scholarly journals Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 437
Author(s):  
Carsten Gründker ◽  
Günter Emons
Keyword(s):  
Ovarian Cancer ◽  
Reproductive Organs ◽  
Gonadotropin Releasing Hormone ◽  
Regulation System ◽  
Ovarian Cancer Cells ◽  
Endocrine Regulation ◽  
Hpg Axis ◽  
Releasing Hormone ◽  
Gnrh Receptors

The hypothalamus–pituitary–gonadal (HPG) axis is the endocrine regulation system that controls the woman’s cycle. The gonadotropin-releasing hormone (GnRH) plays the central role. In addition to the gonadotrophic cells of the pituitary, GnRH receptors are expressed in other reproductive organs, such as the ovary and in tumors originating from the ovary. In ovarian cancer, GnRH is involved in the regulation of proliferation and metastasis. The effects on ovarian tumors can be indirect or direct. GnRH acts indirectly via the HPG axis and directly via GnRH receptors on the surface of ovarian cancer cells. In this systematic review, we will give an overview of the role of GnRH in ovarian cancer development, progression and therapy.

scholarly journals Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway

2006 ◽  
Vol 13 (1) ◽  
pp. 211-220 ◽  
Author(s):  
Ki-Yon Kim ◽  
Kyung-Chul Choi ◽  
Nelly Auersperg ◽  
Peter C K Leung
Keyword(s):  
Ovarian Cancer ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Gonadotropin Releasing Hormone ◽  
Ovarian Cancer Cells ◽  
Releasing Hormone ◽  
Proliferative Effect ◽  
Kinase C

In our previous studies, we demonstrated that ERK1/2 (extracellular signal-regulated protein kinase) and p38 MAPK (mitogen-activated protein kinase) are required for gonadotropin-releasing hormone (GnRH)-II-induced anti-proliferation of ovarian cancer cells. In the present study, we examined the role of the GnRH-I receptor, as well as the activation of protein kinase C (PKC), in the anti-proliferative effect induced by GnRH-I or II in ovarian cancer cells. Our results demonstrated that Antide, a GnRH-I antagonist, reversed the activation of ERK1/2 induced by GnRH-I or II and abolished the anti-proliferative effect of GnRH-I and II in ovarian cancer cells. Transfection of short-interfering RNA to abrogate the gene expression of the GnRH-I receptor reversed GnRH-I and II-induced anti-proliferation. These results indicate that GnRH-I or II induce anti-proliferation through the GnRH-I receptor in ovarian cancer cells. In addition, the activation of ERK1/2 by GnRH-I or II was mimicked by phorbol-12-myristate 13-acetate, a PKC activator. Pretreatment with GF109203X, an inhibitor of PKC, blocked GnRH-induced ERK1/2 activation and anti-proliferation. These results suggest that the activation of PKC is responsible for GnRH-induced ERK1/2 activation and anti-proliferation in ovarian cancer cells. Taken together, these results indicate that binding of GnRH-I and II to the GnRH-I receptor activates ERK1/2 through a PKC-dependent pathway and is essential for GnRH-induced anti-proliferation of ovarian cancer cells.

Autocrine Role of Gonadotropin-Releasing Hormone and Its Receptor in Ovarian Cancer Cell Growth

Endocrine ◽  
2000 ◽  
Vol 13 (3) ◽  
pp. 297-304 ◽  
Author(s):  
Sung K. Kang ◽  
Kwai W. Cheng ◽  
Parimal S. Nathwani ◽  
Kyung-Chul Choi ◽  
Peter C. K. Leung
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Gonadotropin Releasing Hormone ◽  
Cancer Cell Growth ◽  
Releasing Hormone

Gonadotropin-releasing hormone stimulates phospholipase C but not protein phosphorylation/dephosphorylation in plasma membrane from human epithelial ovarian cancer*

1993 ◽  
Vol 3 (5) ◽  
pp. 311-317 ◽  
Author(s):  
A. Imai ◽  
T. Ohno ◽  
T. Furui ◽  
K. Takahashi ◽  
T. Matsuda ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Plasma Membrane ◽  
Protein Phosphorylation ◽  
Inositol Phosphates ◽  
Specific Binding ◽  
Gonadotropin Releasing Hormone ◽  
Free System ◽  
Releasing Hormone ◽  
A Cell

In view of advances in treatment of certain hormone-dependent cancers with analogues of gonadotropin-releasing hormone (Gn-RH), this study was undertaken to establish the signal transduction events interacting with Gn-RH receptor in a cell-free system prepared from human ovarian mucinous cystadenocarcinoma samples. A high affinity specific binding (Kd=8 × 10−9 M) of [3H] Gn-RH was demonstrated in two from two plasma membrane preparations. Gn-RH showed no effects on the rate of protein phosphorylation from [γ-32P] adenosine triphosphate in the plasma membrane preparations. On the other hand, incubation of plasma membrane isolated form [3H]inositol-labeled specimens with Gn-RH in the presence of guanosine thiotriphosphate resulted in the rapid production of inositol phosphates. The Gn-RH effects was concentration-dependent, and half-maximal activation occurred with 1–3 nm Gn-RH. The Gn-RH-stimulated membrane event was observed in all plasma membrane isolations tested, but not in those from uterine endometrial carcinoma of a given case. These results provide the first direct evidence that Gn-RH receptor is coupled to phosphoinositide hydrolysis but not to certain membrane protein phosphorylation/dephosphorylation in ovarian carcinoma plasma membrane. Though the functional role of this event in human ovarian cancer is still obscure, it might be part of a possible point of attack for therapeutic approaches using Gn-RH analogues in this malignancy.

scholarly journals Effect of gonadotropin-releasing hormone agonist on ES-2 ovarian cancer cells

2014 ◽  
Vol 53 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Kuan-Hao Tsui ◽  
Wen-Ling Lee ◽  
Kok-Min Seow ◽  
Lin-Wei Yang ◽  
Shih-Yi Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Gonadotropin Releasing Hormone ◽  
Ovarian Cancer Cells ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Agonist

Potential role of gonadotrophin-releasing hormone (GnRH)-I and GnRH-II in the ovary and ovarian cancer.

2003 ◽  
pp. 169-177 ◽  
Author(s):  
S K Kang ◽  
K-C Choi ◽  
H-S Yang ◽  
P C K Leung
Keyword(s):  
Ovarian Cancer ◽  
Potential Role ◽  
Ovarian Surface Epithelium ◽  
Ovarian Tumour ◽  
Surface Epithelium ◽  
Releasing Hormone ◽  
Gnrh Receptors ◽  
Ovarian Cells ◽  
Gonadotrophin Releasing Hormone

Gonadotrophin-releasing hormone (GnRH) functions as a key neuroendocrine regulator of the hypothalamic-pituitary-gonadal axis. In addition to the hypothalamus and pituitary gland, GnRH and its receptor have been detected in other reproductive tissues including the gonads, placenta and tumours arising from these tissues. Recently, a second form of GnRH (GnRH-II) and type II GnRH receptor have been found in normal ovarian surface epithelium and neoplastic counterparts. The two types of GnRH may play an important role as an autocrine/paracrine regulator of reproductive functions and ovarian tumour growth. In this review, the distribution and potential roles of GnRH-I/-II and their GnRH receptors in the ovarian cells and ovarian cancer will be discussed.

Sign in / Sign up

Export Citation Format

Share Document