scholarly journals Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 45
Author(s):  
Hai Xin ◽  
Sina Naficy
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Structural Integrity ◽  
Delivery Systems ◽  
Cancer Therapies ◽  
Stimuli Responsive ◽  
Injectable Hydrogels ◽  
Drug Efficiency

Breast cancer is the most common and biggest health threat for women. There is an urgent need to develop novel breast cancer therapies to overcome the shortcomings of conventional surgery and chemotherapy, which include poor drug efficiency, damage to normal tissues, and increased side effects. Drug delivery systems based on injectable hydrogels have recently gained remarkable attention, as they offer encouraging solutions for localized, targeted, and controlled drug release to the tumor site. Such systems have great potential for improving drug efficiency and reducing the side effects caused by long-term exposure to chemotherapy. The present review aims to provide a critical analysis of the latest developments in the application of drug delivery systems using stimuli-responsive injectable hydrogels for breast cancer treatment. The focus is on discussing how such hydrogel systems enhance treatment efficacy and incorporate multiple breast cancer therapies into one system, in response to multiple stimuli, including temperature, pH, photo-, magnetic field, and glutathione. The present work also features a brief outline of the recent progress in the use of tough hydrogels. As the breast undergoes significant physical stress and movement during sporting and daily activities, it is important for drug delivery hydrogels to have sufficient mechanical toughness to maintain structural integrity for a desired period of time.

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

2020 ◽  
Vol 21 (11) ◽  
pp. 1084-1098
Author(s):  
Fengqian Chen ◽  
Yunzhen Shi ◽  
Jinming Zhang ◽  
Qi Liu
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Epigenetic Therapy ◽  
Cancer Therapies ◽  
Therapeutic Benefits ◽  
High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

scholarly journals Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Gels ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. 14 ◽  
Author(s):  
Esfandyar Askari ◽  
Amir Seyfoori ◽  
Meitham Amereh ◽  
Sadaf Samimi Gharaie ◽  
Hanieh Sadat Ghazali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
High Capacity ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Post Surgery ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.

scholarly journals Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 837 ◽  
Author(s):  
Shi Su ◽  
Peter M. Kang
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Surface Stabilization ◽  
Recent Advances

Nanotechnologies have attracted increasing attention in their application in medicine, especially in the development of new drug delivery systems. With the help of nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization have also significantly improved the targeting capacity and therapeutic efficacy of the nanocarrier assisted drug delivery system. In this review, we evaluate recent advances in the development of different nanocarriers and their applications in therapeutics delivery.

Stimuli-responsive Drug Delivery Systems as an Emerging Platform for Treatment of Rheumatoid Arthritis

2019 ◽  
Vol 25 (2) ◽  
pp. 155-165 ◽  
Author(s):  
Xiao-Ling Xu ◽  
Kong-Jun Lu ◽  
Xiao-Qin Yao ◽  
Xiao-Ying Ying ◽  
Yong-Zhong Du
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Drug Exposure ◽  
Redox Status ◽  
Considerable Effect ◽  
Delivery Systems ◽  
Systemic Autoimmune Disease ◽  
Stimuli Responsive

Rheumatoid Arthritis (RA) is a systemic autoimmune disease accompanied by chronic inflammation. Due to the long-term infiltration in inflammatory sites, joints get steadily deteriorated, eventually resulting in functional incapacitation and disability. Despite the considerable effect, RA sufferers treated with current drug therapeutic efficacy are exposed to severe side effects. Application of Drug Delivery Systems (DDS) has improved these situations while the problem of limited drug exposure remains untackled. Stimuli-responsive DDS that are responsive to a variety of endogenous and exogenous stimuli, such as pH, redox status, and temperature, have emerged as a promising therapeutic strategy to optimize the drug release. Herein, we discussed the therapeutic regimes and serious side effects of current RA therapy, as well as focused on some of the potential stimuliresponsive DDS utilized in RA therapy. Besides, the prospective room in designing DDS for RA treatment has also been discussed.

