Pilomatrixcarcinoma of the Foot: A New Localization of an Extremely Rare Adnexal Tumour

Pilomatrixcarcinoma is a very rare follicular neoplasm that shows matrical differentiation. The majority of these lesions originate de novo, while only a few cases of transformation of pilomatricoma (calcifying epithelioma of Malherbe) have been described in the literature. The neoplasm affects mostly middle-aged males with a male-to-female ratio of 3–4:1. The most common localizations are the face, head, trunk and extremites, though there are a few reports of pilomatrixcarcinoma of the eyelid, eyebrow, axilla and clitorid. Here, we describe the first case of a pilomatrixcarcinoma on the anterolateral surface of the first toe of the left foot of an 83-year-old patient, which developed in less than six months and led to amputation of the distal phalanx. We report a brief review of the current literature with particular emphasis on histopathological features useful for diagnosis.

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Multifocal Adult Rhabdomyoma of the Head and Neck Manifestation in 7 Locations and Review of the Literature

Case Reports in Otolaryngology ◽

10.1155/2013/758416 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Lorraine A. de Trey ◽

Stephan Schmid ◽

Gerhard F. Huber

Keyword(s):

Head And Neck ◽

Striated Muscle ◽

Neck Region ◽

Review Of The Literature ◽

Female Ratio ◽

First Case ◽

Pet Ct ◽

Rare Benign Tumour ◽

Fdg Pet Ct ◽

Male To Female

Background. Adult rhabdomyoma is a rare benign tumour with the differentiation of striated muscle tissue, which mainly occurs in the head and neck region. Twenty-six cases of multifocal adult rhabdomyoma are documented in the literature.Method. We report a 55-year-old male with simultaneous diagnosis of 7 adult rhabdomyomas and review the literature of multifocal adult rhabdomyoma.Result. Review of the literature revealed 26 cases of multifocal adult rhabdomyoma, of which only 7 presented with more than 2 lesions. Mean age at diagnosis was 65 years with a male to female ratio of 5.5 : 1. Common localizations were the parapharyngeal space (36%), larynx (15%), submandibular (14%), paratracheal region (12%), tongue (11%), and floor of mouth (9%). Besides the known radiological features of adult rhabdomyoma, our case showed FDG-uptake in (18) F-FDG PET/CT.Conclusion. This is the first case of multifocal adult rhabdomyoma published, with as many as 7 simultaneous adult rhabdomyomas of the head and neck.

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Inter personal violence-related facial injuries: a 10-year survey

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2017038 ◽

2018 ◽

Vol 24 (1) ◽

pp. 2-5 ◽

Cited By ~ 1

Author(s):

Toua Antoine Coulibaly ◽

Rasmané Béogo ◽

Ibraïma Traoré ◽

Héra Michel Kohoun ◽

Biévianda Vincent Ili

Keyword(s):

Interpersonal Violence ◽

Soft Tissues ◽

Dental Trauma ◽

Tertiary Hospital ◽

Female Ratio ◽

Facial Injuries ◽

The Face ◽

Limb Fractures ◽

Male To Female ◽

Zygomatic Fractures

Introduction: Interpersonal violence (IPV) has emerged as a worldwide health problem affecting predominantly the face. Patients and methods: This study reports the characteristics of violence, victims and injuries in IPV-related facial injuries patients, in a 10-year survey, in a tertiary hospital of Burkina Faso. Results: Patients’ age ranged from 11 to 75 years (mean 31 years) and 58.2% of the patients were aged between 20 and 39 years. There were 74 males and females 24 giving a male-to-female ratio of 3.1:1. The circumstances of injuries were brawls (80.6%) consisting mostly in facial blows, and hold-ups (19.4%). Fractures involving predominantly the mandible or the zygomatic complex were the most common injury, accounting for 53.2%. Soft tissues injuries accounted for 37.2% and dental trauma for 9.2%. In 27.5% of the patients, extra facial injuries were encountered, dominated by cerebral trauma and limb fractures. Conclusion: In this study, IPV-related facial injuries are mostly mandibular or zygomatic fractures in young and males adults involved in brawls. These findings command strategies for prevention of violence in this specific group.

