scholarly journals The Relationship between Diabetes Mellitus Type II and Intervertebral Disc Degeneration in Diabetic Rodent Models: A Systematic and Comprehensive Review

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2208
Author(s):  
Mohamed Mahmoud ◽  
Maria Kokozidou ◽  
Alexander Auffarth ◽  
Gundula Schulze-Tanzil
Keyword(s):  
Diabetes Mellitus ◽  
Intervertebral Disc ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Rodent Models ◽  
Disc Disease ◽  
Diabetes Mellitus Type Ii ◽  
Glycation End Products ◽  
The Relationship

The number of diabetic patients grows constantly worldwide. Many patients suffer simultaneously from diabetes mellitus type 2 (T2DM) and intervertebral disc disease (IVDD), suggesting a strong link between T2DM and IVDD. T2DM rodent models provide versatile tools to study this interrelation. We hypothesized that the previously achieved studies in rodents approved it. Performing a search in the publicly available electronic databases according to our inclusion (e.g., experimental study with clearly outlined methods investigating IVDD in diabetic rodent models) and exclusion (e.g., non-experimental) criteria, we included 23 studies from 1992 to 2020 analyzing different aspects of IVDD in diabetic rodents, such as on pathogenesis (e.g., effects of hyperglycemia on IVD cells, sirtuin (SIRT)1/p53 axis in the interrelation between T2DM and IVDD), risk factors (e.g., high content of advanced glycation end-products (AGEs) in modern diets), therapeutical approaches (e.g., insulin-like growth factor (IGF-I)), and prophylaxis. Regarding their quality, 12 studies were classified as high, six as moderate, and five as low. One strong, 18 moderate, and three mild evidences of the link between DM and IVDD in rodents were found, while only one study has not approved this link. We concluded that T2DM has a devastating effect on IVD, particularly in advanced cases, which needs to be further evaluated.

Evaluation of the alterations in the serum blood sugar level, the activity of AST and ALT enzymes of diabetes mellitus type 2 in Iraqi women patients

2021 ◽  
Vol 16 (8) ◽  
pp. 98-102
Author(s):  
Hashim Abdul Razzaq Iman ◽  
Hussein Murtadha Jinan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Diabetes Mellitus Type 2 ◽  
Correlation Factor ◽  
Diabetes Mellitus Type ◽  
Fasting Blood Sugar ◽  
Diabetic Patients ◽  
Cell Dysfunction ◽  
Iraqi Women

Diabetes mellitus type 2 (T2DM) results from beta cell dysfunction or reduced action of insulin responsive. The objective of this study was to examine the relevance between blood sugar, the activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in fasting women diabetic patients in different durations. A total of sixty-eight women were divided into three groups: first a healthy group – non-diabetic (twenty-six women), second and third groups (twenty-one) were diabetic patients of age 35 – 50 and 51 – 69 years respectively. Serum fasting blood sugar was significantly (P < 0.05) elevated to 181.60 mg/dl in female patients with 35 – 50 years. The same effect happened in activity of AST to 32.91 u/L in 51 – 69 years and ALT was 28.43 u/L in 35 – 50 years. No significant differences were found between the aged and fasting blood sugar, AST and ALT in diabetic patients. The correlation factor (r) between fasting blood sugar and the activity of ALT was highly significant.

ARTIFICIAL NEURAL NETWORKS FOR ESTIMATING GLOMERULAR FILTRATION RATE BY URINARY DIPSTICK FOR TYPE 2 DIABETIC PATIENTS

2016 ◽  
Vol 28 (03) ◽  
pp. 1650016
Author(s):  
Yu Chu-Su ◽  
Chien-Sheng Liu ◽  
Ruey-Shin Chen ◽  
Chii-Wann Lin
Keyword(s):  
Diabetes Mellitus ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Diabetes Mellitus Type 2 ◽  
Filtration Rate ◽  
Optimal Combination ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Test Items

