scholarly journals Host Defence Peptides in Diabetes Mellitus Type 2 Patients with Periodontal Disease. A Systematic Review

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2210
Author(s):  
Muhammad Saad Shaikh ◽  
Muhammad Sohail Zafar ◽  
Farhan Saleem ◽  
Ahmad Alnazzawi ◽  
Mohid Abrar Lone ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Periodontal Disease ◽  
Diabetes Mellitus Type 2 ◽  
Periodontal Diseases ◽  
Diabetes Mellitus Type ◽  
Host Defence ◽  
Screening Process ◽  
Cross Sectional

The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case-control, 6 cross-sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents.

scholarly journals Russel’s score and diabetes mellitus type 2 “finding the association”: a cross sectional study from one of the districts in Bihar, India

2019 ◽  
Vol 7 (3) ◽  
pp. 854
Author(s):  
Neeraj Kumar ◽  
Rishabh Kumar Rana ◽  
Vivek Kumar ◽  
Rohit . ◽  
Pramod Kumar Sinha
Keyword(s):  
Diabetes Mellitus ◽  
Periodontal Disease ◽  
Blood Sugar ◽  
Diabetes Mellitus Type 2 ◽  
Blood Sugar Level ◽  
Diabetes Mellitus Type ◽  
Cross Sectional ◽  
Terminal Disease ◽  
Sugar Levels

Background: Diabetes has been on the rise since last decade or so with prevalence rate changing as more research is being done. India is one of the most burdened country from diabetes specially type 2. With changing life style other diseases are also on the rise and evidence is being generated to find tangible association. One such disease is periodontitis. As evidence from the State of Bihar for association between periodontitis and diabetes mellitus is negligible this study was conducted to find the same.Methods: A cross sectional observational study in community settings was done for three months on 200 diabetic willing participants. Data was generated using a semi structured pretested questionnaire. Data analysis was done using SPSS version 22.0 and statistical measures of central tendency like mean, mode, median and standard deviation were used.  For establishing association chi square tests were used. P values<0.05 were considered to be statistically significant.Results: 61.5% of the participants were male while 65.5% were from rural area. The study population was on an average on the older side with a mean age of 52±12.15 and on the bulky size with a BMI of 28.85±4.08. Authors got the average Russel’s score to be 1.1±1.79. The mean blood sugar level for fasting was 146.40±59.99 and post prandial levels was 211.59±82.49. A Russel score category of established periodontal disease and terminal disease was present in 77.5% of participants having an altered fasting blood sugar level. Majority of the males had established periodontal disease and terminal disease. Patients with elevated postprandial blood sugar levels had more established periodontal disease and terminal disease.Conclusions: Oral health is definitely associated with diabetes mellitus type 2 and its other factors like duration, glycaemic control, blood sugar levels etc. Public awareness regarding this is minimal. More research and awareness regarding this will help in keeping the diabetic population healthy.

scholarly journals Association between obesity and depression in patients with diabetes mellitus type 2; a study protocol

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 7 ◽  
Author(s):  
Eduardo De la Cruz-Cano ◽  
Carlos Alfonso Tovilla-Zarate ◽  
Emilio Reyes-Ramos ◽  
Thelma Beatriz Gonzalez-Castro ◽  
Isela Juarez-Castro ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Diabetes Mellitus Type 2 ◽  
Cross Sectional Study ◽  
Diabetes Mellitus Type ◽  
Sectional Study ◽  
Cross Sectional ◽  
The World ◽  
Patients With Diabetes

Background: Diabetes mellitus and depression are highly prevalent conditions throughout the world and have significant impact on health outcomes. It has been estimated that diabetes mellitus type 2 affects about 246 million people in the world; nevertheless, incidence varies among countries. There is evidence that depression is associated with a poor metabolic control in patients with type 2 diabetes mellitus that present other health problems (such as hypertension and obesity). The aim of this study protocol is to determine if obesity increases the risk for depression in patient with diabetes type 2.Methods: The analysis will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).The studies suitable for inclusion will be assessed by the Newcastle-Ottawa Scale (NOS) to determine their methodological quality. To identify the studies of interest, we will search on PubMed and EBSCO databases. We will use the following keyword combinations: "Diabetes Mellitus type 2 AND obesity AND depression", "depression AND Diabetes Mellitus type 2", "Diabetes Mellitus type 2 AND body mass index cross sectional study", "depression AND obesity cross-sectional study". Causes for exclusion will be publications that studied patients diagnosed with diabetes mellitus type 1; articles that focused on the treatment and complications of diabetes mellitus type 2; publications that have studied other clinical or psychiatric conditions (for instance, seizure disorder or history of schizophrenia, bipolar disorder, psychotic symptoms or dementia).Conclusion: The results of this study will form the basis for a better understanding of the association between obesity and depression in patients with diabetes mellitus type 2, and will allow development of prediction tools and better interventions. It is evident that several modifiable and non-modifiable risk factors play an important role in the pathogenesis of diabetes among population. Currently, evidence for the deleterious effects of diabetes mellitus type 2 are based on cross-sectional or other observational designs. Therefore, this study will have important implications for future research and public health guidance.

