scholarly journals Amino Acid Metabolism in Cancer Drug Resistance

Cells ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 140
Author(s):  
Hee-Chan Yoo ◽  
Jung-Min Han
Keyword(s):  
Drug Resistance ◽  
Amino Acid ◽  
Cancer Cells ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Epigenetic Modification ◽  
Redox Homeostasis ◽  
Resistance Mechanisms ◽  
Cancer Drug ◽  
Cancer Therapies

Despite the numerous investigations on resistance mechanisms, drug resistance in cancer therapies still limits favorable outcomes in cancer patients. The complexities of the inherent characteristics of tumors, such as tumor heterogeneity and the complicated interaction within the tumor microenvironment, still hinder efforts to overcome drug resistance in cancer cells, requiring innovative approaches. In this review, we describe recent studies offering evidence for the essential roles of amino acid metabolism in driving drug resistance in cancer cells. Amino acids support cancer cells in counteracting therapies by maintaining redox homeostasis, sustaining biosynthetic processes, regulating epigenetic modification, and providing metabolic intermediates for energy generation. In addition, amino acid metabolism impacts anticancer immune responses, creating an immunosuppressive or immunoeffective microenvironment. A comprehensive understanding of amino acid metabolism as it relates to therapeutic resistance mechanisms will improve anticancer therapeutic strategies.

Abstract 1002: Induced dependency on amino acid metabolism in proliferating cancer cells upon PKM2 activation

2012 ◽  
Author(s):  
Charles Kung ◽  
Shengfang Jin ◽  
Jeff Hixon ◽  
Stefan Gross ◽  
Yi Gao ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cancer Cells ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

scholarly journals Current Therapeutics, Their Problems, and Sulfur-Containing-Amino-Acid Metabolism as a Novel Target against Infections by “Amitochondriate” Protozoan Parasites

2007 ◽  
Vol 20 (1) ◽  
pp. 164-187 ◽  
Author(s):  
Vahab Ali ◽  
Tomoyoshi Nozaki
Keyword(s):  
Drug Resistance ◽  
Amino Acid ◽  
Trichomonas Vaginalis ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Protozoan Parasites ◽  
Novel Target ◽  
Sulfur Containing

SUMMARY The “amitochondriate” protozoan parasites of humans Entamoeba histolytica, Giardia intestinalis, and Trichomonas vaginalis share many biochemical features, e.g., energy and amino acid metabolism, a spectrum of drugs for their treatment, and the occurrence of drug resistance. These parasites possess metabolic pathways that are divergent from those of their mammalian hosts and are often considered to be good targets for drug development. Sulfur-containing-amino-acid metabolism represents one such divergent metabolic pathway, namely, the cysteine biosynthetic pathway and methionine γ-lyase-mediated catabolism of sulfur-containing amino acids, which are present in T. vaginalis and E. histolytica but absent in G. intestinalis. These pathways are potentially exploitable for development of drugs against amoebiasis and trichomoniasis. For instance, l-trifluoromethionine, which is catalyzed by methionine γ-lyase and produces a toxic product, is effective against T. vaginalis and E. histolytica parasites in vitro and in vivo and may represent a good lead compound. In this review, we summarize the biology of these microaerophilic parasites, their clinical manifestation and epidemiology of disease, chemotherapeutics, the modes of action of representative drugs, and problems related to these drugs, including drug resistance. We further discuss our approach to exploit unique sulfur-containing-amino-acid metabolism, focusing on development of drugs against E. histolytica.

scholarly journals Metabolism of Amino Acids in Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhen Wei ◽  
Xiaoyi Liu ◽  
Chunming Cheng ◽  
Wei Yu ◽  
Ping Yi
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Therapeutic Strategy ◽  
Acid Metabolism ◽  
Epigenetic Modification ◽  
Mammalian Target Of Rapamycin ◽  
Metabolic Reprogramming ◽  
Mtorc1 Signaling ◽  
Uptake And Metabolism

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications.

scholarly journals Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism

Theranostics ◽  
2018 ◽  
Vol 8 (16) ◽  
pp. 4520-4534 ◽  
Author(s):  
Austin Yeon ◽  
Sungyong You ◽  
Minhyung Kim ◽  
Amit Gupta ◽  
Myung Hee Park ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Amino Acid ◽  
Cancer Cells ◽  
Epigenetic Regulation ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Bladder Cancer Cells

Sulfur amino acid metabolism in doxorubicin-resistant breast cancer cells

2011 ◽  
Vol 255 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Chang Seon Ryu ◽  
Hui Chan Kwak ◽  
Kye Sook Lee ◽  
Keon Wook Kang ◽  
Soo Jin Oh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amino Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Sulfur Amino Acid

Effect of oncogene activating mutations and kinase inhibitors on amino acid metabolism of human isogenic breast cancer cells

2015 ◽  
Vol 11 (12) ◽  
pp. 3378-3386 ◽  
Author(s):  
Eung-Sam Kim ◽  
Animesh Samanta ◽  
Hui Shan Cheng ◽  
Zhaobing Ding ◽  
Weiping Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amino Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Amino Acid Metabolism ◽  
Kinase Inhibitors ◽  
Acid Metabolism ◽  
Wild Type ◽  
Activating Mutations ◽  
Intracellular Amino Acid

K-Ras/PI3K knock-in mutation and treatment of kinase inhibitors altered the intracellular amino acid metabolism compared to the wild-type breast cell.

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