Background: The result of a standard urinary dipstick from a patient with diabetes mellitus type 2 can be used to predict the estimated glomerular filtration rate (eGFR). We designed a multilayer perceptron (MLP) to investigate the possibility and optimal number of variables for the prediction. Methods: A total of 299 volunteers with diabetes mellitus type 2 were included. The blood and urine samples from volunteers were analyzed for blood sugar, glycated hemoglobin, serum creatinine, and urine chemistry. The urine chemistry was examined by a standard urinary dipstick. Volunteer age and gender and six test items of the dipstick were set as eight variables for this study. The eight variables were grouped and examined for the optimal combination. The eight variables from 232 of 299 volunteers were used to train an MLP for the optimal variables. The performance of trained MLP was validated by the data from 69 of 232 volunteers. Results: The optimal combination for variables was the six test items of the dipstick and volunteer age. The area under the curve (0.928), accuracy (0.879), sensitivity (0.83), and specificity (0.88) of the trained MLP were examined. Conclusions: The results demonstrate the eGFR prediction potential of the results of a urinary dipstick using this method.

scholarly journals Narushenie purinovogo obmena u patsienta s pervichnym giperparatireozom i sakharnym diabetom 2 tipa

2010 ◽  
Vol 7 (3) ◽  
pp. 43-48
Author(s):  
N G Mokrysheva ◽  
A Yu Tokmakova ◽  
I A Voronkova ◽  
L Ya Rozhinskaya ◽  
A I Bukhman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Primary Hyperparathyroidism ◽  
Diabetes Mellitus Type 2 ◽  
Clinical Case ◽  
Diabetes Mellitus Type ◽  
The Relationship

In this article we describe a clinical case of primary hyperparathyroidism, gout tophus and diabetes mellitus type 2. The relationship between hyperuricemia and hypercalcemia linked to primary hyperparathyroidism is discussed.

scholarly journals Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors

2020 ◽  
Vol 17 (21) ◽  
pp. 8125
Author(s):  
Cristina Naranjo ◽  
María Dueñas ◽  
Carlos Barrera ◽  
Guillermo Moratalla ◽  
Inmaculada Failde
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Neuropathic Pain ◽  
Sleep Quality ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Diabetic Patients ◽  
The Relationship

This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sectional study was performed in patients with type-2 diabetes mellitus and neuropathy. Patients were classified into two groups—with or without neuropathic pain—according to the “Douleur Neuropathique-4 (DN4)” scale. Sleep characteristics and quality (Medical Outcomes Study—MOS-sleep), pain phenotype (Neuropathic Pain Symptom Inventory—NPSI), mood status (Hospital Anxiety and Depression scale—HADS), pain intensity (Visual Analogue Scale—VAS), and quality of life (SF-12v2) were measured. The sample included 130 patients (65 with DNP). The mean scores in all the dimensions of the MOS-sleep scale were higher (more disturbances) in the DNP patients. Higher scores in anxiety or depression, greater intensity of pain or a higher score in the paroxysmal pain phenotype were associated with lower sleep quality in DNP patients. A shorter duration of the diabetes and lower levels of glycated hemoglobin were also associated with lower sleep quality. The results show the relationship between DNP and sleep quality, and the importance of assessing sensory phenotypes and mental comorbidities in these patients. Taking these factors into consideration, to adopt a multimodal approach is necessary to achieve better clinical results.

scholarly journals Analysis of the Efficacy of Cinnamon for Patients with Diabetes Mellitus Type II Based on Traditional Persian Medicine Syndrome Differentiation: A Randomized Controlled Trial

2020 ◽  
Vol 21 (7) ◽  
Author(s):  
Roghayeh Zare ◽  
Mesbah Shams ◽  
Mojtaba Heydari ◽  
Azadeh Najarzadeh ◽  
Mehdi Zarshenas
Keyword(s):  
Diabetes Mellitus ◽  
Controlled Trial ◽  
Diabetes Mellitus Type ◽  
Syndrome Differentiation ◽  
Diabetic Patients ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Persian Medicine ◽  
Patients With Diabetes ◽  
Traditional Persian Medicine