scholarly journals Tingkat pengetahuan dan dukungan keluarga tidak berhubungan dengan kepatuhan menjalani terapi diet penderita diabetes mellitus tipe 2 di Puskesmas Kasihan II Bantul Yogyakarta

2016 ◽  
Vol 3 (2) ◽  
pp. 105
Author(s):  
Sri Astuti ◽  
Yhona Paratmanitya ◽  
Wahyuningsih Wahyuningsih
Keyword(s):  
Diabetes Mellitus ◽  
Family Support ◽  
Diabetes Mellitus Type 2 ◽  
Diet Therapy ◽  
Diabetes Mellitus Type ◽  
Knowledge Level ◽  
Cross Sectional ◽  
Kolmogorov Smirnov ◽  
Quota Sampling

<p><strong>ABSTRACT</strong></p><p><em><strong>Background</strong>: Diabetes mellitus (DM) can cause various chronic complications on the eyes, kidney, neuronal, and blood vessel. Family support is very important to motivate the patient in performing the treatment of diabetes mellitus or diet. Therefore, knowledge and family support can influence the undergoing treat mentor therapy of diabetes mellitus. Having the knowledge, patient can know impact of the disease and in the treatment of therapy that must be done. Good knowledge and family supports can improve patient compliance in undergoing diet.</em></p><p><em><strong>Objectives</strong>: To know the association between the knowledge level and family support with compliance in the diet therapy among the patients with diabetes mellitus type 2 in Puskesmas Kasihan II Bantul Yogyakarta.</em></p><p><em><strong>Methods</strong>: This was a quantitative descriptive research with cross sectional design. Sampling technique used was quota sampling, where sample were gained in accordance with research criteria of 68 people. Initially, data analysis used was Kolmogorov-Smirnov. Multivariate analysis used was multiple linier regression.</em></p><p><em><strong>Results</strong>: The research showed that the most of respondents had good knowledge level (82.4%) and also family support of the respondent towards compliance in the diet therapy of DM type 2 (51.5%). The compliance level of the respondents in the diet therapy of DM type 2 that was in the sufficient category as many as</em><br /><em>76.5%. Knowledge and family support did not relate with compliance in the diet of diabetes mellitus type 2 with p-value consecutively was 0.537 and 0.937. Knowledge level and family support had influence as many 11.5% toward diet pursuance. Knowledge level influenced more toward diet compliance (p=0.041).</em></p><p><em><strong>Conclusions</strong>: There was no association between knowledge level and family support with compliance in the diet therapy on the patient with diabetes mellitus type 2 in Puskesmas Kasihan II Bantul Yogyakarta.</em></p><p><strong>KEYWORDS</strong><em>: knowledge, family support, diabetes mellitus</em></p><p><strong>ABSTRAK</strong></p><p><em><strong>Latar belakang</strong>: Diabetes mellitus adalah keadaan hiperglikemi kronik yang disertai berbagai kelainan akibat gangguan hormonal yang menimbulkan berbagai komplikasi kronik pada mata, ginjal, saraf, dan pembuluh darah. Dukungan keluarga sangat penting untuk memotivasi pasien dalam menjalankan</em><br /><em>pengobatan ataupun diet diabetes mellitus. Oleh karena itu pengetahuan dan dukungan keluarga sangat mempengaruhi dalam menjalankan pengobatan maupun terapi diabetes mellitus, karena dengan pengetahuan yang dimiliki pasien bisa mengetahui tentang penyakitnya, dampak-dampak dari penyakitnya, </em><em>serta berpengaruh dalam pengobatan maupun terapi yang harus dilakukan, salah satunya adalah diet diabetes mellitus dan pengetahuan yang baik serta adanya dukungan dari keluarga dapat meningkatkan kepatuhan pasien dalam menjalani diet.</em></p><p><em><strong>Tujuan</strong>: Mengetahui hubungan pengetahuan dan dukungan keluarga dalam menjalani terapi diet di Puskemas Kasihan II Bantul Yogyakarta.</em></p><p><em><strong>Metode</strong>: Penelitian ini bersifat deskriptif kuantitatif dengan rancangan cross sectional. Teknik pengambilan sampel yang digunakan yaitu quota sampling dan diperoleh 68 orang. Teknik analisis data yang digunakan yaitu uji Kolmogorov-Smirnov. Analisis multivariat menggunakan regresi linear.</em></p><p><em><strong>Hasil</strong>: Penelitian menunjukkan tingkat pengetahuan responden sebagian besar tergolong baik yaitu sebanyak 82,4% (56 orang), dukungan keluarga responden terhadap kepatuhan dalam menjalani terapi diet DM tipe 2 yaitu sebagian besar dengan kategori baik sebanyak 51,5% (35 orang), tingkat kepatuhan responden dalam menjalani terapi diet DM tipe 2 yaitu dalam kategori cukup yaitu sebanyak 76,5% (52 orang). Untuk pengetahuan dan dukungan keluarga tidak ada hubungan dengan kepatuhan dalam menjalani diet diabetes mellitus tipe 2 dengan menggunakan rumus Kolmogorov-Smirnov didapatkan nilai p=0,537;&gt;0,05, nilai p=0,937; &gt;0,05. Koefi sien determinasi variabel bebas mempengaruhi variabel terikat sebesar 11,5 % oleh variabel tingkat pengetahuan dan dukungan keluarga.</em></p><p><em><strong>Kesimpulan</strong>: Tidak ada hubungan antara pengetahuan dan dukungan keluarga dengan kepatuhan dalam menjalani diet diabetes mellitus tipe 2 di Puskesmas Kasihan II Bantul Yogyakarta.</em></p><p><strong>KATA KUNCI</strong><em>: pengetahuan, dukungan keluarga, diabetes mellitus</em></p>

