Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women

ObjectiveSugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined.DesignIn the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake in adulthood and adolescence with EO-CRC risk among 95 464 women who had reported adulthood beverage intake using validated food frequency questionnaires (FFQs) every 4 years. A subset of 41 272 participants reported beverage intake at age 13–18 years using a validated high school-FFQ in 1998. Cox proportional hazards models were used to estimate relative risks (RRs) with 95% CIs.ResultsWe documented 109 EO-CRC cases. Compared with individuals who consumed <1 serving/week of SSBs in adulthood, women who consumed ≥2 servings/day had a more than doubled risk of EO-CRC (RR 2.18; 95% CI 1.10 to 4.35; ptrend=0.02), with a 16% higher risk (RR 1.16; 95% CI 1.00 to 1.36) per serving/day increase. Each serving/day increment of SSB intake at age 13–18 years was associated with a 32% higher risk of EO-CRC (RR 1.32; 95% CI 1.00 to 1.75). Replacing each serving/day of adulthood SSB intake with that of artificially sweetened beverages, coffee, reduced fat milk or total milk was associated with a 17%–36% lower risk of EO-CRC.ConclusionHigher SSB intake in adulthood and adolescence was associated with a higher risk of EO-CRC among women. Reduction of SSB consumption among adolescents and young adults may serve as a potential strategy to alleviate the growing burden of EO-CRC.

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Abstract 838: Sugar-sweetened beverage intake and risk of early-onset colorectal cancer

10.1158/1538-7445.am2021-838 ◽

2021 ◽

Author(s):

Jinhee Hur ◽

Ebunoluwa Otegbeye ◽

Hee-Kyung Joh ◽

Katharina Nimptsch ◽

Kimmie Ng ◽

...

Keyword(s):

Colorectal Cancer ◽

Early Onset ◽

Sugar Sweetened Beverage ◽

Sweetened Beverage ◽

Early Onset Colorectal Cancer

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Sugar-Sweetened Beverage Intake Linked to Early-Onset Colorectal Cancer Risk

AJN American Journal of Nursing ◽

10.1097/01.naj.0000794268.40128.c1 ◽

2021 ◽

Vol 121 (10) ◽

pp. 52-52

Author(s):

Karen Rosenberg

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Early Onset ◽

Colorectal Cancer Risk ◽

Sugar Sweetened Beverage ◽

Sweetened Beverage ◽

Early Onset Colorectal Cancer

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Social Determinants Associated with the Rising Incidence of Early-Onset Colorectal Cancer in the U.S.: A PRISMA Systematic Review

Current Developments in Nutrition ◽

10.1093/cdn/nzaa044_001 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 302-302

Author(s):

Laura Amweg ◽

Laura Hayman

Keyword(s):

Physical Activity ◽

Colorectal Cancer ◽

United States ◽

Young Adults ◽

Early Onset ◽

The United States ◽

Literature Study ◽

Funding Sources ◽

Prospective Longitudinal ◽

Early Onset Colorectal Cancer

Abstract Objectives To examine the behavioral, socioeconomic, clinical and systemic characteristics of colorectal cancer (CRC) in young adults (19–49 years of age) in the United States (U.S). Methods A systematic literature review was performed using PRISMA methodology. Eleven electronic databases were searched for the extant literature. Study eligibility criteria included colorectal cancer patients in the United States aged 19–49 years. Articles published in peer-reviewed journals in English between January 2009-April 2019 were included. Results Diet, smoking, low physical activity, and gut microbiome changes were identified as modifiable risk factors associated with early-onset colorectal cancer (EOCRC). Racial disparities existed where African American and Hispanic populations had a higher incidence of EOCRC compared to non-Hispanic Whites. Results suggested that delays in EOCRC diagnosis were caused by delays between symptom presentation and appropriate screening. Limitations included use of non-longitudinal cross-sectional analysis, which cannot explain etiologic causes. Conclusions Public health efforts are needed for better adherence to a healthy dietary pattern and increasing physical activity, to bring awareness to young adults and clinicians alike to know the symptoms of EOCRC, and for young people to get screened early in an ethnically-inclusive manner to reduce disparities. Findings suggest more prospective, longitudinal studies need to be conducted and analyzed to study the etiologic factors of EOCRC. Funding Sources The authors have no funding sources to report.

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The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review

Cancers ◽

10.3390/cancers13235933 ◽

2021 ◽

Vol 13 (23) ◽

pp. 5933

Author(s):

Marta Puzzono ◽

Alessandro Mannucci ◽

Simone Grannò ◽

Raffaella Alessia Zuppardo ◽

Andrea Galli ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Systematic Review ◽

Young Adults ◽

Early Onset ◽

Current Evidence ◽

Exogenous Factors ◽

Diet And Lifestyle ◽

Early Onset Colorectal Cancer

The incidence of early-onset colorectal cancer, defined as colorectal cancer occurring in young adults under the age of 50, is increasing globally. Knowledge of the etiological factors in young adults is far from complete. Questionable eoCRCs’ exogenous factors are represented by processed meat, sugary drinks, alcohol, Western dietary pattern, overweight and obesity, physical inactivity, and smoking, though with heterogeneous results. Therefore, we performed a systematic review to summarize the current evidence on the role of diet and lifestyle as eoCRC risk factors. We systematically searched PubMed, Scopus, and EMBASE up to July 2021, for original studies evaluating diet, alcohol, physical activity, BMI, and smoking in eoCRC and included twenty-six studies. Indeed, the exogenous factors could represent modifiable key factors, whose recognition could establish areas of future interventions through public health strategies for eoCRC primary prevention. Additionally, we discussed the role of additional non-modifiable risk factors, and of epigenetic regulation and microbiota as mediators of the eoCRC triggered by diet and lifestyle.

