scholarly journals From NSAIDs to Glucocorticoids and Beyond

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3524
Author(s):  
Ajantha Sinniah ◽  
Samia Yazid ◽  
Rod J. Flower
Keyword(s):  
Salicylic Acid ◽  
Side Effects ◽  
Pharmaceutical Industry ◽  
Annexin A1 ◽  
New Era ◽  
Inflammatory Protein ◽  
Willow Bark ◽  
Ancient Times ◽  
Anti Inflammatory ◽  
Acute Inflammatory Disease

Our interest in inflammation and its treatment stems from ancient times. Hippocrates used willow bark to treat inflammation, and many centuries later, salicylic acid and its derivative aspirin’s ability to inhibit cyclooxygenase enzymes was discovered. Glucocorticoids (GC) ushered in a new era of treatment for both chronic and acute inflammatory disease, but their potentially dangerous side effects led the pharmaceutical industry to seek other, safer, synthetic GC drugs. The discovery of the GC-inducible endogenous anti-inflammatory protein annexin A1 (AnxA1) and other endogenous proresolving mediators has opened a new era of anti-inflammatory therapy. This review aims to recapitulate the last four decades of research on NSAIDs, GCs, and AnxA1 and their anti-inflammatory effects.

scholarly journals Expression of the anti‐inflammatory protein Annexin A1 in the renal interstitium during the time course of acute Thy1 nephritis

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Stephan Frank Hohberger ◽  
Daniel Brand ◽  
Tanja Loof ◽  
Harm Peters ◽  
Sebastian Bachmann ◽  
...  
Keyword(s):  
Time Course ◽  
Annexin A1 ◽  
Renal Interstitium ◽  
Inflammatory Protein ◽  
Anti Inflammatory

scholarly journals Biotransformation of Cortisone with Rhodococcus rhodnii: Synthesis of New Steroids

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1352
Author(s):  
Federico Zappaterra ◽  
Stefania Costa ◽  
Daniela Summa ◽  
Valerio Bertolasi ◽  
Bruno Semeraro ◽  
...  
Keyword(s):  
Immune System ◽  
Side Effects ◽  
Pharmaceutical Industry ◽  
Green Chemistry ◽  
Industrial Processes ◽  
High Dose ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
New Compounds

Cortisone is a steroid widely used as an anti-inflammatory drug able to suppress the immune system, thus reducing inflammation and attendant pain and swelling at the site of an injury. Due to its numerous side effects, especially in prolonged and high-dose therapies, the development of the pharmaceutical industry is currently aimed at finding new compounds with similar activities but with minor or no side effects. Biotransformations are an important methodology towards more sustainable industrial processes, according to the principles of “green chemistry”. In this work, the biotransformation of cortisone with Rhodococcus rhodnii DSM 43960 to give two new steroids, i.e., 1,9β,17,21-tetrahydoxy-4-methyl-19-nor-9β-pregna-1,3,5(10)-trien-11,20-dione and 1,9β,17,20β,21-pentahydoxy-4-methyl-19-nor-9β-pregna-1,3,5(10)-trien-11-one, is reported. These new steroids have been fully characterized.

scholarly journals Down-regulation of the Anti-inflammatory Protein Annexin A1 in Cystic Fibrosis Knock-out Mice and Patients

2005 ◽  
Vol 4 (10) ◽  
pp. 1591-1601 ◽  
Author(s):  
Noura Bensalem ◽  
Ana Paula Ventura ◽  
Benoît Vallée ◽  
Joanna Lipecka ◽  
Danielle Tondelier ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Annexin A1 ◽  
Down Regulation ◽  
Knock Out ◽  
Inflammatory Protein ◽  
Anti Inflammatory ◽  
Knock Out Mice

scholarly journals Herbal medicines in dentistry: history, obtainment methods, and properties of Copaifera multijuga hayne and Baccharis dracunculifolia dc

2016 ◽  
Vol 3 (6) ◽  
pp. 859 ◽  
Author(s):  
Bruna Pinto De los Santos ◽  
Luiz Alberto Kanis ◽  
Jefferson Ricardo Pereira
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Literature Review ◽  
Herbal Medicines ◽  
Hand Search ◽  
Electronic Search ◽  
Improper Use ◽  
Ancient Times ◽  
Medicinal Properties ◽  
Anti Inflammatory

The aim of this study was to do a literature review on herbal medicines used in dentistry. For that purpose, an electronic search of papers in Portuguese, Spanish, and English was performed in the following databases: PubMed, MEDLINE, SciELO, Science Direct, LILACS, and BBO, supplemented by hand search in books, theses, and journals. For the search, the following keywords were used: phytotherapy, Copaifera, and Baccharis dracunculifolia. Medicinal plants have been used since ancient times and some of them such as the Copaifera multijuga Hayne and Baccharis dracunculifolia DC have shown medicinal properties. Different ways to obtain extracts from those plants have been described, as well as their many important properties, such as antimicrobial, anti-inflammatory, and antiseptic effects. However, studies on their medicinal properties are still scarce, which indicates the need for further studies to unravel their effects and possible side effects, as well as implications of improper use of these plants.