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Ameloblastoma of the mandible: analysis of radiographic and histopathological features

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2020051 ◽

2020 ◽

Vol 27 (1) ◽

pp. 6

Author(s):

Sanjay Ranchod ◽

Fadi Titinchi ◽

Nashreen Behardien ◽

Jean Morkel

Keyword(s):

Root Resorption ◽

Anatomical Variation ◽

Female Ratio ◽

Black African ◽

Histopathological Features ◽

Patient Demographics ◽

Odontogenic Origin ◽

African Patients ◽

Male To Female ◽

Common Benign Tumour

Introduction: Ameloblastoma is the most common benign tumour of odontogenic origin in Africa and presents five times more in the mandible than the maxilla. The presentation of ameloblastoma in the mandible is unique due to its anatomical variation and hence the aim of this study was to analyse the radiographic and histopathological features of ameloblastoma involving the mandible. Materials and methods: This was a retrospective, descriptive study of all histopathologically diagnosed ameloblastoma of the mandible over a period of 45 years. Patient demographics, radiographic and histopathological features were recorded and compared to previous studies. Results: A total of 148 lesions were included. The male to female ratio was nearly equal (1.05:1). The majority of patients were below 50 years of age (83.77%) and were black African (58.8%). The posterior region was the most affected site with majority of lesions presenting with multilocular appearance (68.24%) and root resorption (66.38%). Histologically, conventional ameloblastoma was the most common variant (48.65%). Conclusions: Mandibular ameloblastoma had a higher predilection for black African patients with higher prevalence of mixed density lesions when compared to previous studies. The size of lesions in this sample was considerably larger than those reported in previous studies. In addition, lesions in this sample also exhibited marked cortical expansion as well as root resorption.

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A retrospective study on clinicopathological correlation of cutaneous tuberculosis

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20184468 ◽

2018 ◽

Vol 4 (4) ◽

pp. 595 ◽

Cited By ~ 1

Author(s):

Rajkumar Kannan ◽

Lakshmanan Chellappan ◽

Sridhar Venu ◽

Muthusubramanian Chandrasekar

Keyword(s):

Skin Biopsy ◽

Lupus Vulgaris ◽

Active Lesion ◽

Female Ratio ◽

Cutaneous Tuberculosis ◽

Histopathological Features ◽

Medical College ◽

Histopathological Correlation ◽

High Clinical Suspicion ◽

Male To Female

Background: Cutaneous tuberculosis is a curable chronic infectious disease. The clinical presentation and histopathological interpretation of skin biopsy may show variations as various types of the disease exist. The clinical diagnosis should be confirmed by histopathological features before starting treatment for particular type of the disease.Methods: A retrospective hospital based study was conducted among patients in Chengalpattu medical college for last 3 years (May 2015 – April 2018) who had cutaneous tuberculosis. Skin biopsy taken from active lesion was stained with routine haematoxylin and eosin (H & E) stain.Results: Out of 20 cases, male to female ratio was 1.5:1. The age of the patients ranged from 11-68 years. Clinically, lupus vulgaris was the most common type of cutaneous tuberculosis with 35% cases followed by tuberculosis verrucosa cutis 20% cases, scrofuloderma 15% and atypical mycobacterial infections 10%, and least common types are lichen scrofulosorum 5% which correlates with the previous study of Aruna et al. Characteristic tuberculoid granulomas were seen in 71.4% cases of lupus vulgaris, all cases of scrofuloderma, lichen scrofulosorum and 80% of tuberculosis verrucosa cutis. The clinical and histopathological correlation was seen in 17 cases (85%).Conclusions: There can be overlap between different types of cutaneous tuberculosis with various other dermatological diseases, both clinically and morphologically and so correlation of clinical and histopathological features appears to be more useful for accurate diagnosis and typing of cutaneous tuberculosis. High clinical suspicion is necessary in cutaneous tuberculosis and early diagnosis and treatment are essential to prevent its complications.

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Containing Coronavirus Disease 2019 (COVID-19) in Belize

10.21203/rs.3.rs-32462/v1 ◽

2020 ◽

Author(s):

Kyle A. Habet ◽

Diomne Habet ◽

Gliselle Marin

Keyword(s):

