EOCRC). Racial disparities existed where African American and Hispanic populations had a higher incidence of EOCRC compared to non-Hispanic Whites. Results suggested that delays in EOCRC diagnosis were caused by delays between symptom presentation and appropriate screening. Limitations included use of non-longitudinal cross-sectional analysis, which cannot explain etiologic causes. Conclusions Public health efforts are needed for better adherence to a healthy dietary pattern and increasing physical activity, to bring awareness to young adults and clinicians alike to know the symptoms of EOCRC, and for young people to get screened early in an ethnically-inclusive manner to reduce disparities. Findings suggest more prospective, longitudinal studies need to be conducted and analyzed to study the etiologic factors of EOCRC. Funding Sources The authors have no funding sources to report.

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