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EARLY-ONSET COLORECTAL CANCER: CLINICO-PATHOLOGICAL IMPLICATIONS (EOCRC)

Romanian Medical Journal ◽

10.37897/rmj.2015.2.18 ◽

2015 ◽

Vol 62 (2) ◽

pp. 189-194

Author(s):

Meda Laura Comandasu ◽

◽

Emel Suliman ◽

Octavia Rusu ◽

C. Savlovschi ◽

...

Keyword(s):

Colorectal Cancer ◽

Young Adults ◽

Early Onset ◽

University Hospital ◽

Heterogenous Group ◽

Risk Patients ◽

Advanced Stages ◽

Poorly Differentiated ◽

And Biological Markers ◽

Early Onset Colorectal Cancer

Objective. The purpose of this study is to analyse histopathological and clinical characteristics of EOCRC. Colorectal cancer was formerly considered as a disease of senescent age; in the last years, it is a noticeable trend of growing incidence among young people (aged between 20 and 45 years). Few of newly diagnosed cases are inherited and most of them are sporadic. Material and method. The authors studied retrospectively a series of 33 cases of early onset colorectal cancer, 17 men and 16 women, with ages below 45 years, admitted between January 2009 and January 2015 in II and IV Surgical Wards of Emergency University Hospital Bucharest. Results. Colorectal cancer in young adults tends to be an aggressive disease with dominant distal location (68.5% of all cases), mostly adenocarcinomas (96.6%) with moderate to poorly differentiated types (51.4% G2 and G3), diagnosed in advanced stages (57.6% stages III and IV), with high frequency of complications (33% presented with peritoneal carcinomatosis and 9% died during hospitalization). Conclusions. EOCRC is a heterogenous group regarding etiopathogeny, localization and histopathological features of the tumor, with aggresive histopathological types, diagnosed in advanced stages. It may be necessary to elaborate new screening protocols for colorectal cancer in young adults and to fi nd clinical and biological markers that are indicating high-risk patients.

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Sugar-sweetened beverage (SSB) consumption is associated with lower quality of the non-SSB diet in US adolescents and young adults

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqaa342 ◽

2020 ◽

Author(s):

Alex M Doherty ◽

Allison M Lacko ◽

Barry M Popkin

Keyword(s):

Young Adults ◽

The United States ◽

Healthy Eating Index ◽

Dietary Guidelines ◽

Adolescents And Young Adults ◽

Dietary Quality ◽

Sugar Sweetened Beverage ◽

Sweetened Beverage ◽

The Us

ABSTRACT Background Since 2003–4, the United States has seen large declines in sugar-sweetened beverage (SSB) intake overall, especially among non-Hispanic white (NHW) subpopulations. However, obesity prevalence has not shown comparable declines in the 2 highest SSB-consuming groups, adolescents and young adults. Little is understood about the quality of the diet excluding SSBs (non-SSB diet). Objectives The objective of this study was to evaluate differences in non-SSB diet quality in SSB consumers and nonconsumers in adolescents and young adults and in the 3 major race/ethnic subgroups. Methods This study utilized data from the NHANES, a cross-sectional, nationally representative survey of the US population. Data from 6426 participants aged 12–29 y from the NHANES (2009–2014) was included. Quality of the non-SSB diet was measured using the 2015 Healthy Eating Index (HEI). Multivariate linear regressions controlled for sociodemographic characteristics and included interactions by race/ethnicity [NHWs, non-Hispanic blacks (NHBs), Hispanics]. Individuals were classified as non-, low- (<10% of daily calories), or high-SSB consumers (≥10% of daily calories), according to the US Dietary Guidelines added sugar intake recommendation. Results Non-SSB HEI scores differed among SSB consumer groups (53 for adolescent nonconsumers compared with 46 for high consumers, P < 0.001; 57 for young adult nonconsumers compared with 45 for high consumers, P < 0.001), although all scores were low and require improvement. Among NHBs, significant differences in non-SSB HEI were found only between non- and low-SSB consumers. In Hispanics, associations varied by age group, with significant differences found for young adults but no association found for adolescents. Conclusions Low non-SSB HEI scores in SSB consumers suggest that reducing SSB consumption alone will not be a sufficient strategy for improving dietary quality in adolescents and young adults. Future policies must also consider improving the non-SSB diet.

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