scholarly journals Microbiota and Human Reproduction: The Case of Male Infertility

2020 ◽  
Vol 9 (2) ◽  
pp. 10 ◽  
Author(s):  
Rossella Tomaiuolo ◽  
Iolanda Veneruso ◽  
Federica Cariati ◽  
Valeria D’Argenio
Keyword(s):  
Human Physiology ◽  
Male Infertility ◽  
Reproductive System ◽  
Pregnancy Outcomes ◽  
Reproductive Tract ◽  
State Of The Art ◽  
The State ◽  
Human Reproduction ◽  
Offspring Health

The increasing interest in metagenomics is enhancing our knowledge regarding the composition and role of the microbiota in human physiology and pathology. Indeed, microbes have been reported to play a role in several diseases, including infertility. In particular, the male seminal microbiota has been suggested as an important factor able to influence couple’s health and pregnancy outcomes, as well as offspring health. Nevertheless, few studies have been carried out to date to deeper investigate semen microbiome origins and functions, and its correlations with the partner’s reproductive tract microbiome. Here, we report the state of the art regarding the male reproductive system microbiome and its alterations in infertility.

The Effect of PDE5 Inhibitors on the Male Reproductive Tract

2020 ◽  
Vol 26 ◽  
Author(s):  
Nikolaos Sofikitis ◽  
Aris Kaltsas ◽  
Fotios Dimitriadis ◽  
Jens Rassweiler ◽  
Nikolaos Grivas ◽  
...  
Keyword(s):  
Male Infertility ◽  
Reproductive Tract ◽  
Tunica Albuginea ◽  
Scientific Data ◽  
Secretory Function ◽  
Pde5 Inhibitors ◽  
Male Reproductive Tract ◽  
Review Study ◽  
Phosphodiesterase 5

The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albuginea and the epididymis. Moreover scientific data suggest that PDE5 inhibitors enhance the prostatic secretory function leading to an improvement in sperm motility. Other studies additionally demonstrate a role of PDE5 inhibitors in the regulation of sperm capacitation process. Placebo-controlled, randomized, blind studies are necessary to unambiguously incorporate PDE5 inhibitors as an adjunct tool for the pharmaceutical treatment of semen disorders and male infertility.

scholarly journals Bitter Taste Receptors Expression in Human Granulosa and Cumulus Cells: New Perspectives in Female Fertility

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3127
Author(s):  
Bianca Semplici ◽  
Francesca Paola Luongo ◽  
Sofia Passaponti ◽  
Claudia Landi ◽  
Laura Governini ◽  
...  
Keyword(s):  
Reproductive System ◽  
Bitter Taste ◽  
Receptor Activation ◽  
Female Fertility ◽  
Human Reproduction ◽  
Receptor Subtype ◽  
Taste Receptors ◽  
Female Reproductive System ◽  
Bitter Taste Receptors

Bitter taste receptors (TAS2RS) expression is not restricted to the oral cavity and the presence of these receptors in the male reproductive system and sperm provides insights into their possible role in human reproduction. To elucidate the potential role of TAS2Rs in the female reproductive system, we investigated the expression and localization of bitter taste receptors and the components of signal transduction cascade involved in the pathway of taste receptors in somatic follicular cells obtained from women undergoing assisted reproductive techniques. We found that TAS2R genes are expressed in both cumulus (CCs) and granulosa (GCs) cells, with TAS2R14 being the most highly expressed bitter receptor subtype. Interestingly, a slight increase in the expression of TAS2R14 and TAS2R43 was shown in both GCs and CCs in young women (p < 0.05), while a negative correlation may be established between the number of oocytes collected at the pickup and the expression of TAS2R43. Regarding α-gustducin and α-transducin, two Gα subunits expressed in the taste buds on the tongue, we provide evidence for their expression in CCs and GCs, with α-gustducin showing two additional isoforms in GCs. Finally, we shed light on the possible downstream transduction pathway initiated by taste receptor activation in the female reproductive system. Our study, showing for the first time the expression of taste receptors in the somatic ovarian follicle cells, significantly extends the current knowledge of the biological role of TAS2Rs for human female fertility.

