scholarly journals The Relationship between Sleep Duration and Perceived Stress: Findings from the 2017 Community Health Survey in Korea

2019 ◽  
Vol 16 (17) ◽  
pp. 3208 ◽  
Author(s):  
Hwi Jun Kim ◽  
So Yeon Oh ◽  
Jae Hong Joo ◽  
Dong-Woo Choi ◽  
Eun-Cheol Park
Keyword(s):  
Community Health ◽  
Sleep Duration ◽  
Perceived Stress ◽  
Health Survey ◽  
Chi Square ◽  
Sleeping Time ◽  
Community Health Survey ◽  
Chi Square Test ◽  
Multivariable Regression ◽  
The Relationship

Sleep is exceedingly important for our physical, physiological, psychological, and social health. Currently, few Koreans get the recommended daily amount of sleep. Stress can also have a major impact on our physiological, neurological, and mental health. In this study, we explored the correlation between sleep duration and perceived stress. The study used data from the Community Health Survey (CHS), 2017, which included 133,444 responses from Koreans. Sleeping time and stress were measured by self-diagnosis. The relationship between sleeping time and stress was analyzed using the chi-square test and multivariable regression. Both men and women felt the most stress when they slept for an average of 6 h a day. The results of the subgroup analysis showed that even when they sleep for the same time, younger people felt more stressed than older people. In the group that slept for an average of 6 h a day, women were the most stressed. We observed a correlation between sleeping time and stress in Korean adults. We found that about 16.7% of Koreans were sleeping for less than 5 h. This is less than the 7–9 h of sleep recommended by the National Sleep Foundation (NSF). In addition, stress was found to increase when sleep was insufficient. In particular, it was also observed that young people who slept for less than 8 h felt stressed more easily.

Association between tumor mutational burden (TMB) and immune-related adverse events (irAEs) in patients (pts) with metastatic urothelial carcinoma (mUC) during checkpoint immunotherapy.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 489-489
Author(s):  
Elie W. Akl ◽  
Pier Vitale Nuzzo ◽  
Elio Adib ◽  
Amin Nassar ◽  
Sarah Abou Alaiwi ◽  
...  
Keyword(s):  
Sequencing Data ◽  
Chi Square ◽  
P Values ◽  
Exact Test ◽  
Radiological Data ◽  
Tumor Mutational Burden ◽  
Chi Square Test ◽  
Metastatic Urothelial Carcinoma ◽  
Multivariable Regression ◽  
The Relationship

489 Background: Immune checkpoint inhibition (ICI) has greatly improved clinical outcomes for pts with mUC and other cancers. ICI is associated with a class of AEs, deemed irAEs due to immune activation. Nonetheless, biomarkers associated with irAE are still lacking. We hypothesized that the immune response against neoantigens is partly responsible for irAEs and investigated the association between irAEs, TMB and response to ICI. Methods: We identified patients with mUC at Dana Farber Cancer Institute who were treated with ICI (monotherapy or combination) and had available tumor sequencing data through Oncopanel. TMB was calculated using the number of non-synonymous exonic mutations per megabase. The severity of irAEs was graded using CTCAE v.5.0. Mann-Whitney U test was performed to identify association between TMB, incidence and grade of irAEs. A cut-off of 10/mb was assigned for TMB. Fisher’s exact test was used to evaluate the radiologic response between pts with and without irAEs and low vs. high TMB. Multivariable linear regression was used to assess the relationship between TMB, irAEs and response. p-values were adjusted using Benjamini-Hochberg method. Results: Of 101 pts with mUC who met the inclusion criteria, 32 (32%) reported irAEs. 6 (6%) were grade (G)1, 20 (20%) were G2, and 6 (6%) were G3. Median(m) time on therapy was 84 days for pts without irAEs and 88 days for pts with irAEs. Pts with irAEs had higher mTMB (15.4/mb) compared to pts with no irAEs (9.8) ( p = 0.01). In pts on monotherapy (93), those with irAEs (n=27) had a higher mTMB (15.13/mb) compared to pts with no irAEs (n=66) (mTMB = 10.20/mb) ( p = 0.01). Out of 94 pts with radiological data, response was achieved in 16 (50%) pts with irAE vs 10 (16%) pts with no irAE ( p < 0.001). When both irAE and response were included in a multivariable regression, the association between irAE and TMB was not significant ( p = 0.4). Pts with both irAE and high TMB had a response rate of 56% which was significantly higher than those with either irAE but low TMB (28.6%) or high TMB but no irAE (21.2 %) or low TMB and no irAE (10.3%) (Chi-square test p = 0.002; FDR corrected p-values for individual comparisons in Table). There was no association between TMB and irAE grade. Conclusions: Higher TMB was associated with higher incidence of irAEs in pts with mUC on ICIs. Moreover, pts with both high TMB and irAEs exhibited better response rates than those with only high TMB or irAEs, suggesting that they may provide complementary tumor and host characteristics. Further evaluation in mUC is needed to confirm this relationship between TMB, irAEs and response in a larger cohort and explore specific mutational signatures that may be associated with irAEs. [Table: see text]