Background: Conflicting results have been obtained from the studies on the hypoglycemic effect of cinnamon in patients with diabetes mellitus type II (T2DM). Objectives: This research aimed at assessing the effect of applying the syndrome differentiation model based on traditional Persian medicine (TPM) to identify the patients who benefit more from cinnamon supplementation. Methods: This study was a randomized, triple-blind, placebo-controlled trial based on a parallel design. One hundred and forty eligible patients referring to the Diabetes Clinic of Yazd University of Medical Sciences, who were diagnosed with T2DM, were randomly divided into the cinnamon and placebo groups. Then, 500-mg capsules of cinnamon bark powder or placebo were administered to them twice a day for three months. All the participants completed a standard questionnaire for syndrome diagnosis in traditional Persian medicine (TPM). Fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), fasting insulin (FI), and insulin resistance (IR), calorie intake, and physical activity were measured before and after the interventions. The glycemic outcomes were analyzed according to the TPM syndrome. Results: There was no statistically significant difference between the patients’ demographic and clinical features in the two groups. Glycemic indices were improved in patients receiving cinnamon supplementation compared to placebo group (-13.1 ± 1.7, -1.7 ± 1.9, P < 0.001 for change in FPG and -0.27 ± 0.039 vs. 0.001 ± 0.019, P < 0.001 for change in HbA1C respectively). All the outcomes were more improved in the patients with wet syndrome compared to dry ones, which was compatible with Persian syndrome differentiation (P < 0.05). Conclusions: Diabetic patients with wet syndrome based on TPM benefit more form cinnamon supplementation.

scholarly journals CLINICAL AND PHARMACOLOGICAL EVALUATION OF THE INFLUENCE OF DIFFERENT CLINICAL FACTORS ON THE DETERMINED LEVEL OF GLYCATED HEMOGLOBIN IN PATIENTS WITH DIABETES MELLITUS TYPE 2

2020 ◽  
Vol 3 (4(73)) ◽  
pp. 26-31
Author(s):  
A.T. Ahverdiev ◽  
N.F. Nagiev ◽  
R.Yu. Mamedov
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Clinical Factors ◽  
Diabetes Mellitus Type Ii ◽  
First Case ◽  
Patients With Diabetes ◽  
Analysis Error ◽  
Medicinal Therapy

With the purpose to determine the prevalence and significance of the influence of various clinical factors on the glycemic control of patients with diabetes mellitus type II, 118 case histories of a therapeutic hospital were analyzed. Analysis of the documentation included the identification of concomitant diseases and conditions, as well as the use of medicines that could directly or indirectly affect the level of HbA1c detected in the patient's blood. In the first case, the presence of such a pathology or condition was revealed in 35 patients (29.7% of the contingent). Moreover, in the 22s they influenced the direction of false understatement, and in 13, on the contrary, its false overestimation. Acceptance of medicines that had significant potential for falsification of the determined level of HbA1c was observed in 39 patients (33.1% of the examined). The quantitative values of the possible analysis error as a result of such influences are discussed. The need for a more thorough analysis of the upcoming course of medicinal therapy for patients with diabetes mellitus type II, including with the participation of a clinical pharmacist (pharmacologist), is indicated.

scholarly journals Grip strength is associated with retinal and choroidal thickness in type 2 diabetes mellitus patients without retinopathy

2020 ◽  
Author(s):  
Zihan Qiu ◽  
Wei Wang ◽  
Yan Tan ◽  
Miao He ◽  
Lanhua Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Grip Strength ◽  
Choroidal Thickness ◽  
Retinal Thickness ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Hand Grip ◽  
Cross Sectional Design ◽  
The Relationship