The Role of Electrolyte’s Organic Additives in Zinc-Air Batteries

2021 ◽  
Author(s):  
Hamed Pourzolfaghar ◽  
Soraya Hosseini ◽  
Marziyeh Alinejad
Keyword(s):  
State Of The Art ◽  
Cost Effective ◽  
The State ◽  
Commercial Application ◽  
Organic Additives ◽  
P Addition ◽  
Zinc Air Batteries

Addition of the organic additives to the electrolyte is one of the state-of-the-art and cost-effective solutions to develop an appropriate rechargeable ZABs able to be promoted towards commercial application. In this mini review, some of the most important organic additives have been reviewed and their functions in the zinc air batteries have been investigated.

Wearable Technologies for Helping Human Thermophysiological Comfort

2018 ◽  
pp. 203-231
Author(s):  
Radostina A. Angelova
Keyword(s):  
State Of The Art ◽  
Wearable Devices ◽  
The State ◽  
The Body ◽  
Cold Environment ◽  
Human Comfort ◽  
Wearable Technologies ◽  
Thermoregulatory System ◽  
Intelligent Clothing

The thermophysiological comfort is one of the aspects of the human comfort. It is related to the thermoregulatory system of the body and its reactions to the temperature of the surrounding air, activity and clothing. The aim of the chapter is to present the state of the art in the wearable technologies for helping the human thermophysiological comfort. The basic processes of body's thermoregulatory system, the role of the hypothalamus, the reactions of the body in hot and cold environment, together with the related injuries, are described. In the second part of the chapter smart and intelligent clothing, textiles and accessories are presented together with wearable devices for body's heating/cooling.

scholarly journals Microbiota and Human Reproduction: The Case of Female Infertility

2020 ◽  
Vol 9 (2) ◽  
pp. 12 ◽  
Author(s):  
Rossella Tomaiuolo ◽  
Iolanda Veneruso ◽  
Federica Cariati ◽  
Valeria D’Argenio
Keyword(s):  
Reproductive Tract ◽  
Assisted Reproductive Technologies ◽  
Embryo Implantation ◽  
Reproductive Technologies ◽  
Human Reproduction ◽  
Microbial Dysbiosis ◽  
Technical Issues ◽  
Almost All ◽  
Generation Sequencing

During the last decade, the availability of next-generation sequencing-based approaches has revealed the presence of microbial communities in almost all the human body, including the reproductive tract. As for other body sites, this resident microbiota has been involved in the maintenance of a healthy status. As a consequence, alterations due to internal or external factors may lead to microbial dysbiosis and to the development of pathologies. Female reproductive microbiota has also been suggested to affect infertility, and it may play a key role in the success of assisted reproductive technologies, such as embryo implantation and pregnancy care. While the vaginal microbiota is well described, the uterine microbiota is underexplored. This could be due to technical issues, as the uterus is a low biomass environment. Here, we review the state of the art regarding the role of the female reproductive system microbiota in women’s health and human reproduction, highlighting its contribution to infertility.

scholarly journals FSH for the Treatment of Male Infertility

2020 ◽  
Vol 21 (7) ◽  
pp. 2270 ◽  
Author(s):  
Livio Casarini ◽  
Pascale Crépieux ◽  
Eric Reiter ◽  
Clara Lazzaretti ◽  
Elia Paradiso ◽  
...  
Keyword(s):  
Male Infertility ◽  
State Of The Art ◽  
Hypogonadotropic Hypogonadism ◽  
Male Reproduction ◽  
Clinical Approach ◽  
Idiopathic Infertility ◽  
Infertile Men ◽  
First Case ◽  
New Compounds

Follicle-stimulating hormone (FSH) supports spermatogenesis acting via its receptor (FSHR), which activates trophic effects in gonadal Sertoli cells. These pathways are targeted by hormonal drugs used for clinical treatment of infertile men, mainly belonging to sub-groups defined as hypogonadotropic hypogonadism or idiopathic infertility. While, in the first case, fertility may be efficiently restored by specific treatments, such as pulsatile gonadotropin releasing hormone (GnRH) or choriogonadotropin (hCG) alone or in combination with FSH, less is known about the efficacy of FSH in supporting the treatment of male idiopathic infertility. This review focuses on the role of FSH in the clinical approach to male reproduction, addressing the state-of-the-art from the little data available and discussing the pharmacological evidence. New compounds, such as allosteric ligands, dually active, chimeric gonadotropins and immunoglobulins, may represent interesting avenues for future personalized, pharmacological approaches to male infertility.