Edward Stone (1702–1768) and Edmund Stone (1700–1768): confused identities resolved

1997 ◽  
Vol 51 (2) ◽  
pp. 211-217 ◽  
Author(s):  
W. S. Pierpoint
Keyword(s):  
Eighteenth Century ◽  
Salicylic Acid ◽  
Western Europe ◽  
Folk Medicine ◽  
Salix Alba ◽  
Synthetic Drugs ◽  
White Willow ◽  
Willow Bark ◽  
Anti Inflammatory ◽  
The Right

On the 25 April 1763 a letter was sent from Chipping Norton in Oxfordshire to the Right Honourable George Parker, Earl of Macclesfield, then President of the Royal Society, extolling the use of willow bark in curing agues and other feverish complaints. The writer describes how about a pound of bark taken from a common white willow ( Salix alba ) was dried in a bag over a baker's oven for more than three months, pulverized and then used to alleviate the agues, ‘intermitting disorders’ and distempers of 50 afflicted people. The undoubted medicinal properties of bark from willow and other Salix species were not new. They were known to a number of preindustrial cultures and also, in a more systematic way, to the medical philosophers of classical Greece and Rome. However, by the eighteenth century in Western Europe, they were in disuse or had been relegated to the level of folk medicine. The letter, duly printed in Philosophical Transactions , is often credited with having brought the anti–inflammatory, antipyretic and analgesic properties of these barks, to the attention of the emerging chemists of the late eighteenth century. Attempts to identify the active principles, and then to synthesize them, led to the discovery of salicylic acid and its derivatives, and eventually to the introduction of acetyl salicylic acid––aspirin––possibly the most widely used of all synthetic drugs. This history is periodically reviewed both for general and specialist audiences; the seminal letter is referred to whenever there is a new monograph on these anti–inflammatory drugs, and is the subject of frequent queries to the Royal Society's library. It would seem, therefore, to be useful to remove a confusion surrounding the name of its author, who has been variously referred to as either Edward or Edmund Stone.

scholarly journals AN OVERVIEW ON PLANTS WITH ANTI-INFLAMMATORY POTENTIAL

2017 ◽  
pp. 1-4
Author(s):  
Karale Pushpa ◽  
Karale Mahesh
Keyword(s):  
Side Effects ◽  
Cell Damage ◽  
Healing Process ◽  
The Body ◽  
Protective Mechanism ◽  
Synthetic Drugs ◽  
Pile Up ◽  
Ancient Times ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Inflammation is a protective mechanism of the body which involves vascular tissues, plasma proteins or cells and chemical mediators for the removal of hazardous stimuli like pathogens, allergens, irritants or cell damage and initiates the healing process. Anti-inflammatory drugs like steroidal and non-steroidal anti-inflammatory drugs are used to treat inflammation. Recently, the synthetic drugs shows a number of side effects such as kidney failure, ulceration and bleeding, liver damage etc. Therefore a search for the other substitute with no or less side effects is necessary. Plants are used from ancient times to treat various serious disorders. Plant constitutes a large number of chemicals which are responsible for the treatment of disease in an archaistic manner. The present review was pile up various plants with anti-inflammatory potential.

A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

2020 ◽  
Vol 24 (5) ◽  
pp. 473-486 ◽  
Author(s):  
Ligia S. da Silveira Pinto ◽  
Thatyana R. Alves Vasconcelos ◽  
Claudia Regina B. Gomes ◽  
Marcus Vinícius N. de Souza
Keyword(s):  
Side Effects ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Present Review ◽  
Pharmacological Properties ◽  
Important Group ◽  
Wide Range ◽  
Anti Inflammatory

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review

2020 ◽  
Vol 17 (4) ◽  
pp. 270-278
Author(s):  
Maha Nasr ◽  
Rawan Al-Karaki
Keyword(s):  
Side Effects ◽  
Therapeutic Efficacy ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Topical Delivery ◽  
Natural Compounds ◽  
Therapeutic Activity ◽  
Dermatological Diseases ◽  
Anti Inflammatory ◽  
Topical Applications

Nanotechnology is currently a hot topic in dermatology and nutraceutical/cosmeceutical delivery, owing to the advantages it provides in terms of enhancing the skin permeation of drugs, as well as increasing their therapeutic efficacy in the treatment of different dermatological diseases. There is also a great interest in the topical delivery of nutraceuticals; which are natural compounds with both therapeutic and cosmetic benefits, in order to overcome the side effects of topically applied chemical drugs. Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration. This review highlights the topical applications of quercetin, and summarizes the nanocarrier-based solutions to its percutaneous delivery challenges.

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