National Level ◽

World Health ◽

Contact Tracing ◽

Female Ratio ◽

Additional Information ◽

First Case ◽

Community Transmission ◽

The Government ◽

Health Organization ◽

Male To Female

Abstract Objective: To demonstrate how Belize, a small country in Central America with limited resources, contained the spread of SARS-CoV-2 (COVID-19).Methods:Information was gathered from official press releases from the Government of Belize. Statistics were accessed from the Ministry of Health’s website. Additional information was acquired from internet searches on Pubmed and the World Health Organization.Results:Total Cases: 18; Male to female ratio: 1:1; Deaths: 2; Total Tests Done: 1,128; Percentage of positive tests: 1.59%, New cases per day since first case to plateau: 0.812.Conclusion: Early intervention on a national level was key to preventing importation of cases and subsequent community transmission. Limiting the conglomeration of people, curfews, closures of school and universities, government-mandated social distancing, and extensive contact tracing may have mitigated the exponential spread of COVID-19. Mandatory mask-wearing in public may have helped to prevent spread between asymptomatic carriers to susceptible individuals. A low population density may have also contributed to containing the virus.

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Myrid of histopathological features of malignancy in Xeroderma pigmentosum

Journal of Pathology of Nepal ◽

10.3126/jpn.v3i6.8996 ◽

2013 ◽

Vol 3 (6) ◽

pp. 472-475

Author(s):

S Karki ◽

G Pandey ◽

N Bhattarai

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Xeroderma Pigmentosum ◽

University Teaching ◽

Computer Data ◽

Female Ratio ◽

Histopathological Features ◽

Increased Risk ◽

The Face

Background: Xeroderma pigmentosum is a rare autosomal recessively inherited disorder affecting 1 in 2,50,000 population. It shows genetic heterogeneity with at least ten different complementation groups identified which have different clinical presentations. They tend to have a more than 1000 fold increased risk of developing cancers in sun-exposed areas as a result of a DNA repair defect. This study presents a myriad of histopathological features of malignancies seen in individuals with this rare. Materials and Methods: Biopsies received from patients with a clinical diagnosis of Xeroderma Pigemntosa at the department of pathology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, from April 2008 to June 2012 were included in the study. Hematoxylin and eosin stained sections were examined. Clinical history was retrieved from the computer data base of the department. Results: During the study period, a total of eleven cases of Xeroderma pigmentosum presented with a biopsied lesion. All of these were malignant lesions. No benign lesions were seen. The age range of these patients was 6-30years with a mean of 18.8 years. The male to female ratio was 4.5:1. The most common malignancy seen was squamous cell carcinoma 7/11 (63.6%) followed by basal cell carcinoma 2/11 (27.2%). A single case presented with basal cell carcinoma of face and melanoma of trunk. The frequently observed site of malignancy was skin of the face followed by conjunctiva. Conclusion: In our population, non melanotic skin cancers affecting the face are more common in young individuals with Xeroderma pigmentosum. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8996 Journal of Pathology of Nepal (2013) Vol. 3, 472-475

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Who Was the ‘Heroine’ of Freud's First Case History? Problems and Issues in the Identification of Freud's patients

Psychoanalysis and History ◽

10.3366/pah.2017.0199 ◽

2017 ◽

Vol 19 (1) ◽

pp. 7-54 ◽

Cited By ~ 3

Author(s):

Richard Skues

Keyword(s):

Case History ◽

The Real ◽

Hypnotic Suggestion ◽

Social Circle ◽

First Case ◽

The Face ◽

Historical Investigation

In 1892–3 Freud published his first substantial case history, which concerned a patient treated by means of hypnotic suggestion. For some years this has been one of the few remaining of Freud's dedicated cases histories where the patient has not been identified. More recently, however, two publications independently arrived at the conclusion that the patient was none other than Freud's wife, Martha. This paper sets out the reasons why this identification should always have been treated with suspicion, even if the real identity was not known. Nevertheless, the paper goes on to offer a more plausible identification from among Freud's known social circle. The second part of the paper questions the circumstances under which the original misidentification could plausibly have been sustained in the face of such glaring evidence to the contrary. It concludes that, among other reasons, recent tendencies in controversies about Freud's trustworthiness have the hazard of leading to unreliable assumptions about Freud's honesty being taken as a basis for sound historical investigation.