AbstractObjectiveTo determine the relationship between grip strength and retinal or choroidal thickness in Chinese patients with type 2 diabetes mellitus.DesignObservational study-cross-sectional design.Setting and ParticipantsThe study was conducted among diabetes patients without retinopathy registered in the community health system in Guangzhou, China.MeasuresGrip strength was measured twice for each hand with a dynamometer in kilograms (kg). The retinal and choroidal thickness in macular Early Treatment Diabetic Retinopathy Study (ETDRS) sectors were measured by commercial swept-source optical coherence tomography (SS-OCT; DRI OCT-2 Triton; Topcon, Tokyo, Japan).ResultsA total of 1,029 patients were included in the study. Both retinal thickness and choroidal thickness increased with the higher quartile of grip strength. Regression analyses indicated that the average retinal and choroidal thickness increased by 0.14 μm (95%CI: 0.03-0.25 μm, P=0.011) and 0.57 μm (95%CI: 0.03-1.11 μm, P=0.037) for each additional kg of grip strength following adjustment for age and gender. Further adjustments were made for axial length, HbA1c, length of time the patient had diabetes, insulin usage, height, weight and systolic and diastolic blood pressure, which resulted in an average retinal and choroidal thickness increase of 0.13 μm (95%CI: 0.02-0.24 μm, P=0.024) and 0.65 μm (95%CI: 0.13-1.16 μm, P=0.013) for each additional kg of grip strength. Consistent results were obtained in the analyses in ETDRS 9 sectors.ConclusionGreater hand grip strength was found to be significantly associated with thicker retinal and choroidal layers in diabetic patients. Grip strength may provide a useful indicator of retinal health in diabetic patients. Further studies are needed to determine directionality and causality, and to examine whether improving muscle strength has a positive effect on retinal and choroidal thickness.Article summaryStrengths and limitations of this studyGrip strength is an indicator of upper limb muscle function and tension, and it is one of the important indicators of aging in the human population. This is one of the few studies to examined the relationship between grip strength and retinal thickness and choroidal thickness in a large sample size of patients with diabetes mellitus.Greater hand grip strength was found to be significantly associated with thicker retinal and choroidal thickness in diabetic patients, and grip strength may provide an easily-administered marker of retinal health in diabetic patients.Causal inferences could not be inferred due to the cross-sectional design of the study.The dynamic changes in grip strength and their impact on retinal and choroidal thickness are warranted to be explored in longitudinal studies.

scholarly journals THE RELATIONSHIP BETWEEN CALPROTECTIN AND PARAMETERS OF LIPID AND CARBOHYDRATE METABOLISM, ANTHROPOMETRIC AND INFLAMMATORY PARAMETERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2

2019 ◽  
Vol 19 (2) ◽  
pp. 16-18
Author(s):  
M. I. Zhuravlova
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Insulin Resistance ◽  
Acute Myocardial Infarction ◽  
Carbohydrate Metabolism ◽  
Diabetes Mellitus Type 2 ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
The Relationship

Nowadays, an acute myocardial infarction is one of the leading causes of mortality among the population. The EHS-DH registry data clearly illustrate the association between the comorbidities and high mortality following acute myocardial infarction during a year period of follow up. The pronounced influence of carbohydrate metabolism disturbances on the survival of such patients has already been reported. The aim of the study was to analyze the immune inflammation relationships based on assessing calprotectin and the parameters of lipid and carbohydrate metabolism, to evaluate the presence and nature of the relationship between these parameters and carbohydrate metabolism parameters based on the study of blood glucose, insulin and insulin resistance (by the indices HOMA, QUICKI, Caro), anthropometric indicators and inflammatory indicators (monocyte and neutrophile levels). Materials and methods. The study included 64 patients (mean age 65, 31 ± 1.62 years) with acute myocardial infarction and concomitant diabetes mellitus type 2. The design of the study included the primary laboratory investigation of patients during the first day since the onset of acute myocardial infarction with the elevation of the ST segment before the initiation of thrombolytic therapy or percutaneous intervention. The direct correlation between the calprotectin concentration and the HOMA insulin resistance index (R = 0.52; p <0.05), insulinemia (R = 0.57; p <0.05), fasting glycaemia (R = 0, 59; p <0.05), as well as inverse correlation relationships between the Caro index (R = 0.68; p <0.05) and the QUICKI index (R = 0.59; p <0.05) were found out. Moreover, a direct correlation between calprotectin and triglyceride levels (R = 0.31; p <0.05), and negative correlation with high density lipoprotein (R = 0.35; p <0.05) was established as well. The level of total cholesterol and low density lipoproteins showed no significant association with the proinflammatory factor (R = 0.12; p> 0.05 and R = 0.18; p> 0.05, respectively). Conclusions. The increase in the body mass index and the activity of serum monocytes and neutrophils is associated with high concentrations of calprotectin that is accompanied by disturbances of carbohydrate homeostasis towards the growth of insulin resistance and changes of lipidograms of proatherrogenic nature.

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