scholarly journals Systematic Review: Are the Elderly With Diabetes Mellitus Type 2 Prone to Fragility Fractures?

Cureus ◽  
2021 ◽  
Author(s):  
Ioannis Papaioannou ◽  
Georgia Pantazidou ◽  
Zinon Kokkalis ◽  
Neoklis Georgopoulos ◽  
Eleni Jelastopulu
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Diabetes Mellitus Type 2 ◽  
Fragility Fractures ◽  
The Elderly ◽  
Diabetes Mellitus Type

scholarly journals Relevance of anthropometric measurements as predictors of prevalent diabetes type 2: a cross-sectional study on a Norwegian population

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e046162
Author(s):  
Anton Hasselgren ◽  
Biraj Man Karmacharya ◽  
Ann-Katrin Stensdotter
Keyword(s):  
Diabetes Mellitus ◽  
Outcome Measures ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Secondary Outcome ◽  
Anthropometric Indices ◽  
Cross Sectional ◽  
Norwegian Population ◽  
Potential Association

ObjectivesThe objective was to determine the predictive potential of anthropometric indices to screen prevalent diabetes mellitus type 2 in a Norwegian population.DesignThis is a cross-sectional design to determine the potential association of waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), waist circumference (WC) and body mass index (BMI) with prevalent diabetes mellitus type 2 through logistic regression analysis. Receiver operating characteristic (ROC) curves were used to determine the predictive potential of the anthropometric indices. Youden’s index was applied to determine the optimal cut-off points for each anthropometric index.SettingThis study used cross-sectional data from the populations-based Health Study in Nord-Trøndelag which invited all citizens in the county above 20 years of age.ParticipantsThis study included all those who were non-pregnant and had complete data (N=50 042), 98.5% of the participants. The sample is to be considered representative for the population of Norway.Primary and secondary outcome measuresOR and ROC of the potential association between diabetes mellitus type 2 and anthropometric indices were the main planned and performed outcome measures.ResultsThe results suggest that the anthropometric indices performed differently within the Norwegian population with WHR and WHtR being the stronger predictor with (ROC) of 0.746 (0.735 to 0.757) and 0.741 (0.730 to 0.752). The predictive potential for the investigated anthropometric indices was generally stronger for women than men.ConclusionAnthropometric indices of size BMI and the highly correlated WC are less associated with prevalent diabetes mellitus type 2 than WHR (WC adjusted for hip circumference) or WHtR (WC adjusted for height) in a Norwegian population.

scholarly journals Faktor-Faktor yang Mempengaruhi Kepatuhan Pengobatan pada Pasien Diabetes Mellitus Rawat Jalan di RSUD Sukoharjo

2020 ◽  
Vol 17 (2) ◽  
pp. 110-120
Author(s):  
Tri Yulianti ◽  
Lusi Anggraini
Keyword(s):  
Diabetes Mellitus ◽  
Medication Adherence ◽  
Diabetes Mellitus Type 2 ◽  
Sampling Technique ◽  
Diabetes Mellitus Type ◽  
P Value ◽  
Affecting Factors ◽  
Chi Square ◽  
Cross Sectional

Diabetes mellitus is a chronic metabolic with high prevalence and it can increase the risk of the complications, if it not handled properly. Medication adherence is one of the determining factor to achive therapeutic outcome. This research aims to determine the affecting factors of adherence in  diabetes mellitus type 2 outpatient at RSUD Sukoharjo in 2020. This research type is  cross sectional with a purposive sampling technique. A total of 85 patients diabetes mellitus type 2 outpatient at RSUD Sukoharjo with inclusion criteria received OAD therapy (Oral Antidiabetic Drugs) or a combination of OAD with insulin for at least 1 month, recruited in this study. The data was collected from medical records and questionnaires. Adherence was measured by using the MARS 5 questionnaire (Medication Adherence Report Scale 5). Factors contributing to medication adherence was analyzed by using chi-square test. The results showed that 37 respondents (43.5%) were obedient. The significant factors of medication adherence are monthly income (p-value = 0.018 and OR = 2.887), Medication (p - value = 0.007 and OR = 3,551), the frequency of treatment (p-value = 0.006 and OR = 3,529) and blood glucose level (p-value = 0.006 and OR = 3,529).

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