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Maxillofacial Bony Considerations in Facial Transplantation

Facial Plastic Surgery ◽

10.1055/s-0041-1726443 ◽

2021 ◽

Author(s):

Aurora G. Vincent ◽

Anne E. Gunter ◽

Yadranko Ducic ◽

Likith Reddy

Keyword(s):

Soft Tissue ◽

Current Literature ◽

Preoperative Planning ◽

Surgical Anatomy ◽

The Past ◽

Facial Transplantation ◽

Tissue Transfer ◽

Reconstructive Ladder ◽

The Face ◽

Facial Wounds

AbstractAlloplastic facial transplantation has become a new rung on the proverbial reconstructive ladder for severe facial wounds in the past couple of decades. Since the first transfer including bony components in 2006, numerous facial allotransplantations across many countries have been successfully performed, many incorporating multiple bony elements of the face. There are many unique considerations to facial transplantation of bone, however, beyond the considerations of simple soft tissue transfer. Herein, we review the current literature and considerations specific to bony facial transplantation focusing on the pertinent surgical anatomy, preoperative planning needs, intraoperative harvest and inset considerations, and postoperative protocols.

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Endovascular repair of de novo post-stenotic aortic coarctation aneurysms with complex collateral supply: two cases with long and medium term follow-up

CVIR Endovascular ◽

10.1186/s42155-020-00193-4 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Omar Abdel-Hadi ◽

John Thomson ◽

Simon J. McPherson

Keyword(s):

Stent Graft ◽

Endovascular Repair ◽

Aortic Coarctation ◽

De Novo ◽

Aortic Aneurysms ◽

Medium Term ◽

First Case ◽

Case Presentations ◽

Selective Embolisation

Abstract Purpose To report the technical details and outcomes of the endovascular repair of two cases of de novo post-stenotic aortic coarctation aneurysms complicated by complex collateral supply. Case presentations Two patients with thoracic aortic aneurysms complicated by complex aneurysm sac collaterals distal to a previously untreated thoracic aortic coarctation have been treated at our institution. Open surgical intervention was deemed to carry a high risk of haemorrhage due to the degree and complexity of arterial collateralisation. In the first case, selective embolisation of collateral vasculature was performed prior to successful exclusion of the aneurysm with a thoracic endovascular stent-graft and then balloon-expandable stent dilatation of the coarctation stenosis. In the second case, the additional technique of using a jailed sheath within the aneurysm sac allowed for selective embolisation of previously inconspicuous collaterals after deployment of the stent-graft and stent combination. Results Technical success was achieved in both patients with successful occlusion of the aneurysm, with no recorded complications or aneurysm sac perfusion in the long and medium term follow up periods respectively. Conclusion De novo post stenotic aortic coarctation aneurysms are rare. Endovascular repair is a safe and durable technique that provides a less invasive alternative to open surgical repair. The use of a jailed sheath allows for complete selective embolisation of complex collaterals avoiding a type II aneurysm endoleak.

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Pustular Rash in Crohn’s Patient on Ustekinumab Raises Concern for Drug-Induced Paradoxical Psoriasis

Case Reports in Gastroenterology ◽

10.1159/000514952 ◽

2021 ◽

pp. 662-666

Author(s):

Mitra Barahimi ◽

Scott Lee ◽

Kindra Clark-Snustad

Keyword(s):

Side Effect ◽

De Novo ◽

Pustular Psoriasis ◽

Initial Weight ◽

Drug Induced ◽

Clinical Recurrence ◽

Potential Side Effect ◽

First Case ◽

Tnf Antagonist ◽

Subcorneal Pustular Dermatosis

We report the case of a 51-year-old male with Crohn’s disease (CD) who developed a reproducible pustular rash after ustekinumab (UST) administration. The patient first presented with a pustular rash on his hands, body, extremities, and scalp starting 5 weeks after his initial weight-based UST induction. The rash resolved spontaneously, then recurred 4 weeks after his first subcutaneous maintenance dose of UST 90 mg. Biopsy of the affected area demonstrated subcorneal pustular dermatosis (SPD). UST was discontinued and the rash resolved. Unfortunately, the patient experienced clinical recurrence of CD, and given prior failure of multiple CD medications, UST was restarted with premedication. Two weeks after UST re-induction, the rash recurred, though less severe. Given improvement in CD symptoms, UST was continued and the rash managed with topical corticosteroids. This is the first case of drug-induced SPD associated with UST. One case report has previously described de novo pustular psoriasis associated with UST in a patient with CD and enteropathic arthritis. Notably, SPD and pustular psoriasis can be histologically indistinguishable. The development of a paradoxical psoriasiform rash is thought to be one of the few dose and duration dependent side effects of TNF-antagonist therapy but has not previously been established as a side effect of UST. This case demonstrates a new potential side effect of UST.

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