Las metafunciones de Halliday en traducción

Babel ◽  
2020 ◽  
Vol 66 (3) ◽  
pp. 484-504
Author(s):  
Eirini Chatzikoumi
Keyword(s):  
State Of The Art ◽  
Systemic Functional Linguistics ◽  
Translation Studies ◽  
The State ◽  
Future Research ◽  
Functional Linguistics ◽  
Research And Teaching ◽  
Translator Training

Abstract This article addresses the contribution of Systemic Functional Linguistics (SFL) to translation and, specifically, the use of Halliday’s metafunctions in translation studies research. The aim is to provide the state of the art of the main findings and proposals of these studies regarding the role of metafunctions in translation and translation teaching, thus evaluating their relevance and applicability in this field. In order to achieve this, six studies were reviewed, three of them dedicated to metafunctional shifts and three to the use of metafunctions in translation teaching and evaluation. This critical bibliographic review allowed for the corroboration of the contribution of SFL to the field of translation, and for the deduction of relevant aspects for future research and teaching proposals. More precisely, the relevance of the incorporation of semantic metafunctions in translator training and evaluation is confirmed, and the possibility of a distinction between obligatory and optional metafunctional translation shifts is suggested.

The role of sustainability in the relationship between migration and smart cities: a bibliometric review

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Ali Mohamad Mouazen ◽  
Ana Beatriz Hernández-Lara
Keyword(s):  
State Of The Art ◽  
Smart Cities ◽  
Developed Countries ◽  
The State ◽  
Social Dimension ◽  
Content Type ◽  
Bibliometric Review ◽  
And Migration ◽  
The Relationship

Purpose Smart cities attract efficient and profitable economic activities, contribute to the societal welfare of their citizens and foster the efficient use and conservation of natural resources. Developing smart cities has become a priority for many developed countries, but as they are preferred destinations for migrants, this raises sustainability issues. They attract people who are seeking a better quality of life, smart services and solutions, a better environment and business activities. The purpose of this paper is to review the state of the art on the relationship between smart cities and migration, with a view to determining sustainability. Design/methodology/approach A bibliometric review and text mining analyses were conducted on publications between 2000 and 2019. Findings The results determined the main parameters of this research topic in terms of its growth, top journals and articles. The role of sustainability in the relationship between smart cities and migration is also identified, highlighting the special interest of its social dimension. Originality/value A bibliometric approach has not been used previously to investigate the link between smart cities and migration. However, given the current relevance of both phenomena, their emergence and growth, this approach is appropriate in determining the state of the art and its main descriptors, with special emphasis on the sustainability implications.

scholarly journals Title-Guided Encoding for Keyphrase Generation

2019 ◽  
Vol 33 ◽  
pp. 6268-6275 ◽  
Author(s):  
Wang Chen ◽  
Yifan Gao ◽  
Jiani Zhang ◽  
Irwin King ◽  
Michael R. Lyu
Keyword(s):  
Language Processing ◽  
Deep Neural Networks ◽  
State Of The Art ◽  
Relevant Information ◽  
The State ◽  
Main Body ◽  
Generation Task ◽  
Leading Role ◽  
Very High

Keyphrase generation (KG) aims to generate a set of keyphrases given a document, which is a fundamental task in natural language processing (NLP). Most previous methods solve this problem in an extractive manner, while recently, several attempts are made under the generative setting using deep neural networks. However, the state-of-the-art generative methods simply treat the document title and the document main body equally, ignoring the leading role of the title to the overall document. To solve this problem, we introduce a new model called Title-Guided Network (TG-Net) for automatic keyphrase generation task based on the encoderdecoder architecture with two new features: (i) the title is additionally employed as a query-like input, and (ii) a titleguided encoder gathers the relevant information from the title to each word in the document. Experiments on a range of KG datasets demonstrate that our model outperforms the state-of-the-art models with a large margin, especially for documents with either very low or very high title length ratios.

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