Promises of Lipid-based Drug Delivery Systems in the Management of Breast Cancer

2021 ◽  
Vol 27 ◽  
Author(s):  
Nagarani Thotakura ◽  
Madan Mohan Gupta ◽  
Jitendra Singh Rajawat ◽  
Kaisar Raza
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Management ◽  
Breast Cancer Management ◽  
Clinical Benefits ◽  
The Common ◽  
Industrial Level

: Breast cancer is one of the leading types among the common non-cutaneous malignancies in women. All the curative methods available for its treatment are minimal due to their toxicity issues and dose-related side effects. Various evolving nanotechnology techniques displayed the opportunity to target breast cancer. One such delivery system is lipid-based drug delivery systems (LDDS). This concept is constrained only for the laboratory scale should be shifted to the industrial level targeting the nanomedicine with clinical benefits. This work tried to portray the advancements in the LDDS along with the lipid-based excipients, advantages, disadvantages and applications. It even helped in highlighting the recently developed lipid-based nanocarriers for breast cancer management.

Nanofibrous drug delivery systems for breast cancer: a review

2021 ◽  
Author(s):  
Tanveer Hussain ◽  
Seeram Ramakrishna ◽  
Sharjeel Abid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Radiation Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Breast Conserving Surgery ◽  
Delivery Systems ◽  
Breast Cancer Cell Lines ◽  
Cancer Drugs ◽  
Anti Cancer

Abstract Breast cancer is the most common type of cancer among women. Breast-conserving surgery (BCS) is becoming a preferred approach for treating non-invasive or early-stage breast cancer cases. However, local-regional recurrence (LRR) is one of the critical risk factors after BCS. As many as 10-20% of BCS cases may show LRR within 5 years and almost 50% within 10 years. Radiation therapy is one of the treatments used to prevent LRR after breast-conserving surgery. However, because of possible side-effects of radiation therapy, targeted drug delivery systems based on nanofibers loaded with anti-cancer drugs have been explored in recent years to control LRR after BCS. This paper aims to review different polymers and anti-cancer drugs used for developing nanofibrous drug delivery systems against other breast cancer cell lines. It was observed that the utilization of nanofibers scaffolds after mastectomy could decrease the recurrence of breast cancer cells to a great extent as these nanofibrous scaffolds release drugs in a sustained manner for a prolonged time. Besides, the side effects of chemotherapy on healthy cells could be avoided. To the best of our knowledge, no such review paper is available in the literature that focuses only on the nanofibers-based system for breast cancer therapy.

scholarly journals Peptide-Based Drug Delivery Systems

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1209
Author(s):  
Dmitriy Berillo ◽  
Adilkhan Yeskendir ◽  
Zharylkasyn Zharkinbekov ◽  
Kamila Raziyeva ◽  
Arman Saparov
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Molecular Mechanisms ◽  
Polymeric Micelles ◽  
Solid Phase ◽  
Cell Penetrating Peptides ◽  
Delivery Systems ◽  
Stimuli Responsive

Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective trends in the development of drug delivery systems was needed. This review paper summarizes data, mainly from the past 5 years, devoted to the use of peptide-based carriers for delivery of various toxic drugs, mostly anticancer or drugs with limiting bioavailability. Peptide-based drug delivery platforms are utilized as peptide–drug conjugates, injectable biodegradable particles and depots for delivering small molecule pharmaceutical substances (500 Da) and therapeutic proteins. Controlled drug delivery systems that can effectively deliver anticancer and peptide-based drugs leading to accelerated recovery without significant side effects are discussed. Moreover, cell penetrating peptides and their molecular mechanisms as targeting peptides, as well as stimuli responsive (enzyme-responsive and pH-responsive) peptides and peptide-based self-assembly scaffolds are also reviewed.

Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery

2020 ◽  
Vol 13 (4) ◽  
pp. 291-300 ◽  
Author(s):  
Srividya Gorantla ◽  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Prem Prakash Singh ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Age Related Macular Degeneration ◽  
Stimuli Responsive ◽  
Duration Of Action ◽  
Age Related ◽  
Aqueous Gels ◽  
Ophthalmic Delivery ◽  
3D Printed

Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.

Sign in / Sign up

Export Citation Format

Share Document