scholarly journals The relationship between stroke and quality of life in Korean adults: based on the 2010 Korean community health survey

2015 ◽  
Vol 27 (1) ◽  
pp. 309-312 ◽  
Author(s):  
Ki-Jong Kim ◽  
Myoung Heo ◽  
In-Ae Chun ◽  
Hyun-Ju Jun ◽  
Jin-Su Lee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Community Health ◽  
Health Survey ◽  
Korean Adults ◽  
Community Health Survey ◽  
The Relationship

The Relationship between Sedentary Activities and Physical Inactivity among Adolescents: Results from the Canadian Community Health Survey

2006 ◽  
Vol 39 (4) ◽  
pp. 515-522 ◽  
Author(s):  
Naoko Koezuka ◽  
Malcolm Koo ◽  
Kenneth R. Allison ◽  
Edward M. Adlaf ◽  
John J.M. Dwyer ◽  
...  
Keyword(s):  
Community Health ◽  
Health Survey ◽  
Physical Inactivity ◽  
Canadian Community Health Survey ◽  
Community Health Survey ◽  
The Relationship ◽  
Sedentary Activities

scholarly journals The effects of mental health on recurrent falls among elderly adults, based on Korean Community Health Survey data

2020 ◽  
Vol 42 ◽  
pp. e2020005
Author(s):  
Kyung Hee Jo ◽  
Jong Park ◽  
So Yeon Ryu
Keyword(s):  
Mental Health ◽  
Community Health ◽  
Health Survey ◽  
Multinomial Logistic Regression ◽  
Treatment Strategies ◽  
Elderly Adults ◽  
Chi Square ◽  
Multinomial Logistic Regression Analysis ◽  
Recurrent Falls ◽  
Community Health Survey

OBJECTIVES: This study aimed to identify the effect of mental health on frequency of falls (single and recurrent falls) among elderly adults.METHODS: Data were drawn from the 2015 Korean Community Health Survey. A chi-square test was conducted to compare differences in fall frequency according to health-related behaviors, chronic diseases, and mental health. Subsequently, multinomial logistic regression analysis was used to identify the effects of mental health on single and recurrent falls based on variables found to be significant in the chi-square test.RESULTS: Recurrent falls were found to be more risky than single falls. Depression was significantly related to single falls (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.12 to 1.44). Depression (OR, 1.56; 95% CI, 1.38 to 1.76), sleep disorder (5 hours or less: OR, 1.12; 95% CI, 1.02 to 1.23; more than 9 hours: OR, 1.24; 95% CI, 1.07 to 1.44, respectively), and subjective stress (OR, 2.30; 95% CI, 1.90 to 2.78) were significantly related to recurrent falls.CONCLUSIONS: The study’s findings suggest that specialized fall prevention programs are needed to address different types of falls in elderly adults. To prevent recurrent falls, systematic treatment strategies and rehabilitation training must improve physical function and mental health.

Sign in / Sign up

Export Citation Format

Share Document